• All Solutions All Solutions Caret
    • Editage

      One platform for all researcher needs

    • Paperpal

      AI-powered academic writing assistant

    • R Discovery

      Your #1 AI companion for literature search

    • Mind the Graph

      AI tool for graphics, illustrations, and artwork

    • Journal finder

      AI-powered journal recommender

    Unlock unlimited use of all AI tools with the Editage Plus membership.

    Explore Editage Plus
  • Support All Solutions Support
    discovery@researcher.life
Discovery Logo
Paper
Search Paper
Cancel
Ask R Discovery Chat PDF
Explore

Feature

  • menu top paper My Feed
  • library Library
  • translate papers linkAsk R Discovery
  • chat pdf header iconChat PDF
  • audio papers link Audio Papers
  • translate papers link Paper Translation
  • chrome extension Chrome Extension

Content Type

  • preprints Preprints
  • conference papers Conference Papers
  • journal articles Journal Articles

More

  • resources areas Research Areas
  • topics Topics
  • resources Resources

Preconception Period Research Articles

  • Share Topic
  • Share on Facebook
  • Share on Twitter
  • Share on Mail
  • Share on SimilarCopy to clipboard
Follow Topic R Discovery
By following a topic, you will receive articles in your feed and get email alerts on round-ups.
Overview
1287 Articles

Published in last 50 years

Related Topics

  • Entire Pregnancy
  • Entire Pregnancy
  • Maternal Pregnancy
  • Maternal Pregnancy
  • Adverse Pregnancy
  • Adverse Pregnancy

Articles published on Preconception Period

Authors
Select Authors
Journals
Select Journals
Duration
Select Duration
1131 Search results
Sort by
Recency
A prospective study of semen quality and fecundability among North American couples planning pregnancy.

Few studies have prospectively evaluated semen quality (using the most up-to-date clinically relevant definitions) and fecundability (the per-cycle probability of conception). To study semen quality in relation to fecundability. We analyzed prospectively collected data from 763 male participants aged ≥21 years from Pregnancy Study Online (PRESTO), a North American preconception cohort study (2015-2024). Eligible participants for the semen testing substudy resided in the contiguous United States, had been attempting conception for ≤6 cycles at cohort entry, and had a female partner aged 21-45 years with regular menses. Participants used an at-home semen testing device to measure semen volume, sperm concentration, and motile sperm concentration. Participants contributed up to two semen tests during the preconception period (1376 total semen samples). We calculated sperm motility, total sperm count, and total motile sperm count. We evaluated results according to 2021 World Health Organization (WHO)-defined thresholds for low semen quality. Female participants reported their pregnancy status on bimonthly follow-up questionnaires for up to 12 cycles or until conception, whichever came first. We used proportional probabilities regression models to estimate fecundability ratios (FRs) and 95% confidence intervals (CIs), adjusting for potential confounders. After accounting for censoring using life-table methods, 80.7% of couples conceived within 12 cycles. FRs were 1.48 (95% CI, 1.05-2.08) for low semen volume (≤1.5 vs. >1.5mL), 0.74 (95% CI, 0.56-0.97) for low sperm concentration (≤16 vs. >16 million/mL), 0.98 (95% CI, 0.81-1.19) for low sperm motility (≤42 vs. >42%), 0.58 (95% CI, 0.38-0.88) for low total sperm count (≤39 vs. >39 million), and 0.73 (95% CI, 0.52-1.04) for low total motile sperm count (≤21 vs. >21 million). Associations between low total motile sperm count and fecundability were stronger among couples with <3 cycles of attempt time at cohort entry. In this prospective preconception cohort study of North American couples, most suboptimal semen parameters based on WHO criteria were associated with reduced fecundability, with the exception of low semen volume. Semen quality at suboptimal levels may adversely affect fecundability.

Read full abstract
  • Journal IconAndrology
  • Publication Date IconJul 11, 2025
  • Author Icon Sharonda M Lovett + 7
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

The Preconception Diet and Folic Acid Intake in a Post-Conflict Setting: Insights from Private Clinics in Benghazi, Libya.

Background: Maternal nutrition during the preconception period is crucial for fetal development and pregnancy outcomes. Aim: This study aims to assess the dietary intake and folic acid (FA) consumption among pregnant women in Benghazi, Libya, following eight years of political instability. Method: A cross-sectional study was conducted with 74 first-trimester pregnant women attending private antenatal clinics between February and June 2019. Dietary intake was evaluated using the European Prospective Investigation into Cancer and Nutrition Food Frequency Questionnaire (EPIC-FFQ), adapted for the Libyan population, and analyzed using the food frequency questionnaire European prospective investigation into cancer andnutrition tool for analysis (FETA). Results: The analysis revealed diets high in energy but deficient in essential nutrients. Only 26% of women-initiated FA supplementation before pregnancy, while 16% did not consume FA at all. The mean fiber intake 15.05 g/day was significantly lower than recommended p &lt; 0.001. Micronutrient deficiencies were observed in iron and folate, while vitamin A intake was excessive. Additionally, 43% of participants were overweight or obese before pregnancy. Socioeconomic factors, including low employment rates 30% and limited household income 54% ≤1000 Libyan Dinar/month, likely contributed to these nutritional challenges. Conclusion: Pregnant women in Benghazi exhibit dietary inadequacies, particularly low fiber, iron, and folate intake, and insufficient pre-conceptional folic acid use, highlighting nutritional vulnerabilities in this conflict-affected area.

Read full abstract
  • Journal IconBenghazi University Medical Journal
  • Publication Date IconJul 10, 2025
  • Author Icon Abeir El Mogassabi + 7
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

The Preconception Diet and Folic Acid Intake in a Post-Conflict Setting: Insights from Private Clinics in Benghazi, Libya.

