Probable Risk Factors Research Articles

Expanding the Phenotypic Spectrum of SPG7 Rare Damaging Variants: Insights From a Hungarian Cohort.

Mitochondria-associated paraplegin dysfunction is primarily linked to spastic paraplegia; however, genetic alterations in SPG7 have been associated with a broader spectrum of clinical symptoms. To identify disease-causing variants in the SPG7 gene, 437 patients with spastic ataxia, mitochondrial dysfunction-associated symptoms, or motoneuron lesions detected by EMG have been tested. We aimed to assess the clinical spectrum and determine the frequency of damaging variants within patient groups, particularly those less studied. Using ACMG criteria, we identified 10 pathogenic or likely pathogenic variants, 5 variants of uncertain significance with predicted damaging effects, and a probable risk factor variant in 58 patients. We identified 25 biallelic and 33 monoallelic cases. The most common variant was p. Leu78Ter (N = 23), followed by p. Ala510Val (N = 21). The point prevalence of SPG7-associated conditions in Hungary in 2024 is 0.46 per 100 000. In addition to well-characterized cohorts, SPG7 alterations were frequently identified in cohorts with multisystemic mitochondrial disease and lower motoneuron lesions. Multiple mtDNA deletions and histological abnormalities were consistently observed across all groups. In monoallelic cases, no evidence of a digenic effect involving AFG3L2 was found. Both autosomal dominant and recessive inheritance patterns were documented, with monoallelic cases typically presenting with a milder phenotype.

Chronic intestinal spirochaetosis and Giardia lamblia infection mimicking eosinophilic enterocolitis.

Chronic intestinal spirochaetosis and Giardia lamblia infection mimicking eosinophilic enterocolitis.

Risk factors of the appearance of anencephaly in Tunisia.

Anencephaly is a serious developmental defect of the central nervous system in which the brain and cranial vault are grossly malformed. The cerebrum and cerebellum are reduced or absent, but the hindbrain is present. Anencephaly is a part of the neural tube defect spectrum. This defect results when the neural tube fails to close during the third to fourth weeks of development, leading to fetal loss, stillbirth, or neonatal death. To find out probable principal risk factors for the appearance of anencephaly. This study was conducted to compare between pregnancies affected by anencephaly in 2002-2011 with those notified in the period 1991-2001. Statistical analysis was undertaken using chi-squared tests. Results had shown that anencephaly fetuses with a weight less than 1500 g were significantly higher in the period 2002-2011 than in 1991-2001 (P=0.003; OR= 4.32; CI= 1.62-11.53). Anencephaly cases aged more than 20 weeks of gestation (WG) were statistically elevated than cases aged less than 20 WG (P= 0.003). Maternal parity was associated with the appearance of anencephaly, where uni- or multiparous cases mothers were more likely to have an offspring with anencephaly than nulliparous mothers. Consanguinity presented a significant risk factor for the occurrence of anencephaly (P= 0.003). A logistic regression was run to examine the impact of several variables, only the maternal age was statistically significant. This study clarified fields where efforts should be intensified, and surveillance data developed to prevent this malformation.

Dental Implant Failure Risk in Patients with Bruxism-A Systematic Review and Meta-Analysis of the Literature.

Background/Objectives: Recent research has indicated that placing dental implants in patients diagnosed with bruxism has led to higher rates of implant failure. This study aimed to provide more accurate knowledge about the relationship between bruxism and implant loss in patients (number, age, gender) with different numbers of implants and prosthetic restorations, considering the follow-up time, compared to non-bruxers. Methods: A systematic search was conducted in PubMed and Cochrane Library using the keyword combination "dental implant", "bruxism", and "implant failure". This search had no language or time restrictions. Results: The review included 15 papers, which were divided into four groups. The first group focused on studies regarding implant loss regardless of the superstructure. In the second group, research on implant-supported removable prostheses was examined. The third group consisted of a single study specifically addressing implant-supported single crowns. Lastly, the fourth group comprised two studies investigating implant-supported single crowns and fixed partial dentures. Only three out of the fifteen studies failed to find a correlation between bruxism and implant failure. The meta-analysis shows a significant pooled effect across the included studies, with an odds ratio of 4.68. Conclusions: Bruxism is a probable risk factor for mechanical issues in implant-supported prostheses and implant-supported crowns. Additionally, elevated failure rates have been documented in patients with bruxism.

Predictive factors of early reactivation after ıntravitreal ranibizumab in agressive retinopathy of prematurity

Predictive factors of early reactivation after ıntravitreal ranibizumab in agressive retinopathy of prematurity

Consumption of Milk a Probable Risk Factor of Hypertension in India: A Study Based on National Family Health Survey-5

Introduction: Chronic high blood pressure, often known as hypertension, can cause a number of cardiovascular issues due to its higher blood pressure levels. A growing body of research points to a possible link between the use of dairy products and a higher risk of hypertension. Objectives: The present study aims to provide information regarding a probable association between dairy consumption and hypertension among the population of India. Methodology: The current study uses data from the fifth series of the National Family Health Survey (NFHS-5) 2019–21 in order to examine this association. The sample size is 724115 in total. This study included eight factors in total: systolic and diastolic blood pressure, age, religion, ethnicity, education, wealth index, and frequency of milk/curd consumption. IMB-SPSS version 26.0 was used for all data analysis. Results: It was found that those consuming milk products daily and weekly have very strong chances of having stage 1(95.3% and 93.2%, respectively in 95% CI) and stage 2 hypertension (92.4% and 90.4%, respectively in 95% CI). daily consumption of milk products also significantly increases 80.3% the chance of having stage 3 hypertension as well (95% CI). Conclusion: It is abundantly obvious from the current study that consuming milk and curd on a daily and weekly basis considerably raises your risk of developing stage 1, stage 2, and stage 3 hypertension. Given that India consumes the most milk globally and that the bulk of it is unpasteurized, it is crucial to consider the connection between milk consumption and hypertension discovered in the current study.

CHANGING TRENDS IN PAPILLARY CARCINOMA THYROID –A STUDY OF LOCAL RECURRENCE AND INCIDENCE IN AGGRESSIVE VARIANTS OF PAPILLARY CARCINOMA, A SINGLE INSTITUTIONAL STUDY

Background: The incidence of papillary carcinoma thyroids have undoubtedlyincreased in India especially in the largely due to various high quality imaging studies obtained. Theclassical papillary carcinoma thyroid (PTC) is highly curable in 85% of the cases due to its slow biological behaviour but the aggressive variants of papillary carcinoma does not have the same biological behaviour.The clinical treatment of these aggressive PTC variants should be tailored to the disease stage, with an understanding that these variants are often associated with higher-risk features. Methods: A prospective and retrospective observational study, where patients who underwent total thyroidectomy for papillary carcinoma thyroid from 2016 November to September 2022 are analysed. The incidence of aggressive variants, local recurrence rate and recurrence site and probable ethological and risk factors are collected. Result: The overall trend among the aggressive variants of papillary carcinoma thyroid is on a steady raise in the past 5 years with female predominance n=105(60%). Out of 175 cases n= 54 (38.3%) showed local recurrence with highest recurrence for clear cell variant n= 4 ( 80%). The association of Long standing thyroiditis Out of 175 patients n=60 (34.3%) patients have thyroiditis at the time of diagnosis of papillary carcinoma and Warthins variant showed strongest association 85% and it was stasistically significant (p =0.005) while other habituations like alcohol, smoking and life style diseases like DM and HTN have no association with aggressive variants of PTC Conclusion: It has been observed that there is consistent yearly increase in the incidence of aggressive variants of papillary carcinoma over the past 5 years with maximum number reported in the year 2021 -2022. The aggressive variants of PTC have been found to have more chance of Local recurrence and the most common site for local recurrence is Lymphnodes.Thyroiditis has been identified as an independent risk factor for developing aggressive variants of PTC, with statistical significance (p < 0.005).

