Background Bipolar disorder (BD) diagnosis is based on specific set of mood and behavioural symptoms although they also exhibit cognitive dysfunction. Immune/inflammatory mechanisms have been implicated in the pathophysiology of BD. Objective To investigate whether cognitive functioning is associated with clinical parameters and immune profile in patients with BD in remission. Methods Twenty patients with BD type I in remission (15/20 female; age [mean ± SD] 43.80 ± 11.72 years; years of education [mean ± SD] 12.40 ± 3.39) and 25 healthy controls (16/25 female; age [mean ± SD] 43.52 ± 11.72 years; years of education [mean ± SD] 11.16 ± 2.66) matched for age, gender, and years of education were enrolled in this study. Subjects were evaluated with the Mini-Plus; Young Mania Rating Scale; Hamilton Depression Rating Scale; and with Brief Assessment of Cognition in Affective Disorders a comprehensive test battery to evaluate visuomotor, immediate affective and non-affective memory, verbal fluency, delayed affective and non-affective memory, inhibition, and problem solving domains. We assessed IL2, IL4, IL6, IL10, IL17, INF, TNF and its soluble receptors in plasma by flow cytometry. Results Patients with BD exhibited poorer performance on all cognitive domains in comparison with controls. Patients with BD also had high levels of soluble TNF receptors, and Th1/Th2/Th17 cytokines (p Conclusion Our data suggest that inflammatory dysfunction might contribute to the cognitive impairment in BD.