The aim of this editorial, linked to a previous one [1], is to discuss and share a fundamental thinking process pertaining to the design of failure analysis procedure. The subject of organization of failure investigation is comprehensively presented in the excellent Ref. [2], highlighting also details, examples, and applications from the real world of industry and engineering. The holistic and quality-based approach is an essential element of failure analysis investigation to reach high performance and success to the preset goals, as it is in line to worldwide-adopted quality management systems, such as ISO 9001. A primary approach based on process-design may serve as a guide or work instruction for failure analysis. The use of flowchart is highly advised in quality systems and process development. A representative and indicative example is shown in Fig. 1, and it has many analogies to the famous Plan-Do-Check-Act (PDCA) cycle of the Quality Guru W. Edwards Deming (1900–1993). The main steps of such process can be summarized as follows: