Introduction: The oral cavity is the permanent residence of various types of microorganisms that live in complex ecosystems,which are not yet sufficiently researched. The normal oral flora always undergoes changes, which depend on many factors:food, immunological factors, hygiene and all the changes that occur during life in the oral cavity. One of the most frequent reasons for these changes is the use of new materials in the mouth, whether they are tooth fillings or fixed or mobile prosthetic works. The spread of prosthetic stomatitis is a long-standing problem among wearers of mobile prostheses. Colonization by Candida spp is of particular clinical importance, in most patients who have encountered prosthetic stomatitis and the presence of Candida spp has been determined. the dominant species is Candida Albicans.Local factors can cause the transformation of Candida albicans from non-pathogenic to pathogenic microorganisms.