Background: Maternal nutrition during the preconception period is crucial for fetal development and pregnancy outcomes. Aim: This study aims to assess the dietary intake and folic acid (FA) consumption among pregnant women in Benghazi, Libya, following eight years of political instability. Method: A cross-sectional study was conducted with 74 first-trimester pregnant women attending private antenatal clinics between February and June 2019. Dietary intake was evaluated using the European Prospective Investigation into Cancer and Nutrition Food Frequency Questionnaire (EPIC-FFQ), adapted for the Libyan population, and analyzed using the food frequency questionnaire European prospective investigation into cancer andnutrition tool for analysis (FETA). Results: The analysis revealed diets high in energy but deficient in essential nutrients. Only 26% of women-initiated FA supplementation before pregnancy, while 16% did not consume FA at all. The mean fiber intake 15.05 g/day was significantly lower than recommended p &lt; 0.001. Micronutrient deficiencies were observed in iron and folate, while vitamin A intake was excessive. Additionally, 43% of participants were overweight or obese before pregnancy. Socioeconomic factors, including low employment rates 30% and limited household income 54% ≤1000 Libyan Dinar/month, likely contributed to these nutritional challenges. Conclusion: Pregnant women in Benghazi exhibit dietary inadequacies, particularly low fiber, iron, and folate intake, and insufficient pre-conceptional folic acid use, highlighting nutritional vulnerabilities in this conflict-affected area.

Read full abstract
  • Journal IconBenghazi University Medical Journal
  • Publication Date IconJul 10, 2025
  • Author Icon Abeir El Mogassabi + 7
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Preconception health beliefs and intentions predict behaviours among expectant male partners: a cross-sectional study

BackgroundThe preconception period allows couples to plan and prepare for pregnancy. However, males can often consider this integral public health topic as a female domain. To better understand and support behaviour change for males before conception, this study aimed to identify and explore the preconception and pregnancy planning health beliefs and intentions of expectant male reproductive partners of pregnant women in Australia.MethodsAn online cross-sectional survey [2020–2021] among males aged 18–49 years who were the reproductive partner (expectant partner) of a pregnant female. Recruitment occurred via social media. The 80-item survey consisted of five sections. Survey items regarding beliefs and intentions were formulated using the Theory of Planned Behaviour. Associations between participants’ beliefs, subjective norms, perceived behavioural control, and intentions related to three outcomes (regular exercise, healthy diet, and alcohol avoidance) were estimated using Structural Equation Modelling.ResultsExpectant partners’ (n = 136) had a mean age of 31 years. Their beliefs toward regular exercise and their perceived behavioural control to exercise regularly were associated with a greater intention to exercise regularly (Standardised estimate β = 0.54; p = 0.0087 and β = 0.43; p = 0.02, respectively). The beliefs of expectant partners toward alcohol avoidance and their perceived behavioural control toward alcohol avoidance were associated with a greater intention to avoid alcohol (β = 0.43; p < 0.001 and β = 0.36; p < 0.001, respectively). For the healthy diet outcome, subjective norms of expectant partners, and perceived behavioural control to adopt a healthy diet were associated with an intention to adopt a healthy diet (β = 0.23; p = 0.04 and β = 0.47; p < 0.001, respectively). Intention was in turn associated with behaviour for all three outcomes.ConclusionOur study demonstrated that the preconception intentions of expectant partners were associated with their preconception behaviours; especially for the intention to exercise regularly or to avoid alcohol. Further studies examining paternal preconception health beliefs, and intentions and the motivations behind health behaviours for males are needed to help develop targeted preconception health promotion messages and interventions that support males to optimise their preconception health.

Read full abstract
  • Journal IconArchives of Public Health
  • Publication Date IconJul 10, 2025
  • Author Icon Tristan Carter + 4
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Diet in Pregnancy: A Review of Current Challenges and Recommendations. A British Nutrition Foundation Briefing Paper.

Pregnancy is a crucial period during which maternal nutrition, weight and lifestyle behaviours have a direct impact on both maternal and fetal health. This briefing paper describes dietary and lifestyle recommendations for women during the preconceptional period and throughout pregnancy, identifying specific factors that can be modified to improve health outcomes for both mother and child. It considers key areas such as nutrient intakes, supplementation, food safety and weight management, and highlights how dietary choices can help reduce the risk of common pregnancy-related conditions. Despite widespread recognition of the importance of a healthy, balanced diet, many women in the UK fall short of recommended intakes for important nutrients, including iron, folate, iodine and vitamin D. These shortfalls are particularly evident among nutritionally vulnerable groups, such as teenagers, women from lower-income households and those experiencing food insecurity; such groups may face barriers to accessing healthy foods and adhering to supplementation guidance. An increasing interest in plant-based diets presents an opportunity to consider a range of dietary patterns that support both maternal health and environmental sustainability. However, such shifts must be carefully managed to ensure adequate intake of nutrients commonly found in animal products, such as vitamin B12, iron, iodine, calcium and long-chain fatty acids. Rates of overweight and obesity among women of childbearing age remain high, reflecting trends in the general population and contributing to growing concern about maternal obesity. Maintaining a healthy weight before and during pregnancy plays a key role in supporting maternal and fetal wellbeing. Both insufficient and excessive weight gain are associated with elevated risks of complications. Excessive weight gain during pregnancy is associated with an increased risk of developing gestational diabetes, hypertensive disorders such as pre-eclampsia, preterm birth and a greater likelihood of long-term obesity in both mother and child. Supporting women to achieve and maintain a healthy weight in the periconceptional period and throughout pregnancy is therefore a public health priority. The antenatal period presents a unique window of opportunity to promote healthier and more sustainable eating patterns, as women are often highly motivated to improve their health and are in more regular contact with healthcare professionals at this time. Yet, research indicates that many women are unaware of dietary recommendations or receive inconsistent advice. To fully harness this opportunity, healthcare providers must be equipped with culturally appropriate, accessible and evidence-based resources to support perinatal conversations around diet, supplementation, physical activity and body weight. Providing appropriate support during the periconceptional and early pregnancy period is essential to addressing health inequalities, improving long-term wellbeing and positively influencing the health of future generations.

