Presentation Of Vitamin B12 Deficiency Research Articles

Neurological presentations of nutritional vitamin B12 deficiency in 42 breastfed infants in Southeast Turkey

Nutritional vitamin B12 deficiency is common in developing and underdeveloped countries and has a wide variety of neurological presentations. The aim of this study was to evaluate the neurological characteristics and laboratory results of infants with vitamin B12 deficiency. Materials and methods: A total of 42 infants were included in this study. All patients were evaluated for clinical, physical, and neurological abnormalities, and an attempt was made to obtain short-term neurologic follow-up. Results: Of 42 patients, 24 (57%) were boys and 18 (43%) were girls. The average age at diagnosis was 13.04 ± 5.68 months. Most of these infants were breastfed only and born from mothers with inadequate animal-derived protein consumption. Hypotonia (100%), anorexia (92.8%), neurodevelopmental (85.7%), and social (80.9%) retardation were the most present symptoms in all infants. Conclusion: Severe neurological and hematological findings may be found in children with vitamin B12 deficiency. Early diagnosis and treatment is crucial in cases of hematological complications and neurologic impairment. Neurologic impairment may be irreversible if the diagnosis is delayed beyond 12 months. We think that dietary management, such as nutritional support with vitamin B12 for the mothers during pregnancy and complementary food for infants, may prevent the neurological deficits and neurodevelopmental retardation.

Autonomic Dysfunction as the Initial Presentation of Vitamin B12 Deficiency: A casereport

Autonomic Dysfunction as the Initial Presentation of Vitamin B12 Deficiency: A casereport

A Case of Acute Behavioral Disturbance Associated With Vitamin B12Deficiency

To the Editor: Neurologic and psychiatric symptoms are well described with vitamin B12 deficiency, and an assay of serum vitamin B12 levels is part of standard protocols when investigating cognitive impairment and dementia.1 Acute behavioral disturbance is, however, not a typical presentation of vitamin B12 deficiency.2 We describe a case of an elderly lady presenting with acute behavioral disturbance associated with vitamin B12 deficiency.

Metformin-Induced Vitamin B12 Deficiency Presenting as a Peripheral Neuropathy

Chronic metformin use results in vitamin B12 deficiency in 30% of patients. Exhaustion of vitamin B12 stores usually occurs after twelve to fifteen years of absolute vitamin B12 deficiency. Metformin has been available in the United States for approximately fifteen years. Vitamin B12 deficiency, which may present without anemia and as a peripheral neuropathy, is often misdiagnosed as diabetic neuropathy, although the clinical findings are usually different. Failure to diagnose the cause of the neuropathy will result in progression of central and/or peripheral neuronal damage which can be arrested but not reversed with vitamin B12 replacement. To my knowledge, this is the first report of metformin-induced vitamin B12 deficiency causing neuropathy.

Diagnostic d’une carence en vitamine B12 ou le signe de l’ordonnance

Vitamin B12 deficiency is a longstanding public health problem which affects more than 20% of the elderly population. Among multiple causes of vitamin B12 deficiency, Biermer's disease is currently mentioned in about 25% of the cases. We report the case of a 71-year-old woman, taking folate substitution therapy who, over 2 years, progressively developed spinal combined sclerosis, subacute dementia and severe neuropathy leading to a bedridden state. The initial assessment revealed normocytic anemia, without vitamin B12 deficiency and without increased plasma level of biological markers. The plasma folate level was high. Vitamin B12 assay was repeated leading to the diagnosis of deficiency associated with the presence of intrinsic factor antibodies. This observation illustrates the broad spectrum of clinical presentations of vitamin B12 deficiency. In the present case, the lack of sensitivity of biological markers delayed diagnosis and had a dramatic impact on outcome. This case highlights the importance of promoting factors such as isolated folate substitution in B12 deficient patients.

Psychotic Disorder and Extrapyramidal Symptoms Associated with Vitamin B12 and Folate Deficiency

Vitamin B12 and folate deficiency causing neuropsychiatric and thrombotic manifestations, such as peripheral neuropathy, subacute combined degeneration of cord, dementia, ataxia, optic atrophy, catatonia, psychosis, mood disturbances, myocardial infarction and portal vein thrombosis are well known. This present report highlights an unusual presentation of vitamin B12 deficiency-psychotic disorder, extrapyramidal symptoms in a 12-year-old boy. His symptoms responded to parenteral vitamin B12 therapy. So with this report we emphasized that serum vitamin B12 and folate levels should be measured, especially in those patients who present with other known neuropsychiatric features of vitamin B12 and folate deficiency.

MLP020 Neurological presentation of vitamin B12 deficiency in infancy

MLP020 Neurological presentation of vitamin B12 deficiency in infancy

Vitamin B12 deficiency presenting as oedema in infants of vegetarian mothers

Vitamin B12 deficiency presenting as oedema in infants of vegetarian mothers

Folate and Vitamin B12 deficiency presenting as pancytopenia in pregnancy: a case report and review of the literature

We present a case of extreme pancytopenia in a 27-year-old pregnant woman. The initial picture was compatible with a severe hematological problem in the category of aplastic anemia, paroxysmal nocturnal hemoglobinuria or even acute leukemia. The further biochemical investigations revealed, however, a folate deficiency.Nowadays this is a very rare cause of pancytopenia. Next to this she also had a Vitamin B12 deficiency due to intrinsic factor failure. The recent literature is discussed.

Vitamin B12 deficiency presenting as dementia in a young adult: a case report

SummaryVitamin B12 deficiency can result in a variety of neurological and psychiatric disorders. We describe a young patient in whom vitamin B12 deficiency presented as dementia with only mild hematological disease and no spinal cord disease.