Prevalence Of Early-onset Dementia Research Articles

Incidence and Prevalence of Early-Onset Dementia in Finland.

Current epidemiologic data of early-onset dementia (EOD), characterized by the onset of the disease before the age of 65, are notably scarce. We evaluated the incidence (from January 2010 to December 2021) and prevalence (on December 31, 2021) of EOD and its subtypes in 2 defined areas in Finland. All visits at the dementia outpatient clinics were manually retrospectively reviewed and reassessed (N = 12,490). In the population aged ≤65 years, crude incidence of EOD was 12.3/100,000 persons at risk/year based on 794 new cases from January 1, 2010, to December 31, 2021. Incidence rates for EOD were 20.5 and 33.7 per 100,000 person years in the age group of 30-64 and 45-64 years, respectively. The prevalence of EOD was 110.4 in the age group of 30-64 years and 190.3 in the age group 45-64. Alzheimer disease (AD) (48.2%) and behavioral variant frontotemporal dementia (12.7%) were the most frequent subtypes. The incidence of AD increased during the follow-up, whereas incidence of other forms of EOD remained stable. We found higher incidence rates of EOD than previously reported. Unlike other forms of EOD, the incidence of early-onset AD seems to be increasing.

Recent insights into Early Onset Dementia (EOD): A Review

The present study aims to review the prevalence and etiology of Early Onset Dementia (EOD) reflected in the population based studies worldwide .For this purpose, Bibliographic database searches and rigorous literature review were performed using the following keywords namely: “Dementia”, “Early onset dementia”, “Alzheimer’s disease” and “Senile Dementia” from the following databases: Pubmed, Medline between the years 2005 to 2019. The summary of report findings suggest that the prevalence of early onset dementia is reported to occur in 3-5% of the Indian population among predisposed individuals. This is an attempt to accumulate and collate in one spot all sort of multifactorial associations behind the pathogenesis of EOD in youth. These causes are Genetic change, Brain comorbidities, Alzheimer's ailment, vascular complications and increasingly other neuropsychiatric complications. We have made an attempt to analyze the pathogenesis of the early onset dementia in relation to their outcomes and a few manifestations which demonstrate the same. Future large-scale systematic reviews and network meta-analysis in this domain would facilitate dissemination of credible information with regards to the causative mechanism and possible therapeutic interventions and viable alternatives to possibly tackle and mitigate EOD.
 Keywords: Dementia, Early onset dementia, Alzheimer’s disease, Genetic alterations.

Estimating the burden of early onset dementia; systematic review of disease prevalence

Dementia is more common in older age but a number of people develop symptoms at a younger age and are said to have early onset dementia (EOD). Those with EOD face different challenges to those with onset later in life. It has been difficult to quantify this disease burden. This is a systematic review of papers reporting on the prevalence of EOD. A search of Medline and Embase was performed. This was followed by a hand search of the references of these papers. Eleven suitable studies were included. All of the data was from more economically developed countries. The studies were heterogeneous in their design hindering direct comparison. The majority of the papers looked at all types of dementia although many gave a breakdown of the prevalence of different subgroups. A variety of diagnostic criteria was employed. Figures of 38 to 260 per 100,000 are quoted by papers looking at various different types of dementia together with an onset of between 30 and 64 or up to 420 per 100,000 for those aged 55-64. Prevalence rises as age approaches 65. Epidemiological data for prevalence rates for EOD are sparse. EOD remains a rare condition with low case numbers. Assimilation and comparison of results from existing studies is difficult due to methodological heterogeneity. Cross-national standardization of methodology should be a priority for future research in this area.