Read full abstract
  • Journal IconNutrition bulletin
  • Publication Date IconJul 6, 2025
  • Author Icon Kathryn H Hart + 5
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Analysis of Factors Associated with Preconception Nutritional Readiness Among Women of Reproductive Age in Kerinci Regency

Women of Reproductive Age (WRA) as prospective mothers are a vulnerable group whose health status, particularly nutritional status, requires attention. The quality of future generations is determined by the mother's condition before pregnancy, as malnutrition during the preconception period can lead to both maternal and fetal malnutrition. This study aims to analyze the factors associated with preconceptions of nutritional readiness among WRA in Kerinci Regency. The study uses an analytical design with a cross-sectional approach. It was conducted at 5 Religious Affairs Offices in Kerinci Regency (The Office of Religious Affairs of East Air Hangat, Depati Tujuh, Sitinjau Laut, Danau Kerinci, and Keliling Danau) from 1 November to 30 November 2023. The sample consisted of 80 pre-marriage WRA registrants. Data were collected using questionnaires and analyzed using Chi-Square tests and Multiple Logistic Regression. The results showed significant associations between age (p-value 0.645), attitudes (p-value 0.005), occupation (p-value 0.006), physical activity (p-value 0.449), lifestyle (p-value 0.001), income (p-value 0.002), culture (p-value 0.018), food access (p-value 0.004), and the role of health workers (p-value 0.015) with preconceptional nutritional readiness. Multivariate analysis indicated that the most dominant factor was lifestyle, with an odds ratio (OR) of 17.75. In conclusion, the study found significant associations between various factors and preconceptions of nutritional readiness, with lifestyle being the most influential. Cross-sectoral cooperation and education are needed to intervene during the preconception period to prepare women for a healthy pregnancy and a positive pregnancy outcome.

Read full abstract
  • Journal IconJournal La Medihealtico
  • Publication Date IconJul 4, 2025
  • Author Icon Ela Sintia + 2
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

A Preconception Cohort Study of Nicotine Vaping and Incidence of Spontaneous Abortion.

We evaluated association of preconception nicotine vaping among female and male partners with spontaneous abortion (SAB) incidence, and the extent to which associations vary by cigarette smoking. In a prospective cohort study, 6136 participants assigned female-at-birth and 1688 of their partners assigned male-at-birth reported preconception nicotine vaping and cigarette smoking via online questionnaire. Female partners reported incident pregnancies and outcomes (e.g., SAB) on follow-up questionnaires completed every 8weeks and in early and late pregnancy. We used multivariable Cox proportional hazards regression models estimated adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for association between vaping and SAB incidence, overall and by smoking history. Mean age was 30 and 32 for females and males respectively. Among females, 13% reported ever-vaping and 14% reported ever-smoking, while 19% of males reported ever-vaping and 24% reported ever-smoking. Relative to female never-vapers, aHRs were 1.03 for former vaping (95% CI 0.86-1.24) and 0.91 for current vaping (95% CI 0.61-1.36). Former and current vaping were also not appreciably associated with SAB rate among ever-smokers. In the couple-based cohort, relative to male never-vapers, aHRs were 1.00 for male former-vapers (95% CI: 0.74-1.35) and 0.67 for male current-vapers (95% CI: 0.35-1.25). Additional analysis of female participants after stratifying by finer categories of smoking status did not identify any meaningful association with SAB incidence. The current study found that vaping in either partner during the preconception period was not associated with SAB incidence. Cigarette smoking also did not modify this association. The rising prevalence of vaping invokes greater scrutiny on its possible adverse reproductive effects. Studies have linked vaping to adverse birth events, and clear guidance is made to avoid vaping in pregnant people. However, guidance about vaping during preconception is less clear despite research showing how preconception behaviors are linked to adverse pregnancies and birth outcomes. Our cohort study finds little association between preconception vaping and spontaneous abortion. In context of established risks of vaping on fetal outcomes, this study highlights the need for additional evidence-based information about preconception vaping to help couples make lifestyle decisions for optimal reproductive outcomes.

Read full abstract
  • Journal IconNicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • Publication Date IconJul 3, 2025
  • Author Icon Austen D Le + 12
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Investigating the relationship between dairy dam preconception and gestation characteristics and heifer offspring variables from birth to lactation.

