Print Volumes Research Articles

Methodology for determining the hardness and depth of the hardened layer (in Kazakh language)

The article discusses methods for determining the hardness and depth of the hardened layer. Stiffness is defined as the ratio of the amount of load to the surface area, projection area, or print volume. The following types of surface, projection and volumetric stiffness are distinguished:surface hardness-the ratio of the load to the surface area of the print; projection stiffness-the ratio of the load to the area of the print projection; volumetric stiffness-the ratio of the load to the print volume. Hardness is measured in three ranges: macro, micro, nano. Hardness is the degree to which mineralogy often encounters this when scratching one mineral with another. In addition, the hardness of a mineral is also known as the degree of resistance to the influence of external mechanical force. But the external mechanical effect itself will be slightly different, depending on how strongly the mineral resists.The article conducted research with examples of several methods for determining the hardness of the layer.

3D Printed Microneedles for the Transdermal Delivery of NAD+ Precursor: Toward Personalization of Skin Delivery.

3D printing of microneedles (μNDs) for transdermal therapy has the potential to enable patient personalization based on the target disease, site of application, and dosage requirements. To convert this concept to reality, it is necessary that the 3D printing technology can deliver high resolution, an affordable cost, and large print volumes. With the introduction of benchtop 4K and 8K 3D printers, it is now possible to manufacture medical devices like μNDs at sufficient resolution and low cost. In this research, we systematically optimized the 3D printing design parameters such as resin viscosity, print angle, layer height, and curing time to generate customizable μNDs. We have also developed an innovative 3D coating microtank device to optimize the coating method. We have applied this to the development of novel μNDs to deliver an established NAD+ precursor molecule, nicotinamide mononucleotide (NMN). A methacrylate-based polymer photoresin (eSun resin) was diluted with methanol to adjust the resin viscosity. The 3D print layer height of 25 μm yielded a smooth surface, thus reducing edge-ridge mismatches. Printing μNDs at 90° to the print platform yielded 84.28 ± 2.158% (n = 5) of the input height thus increasing the tip sharpness (48.52 ± 10.43 μm, n = 5). The formulation containing fluorescein (model molecule), sucrose (viscosity modifier), and Tween-20 (surface tension modifier) was coated on the μNDs using the custom designed microtank setup, and the amount deposited was determined fluorescently. The dye-coated μND arrays inserted into human skin (in vitro) showed a fluorescence signal at a depth of 150 μm (n = 3) into the skin. After optimization of the 3D printing parameters and coating protocol using fluorescein, NMN was coated onto the μNDs, and its diffusion was assessed in full-thickness human skin in vitro using a Franz diffusion setup. Approximately 189 ± 34.5 μg (5× dipped coated μNDs) of NMN permeated through the skin and 41.2 ± 7.53 μg was left in the skin after 24 h. Multiphoton microscopy imaging of NMN-coated μND treated mouse ear skin ex vivo demonstrated significantly (p < 0.05) increased free-unbound NADPH and reduced fluorescence lifetime of NADPH, both of which are indicative of cellular metabolic rates. Our study demonstrates that low-cost benchtop 3D printers can be used to print high-fidelity μNDs with the ability to rapidly coat and release NMN which consequently caused changes in intracellular NAD+ levels.

Step-by-Step Implementation of Three-Dimensional Print Technology in Preoperative Neurosurgery Planning.

