This paper addresses the prescribed performance tracking control problem for a class of nonlinear systems subject to mismatched uncertainties. A novel disturbance observer-based control (DOBC) scheme is proposed through combining radial basis function neural network (RBFNN) and prescribed performance function (PPF). In contrast to traditional DOBC, the proposed approach employs RBFNN technology to approximate unknown nonlinear functions in the system, instead of treating them as part of lumped disturbances. A novel disturbance observer is developed to estimate disturbances characterised by a nonlinear exogenous system. To enhance control performance, a PPF that characterises both transient and steady-state behaviour is used for the transformation of tracking errors. It can be proved that all the states of the closed-loop system can be guaranteed to be uniformly ultimately bounded (UUB), and that the tracking error evolves within the prespecified boundaries. Theoretical results are validated and supported by two simulation examples.
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