Chest pain is a common complaint among pediatric patients, often leading to visits to Emergency Departments or outpatient clinics. While most cases are benign, timely diagnosis is essential to prevent fatalities in those with serious conditions. The COVID-19 pandemic has shifted healthcare dynamics, necessitating an understanding of its impact on pediatric health, including potential complications such as chest pain, fever, cough, shortness of breath, sore throat, and headache. This study aims to explore the prevalence, characteristics, and potential association between COVID-19 and chest pain in children during two time periods: 2019 (before the COVID-19 pandemic) and 2021 (the full year during the pandemic). Data were collected from medical records and telephone interviews with pediatric patients presenting with chest pain at the University of Jordan Hospital. The study included a sample size of 3294 patients with selection criteria based on presenting symptoms and COVID-19 status. Data collection occurred from 2019 and 2021, and demographic information (age, gender, weight), medical history (perinatal and family history), COVID-19 status (vaccination, infection history), and details about chest pain (frequency, onset) were documented. Statistical analyses were performed to evaluate differences between the two time periods using IBMSPSSStatistics for Windows, Version 28 (Released 2021; IBM Corp., Armonk, New York, United States). The results indicate a significant increase in the number of patients presenting with chest pain in 2021 compared to 2019 (P value = .0157). The mean age of patients was 11 years, predominantly male. There was a notable increase in the percentage of patients with comorbidities in 2021. Echocardiography results were normal in approximately 84% of cases across both years, with no significant differences in ECG outcomes. Palpitations remained the most common associated symptom. 4.6 % of patients in 2021 were confirmed to have COVID-19, most of whom were diagnosed with muscular causes of chest pain. Notably, none of the patients had received the COVID-19 vaccine. This study highlights a marked increase in pediatric patients presenting with chest pain during the pandemic, although characteristics and underlying causes remained consistent between years. The rise in cases may be attributed to heightened awareness rather than a direct link to COVID-19. Recommendations for clinical practice include careful evaluation of chest pain in pediatric patients during the pandemic, considering psychosocial factors and the broader impact of COVID-19 on health-seeking behaviors. Future research should investigate the long-term effects of COVID-19 on pediatric populations and explore the psychological implications on health service utilization. This study underscores the need for ongoing assessment of pediatric healthcare practices amid evolving pandemic conditions.
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