This study presents a detailed methodology for integrating three-dimensional (3D) printing technology into preoperative planning in neurosurgery. The increasing capabilities of 3D printing over the last decade have made it a valuable tool in medical fields such as orthopedics and dental practices. Neurosurgery can similarly benefit from these advancements, though the creation of accurate 3D models poses a significant challenge due to the technical expertise required and the cost of specialized software. This paper demonstrates a step-by-step process for developing a 3Dphysical model for preoperative planning using free, open-source software. A case involving a 62-year-old male with a large infiltrating tumor in the sacrum, originating from renal cell carcinoma, is used to illustrate the method. The process begins with the acquisition of a CT scan, followed by image reconstruction using InVesalius 3, an open-source software. The resulting 3D model is then processed in Autodesk Meshmixer (Autodesk, Inc., San Francisco, CA), where individual anatomical structures are segmented and prepared for printing. The model is printed using the Bambu Lab X1 Carbon 3D printer (Bambu Lab, Austin, TX), allowing for multicolor differentiation of structures such as bones, tumors, and blood vessels. The study highlights the practical aspects of model creation, including artifact removal, surface separation, and optimization for print volume. It discusses the advantages of multicolor printing for visual clarity in surgical planning and compares it with monochromatic and segmented printing approaches. The findings underscore the potential of 3D printing to enhance surgical precision and planning, providing a replicable protocol that leverages accessible technology. This work supports the broader adoption of 3D printing in neurosurgery, emphasizing the importance of collaboration between medical and engineering professionals to maximize the utility of these models in clinical practice.

Construct functional PEGDA/CSMA/CuII photosensitive ink for SLA 3D printing of blood contact appliance

Stereolithography (SLA) is an emerging technology in three-dimensional printing that has garnered significant attention in the biomedical field due to its high printing fidelity, good biocompatibility, and high spatial resolution. Polyethylene glycol diacrylate (PEGDA) is commonly used as a photosensitive printing ink in SLA, and it possesses excellent biocompatibility, photosensitivity, processability, water solubility, and biomechanical tunability. Additionally, PEGDA exhibits unique anti-protein, platelet, and cell adhesion possibilities, making it a promising material for blood contact applications. However, cross-linking PEGDA using chain growth photopolymerization results in a high concentration of reactive functional groups, leading to high print volume shrinkage, decreased precision of the finished product, warping, deformation, and cracking. This study introduces a chemically modified methacryloylated chitosan (CSMA) as a cross-linking agent into the PEGDA ink. This strategy effectively reduces the volume shrinkage of the ink and imparts antimicrobial properties to the final product. The dual anticoagulation properties of PEGDA were achieved by loading divalent copper ion (CuII) into the ink, which better addresses the antimicrobial and anticoagulant needs in the physiological environment of blood. The results show that SLA printable inks based on PEGDA/CSMA/CuII have low swelling, high print fidelity, high stability, and good cell compatibility. Furthermore, by verifying the functionality of PEGDA/CSMA/CuII, the research shows that the bioprinting ink exhibits excellent antibacterial and anticoagulant properties, making it a promising material candidate for SLA 3D printing of blood purification, central venous catheter, and other semi-implanted blood materials. This study provides new ideas for developing multifunctional photosensitive inks in biomedical engineering.

FABRICACIÓN ADITIVA DE FÓRCEPS CON FIBRA DE CARBONO CONTINUA PARA EL ENTRENAMIENTO VIRTUAL DEL PARTO

Vaginal delivery assisted with forceps (FAVD) is an obstetric technique that involves the extraction of the fetus by traction and/or expansion of the birth canal with an instrument. Currently, the use of forceps allows for the resolution of pathological situations that would otherwise require a cesarean section with the risks of morbidity and mortality that this surgery entails. For this reason, there is a growing interest in increasing the percentage of FAVD, after obstetricians feel more confident after practicing in simulation workshops with mannequins and acquiring the necessary competencies for their correct use. The forceps is an instrument that requires a precise introduction and placement, so an electromagnetic tracking tool has been developed that knows, with high precision, the position of the instrument both inside the vagina and around the fetal head. With this, childbirth training is complemented by a virtual simulation, in real-time, that allows the internal position of the forceps to be seen, thus facilitating the learning and improvement of the introduction and placement technique. For this, the instrument must not contain any ferrous residue that interferes electromagnetically, so commercial forceps (made of stainless steel) are not valid. In this context, the reproduction of forceps has been proposed through additive manufacturing based on material extrusion (MEX). To obtain forceps that are as realistic as possible in terms of rigidity compared to commercial models, a nylon filament reinforced with carbon microfibers (Onyx) has been used to which continuous carbon fiber is added in successive layers. Given the limitations in the printing volume of the technology used (Mark Two), numerical simulations were carried out by finite element analysis and different proposals for dividing each piece and subsequent union by adhesives were made, finally developing the final solution. Keywords: additive manufacturing; carbon fiber extrusion; vaginal delivery forceps; medical training; electromagnetic tracking.