Multicenter population‐based study on the prevalence of early onset dementia in Japan: Vascular dementia as its prominent cause

In Japan, the government and media have become aware of the issues of early onset dementia (EOD), but policies for EOD have not yet been established and support systems are inadequate. To provide practical data about EOD, a two-step postal survey was performed. A questionnaire requesting information on EOD cases was sent to target institutions in five catchment areas in Japan. According to the answers from the institutions, we estimated the prevalence of EOD using census data and determined the illnesses causing EOD. As a quality control study, the authors reviewed every diagnosis in a quarter of the reported cases using the medical and psychiatric records and neuroimaging data. This study was conducted from 2006 to 2007. Information from 2469 patients was collected from 12,747 institutions, and 2059 subjects with EOD were identified. The estimated prevalence of EOD was 47.6 per 100,000 (95% confidence interval, 47.1-48.1) for all of Japan. Of the illnesses causing EOD, vascular dementia (VaD) was the most frequent (39.8%), followed by Alzheimer's disease. The prevalence of EOD in Japan appeared to be similar to that in Western countries. However, unlike previously reported international experience, VaD was the most frequent cause of EOD in all catchment areas in Japan.

Epidemiology of early-onset dementia: a review of the literature

Presenile Dementia or Early Onset Dementia (EOD) is a public health problem, it differs from Senile Dementia, and encloses a significant number of cases; nevertheless, it is still poorly understood and underdiagnosed. This study aims to review the prevalence and etiology of EOD, comparing EOD with Senile Dementia, as well as to show the main causes of EOD and their prevalence in population and non-population based studies. The computer-supported search used the following databases: Pubmed/Medline, ISI Web of Knowledge and Scielo. The search terms were alcohol-associated dementia, Alzheimer's disease, dementia, Creutzfeldt-jakob disease, dementia with lewy bodies, early onset dementia, frontotemporal lobar degeneration, Huntington's disease, mixed dementia, neurodegenerative disorders, Parkinson's disease dementia, presenile dementia, traumatic brain injury, vascular dementia. Only papers published in English and conducted from 1985 up to 2012 were preferentially reviewed. Neurodegenerative diseases are the most common etiologies seen in EOD. Among the general population, the prevalence of EOD was found to range between 0 to 700 per 100.000 habitants in groups of 25-64 years old, with an increasing incidence with age. The progression of EOD was found to range between 8.3 to 22.8 new cases per 100.000 in those aged under 65 years. Alzheimer's disease (AD) is the major etiology, followed by Vascular Dementia (VaD) and Frontotemporal Lobar Degeneration (FTLD). A larger number of epidemiological studies to elucidate how environmental issues contribute to EOD are necessary, thus, we can collaborate in the planning and prevention of services toward dementia patients.

Epidemiology of early-onset dementia: a review of the literature

Presenile Dementia or Early Onset Dementia (EOD) is a public health problem, it differs from Senile Dementia, and encloses a significant number of cases; nevertheless, it is still poorly understood and underdiagnosed. This study aims to review the prevalence and etiology of EOD, comparing EOD with Senile Dementia, as well as to show the main causes of EOD and their prevalence in population and non-population based studies. The computer-supported search used the following databases: Pubmed/Medline, ISI Web of Knowledge and Scielo. The search terms were alcohol-associated dementia, Alzheimer’s disease, dementia, Creutzfeldt-jakob disease, dementia with lewy bodies, early onset dementia, frontotemporal lobar degeneration, Huntington’s disease, mixed dementia, neurodegenerative disorders, Parkinson’s disease dementia, presenile dementia, traumatic brain injury, vascular dementia. Only papers published in English and conducted from 1985 up to 2012 were preferentially reviewed. Neurodegenerative diseases are the most common etiologies seen in EOD. Among the general population, the prevalence of EOD was found to range between 0 to 700 per 100.000 habitants in groups of 25-64 years old, with an increasing incidence with age. The progression of EOD was found to range between 8.3 to 22.8 new cases per 100.000 in those aged under 65 years. Alzheimer's disease (AD) is the major etiology, followed by Vascular Dementia (VaD) and Frontotemporal Lobar Degeneration (FTLD). A larger number of epidemiological studies to elucidate how environmental issues contribute to EOD are necessary, thus, we can collaborate in the planning and prevention of services toward dementia patients.