Little is known about effects of maternal characteristics around gestation in cows on their female offspring in early and later life. The objective of the current study was to investigate the relationship between cow characteristics during the preconception and gestation period, and the BW, energy metabolism, hormones, immune function, liver enzymes, and milk variables of their female offspring from birth until the first 100 d after their first calving. Holstein-Friesian dairy cows (n = 154) were blocked according to parity, milk yield, and SCC, and randomly assigned to a voluntary waiting period (VWP) of 50, 125, or 200 d. Female offspring (n = 62) from those cows were monitored from birth until the first 100 DIM of the offspring's first lactation. Not all dams were inseminated successfully soon after the planned VWP, resulting in differences between the planned VWP and intended calving interval (CInt) and the actual CInt. Dam-offspring pairs were regrouped according to the dam's actual CInt (CInt_1: 324 - 408 d; CInt_2: 409 - 468 d; CInt_3: 469 - 586 d). For data analysis, the dam variables were divided into 4 stages: 4 wk before conception, and the 3 trimesters of gestation. Similarly, the heifer calf variables were divided into 3 stages: calves from birth to weaning, heifers from weaning to calving, and lactating offspring during first 100 DIM after calving. To analyze the effects of preconception and gestation characteristics in dams on female offspring, each dam variable from 4 wk before conception until calving was included separately in a regression model, with fixed effects for dam's CInt, parity, offspring's age, and their 2-way interactions, with an repeated effect of time with female offspring as the repeated subject. Higher milk lactose in dams during the preconception period and the first 2 trimesters of gestation was related to higher BW in heifers from weaning to calving. Heavier dams during the preconception period and gestation had heifers with higher levels of plasma antikeyhole limpet hemocyanin IgG and IgM from weaning to calving. Higher plasma IGF-І concentration in dams in all stages was related to higher plasma IGF-І and insulin concentrations in heifers from weaning to calving, with increasing effect size over dam's stages. Higher milk yield of dams across all stages was associated with lower milk fat content, lower plasma nonesterified fatty acids, and higher glucose concentrations of lactating offspring during the first 100 DIM of their first lactation. Greater milk lactose and lower milk fat content in dams before conception and in the first 2 trimesters of gestation were related to greater BW in lactating offspring. In conclusion, some associations between dam in different stages and female offspring variables were present for all dam periods, but some disappeared over the course of gestation. Moreover, the greatest percentage of associations (16.56%, 159 out of 960 associations with a P-value <0.05) was present when the lactation periods of dams and their female offspring were compared, that is, when dam and offspring were in a similar life stage, compared with earlier life stages of the offspring during weaning (6.17%, 37 out of 600 associations with a P-value <0.05) and rearing (11.67%, 70 out of 600 associations with a P-value <0.05).

Read full abstract
  • Journal IconJournal of dairy science
  • Publication Date IconJul 1, 2025
  • Author Icon Yapin Wang + 7
Open Access Icon Open AccessJust Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Preconception, prenatal and early childhood exposure to green space and risk of neurodevelopmental delays: a national cohort study among Medicaid enrollees.

Preconception, prenatal and early childhood exposure to green space and risk of neurodevelopmental delays: a national cohort study among Medicaid enrollees.

Read full abstract
  • Journal IconEnvironment international
  • Publication Date IconJul 1, 2025
  • Author Icon Hayon Michelle Choi + 14
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Kelas pranikah dan prakonsepsi untuk pencegahan stunting pada sekolah pranikah

Stunting is a growth disorder of children under five due to malnutrition, with the prevalence rate in Indonesia in 2022 reaching 21.6%. In order to reduce stunting rates, premarital and preconception classes are very important in providing knowledge and skills to prospective parents to prevent stunting. This research aims to develop a stunting risk detection tools and management modules through premarital and preconception classes plus copping skills as an effort to prevent and reduce stunting. This study is an experimental study with a one-group pretest-posttest design. The population in this study were women in the premarital and preconception period. The sampling technique used was probability sampling type simple random sampling of 41 people. Data analysis using the Wilcoxon Test. The study results showed significant differences in three variables after the premarital class intervention. The stress perception scale experienced a decrease in mean score from 20.93 to 18.83 with a difference of -2.10 (p=0.002). Self-confidence experienced an average increase from 44.76 to 48.27 with a difference of 3.51 (p=0.002). Coping strategies also increased the average score from 97.34 to 99.24 with a difference of 1.90 (p=0.023). Premarital classes are effective in reducing stress, increasing self-confidence and coping strategies. Premarital classes and preconception programs with copping skills need to be expanded to prevent stunting.

Read full abstract
  • Journal IconJURNAL INFO KESEHATAN
  • Publication Date IconJun 30, 2025
  • Author Icon Runjati Runjati + 5
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Are Inflammatory Markers and Periodontitis Effective in Predicting Miscarriage?

Background/Objectives: Miscarriage is a common pregnancy complication that significantly impacts individuals' health due to its physical and psychological effects. This study aimed to investigate the association between periodontal health and hematological parameters in women who experienced miscarriage before the 20th week of gestation, and to assess the potential predictive value of these parameters for miscarriage risk by comparing them with those of women with an uncomplicated pregnancy course. Methods: This study was a prospective case-control and cross-sectional study. It included a total of 82 participants, comprising 41 women with miscarriage and 41 healthy pregnant controls. The periodontal examinations included measurements of the Gingival Index (GI), Plaque Index (PI), Probing Depth (PD), Clinical Attachment Loss (CAL), and Simplified Calculus Index (SCI). Additionally, complete blood counts (CBCs) were obtained from all participants. Appropriate statistical analyses, including non-parametric, correlation, logistic regression, and ROC analyses, were conducted, with the significance level set at p < 0.05. Results: The primary outcome measure was CAL as an indicator of periodontal disease severity and its association with miscarriage risk. Additional outcomes included Plateletcrit (PCT), the Platelet Count (PLT), and the Neutrophil-to-Lymphocyte Ratio (NLR) to evaluate systemic inflammatory responses and their correlations with periodontal parameters. CAL was significantly elevated in the miscarriage group (p < 0.001) and emerged as the strongest predictor of miscarriage risk (OR = 0.0537, p < 0.001, AUC = 0.8691). PCT was significantly higher in the miscarriage group (p = 0.017) and positively correlated with the GI (p = 0.041), suggesting a link between systemic inflammation and periodontal health. Conclusions: Considering this study's limitations, CAL was the strongest predictor of miscarriage, while PLT and PCT had some discriminative power. Collaboration between obstetricians and dentists can facilitate early diagnosis and intervention by promoting routine oral health check-ups before and during pregnancy. Additionally, integrating oral health assessments into prenatal care and developing public health policies could enhance access to dental services during both preconception and pregnancy periods.