Tensile response of additively manufactured carbon/nylon joints using optical fibers and digital image correlation

ABSTRACT Additive manufacturing (AM) has gained popularity due to reduced production times of low-cost and geometrically complex structures. Due to technological constraints such as print volume, time, and thermal stability of large AM parts, adhesive joints are commonly used in assembling smaller components in large-scale polymeric structures. This work investigates the feasibility of using embedded optical fibers to monitor strain distributions within AM composite (carbon fiber/nylon) single-lap shear (SLS) joints. Internal strain distributions within the adhesive and surface strain fields of the SLS joints with AM adherends under tensile loads were obtained using optical fibers and digital image correlation, respectively. Results indicate negligible influence of optical fibers on the failure strength and axial stiffness of 3D-printed SLS joints under quasi-static loading. Higher strains were observed at the bond edges within the adhesive (using optical fiber) and the surface (using DIC) of the joints due to the rotation of the bond under loading. All specimens failed in the adherends beyond the bonded region due to their low interlaminar strength.

Анализ применения различных типов 3D-принтеров в машиностроении

Relevance. The article discusses the main types of 3D-printers that can be used in mechanical engineering. The analysis of the basic principles of operation, as well as the advantages, disadvantages and features of the use of these types of devices. In the end, the author will consider the possibilities of future research in the field of additive technologies. The purpose of the research. To conduct an in-depth analysis of the use of 3D-printing in mechanical engineering. The purpose of the article is to study the application, advantages and limitations of various types of 3D-printers used in mechanical engineering. It also evaluates factors that influence the choice of printer, such as material compatibility, resolution, print volume and print speed. The study highlights the problems faced when integrating 3D-printing into mechanical engineering. The article concludes with a summary of the main conclusions, a discussion of the implications for management and decision-making, as well as the definition of future research opportunities. The objectives of the study are to identify existing problems in the use of additive technologies in mechanical engineering and to consider possible applications in the future. The results of the study. The study provides an overview of 3D-printing in mechanical engineering, its importance and application. It discusses various types of 3D-printers, their features and capabilities. The article analyzes the use of 3D-printers in mechanical engineering, assesses the advantages, limitations and impact on product quality, production time and economic efficiency. Factors influencing the choice of printer are investigated, such as compatibility of materials and requirements, resolution, print volume, print speed, post-processing and scalability requirements. The study also identifies challenges and future directions of 3D-printing integration, including potential advances in printing technology. In conclusion, the main conclusions are presented, their importance for decision-making in mechanical engineering and recommendations for improving the printer selection process. Future research opportunities are also highlighted.

Influence of manufacturing factors on compressive behavior of soft architected composite with a 3D-printed cellular core

Soft material is widely used for energy dissipation in a diverse range of applications from shoe soles to bridge bearings. Recent advances in additive manufacturing enable more new classes of materials such as soft architected composites (SAC) with 3D-printed cores that are embedded into a soft matrix. SAC has demonstrated excellent load-carrying capacity, ductility, and energy absorption under compression compared to soft material alone, but the influence of key manufacturing factors remains unknown. In this work, we conducted experimental investigations on SAC specimens considering various manufacturing parameters, including the printing materials, volume fraction, filling pattern, and printing parameters. Notably, the SAC with the gyroid filling pattern demonstrates superior specific stiffness and specific energy absorption. The effect of the printing parameters on the SAC was non-linear, and the optimal values were influenced by the core geometries. The SAC unit filled with gyroid pattern and manufactured using optimized printing parameters exhibited significant improvement in specific stiffness and specific energy absorption over those with the same mass of reinforcing phase. These results can guide the further design of similar architected composite by considering the appropriate selection of manufacturing parameters and geometric designs. With the improved mechanical properties, the concept of SAC can be further used in developing lightweight and high-performing energy absorption and dissipation components and devices.