Monitoring the frequency and risk factors of birth of children with congenital cleft lip and palate in the Volgograd region

The results of a study of the frequency, prevalence, structure, and probable risk factors of congenital cleft lip and palate (CCLP) in the Volgograd region for 2010–2021 are presented. There were no dynamics of increase or decrease in the birth rate of children with congenital cleft lip and palate. Over the past decade, the birth rate of children with CCHD varied from (1.25 ± 0.35) to (1.72 ± 0.41) per 1000 live births. Risk factors for the formation of CCLP in the form of an infectious disease suffered by the mother in the first trimester of pregnancy and taking drugs have been confirmed.

Association of HHV‑6 reactivation and SLC6A3 (C>T, rs40184), BDNF (C>T, rs6265), and JARID2 (G>A, rs9383046) single nucleotide polymorphisms in depression.

Major depressive disorder (MDD) is a global health concern with a complex etiology involving genetic, environmental and infectious factors. The exact cause of MDD remains unknown. The present study explored the association between genetic factors, human herpesvirus 6 (HHV-6) and MDD. The present study analyzed single nucleotide polymorphisms (SNPs) and HHV-6 viral load in oral buccal samples from patients with MDD (with and without blood relatives with MDD) and healthy controls. The study used high-resolution melt analysis to examine rs40184 (C>T) in the solute carrier family 6 member 3 (SLC6A31) gene, rs6265 (C>T) in the brain-derived neurotrophic factor (BDNF) gene and rs9383046 (G>A) in the jumonji and AT-rich interaction domain-containing 2 (JARID2) gene. HHV-6 infection and viral load was assessed using the quantitative PCR. Whole-exome sequencing was used to examine SNPs. The variant alleles of SNPs rs40184 [18/40 (45.00) vs. 29/238 (12.55%)] and rs6265 [30/54 (55.46) vs. 117/292 (40.06%)] were significantly more common in patients with MDD than in healthy controls, indicating they may be probable hereditary risk factors for MDD. HHV-6 positivity was significantly more common in carriers of the G/A genotype (12/15, 80%) than carriers of the G/G genotype (75/363, 20.7%) for rs9383046, implying that genetic variations may affect HHV-6 risk and MDD onset. Similarly, HHV-6 viral loads were significantly higher in carriers of the G/A genotype (99,990.85±118,392.64 copies/ng DNA) than carriers of the G/G genotype (48,249.30±101,216.28 copies/ng DNA) for rs9383046. Whole-exome sequencing identified two SNPs in JARID2 (rs11757092 and rs9383050) associated with MDD, highlighting its genetic complexity. The present study helps explain the complex interactions between HHV-6 infection, genetics and MDD onset, improving understanding of how SNPs in JARID2 contribute to HHV-6 infection and MDD onset; these findings may impact future approaches to diagnosing and treating MDD.

Phthalate Exposure and Pediatric Asthma: A Case Control Study Among Egyptian Children

Background: Phthalates, which are diesters of phthalic acid, are commonly used as plasticizers and additives in various consumer products. Several phthalates have been identified as substances of high concern. Exposure to phthalate esters (PAEs) has been linked to asthma in children, but the specific impacts of PAEs on asthmatic children were not well understood. Objective: The objective of this study was to compare urinary phthalate concentrations in asthmatic and non-asthmatic children and to identify potential sources of exposure as risk factors for asthma. Methods: A case control study was conducted for 100 Egyptian children aged 8-16 years (50 asthmatics and 50 healthy controls). Asthma was identified using GINA guidelines. Socio-demographic and probable risk factors were assessed, in addition to measuring phthalate levels in urine samples using high-performance liquid chromatography. Results and conclusion: Mean urinary Mono-methyl as well as Mono-benzyl levels were highly significant in asthmatic children compared to control group (895.26ng/ mL vs 548.55 ng/mL and 13.5 ng/mL vs 2.07 ng/mL respectively) (p= 0.001). The number of asthmatic children living in houses painted with non-plastic paint was significantly lower (P<0.05) than children living in houses painted with other paints. No association between floor type and asthma was reported. The frequent use of personal care products and plastic painting of walls were identified by multiple logistic regression analysis as the highly significant predictors of asthma in the studied subjects. The declared higher levels of urinary phthalate metabolites (Mono-methyl and Mono-benzyl) in Egyptian asthmatic children may reveal the probable risk of phthalate exposure in triggering bronchial asthma.