Read full abstract
  • Journal IconHealthcare (Basel, Switzerland)
  • Publication Date IconJun 30, 2025
  • Author Icon Isa Temur + 5
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Perceptions of preconception health messaging and responsibility: engaging with 'health helpers' in the Healthy Life Trajectories Initiative-South Africa trial.

Premised on the Developmental Origins of Health and Disease theory and on the limited effectiveness of antenatal interventions, interventions in the preconception period are being conducted to potentially improve intergenerational health and non-communicable disease burdens. The Healthy Life Trajectories Initiative (HeLTI) is an international health research consortium primarily investigating the intergenerational effects of behavioural interventions on obesity via a complex four-phase intervention initiated preconceptionally, through pregnancy, and into early childhood. HeLTI, in partnership with the World Health Organization, aims to generate evidence that will shape health policy focused on preconception as part of a life course approach to population health. It is necessary to ensure that a renewed public health focus on preconception prioritises justice and equity in its framing. This article presents collaborative interdisciplinary work with HeLTI-South Africa. It applies a feminist bioethics methodology, which is empirical, situated, intersectional, and fundamentally concerned with justice, to investigate what South African HeLTI community health workers, or 'Health Helpers', who deliver the complex behavioural intervention, think about preconception health and responsibility. Seven semi-structured interviews were conducted with HeLTI-SA Health Helpers, and data were analysed using reflexive thematic analysis. Our findings show that Health Helpers' perceptions of preconception health and related responsibility were significantly gendered, heteronormative, and concerned with child-bearing intentionality and desires. These themes were inflected with Health Helpers' perceptions about how attributions of responsibility are shaped by culture, demonstrating the situated nature of epistemologies. Their ideas also highlight how preconception health knowledge can distribute responsibility unjustly. Understanding the contextual impact and relevance of values around responsibility is critical to prospectively design preconception health interventions that promote equity and fairness. This understanding can then be used for effective policy translation, with the goal that public health policy is founded upon contextual responsivity and justice for the public it aims to serve.

Read full abstract
  • Journal IconJournal of biosocial science
  • Publication Date IconJun 24, 2025
  • Author Icon Caitlin Victoria Gardiner + 9
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

1252-P: Glucagon-Like Peptide 1 Receptor Agonist Prescription prior to Pregnancy According to Health Insurance Type and Race/Ethnicity

Introduction and Objective: Prior studies have found disparities in prescription of glucagon-like peptide-1 receptor agonists (GLP1 RAs) in the general population. We investigated GLP1 RA prescription patterns in the preconception period. Methods: In a retrospective electronic health record-based cohort, we studied GLP1 RA prescription in the 3 years before conception (outcome), among those with pre-pregnancy BMI ≥ 25 kg/m2. In separate models, we examined associations between the following binary predictor variables and GLP1 RA prescription: health insurance (public or private), minoritized race/ethnicity (not self-identified as non-Hispanic White), Asian race, Black race and Hispanic ethnicity. We fit generalized estimating equation models to examine the odds of receiving a GLP1 RA prescription; covariates included age, BMI, diabetes, hypertension, obesity class, insurance (in race/ethnicity models), and race/ethnicity (in insurance models). Results: Among a cohort of 53,404 pregnancies in 41,932 individuals, 21.7% had public insurance, 41.4% had a minoritized race/ethnicity and 0.4% were exposed to GLP1 RA prior to pregnancy. In adjusted models, pregnancies with public insurance had lower odds of preconception GLP1 RA prescription (OR 0.30, 95% CI 0.19-0.46) compared to those with private insurance. The odds of a GLP1 RA prescription were higher among pregnancies with a minoritized race/ethnicity (OR 2.39, 95%CI 1.76-3.25) compared to those with a non-minoritized race/ethnicity. In comparison to pregnancies of non-Hispanic individuals, those of Hispanic individuals had higher odds of GLP1 RA prescription (OR 2.56, 95% CI 1.86-3.54). Asian or Black race was not associated with GLP1 RA prescription. Conclusion: Private insurance and Hispanic ethnicity are associated with preconception GLP1 RA prescription. These findings may inform understanding of disparities in pregnancy outcomes associated with preconception GLP1 RA use. Disclosure C.I. Batlle: None. S. Hsu: None. K. James: None. D. Pant: None. T. Thaweethai: None. C.E. Powe: Research Support; Dexcom, Inc. Other Relationship; Mediflix, Wolters Kluwer Health. J. Maya: None. Funding American Diabetes Association (9-24-JDFWH-010); NIDDK (K26DK138346, T32DK007028MGH ); Physician/Scientist Development Award

Read full abstract
  • Journal IconDiabetes
  • Publication Date IconJun 20, 2025
  • Author Icon Carolina I Batlle + 6
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

1255-P: Association of Gestational Diabetes with Maternal Weight Change in the Two Years prior to Pregnancy