1818 – Early onset dementia: socio-demographic and clinical characteristics

Introduction Early onset dementia (EOD) is conventionally defined by age of onset less than 65 years. It is increasingly recognized as a real public health problem because it reaches potentially active people. Although little studied, it is not uncommon and has some clinical and etiological features. Objective The aim of our study was to evaluate the prevalence of early onset dementia in psychiatric consultation to examinate sociodemographic, clinical and etiological characteristics of this entity. Materials and methods It is a cross-sectional study in external consultation of the psychiatric hospital Razi. We collected the records of patients seen between 01/09/2011 and 01/09/2012 and in whom the diagnosis of dementia was retained as the diagnostic criteria of DSM IV. We compared the epidemiological, clinical, and evolutionary dementia, beginning before the age of 65 with late onset dementia (LOD) (after 65 years). Results 50 patients were included. The prevalence of EOD was estimated at 20% of all dementias. There was an over representation of men in the early onset group. MMS average score of our patients was 16. This score did not differ between the two groups but differed significantly according to the etiological diagnosis. Alzheimer's disease was the main etiology for both groups. Compared to late-onset dementia, the EOD is characterized by greater heterogeneity in the etiologic diagnosis. Conclusion The EOD and the LOD seem to have common characteristics, but some features of the EOD especially etiological, emphasize the value of a more comprehensive approach to the research of curable dementia.

Diagnosing early onset dementia and then what? A frustrating system of aftercare resources

Recent studies indicate that the prevalence of early onset dementia (EOD) is more common than it was once presumed. As such, and considering the substantial challenges EOD presents to the patient, caregivers, and health care providers, this study sought to investigate the mechanism of care delivered to these patients. A medical record chart review was conducted for 85 patients attending a memory disorder unit who initially presented to rule out EOD as a working diagnosis. The results suggest that while the majority of these patients received an extensive work-up and were heavily medicated, they remained at home, where they lacked adequate age-related services and could not be placed, despite the crippling caregiver burden. This manuscript is a platform to discuss our current system limitations in the care of these patients with an eye on new opportunities for this challenging group.

Prevalence and Causes of Early-Onset Dementia in Japan

Few studies are available that have addressed the prevalence of early-onset dementia (EOD), including early-onset Alzheimer disease and other forms of dementia in Japan. A 2-step postal survey was sent to all of the 2475 institutions providing medical or care services for individuals with dementia in Japan's Ibaraki prefecture (population, 2 966 000) requesting information on EOD cases. Data were then reviewed and collated. We identified 617 subjects with EOD. The estimated prevalence of EOD in the target population was 42.3 per 100 000 (95% CI, 39.4 to 45.4). Of the illnesses that cause EOD, vascular dementia was the most frequent (42.5%) followed by Alzheimer disease (25.6%), head trauma (7.1%), dementia with Lewy bodies/Parkinson disease with dementia (6.2%), frontotemporal lobar degeneration (2.6%), and other causes (16.0%). The prevalence of EOD in Japan appeared to be similar to that in Western countries with the notable exception that vascular dementia was the most frequent cause of EOD in Japan.

How we developed a multidisciplinary screening project for people with Down’s syndrome given the increased prevalence of early onset dementia

Accessible summary • People with Down's syndrome are more likely to develop dementia than the general population and at a younger age. • Researchers and clinicians who have looked into this have said that all people with Down's syndrome should be assessed once in early adulthood so that people know what their skill level is in case changes occur later on. • This article talks about how we did this in Manchester. Summary There has been much research that has identified an increased prevalence of Dementia in adults with Down’s syndrome when compared with the general population. Neuropathological changes associated with Alzheimer’s dementia in the brain have been found in most people with Down’s syndrome who die over the age of 35 years. Given the limitations of many assessments for dementia in relation to people with Down’s syndrome for a single completion, it has been recommended that all people with Down’s syndrome are assessed at least once in early adulthood in order that they have their own baseline which can be compared with in the future if changes in skills and abilities occur. The authors have had many requests from other services enquiring about this project and how a similar initiative could be set up in their area which is what has led us to write this article. Therefore, this article focuses on the way the Manchester Learning Disability Partnership approached screening 135 adults with Down’s syndrome and details the assessments used, practical considerations, what has been learned and future service implications.