An estimation of the tower crane safety risk factors in the Vietnamese construction industry

The construction industry is among the riskiest sectors worldwide due to its involvement in complex and hazardous activities, primarily because of the use of tower cranes. Tower cranes are considered the most hazardous construction machinery, contributing to a high rate of serious accidents, including fatalities and disabling injuries, not only in Vietnam but also globally. In this paper, we identify and evaluate 42 tower crane safety risk factors specific to the Vietnamese construction industry based on their probability of occurrence, severity of impact, and associated risk levels. The paper reveals that the most probable risk factor is “Unfavorable winds (including intensity, direction, etc.)” with a mean value of 3.641. The factor with the highest severity is “Wire rope is broken” with a mean value of 4.179. Furthermore, the study shows that twenty-five out of forty-two (59.52%) factors present a moderate risk level, with a Relative Significant Index Score (RSIS) ranging from 8.019 to 13.047. Among these, the factor “Bad maintenance management of the tower crane and auxiliary aids” poses the highest risk level, with an RSIS value of 13.047. This paper aims to enhance the understanding oftower crane safety among subcontractors, government safety regulators, main contractors, maintenance personnel, and workers in the Vietnamese construction industry. Additionally, the methodology presented in this paper can be adapted for assessing safety risk factors in other industries within Vietnam.

Elucidating the effect of drug-induced mitochondrial dysfunction on insulin signaling and glucose handling in skeletal muscle cell line (C2C12) in vitro.

Efavirenz, tenofovir, rifampicin, simvastatin, lamotrigine and clarithromycin are known potential mitochondrial toxicants. Mitochondrial toxicity has been reported to disrupt the chain of events in the insulin signalling pathway. Considering the upward trajectory of diabetes mellitus prevalence, studies which seek to uncover probable risk factors for developing diabetes should be encouraged. This study aimed to evaluate the intracellular mechanisms leading to the development of insulin resistance in the presence of various conventional pharmacological agents reported as potential mitochondrial toxicants in skeletal muscle cell line. Differentiated C2C12 preparations were exposed to multiple concentrations of efavirenz, tenofovir, rifampicin, simvastatin, lamotrigine, and clarithromycin, separately. Glucose handling was evaluated by observing the changes in insulin-stimulated glucose uptake and assessing the changes in GLUT4 translocation, GLUT4 expression and Akt expression. The changes in mitochondrial function were evaluated by assessing mitochondrial membrane integrity, cellular ATP production, generation of intracellular reactive oxygen species, expression of tafazzin and quantification of medium malonaldehyde. Insulin stimulated glucose uptake was perturbed in C2C12 pre-treated with potential mitotoxicants. Additionally, ATP synthesis, alterations in mitochondrial membrane potential, excessive accumulation of ROS and malonaldehyde were observed in the presence of potential mitotoxicants. Particularly, we observed suppression of proteins involved in the insulin signalling pathway and maintenance of mitochondrial function namely GLUT4, Akt and tafazzin. Mitochondrial toxicants can potentially induce insulin resistance emanating from mitochondrial dysfunction. These new findings will contribute to the understanding of underlying mechanisms involved in the development of insulin resistance linked to mitochondrial dysfunction.

