Introduction: Background: Advances in technology have allowed us to explore the possibility of performing Esophagectomy using minimal invasive surgical technique. Minimal invasive esophageal surgery has the potential to improve morbidity, mortality, hospital stay and functional outcomes when compared with open method. Although technically complex, combined laparoscopic and thoracoscopic esophageal resection is feasible. Most studies shows thoracoscopic mobilization of the esophagus in left lateral position with single lung ventilation with respiratory complication up to 8–9% where our series show potential of the thoracoscopic part of the procedure in prone position to overcome the difficulty. Methods: From March 2009 through December 2015, TLE was performed in 50 patients. All patients had histologically proved squamous cell carcinoma of the middle and lower third of the esophagus. Only one (0.77%) patient received neoadjuvant chemotherapy. The Thoracoscopic part of the procedure was performed in prone position with double lung ventilation and comfortable port placement for better view and ergonomics which significantly decreased the operative time and better post operative respiratory result. Laparoscopy done for gastric mobilization and conduit formation, minilaparotomy done to retrieved the specimen. Feeding jejunostomy was done in selective patients. Results: There were 38 men and 18 women. Median age was 64.5 years (range 34 to 72 years). There was no conversion to open method. Median ICU stay was 1 day (range 1 to 15 days) and median hospital stay was 7 days (range 4 to 22days). Perioperative mortality was 0.5% (n = 1). Anastomotic leak rate was 0.5% (n = 1). There was no incidence of tracheal or lung injury and a very low incidence of postoperative pneumonia. At mean follow up of 24month (range 2 to 7- month), stage–specific survival was similar to open and other minimally invasive series. Conclusion: Thoracolaparoscopic Esophagectomy is complex and technically difficult, but its safe in experience hand. Due to its comfortable view and excellent ergonomics in the prone position for thoracoscopy, patient do well and benefit from a shorted stay and more rapid recovery compared with open esophagectomy. It provides comparable outcomes with other techniques of minimally invasive esophagectomy and most open series. In our experience, we observed a low mortality rate (0.5%), hospital stay of 7 days, and low incidence of postoperative pneumonia. It has the potential to replace conventional and other techniques of minimally invasive esophagectomy.