The Binding Fragments of Xavier University (Cincinnati, Ohio)

Abstract: This article provides an overview of the medieval manuscript items found in University Archives and Special Collections at Xavier University in Cincinnati, Ohio. After describing the history of the Xavier University collection, it offers descriptions of nineteen binding fragments recently found within twelve early print volumes and includes provenance information for those volumes when possible. The article ends by reflecting on the benefits of participation in the Peripheral Manuscripts Project and sharing how project outcomes are influencing Special Collections work at Xavier.

Development of a low-cost quad-extrusion 3D bioprinting system for multi-material tissue constructs

This study presents the development and characterization of a low-cost bioprinting system with a compact low-profile quad-extrusion bioprinting head for producing multi-material tissue constructs. The system, created by modifying an off-the-shelf three-dimensional (3D) printer, enables larger print volumes compared to extant systems. Incorporating gelatin methacrylate (GelMA) as a bioink model, the bioprinting system was systematically tested with two different printing techniques, namely the traditional in-air printing (IAP) mode along with an emerging support bath printing (SBP) paradigm. Structural fidelity was assessed by comparing printed structures under different conditions to the computer-aided design (CAD) model. To evaluate biological functionality, a placental model was created using HTR-8 trophoblasts known for their invasive phenotype. Biological assays of cell viability and invasion revealed that the cells achieved high cell proliferation rates and had over 93% cell viability for a 3-day incubation period. The multi-compartmental 3D-bioprinted in vitro placenta model demonstrates the potential for studying native cell phenotypes and specialized functional outcomes enabled by the multi-material capability of the quad-extrusion bioprinter (QEB). This work represents a significant advancement in bioprinting technology, allowing for the printing of complex and highly organized tissue structures at scale. Moreover, the system&amp;rsquo;s total build cost is only US$ 297, making it an affordable resource for researchers.

Silica Nanoparticle-Based Photoresin for THz High-Resolution 3-D Microfabrication by Two-Photon Polymerization

Two-photon polymerization is a promising fabrication technique for complex three-dimensional (3D) structures operating at TeraHertz (THz) given its sub- <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$\mu$</tex-math></inline-formula> m resolution with hundreds of mm <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex-math notation="LaTeX">$^{3}$</tex-math></inline-formula> print volume capability. However, standard photoresins exhibit unsuitably high THz absorption and have poor mechanical, chemical, and thermal stability. To address the latter three issues, a new photoresin (commercially known as GP-Silica) based on silica nanoparticles dispersed in a photocurable binder matrix has been recently developed. To assess its suitability for THz devices, we report the THz dielectric properties of GP-Silica and compare them with standard 3D printable materials. We find that GP-Silica outperforms the other photoresins by almost 5 times in terms of absorption, which finally unlocks additive manufacturing for THz applications.

Ultrasonic welding of printed/molded sustainable polymer specimens with energy directors

Fused deposition modeling is preferred to fabricate the biodegradable poly lactic acid (PLA) parts, owing to its impeccable characteristics, such as, customization, waste minimization and scalability. However, limited printing volume constraint restricts the ubiquitous applications of this technique. The current experimental investigation is focused on the employment of ultrasonic welding technique to address the printing volume challenge. The effect of infill density, type of energy directors (triangular (TED), semicircular (SCED) and cross energy directors (CED)) and different levels of welding parameters have been investigated on the mechanical and thermal behavior of welded joints. Presence of rasters and gap between them plays a pivotal role in overall heat generation at weld interface. The joint performance of 3D printed parts has also been compared with injection molded specimens of same material. All printed/molded welded specimens with CED recorded higher tensile strength than equivalent specimens with TED and SCED. Moreover, These specimens also performed better than specimens without energy directors and recorded higher tensile strength, that is, 317, 73.5, 59.7 and 42% higher for injection molded (IM), 80%, 90% and 100% infill density (IF) specimens without energy directors at lower level of welding parameters (LLWP). These specimens also exhibited higher tensile strength at optimal levels of welding parameters. Although, at medium and higher levels of welding parameters, both printed/molded specimens with CED observed comparatively more degradation of joints due to higher concentration of energy at weld interface. The dynamic mechanical analysis (DMA), thermogravimetric analysis (TGA), derivative thermogravimetry (DTG) and field emission scanning electron microscopy (FESEM) analysis have been performed to substantiate the experimental results.

