The study explores the significant role of Human Resource Management (HRM) practices in shaping employee performance within healthcare settings. Grounded in Sociotechnical Systems Theory, Herzberg’s Two-Factor Theory, and Human Capital Theory, the research employs a descriptive design, collecting primary data through a structured questionnaire. The study focuses on personnel from Accident and Emergencies, Nursing, and Nutrition departments, given their vital contributions to patient care and service delivery. These departments require specialized HRM strategies tailored to their unique operational demands, allowing for an in-depth evaluation of HRM practices across diverse healthcare functions. A pilot study involving ten respondents helped refine the research instrument. Stratified random sampling was applied, with secondary data from policy documents and internal reports complementing the study. Cronbach’s alpha tested instrument reliability, aiming for a minimum threshold of 0.7. Validity was ensured through content validity, aligning questionnaire items with study objectives while establishing content, construct, and criterion validity logically and statistically. The data collection process entailed securing approvals, identifying and categorizing respondents, and distributing questionnaires. A ten-day window was given for completion, with follow-ups to maximize response rates and maintain data integrity. An in-depth analysis of KNH's HRM practices and employee performance was facilitated by this comprehensive approach, delivering important insights to healthcare management. Findings indicated that employee remuneration, management styles, recruitment and selection methods, and workplace design significantly influenced performance at Kenyatta National Hospital, Nairobi City County, Kenya. The study concludes that fair compensation enhances job satisfaction, commitment, and engagement. Transparent communication, active employee participation, and supportive leadership create a motivating work environment. Effective recruitment strategies improve the selection of candidates with the right skills, qualifications, and organizational fit. A well-structured workplace design boosts efficiency, productivity, and overall job satisfaction for healthcare professionals. Recommendations include regular assessment and adjustment of compensation packages to match industry standards and employee expectations. Hospital management should continually refine strategies to meet workforce needs.
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