'Cheering on from the side-lines': The perceived impact of romantic partner's commentary and behaviour on maintaining women's appearance anxiety.

Appearance anxiety (AA) is a probable risk factor for body dysmorphic disorder and a prevalent and debilitating concern. Extant literature suggests that romantic partners' commentary and accommodation behaviour may contribute to women's appearance concerns. The aim of this study is to explore how women experience and make sense of romantic partner feedback about their appearance. Qualitative semi-structured interview study. Semi-structured interviews with 13 cis-gender women explored how they make sense of appearance anxiety in the context of romantic relationships. Reflexive thematic analysis with a hybrid inductive-deductive coding approach was utilised, drawing on cognitive behavioural theory (CBT) as a theoretical lens to interpret the data. Four themes were created from the data: (1) 'Then he said to me … you could probably tone up a bit': Maintaining cycles; (2) 'I think those comments down the line do eventually help': breaking out of maintenance cycles, (3) 'It's like they're talking in a foreign language'; beliefs as a filter and (4) 'Cheering me on from the side-lines'; romantic partner a supportive coach. These themes highlight the perceived unhelpful (e.g. accommodation of behaviours) and helpful (e.g. affection) impact of romantic partners' behaviours and commentary on participants' AA. Romantic partners are perceived by women to have a potent impact on their AA. Clinical practice implications include involving romantic partners in treatment, and clinicians using their formulation and CBT skills (e.g. Socratic questioning), to understand and target these possible maintenance processes within couples.

Impact on the nervous system of long COVID-19 infection in children.

The coronavirus disease 2019 (COVID-19) pandemic has had a profound global impact, raising concerns about its long-term effects, particularly neurological complications. While studies have highlighted such complications in adults, there is a paucity of research focusing on children. To examine the medium- to long-term neurological and cognitive symptoms in 18 year old children and below with positive versus negative COVID-19 antigens and to identify the probable risk factors to promote specific health actions. An observational study was carried out to determine neurological symptoms in the medium and long terms after COVID 19. A random sample of 124 children, both symptomatic or asymptomatic, tested positive or negative for COVID-19 through swab tests. Neurological symptoms were assessed between 6 to 12 months and 2 years after the infection. Acute symptoms, including headache, anosmia, ageusia, and myalgia, were observed in more than 20% of the children, but they generally resolved within 6 to 12 months. Persistent functional difficulties, such as in studying, paying attention, and socializing, were reported in 3% of the cases. Behavioral symptoms at baseline were noted in 7.8% of children, but they were remitted in most cases, except for those with prior involvement. These findings underscore the need for continued monitoring of children following COVID-19 infection and the importance of tailored health interventions.

Growth patterns and characteristics of cardiac pediatric patients attending Assiut University Children’s Hospital and Sidi Galal Health Insurance Clinic

Background and objectives Congenital heart disease (CHD) is the most common congenital anomaly, and it is one of the most debilitating diseases that affect physical growth disorders in children. Aim This study aims to assess growth patterns and identify probable risk factors in children with CHD. Patients and methods A case series study included 150 pediatric patients with CHD. The study comprised patients who visited Assiut University Children’s Hospital from July 2023 to February 2024. A personal interview questionnaire was used, which included sociodemographic characteristics, obstetric and neonatal history, feeding history, type of CHD, and anthropometric measurements. Results The noncyanotic group exhibited low weight for height/length and low height/length for age (P=0.028 and 0.003), whereas the cyanotic group only showed low weight for height/length (P=0.007). For the noncyanotic group, higher maternal age (P=0.023), multiparity (P=0.026), and delayed diagnosis of cardiac disease (P=0.005) could be risk factors for malnutrition, while vaginal delivery (P=0.034) and delayed physical development (P=0.034) could be risk factors for malnutrition in the cyanotic group. Conclusion Patients with noncyanotic cardiac lesions could suffer from acute or chronic malnutrition, while cyanotic lesions could suffer mainly from chronic malnutrition.