Rudolf Richard Buchheim, the founder of pharmacology.

Today, the University of Tartu (earlier Dorpat) belongs among the 250 best universities of the world. Its international team of pharmacologists uses powerful confocal microscopes to study apoptosis and cell death within an international consortium. Science is working on solutions to fight Alzheimer disease, which is a torture for humankind. For this to happen today, the foundation was laid by scientists of previous centuries who deserve our great respect, all of them together and everyone separately. Johannes Piiper, a well-known professor of physiology, once told me in a conversation that articles should be published in every 10years about the men who have served as examples for the science of the present-day world and about the conditions in which their research was done. It is essential that researchers working in modern laboratories would not forget in their smugness that the laboratory has not always been a warm and well-lit room full of expensive technology, and not always have millions been allocated for research grants. Electricity came to Dorpat as late as in 1892. In the harsh Estonian winter, ice sometimes covered the inner walls of the Old Anatomical Theatre. Dorpat received railway connection in 1876. When I have made presentations in American countries, I have repeatedly been asked why the pharmacologists of the University of Tartu have not published an illustrated biography of Rudolf Richard Buchheim. As I have worked in the rooms the construction of which was directed by R. Buchheim as Dean of the Faculty of Medicine, I am trying to correct this shortcoming at least to some extent. I have written about Buchheim earlier, but then the print volume was limited. In this article, I have attempted to fill the gaps where the earlier materials have been erroneous or incomplete. So, the article will explain the formation of the large family of Buchheims. Several articles have given the impression that when Buchheim arrived in Dorpat, there were no facilities at all, and, therefore, he founded the laboratory in the basement of his dwelling house. This article will also bring clarity to that. Through O. Schmiedeberg's memories, we will see the great difficulties with which Buchheim's viewpoints broke through and were accepted. The question where Buchheim's laboratory was situated after Buchheim moved house in 1852 until the completion of the annex to the Old Anatomical Theatre in 1860 will also be answered. The article also brings some clarity about R. Buchheim's children. For the first time, it has been summed up how R. Buchheim is commemorated in different towns and countries. The article includes photos from Estonian and foreign archives; some photos have also been received from cooperation partners. Photos available on the Internet as freeware have also been used. The mid-nineteenth century brought a whole constellation of talented scientists to the German-language University of Dorpat (now Tartu in Estonia, founded 1632) on the outskirts of the Russian Empire. They did not tinker on their own but were engaged in successful cooperation. Thus, the celebrities who happened to work in Tartu simultaneously included Professor of Anatomy and Physiology Georg Friedrich Karl Heinrich Bidder; founder of physiological chemistry, chemist Carl Ernst Heinrich Schmidt; and Rudolf Richard Buchheim whom Professors E. A. Carus and F. Bidder had invited to Tartu to work as Head of the Department of Materia Medica, Dietetics and History of Medicine. Together, the three talented and hardworking scientists cleared the path to research-based medicine and wrote their names into the history of world medicine forever. By introducing chemical analysis and animal experiments, R. Buchheim laid the foundation to scientific pharmacology.