Introduction and Objective: Although achieving a healthy weight prior to pregnancy is recommended, data on the association between preconception weight changes and pregnancy outcomes are limited. We examined the relationship between preconception weight trajectories and risk of GDM in a large, diverse cohort. Methods: We conducted a retrospective cohort study of 257,017 pregnancies resulting in singleton, live birth at ≥28.0 weeks gestation for whom GDM screening was completed within 4 health care systems. Eligible pregnancies had ≥2 weight measurements in the electronic medical record in the 2 years prior to pregnancy with at least one in each of these periods: 0-12 months and 13-24 months prior to pregnancy onset. Preconception weight change rate was estimated using linear mixed effects trajectory models. GDM diagnosis was determined based on glucose levels from oral glucose tolerance testing. We modeled GDM as a function of preconception weight change, BMI category at the start of the preconception period (&amp;lt;25, 25-&amp;lt;30, ≥30 kg/m2) and covariates (maternal age, race and ethnicity, parity, insurance status, health care system) using a multilevel Poisson model with robust standard errors to estimate relative risk and absolute risk, accounting for multiple pregnancies within women. Results: Of included pregnancies, 62% were parous; 45% were Hispanic, 30% non-Hispanic White, 9% non-Hispanic Black, and 17% other races; and 11.7% had diagnosed GDM. Mean preconception BMI was 27 kg/m2 and 27% had a BMI≥30. Mean rate of weight change in the 2 years prior to pregnancy was +0.44 kg/yr (SD=3.73). Every kg/yr of increased weight was associated with 4.8% greater risk of GDM (RR=1.048, 95% CI [1.044, 1.052]). Adjusted risk of GDM was lower among those who lost weight prior to pregnancy compared to those who gained weight (9% risk of GDM for 5 kg/year loss vs 14.5% for 5 kg/yr gain). Conclusion: In this diverse, U.S. cohort, preconception weight change was positively associated with GDM risk. Disclosure K.K. Vesco: None. E.S. LeBlanc: None. C.E. Oshiro: None. M. Lee: None. M.C. Leo: Research Support; PreludeDx. M. Mayhew: None. D.R. Young: None. C. McCracken: None. A. Owen-Smith: None. N.A. Rosenquist: None. J. Boone-Heinonen: None. Funding Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01HD102477)

Read full abstract
  • Journal IconDiabetes
  • Publication Date IconJun 20, 2025
  • Author Icon Kimberly K Vesco + 10
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Comparison of Preconception Diet Scores Across Studies: The PrePARED Consortium

Background: Preconception diet and nutritional status are important determinants of reproductive and pregnancy health. As a comprehensive evaluation, this paper describes harmonization of diet data across multiple cohorts including over 50,000 participants and the differences between them. This information may be useful for developing targeted strategies to improve women’s diet prior to pregnancy for optimal prenatal health outcomes. Methods: The Preconception Period Analysis of Risks and Exposures influencing health and Development (PrePARED) consortium incorporates studies covering the preconception period and includes both couples planning pregnancy and studies covering the reproductive period but not focused on pregnancy. We harmonized data on 56,520 participants from seven cohort studies that collected data during the preconception period. We generated data on diet quality according to the International Federation of Gynecology and Obstetrics (FIGO) nutrition checklist to examine diet quality measures across the cohorts and compare estimates of diet quality across studies. Four studies used food frequency questionnaires; one used a study-specific diet history; one used two 24 h dietary recalls; and one used a short series of general diet questions. Positive responses on the six FIGO questions were tallied to calculate a total diet quality score. Results: Cohort samples varied in terms of age; socioeconomic status; race; ethnicity; and geographic region. Across the cohorts, participants met a median of three or four of the FIGO criteria for diet quality; those most commonly met were recommendations for consumption of meat and protein, while those least commonly met were recommendations for limiting consumption of processed foods and snacks. There was greater variation in meeting recommendations for the consumption of fruits and vegetables; dairy; fish; and whole grains. The percentage meeting ≤ 2 criteria ranged from 6.4% (Coronary Artery Risk Development in Young Adults) to 40.4% (Bogalusa Heart Study). Discussion: There was wide variability across preconception cohort studies in the extent to which participants met FIGO dietary guidelines. Although studies were conducted in populations that were not likely to be malnourished, it was rare for women to meet all the preconception dietary recommendations. These findings illustrate a need for strategies to promote meeting dietary guidelines prior to conception to improve health outcomes.

Read full abstract
  • Journal IconNutrients
  • Publication Date IconJun 18, 2025
  • Author Icon Lixuan Ji + 12
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Targeting Metabolic Syndrome with a Pre-Conception True-Couples-Based Lifestyle Intervention: A Pre-Post Mixed-Methods Evaluation

Background/Objectives: Metabolic syndrome (Mets) risk is influenced by both parents’ preconception lifestyle, yet most interventions target individuals rather than couples. True couples-based interventions that engage both partners equally remain rare. This study aimed to assess the feasibility and adherence of a 10-week lifestyle intervention delivered to heterosexual couples in the preconception period. Methods: This was a pre-post mixed-methods study involving eight nulliparous, cohabiting couples (N = 16 participants) planning a pregnancy within three years. Couples received tailored dietary and physical activity advice via remote sessions. Qualitative data were collected through post-intervention dyadic interviews and thematically analysed to explore participants’ experiences and perspectives on feasibility and adherence. Quantitative data on anthropometry, dietary intake (serves from five food groups), and sedentary behaviour were descriptively analysed. Wilcoxon signed-rank tests were used to assess changes in paired outcomes. Results: qualitative findings highlighted shared motivation, mutual accountability, cultural barriers, and the practicality of the intervention structure. All couples completed the intervention (100% retention). Among participants who required change, improvements were observed in all eight individuals for body mass index and in five out of seven individuals for waist-to-hip ratio. Statistically significant improvements were found in BMI (p = 0.027) and grain intake (p = 0.002), while other dietary and anthropometric changes were not significant. Dietary improvements were noted in 43 out of 80 observations across vegetables, fruits, grains, protein, and dairy intake. Sedentary hours were reduced in 12 of 16 participants, though increases in physical activity intensity were limited. Conclusions: A true-couples-based lifestyle intervention is feasible and acceptable in the preconception period. The approach shows potential for improving diet and reducing sedentary behaviour. Future research with a larger sample and longer duration is recommended to assess long-term effectiveness and broader applicability.