Seroprevalence of brucellosis among high-risk individuals in Madinah, Saudi Arabia.

Brucellosis is a highly contagious, neglected zoonotic disease of major importance worldwide. The disease is endemic in many countries, burdening healthcare systems and the livestock industry and representing a persistent public health concern in these countries. Brucellosis is considered an important occupational hazard for livestock workers. Limited studies have investigated human brucellosis in Saudi Arabia. Therefore, this study aimed to estimate the prevalence of brucellosis among employees of high-risk brucellosis professions, including veterinarians, animal herders, and abattoir workers in Madinah, Saudi Arabia, and to determine the associated risk factors. A cross-sectional study was conducted in Madinah, Saudi Arabia, during the period of January-March 2023. Ninety blood samples were collected from individuals occupationally at risk of exposure to Brucella infections. Serum samples were examined for immunoglobulins (Ig)M and IgG antibodies against Brucella using an indirect enzyme-linked immunosorbent assay. Before sample collection, a predesigned online questionnaire was used to collect the participants' sociodemographic characteristics and the probable risk factors for human brucellosis. A Chi-square test was used to compare the differences among groups; p < 0.05 were considered statistically significant. Among the 90 participants among the high-risk individuals, Brucella IgM and IgG seropositivity were found in 8 (8.8%) and 11 (12.12%) cases, respectively. IgM mono antibody positivity was observed in 4 (4.44%) and 7 (7.77%) of the study population who tested positive for IgG only. Dual positivity for IgM and IgG antibodies was observed in 4 (4.44%) participants. No significant association was determined between seropositivity and age, urbanicity, education, occupation, and duration of exposure (p > 0.05). Brucellosis is a high-risk occupational disease among workers with close contact with livestock. This study demonstrates that the seroprevalence of brucellosis among occupationally high-risk individuals in Madinah, Saudi Arabia, is relatively low compared to other countries in the region. Nevertheless, educational programs should be implemented to improve knowledge regarding brucellosis, particularly among high-risk individuals.

Diabetes Mellitus and Gynecological and Inflammation Disorders Increased the Risk of Pregnancy Loss in a Population Study.

(1) Background: Diabetes mellitus (DM) induces oxidative stress and inflammation with negative effect on pregnancy outcomes. This study aimed to determine whether DM increases the risk of pregnancy loss and to identify other potential risk factors; (2) Methods: We identified female patients diagnosed with DM from 2000-2015 in the Taiwanese National Health Insurance Research Database according to the International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9 CM) code 250. The event was pregnancy loss, defined as ICD-9 CM codes 630-639, which was tracked until 31 December 2015. The control group included 4-fold more non-DM female patients who were matched for age and disease severity. Multivariate Cox regression was employed to determine the risk factors associated with pregnancy loss; (3) Results: The hazard ratio (HR) for the risk of pregnancy loss due to DM was 1.407 (95% confidence interval: 1.099-1.801, p = 0.007), and the risk factors for older age, gynecological disorders and inflammation disorders were included. (4) Conclusions: The study concluded that women with DM have a greater risk of experiencing pregnancy loss. Healthcare providers should proactively manage and educate diabetic patients to reduce their risk of pregnancy loss. Understanding other probable risk factors can help in developing targeted interventions and support systems for women to improve pregnancy outcomes.

The causal relationship of serum uric acid on colorectal cancer: A Mendelian randomization study.