Text Recognition Using Image Processing Technology for Visiting Card

Abstract: Image recognition and optical character recognition technologies have become an integral part of our daily lives due to increasing computing power and the proliferation of scanning devices. A printed document can be quickly converted to a digital text file using optical character recognition and edited by the user. The time required to digitize documents is therefore minimal. This is especially useful when archiving large print volumes. In this study, we show how image processing techniques can be used in combination with optical character recognition to improve recognition accuracy and improve efficiency in extracting text from images. Two of his software systems are developed and tested in this study: a character recognition system applied to cosmetics-related advertising images and a recognition and text recognition system for natural scenes. Experimental results show that the proposed system can accurately recognize text in images. Keywords: Image processing, Text detection, Visiting card, Optical character recognition (OCR),Named entity recognition (NER),Computer vision, OpenCV, Pytesseract, Tesseract OCR engine, Grayscale conversion, Noise removal, Thresholding, Named entities, Business name extraction, Owner name extraction, Address extraction, Contact number extraction, Email address extraction, Website extraction, Data categorization, Information extraction, Data organization, Spreadsheet integration, Accuracy enhancement, Efficiency improvement, Error reduction, Python programming, Data processing, Data extraction, Text extraction

A case study on occupational exposure assessment and characterization of particles in a printing shop in China.

Printers can release numerous particles to contaminate indoor environments and pose health risks. Clarifying the exposure level and physicochemical properties ofprinter-emitted particles (PEPs) will help to evaluate the health risks of printer operator. In our study, the particles concentration in the printing shop was monitored in real time for a long time (12h/day, total 6days), and the PEPs were collected to characterize their physicochemical properties including shape, size and compositions. The result showed that the concentration of PEPs is closely related to the printing workload and the highest particle mass concentration of PM10 and PM2.5 was 212.73μgm-3 and 91.48μgm-3, respectively. The concentration of PM1 in the printing shop was in the range of 11.88-80.59μgm-3 for mass value, and 174.83-1348.84 Pcm-3 for count value which changed with the printing volume. The particle sizes of PEPs were less than 900nm, 47.99% of PEPs was less than 200nm, and 14.21% of the particles were at the nanoscale. PEPs contained 68.92% organic carbon (OC), 5.31% elemental carbon (EC), 3.17% metal elements, and 22.60% other inorganic additives, which contained more OC and metal elements than toners. Total polycyclic aromatic hydrocarbons (PAHs) levels were 18.95ng/mg in toner and 120.70ng/mg in PEPs. The carcinogenic risk of PAHs in PEPs was 1.40 × 10-7. These findings suggested future studies should pay more attention to the health effects of printing workers exposed to nanoparticles.

Collecting Sarah Piatt at the Ohio State University's Rare Books &amp; Manuscripts Library

Collecting Sarah Piatt at the Ohio State University's Rare Books &amp; Manuscripts Library

A Conformal Mapping-Based Broadband Method to Extract Propagation Properties of Dielectrics Using Coplanar Waveguides With Air Pockets

In recent years, advances in material science for high-frequency electronics have generated novel materials that offer superior performance. Additive manufacturing (AM) has expanded the frontiers of microwave material manufacturing going beyond flat geometries and unique properties such as graded permittivity materials. Accurate electromagnetic (EM) material characterization for AM materials remains challenging given the printing volume constraints for manufacturing processes, as traditional EM property extraction techniques often require electrically large samples. Furthermore, loss extraction techniques typically cannot differentiate dielectric and conductor losses in waveguides. This paper presents a novel conformal mapping-based characterization technique using coplanar waveguides (CPW) with air pockets that allows for dielectric permittivity and dielectric loss extraction. The underlying principle of the techniques is to use a set of CPWs with different air slot depths to extract the loss behavior as a function of the slot depth. A new loss-slot rate metric is introduced to decouple the dielectric and conductor losses in the structure. The theoretical foundation of the technique is used to develop a physical-mathematical model for dielectric property extraction that is verified with simulations and experiments for materials with permittivity in the range 2.33–29, and loss tangents of 0.02–0.055. The average error for the equivalent capacitance of the CPW with air pockets (CPW-AP) between the presented model and simulated or measured data is 2.4% for all the studied cases. The experimental confirmation is performed with traditionally manufactured FR-4 and additively manufactured yttria-stabilized zirconia (YSZ) dielectrics up to 10 GHz.

