Background: Osteoporosis, chronic, progressive disease of multifactorial etiology, is systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue with consequent increase in bone fragility. It is most common metabolic bone disease in sexes, races, and ages, therefore, screening at-risk population is essential. Warfarin increases the risk of osteoporosis because of its acting as vitamin K antagonist which is essential as co- factor in bone formation. Objectives: is to determine which gender and race (Malay, Chinese, and Indian) are more affected by the risk of osteoporotic condition and as osteopenia and osteoporosis dependent on definition of World Health Organization which based on bone mineral density (BMD) for each standard deviation (SD) reduction in BMD the relative risk of osteoporosis is increase 1.5-3 times. Methods: quantitative ultrasound machine is used to measure the T-score (BMD) for 270 subjects were divided in two groups; first group involved males and the second involved females. The subjects were also categorised based on using of warfarin more than one year of therapy and compared which factures influence on reduction of BMD. Results: There were 149 females showed significant difference of mean T-score of them when divided in two groups, the first group females less or equal to50 year’s old, non-using warfarin, premenopausal status, females had no history of fracture. Second group included females more than 50 years old, using warfarin more than one year, postmenopausal status, and had history with fractures. While no significant difference for males based on warfarin use. Results showed, Chinese females had more risk of osteoporosis (osteopinia, osteoporosis), than females non-using warfarin (odds ratio [OR] =2.4, 95% CI: 1.04- 5.75). Finally 25% changing of T-score for females was explained by interactions of risk factors; first using of warfarin more than 1 year and races and the second for using of warfarin more than one year and patients aged more than 50 years old. Conclusion: Chinese females with age more than 50 years old are more susceptible for the lower levels of BMD when they used warfarin therapy more than one year.