Colorectal cancer (CRC) is a significant public health issue owing to its widespread occurrence and substantial morbidity and mortality rates. Recent studies have highlighted serum uric acid (SUA) level as a probable risk factor for CRC; however, the inconsistency in these findings has created doubt. We performed a Mendelian randomization (MR) study utilizing extensive cohort data from the UK BioBank and the NHGRI-EBI Genome-Wide Association Study (GWAS) Catalog to investigate the causal connection between SUA levels and CRC incidence. Our MR study addresses the constraints of earlier studies, including limited sample sizes and inconsistent results. Considering SUA levels as the exposure and CRC as the outcome, the inverse variance-weighted (IVW) approach in MR showed that the odds ratios (ORs) for CRC for each unit increase in SUA were 0.232 (95% confidence interval [CI] of OR 0.094-0.570; P = .001) and 0.551 (95% CI of OR 0.325-0.934; P = .027). Pleiotropic tests and sensitivity analysis confirmed minimal horizontal pleiotropy and the robustness of causality. Our research deepens the understanding of the association between SUA levels and CRC, offering insights into prevention strategies and patient outcomes prediction.

Detection of Salmonella, Arcobacter, and Campylobacter spp. Among Dogs in Amol, Northern Iran

Background: Augmenting the care of pets can have a significant effect on the transmission of microorganisms between humans and animals. Having pets creates a suitable environment for harmful microorganisms, such as intestinal pathogens, to transmit to humans in various ways. Pathogenic bacteria such as Salmonella, Campylobacter, and Arcobacter species are of significant importance as they are the main intestinal pathogens in humans and inhabit the digestive system of various animals. Objective: The purpose of this research was to investigate the prevalence of Salmonella, Campylobacter, and Arcobacter and to explore the probable risk factors associated with bacterial infections in dogs residing in Amol. Materials and Methods: In this study, 150 fresh stool samples were collected from the domestic dog population in Amol, northern Iran. To perform the test, DNA preparation and enrichment were first performed, and polymerase chain reaction (PCR) was then used to identify bacteria. Information about possible risk factors related to bacterial infection was collected using a questionnaire, and data analysis was done using SPSS version 21.0. Results: None of the samples tested in the study were infected with Arcobacter. A total of 35 samples were positive for Salmonella, and 43 samples were positive for Campylobacter. Conclusion: The study discovered the existence of harmful Campylobacter and Salmonella bacteria in the feces of dogs living with humans in Amol, northern Iran. Based on the results of the study, pet dogs can harbor harmful strains of Campylobacter and Salmonella that pose a risk to human health. Therefore, it can be stated that owning pet dogs poses a potential threat to humans and may present a health issue that requires control.

Long-term results of arthroscopic capsulolabral revision repair for failed anterior shoulder instability repair using suture anchors at a minimum of 10 years follow-up.

Arthroscopic revision anterior shoulder instability repair has been proposed, and early clinical results have been promising. However, long-term results after this procedure and the probable risk factors for failure have not been sufficiently discussed in the literature. Thirty-eight patients who were diagnosed with recurrent anteroinferior shoulder instability after failed Bankart repair, treated with ACRR between September 1998 and November 2003 and able to be contacted were included. Of these patients, 2 were excluded from the study due to the use of SureTak anchors for fixation, and 5 other patients refused to participate in the study due to lack of interest (3 patients) or lack of time (2 patients). The remaining shoulders were clinically examined at a minimum of ten years after surgery via the ASES, Constant, AAOS, Rowe, Dawson and VAS scores for pain and stability. Degenerative arthropathy was assessed with the modified Samilson-Prieto score. All 31 remaining shoulders were evaluated at a mean time of 11.86 years (142.4 months) after surgery. Six patients (19.35%) reported redisolcation after the revision procedure, 4 of whom were affected by a new significant shoulder trauma. The ROWE and Constant scores improved significantly. Moderate to severe dislocation arthropathy was observed in 19.4% of patients. Five patients (16.2%) were not satisfied with the procedure. Long-term follow-up after ACRR shows predictable results, with a high degree of patient satisfaction, good to excellent patient-reported outcome scores and minimal radiological degenerative changes. However, with an average recurrence rate of 19.3% after 11.86 years, the redislocation rate appears high. With careful patient selection, recurrence rates can be significantly reduced.