Prevalence Of Vitamin D Deficiency In Patients Research Articles

Association of Serum Vitamin D Concentration With Clinical Symptoms and Quality of Life in Patients With Irritable Bowel Syndrome

Objective: A high prevalence of vitamin D deficiency (VDD) in gastrointestinal (GI) disorders and the role of vitamin D in the function of the gut have been shown previously. Therefore, we aimed to evaluated the VDD and the possible association of the GI symptoms severity and quality of life (QoL) score with the serum levels of vitamin D in irritable bowel syndrome (IBS).Methods: A total of 90 patients with IBS based on Rome III criteria enrolled in the study from the tertiary referral university hospital. In addition, 90 sex- and age-matched healthy controls (HCs) were recruited. To measure the serum levels of 25(OH)D3, blood samples were taken from all the participants. Severity of clinical symptoms, IBS quality of life (IBS-QoL), and IBS symptom severity score (IBSSS) were assessed.Results: In 66.7% of IBS patients, serum 25(OH)D3 concentrations were <20 ng/mL. The mean serum 25(OH)D3 of IBS patients was statistically (p < 0.05) lower vs. HCs. When different subtypes were analyzed, the serum 25(OH)D3 concentrations in diarrhea-predominant IBS were statistically (p < 0.05) lower as compared to HCs. Furthermore, the lower serum concentrations of 25(OH)D3 were associated (p < 0.05) with higher severity of abdominal pain and distention, flatulence, overall GI symptoms, and IBSSS. However, a direct significant association was seen between IBS-QoL and serum 25(OH)D3.Conclusion: Results of this study showed a high prevalence of VDD in patients with IBS. In addition, VDD was associated with a higher severity of clinical symptoms and lower QoL in IBS.

Vitamin D and primary hypothyroidism: Is there an association?

Background: Association studies between the vitamin D deficiency (VDD) and hypothyroidism have given mixed results. Because of this controvery and relatively common prevalence of these two conditions, we conducted a case-control study investigating the prevalence of VDD in patients with hypothyroidism (both TPO-Ab positive and negative) and compared it with euthyroid controls. Methodology: This is a single centre cross sectional study. Adults (aged 18 years or more) of both the sexes diagnosed with primary hypothyroidism (TSH >5.1 mIU/L) were included (n = 115) along with age and sex matched euthyroid (TSH Results: Patients in the hypothyroid group [38 (males) and 77 (females)] had a mean (SD) age 46 (15) years, while the euthyroid control group [24 (males) and 96 (females) had a mean (SD) age of 45 (17) years. In the hypothyroid group, 96% (110/115) had VDD as compared to 90% (108/120) in the control group with a significantly lower mean Vit D level was observed in the hypothyroid group as compared to the euthyroid group (12+8.6 vs 17.49+11.89 ng/ml; P Conclusion: The vitamin D levels in patients with hypothyroidism were significantly lower compared to euthyroid controls.TPO-Ab positive patients had lower levels of vitamin D in comparison with negative

High prevalence of Vitamin D deficiency during pregnancy: A social health problem in India

Abstract Background: Vitamin D deficiency (VDD) is an important public health problem and is implicated as a risk factor for glucose intolerance during pregnancy. We studied the prevalence of VDD in patients with gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM). Materials and Methods: All GDM and T2DM patients evaluated between October and December 2014 were included in this cross-sectional, observational study. Patients with the use of vitamin D, glucocorticoids, and secondary diabetes were excluded. We diagnosed VDD as a serum 25-hydroxyvitamin D (25OHD) less than 30 ng/ml and GDM based on the World Health Organization (WHO) criteria. The data were compared with 10 gestational, age-matched controls with normal glucose tolerance (NGT). Appropriate statistical methods were used for comparison between the three groups. Results: The study participants (37 GDM, 13 T2DM, and 10 NGT) had a median (25th-75th interquartile) age of 26 (24.3, 30) years, gestational age of 24.5 (21, 27) weeks, and 25OHD of 10.5 (8.1, 14.8) ng/ml. VDD was seen in 35 GDM, 12 T2DM, and eight patients with NGT (P = 0. 9637). The median 25OHD levels were comparable between the three groups (10, 10.6, and 13.95; P = 0. 1192). Univariate analysis did not show higher odds of GDM or T2DM in patients with VDD (P = 0. 1903). Conclusion: Our data showed that the prevalence of VDD is high during pregnancy, irrespective of the glucose intolerance. Large scale population studies are required to determine the association between the VDD and GDM.

Vitamin D Defficiency in Rheumatology Clinic Practice in Qatar

In order to assess the prevalence ofvitamin-D deficiency in patients attending the rheumatology outpatient clinic at Hamad Medical Corporation, Qatar; 360 consecutive pa-tients (97% female) were tested for fasting levels of 25-hydroxyvitamin D, parathyroid hormone, calciumphos-phorus, albumin and alkaline phosphatase. Two hundred and three patients (56%) showed vitamin D levels below 20 ng/ml. From the results obtained it is concluded that lev-els of serum calcium, phosphorus, and alkaline phos-phatase are of limited value in predicting vitamin-D sta-tus. The difficulty of skin synthesis in heavily-robed women is discussed and it is concluded that hypovitaminosis D is frequent in such women and that routine assays of vitamin D and parathyroid hormone and vitamin D supplementa-tion would be beneficial.