Read full abstract
  • Journal IconNutrients
  • Publication Date IconJun 18, 2025
  • Author Icon Sundus Nizamani + 4
Just Published Icon Just Published
Cite IconCite
Chat PDF IconChat PDF
Save

Dietary Iron Supplementation Protects Against Growth Restriction and Metabolic Dysfunction‐Associated Steatotic Liver Disease in Perinatal Cadmium‐Exposed Mice

ABSTRACTIron (Fe)‐deficiency (ID) and Fe‐deficiency anemia (IDA) are highly prevalent conditions and are of particular concern to maternal–child health. ID and IDA are typically linked to nutritional deficiencies, but maternal exposure to heavy metals including cadmium (Cd) also leads to offspring with low levels of circulating Fe. Another comorbidity of ID and IDA is metabolic dysfunction‐associated steatotic liver disease (MASLD), a liver condition characterized by lipid accumulation and fibrosis. We have previously shown that maternal Cd exposure also leads to the development of MASLD in offspring. We hypothesized that providing Fe fortification would prevent Cd‐induced ID, which would in turn rescue offspring from growth restriction and MASLD. To test this, virgin dams were exposed to 30 ppm of cadmium chloride (CdCl2) in their drinking water during the preconception, gestation, and lactation periods. Fe fortification was supplied in the form of dietary ferric citrate, which amounted to two (2×) or five times (5×) the normal dietary Fe in standard chow. Our study provides evidence that perinatal Cd exposure does not prevent absorption of supplemental Fe, and that the chosen Fe supplementation dosages are sufficient to prevent Cd‐induced growth restriction, ID, IDA, and MASLD in offspring at postnatal day 21 (PND21). Our findings suggest that Fe supplementation may be a viable therapy to prevent these developmental effects of maternal Cd exposure.

Read full abstract
  • Journal IconFASEB BioAdvances
  • Publication Date IconJun 17, 2025
  • Author Icon Rebecca Lichtler + 4
Cite IconCite
Chat PDF IconChat PDF
Save

Dietary patterns and recurrent pregnancy loss: a comparison of the American Heart Association diet, Mediterranean diet and others

BackgroundRecurrent pregnancy loss (RPL) presents a major challenge in reproductive medicine, with lifestyle factors, especially dietary patterns, potentially influencing pregnancy outcomes. This study aimed to explore the relationship between adherence to preconception dietary patterns and pregnancy outcomes in women with RPL.MethodsThe study included 475 women with RPL at Renji Hospital, Shanghai Jiao Tong University School of Medicine. Participants completed a semi-quantitative food frequency questionnaire (FFQ) to assess adherence to six pre-defined dietary patterns at preconception: the American Heart Association Diet (AHA), Trichopoulou Mediterranean Diet (TMED), Panagiotakos Mediterranean Diet (PMED), Alternate Mediterranean Diet (AMED), Healthy Eating Index-2015 (HEI-2015), and Dietary Approaches to Stop Hypertension (DASH). Pregnancy loss, gestational diabetes mellitus (GDM), hypertensive disorders of pregnancy (HDP), and other adverse pregnancy outcomes (APO) (e.g., preterm birth, low birth weight) were ascertained using medical records.ResultsSignificant associations were observed between adherence to the AHA diet and reduced risks of pregnancy loss [adjusted RR (95% CI), highest quartile (Q4) vs. lowest quartile (Q1): 0.36 (0.17, 0.78), P-trend = 0.043], GDM [adjusted RR (95% CI), highest quartile (Q4) vs. lowest quartile (Q1): 0.28 (0.10, 0.75), P-trend = 0.006], HDP [adjusted RR (95% CI), highest quartile (Q4) vs. lowest quartile (Q1): 0.12 (0.03, 0.57), P-trend = 0.008], and other adverse pregnancy outcomes [adjusted RR (95% CI), highest quartile (Q4) vs. lowest quartile (Q1): 0.04 (0.01, 0.35), P-trend = 0.001]. Similar associations were found for the AHEI, AMED, and TMED diets regarding pregnancy loss, GDM, and HDP, while the PMED and DASH diets showed no significant associations. Additionally, higher levels of moderate-to-vigorous physical activity and lower energy and fat intake were associated with increased live birth rates.ConclusionGreater adherence to the AHA diet during the preconception period was linked to lower risks of pregnancy loss, and adverse pregnancy outcomes. These findings support the AHA diet for patients with recurrent pregnancy loss, indicating that healthy dietary patterns may improve pregnancy outcomes and highlight the need for further research on their impact on fertility.