Rapid Continuous 3D Printing via Orthogonal Dual-Color Photoinitiation and Photoinhibition.

Stereolithographic additive manufacturing technology has developed from point-by-point scanning exposure to layer-by-layer masking curing and even volumetric printing. Rapid prototyping is one of the important goals pursued by researchers. A continuous three-dimensional (3D) printing system based on the dual-color photoinitiation and photoinhibition is proposed with the aim of further improving printing speed. The process of continuous 3D printing is realized through the anti-polymerization layer between the cured part and the window generated by the ultraviolet (UV) light sheet (355 nm), and dynamic masking with the blue light (470 nm). The volume of the anti-polymerization layer can be adjusted by the intensity ratio of the incident lights (IUV, 0/Iblue,0) and the size of UV laser spot to enhance the reflow filling rate of the liquid resin. For the orthogonal Gaussian anti-polymerization layer, an intensity ratio of 28.6 allows for an inhibition volume of 97.1% of the desired rectangular anti-polymerization zone with a height of 1 mm. The simulation analysis of continuous 3D printing process by flow-structure interaction reveals that the increase of the thickness of the anti-polymerization layer effectively improves the filling rate of the resin and the cross-sectional area of printing, and reduces the stress of the cured part. The experiments with two different 3D structures printing demonstrate that the filling rate and the stress have virtually no effect on the printing process at a large-scale thickness of the anti-polymerization layer, and the printing speed is capable of reaching 200 μm/s. Certainly, the printing volume and complexity can be further improved with the improvement of the system and the optimization of the resin.

Appropriate Solutions for Traditional Media and New Media to Establish in Contemporary Society

New media penetrates people’s lives in thorough aspects, and the majority of people are inclined to receive information through the Internet instead of purchasing newspapers or other approaches to get to know the events around the world. Some experts think it is undisputed that the promising prospect of new media will harm traditional media. As a result, the status of the traditional media arouse the public concern and at the same time provoke a heated discussion among individuals. The total printing volume has declined for nine consecutive years since 2012, and especially since 2020, the COVID-19 impacted the traditional media severely. The article aims at claiming the benefits of the fusion of new media and traditional media and studying the attitude towards each of the media and the fusion of two kinds of media. The research involves the literature reference method to illustrate the two-sides of each type of media. The article analyzes a lot of data from official website and the essay [1]. The impact of new media on traditional media was written by Lavanya Rajendran and Preethi Thesinghraja to identify the tendency of these media. Eventually, conclusions are drawn that it is profitable to combine the new media with the traditional media.

Pilot-scale binder jet 3D printing of sustained release solid dosage forms

The additive nature and versatility of 3D printing show great promise in the rapid prototyping of solid dosage forms for clinical trials and mass customization for personalized medicine applications. This paper reports the formulation and process development of sustained release solid dosage forms, termed “printlets”, using a pilot-scale binder jetting (BJT) 3D printer and acetaminophen (APAP) as the model drug. With the inclusion of hydroxypropyl methylcellulose (HPMC) as a release retardant polymer in the print powder, the drug release time of APAP increased considerably from minutes to hours. However, given the swelling propensity of HPMC, a thicker layer of powder must be laid down during printing to avoid any shape distortion of the printlets. For a fixed print volume, the level of binder saturation (i.e., ratio between the liquid binder and powder in the as-printed sample) is inversely proportional to the thickness of the spread powder layer. An increase in the spread powder layer inadvertently resulted in a lower level of binder saturation and consequently weaker printlets. By increasing the level of binder saturation with jetting from more print heads, the mechanical strength of printlets containing 18% HPMC was successfully restored. The resultant printlets have a drug release time of 3.5 h and a breaking force of 12.5 kgf that is comparable to the fast-disintegrating printlets containing no HPMC and surpasses manually pressed tablets with the same HPMC content.