Read full abstract
  • Journal IconFrontiers in Nutrition
  • Publication Date IconJun 4, 2025
  • Author Icon Yan Ma + 3
Cite IconCite
Chat PDF IconChat PDF
Save

Dietary pattern and nutritional assessment in a cohort of mothers identified by neonatal screening for cobalamin deficiency in offspring: an Italian single center experience

During pregnancy, nutrient requirements increase while deficiencies can significantly affect pregnancy outcomes. Deficiencies may result from inadequate dietary intake, impaired absorption, or restrictive diets. This study aimed to retrospectively assess the nutritional status and dietary intakes in a cohort of mothers whose newborns were identified with vitamin B12 deficiency of maternal origin through Newborn Screening. Between 2021 and 2024, 107 newborn-mother dyads with altered biomarkers of cobalamin metabolism were identified and referred to the Metabolic Disease Unit for further evaluation and treatment. Mothers underwent biochemical assessments and nutritional interviews regarding pregnancy diet history, and dietary intakes were quantified using a dedicated software (MetadietaVR). Most of the cohort (47%) was from Asia, with an average age of 32.5 years. Plasma vitamin B12 levels averaged 240 pg/ml. Mothers who reported taking vitamin B12 supplements had higher plasma levels compared to those who did not supplement with B12 (255.5 ± 113 vs. 231.2 ± 104 pg/ml). Dietary habits during pregnancy revealed that 71% of mothers were omnivorous (O), 16% followed a lacto-vegetarian (LV) diet, 12% a lacto-ovo-vegetarian (LOV) diet, and 1% a vegan (V) diet. Most mothers (90%) were taking supplements during pregnancy, with 70.7% taking folic acid, 68.7% iron and 15% vitamin B12. Among women who achieved adequate vitamin B12 intake through both diet and supplementation, 95% were omnivores while 5% followed a LOV diet. This study emphasizes the importance of addressing maternal nutritional needs from the pre-conception period, as dietary patterns may not adequately reflect micronutrient intake. Even omnivorous diets, if unbalanced, can result in insufficient nutrient intake, underlying the necessity of targeted nutritional support during pregnancy.

Read full abstract
  • Journal IconFrontiers in Nutrition
  • Publication Date IconJun 4, 2025
  • Author Icon Martina Tosi + 14
Cite IconCite
Chat PDF IconChat PDF
Save

Epidemiology of folic acid/folates use in the preconceptional period and during pregnancy in Italy: results from a cross-sectional observational study.

Epidemiology of folic acid/folates use in the preconceptional period and during pregnancy in Italy: results from a cross-sectional observational study.

Read full abstract
  • Journal IconEuropean journal of obstetrics, gynecology, and reproductive biology
  • Publication Date IconJun 1, 2025
  • Author Icon Fabio Parazzini + 16
Cite IconCite
Chat PDF IconChat PDF
Save

  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • .
  • .
  • .
  • 10
  • 1
  • 2
  • 3
  • 4
  • 5

Popular topics

  • Latest Artificial Intelligence papers
  • Latest Nursing papers
  • Latest Psychology Research papers
  • Latest Sociology Research papers
  • Latest Business Research papers
  • Latest Marketing Research papers
  • Latest Social Research papers
  • Latest Education Research papers
  • Latest Accounting Research papers
  • Latest Mental Health papers
  • Latest Economics papers
  • Latest Education Research papers
  • Latest Climate Change Research papers
  • Latest Mathematics Research papers

Most cited papers

  • Most cited Artificial Intelligence papers
  • Most cited Nursing papers
  • Most cited Psychology Research papers
  • Most cited Sociology Research papers
  • Most cited Business Research papers
  • Most cited Marketing Research papers
  • Most cited Social Research papers
  • Most cited Education Research papers
  • Most cited Accounting Research papers
  • Most cited Mental Health papers
  • Most cited Economics papers
  • Most cited Education Research papers
  • Most cited Climate Change Research papers
  • Most cited Mathematics Research papers

Latest papers from journals

  • Scientific Reports latest papers
  • PLOS ONE latest papers
  • Journal of Clinical Oncology latest papers
  • Nature Communications latest papers
  • BMC Geriatrics latest papers
  • Science of The Total Environment latest papers
  • Medical Physics latest papers
  • Cureus latest papers
  • Cancer Research latest papers
  • Chemosphere latest papers
  • International Journal of Advanced Research in Science latest papers
  • Communication and Technology latest papers

Latest papers from institutions

  • Latest research from French National Centre for Scientific Research
  • Latest research from Chinese Academy of Sciences
  • Latest research from Harvard University
  • Latest research from University of Toronto
  • Latest research from University of Michigan
  • Latest research from University College London
  • Latest research from Stanford University
  • Latest research from The University of Tokyo
  • Latest research from Johns Hopkins University
  • Latest research from University of Washington
  • Latest research from University of Oxford
  • Latest research from University of Cambridge

Popular Collections

  • Research on Reduced Inequalities
  • Research on No Poverty
  • Research on Gender Equality
  • Research on Peace Justice & Strong Institutions
  • Research on Affordable & Clean Energy
  • Research on Quality Education
  • Research on Clean Water & Sanitation
  • Research on COVID-19
  • Research on Monkeypox
  • Research on Medical Specialties
  • Research on Climate Justice
Discovery logo
FacebookTwitterLinkedinInstagram

Download the FREE App

  • Play store Link
  • App store Link
  • Scan QR code to download FREE App

    Scan to download FREE App

  • Google PlayApp Store
FacebookTwitterTwitterInstagram
  • Universities & Institutions
  • Publishers
  • R Discovery PrimeNew
  • Ask R Discovery
  • Blog
  • Accessibility
  • Topics
  • Journals
  • Open Access Papers
  • Year-wise Publications
  • Recently published papers
  • Pre prints
  • Questions
  • FAQs
  • Contact us
Lead the way for us

Your insights are needed to transform us into a better research content provider for researchers.

Share your feedback here.

FacebookTwitterLinkedinInstagram
Cactus Communications logo

Copyright 2025 Cactus Communications. All rights reserved.

Privacy PolicyCookies PolicyTerms of UseCareers