Pressure-induced formation of KBr monohydrate and bromide substitution effects in alkali halide monohydrates.

Specific ion effects are often unpredictable in their manifestation within collective behavior, as the underlying principles of how they mediate water-solute interactions remain unclear. In this study, we investigate the influence of simple ions on amino acids in electrolyte solutions, focusing on arginine, lysine, and serine in potassium iodide, potassium bromide, potassium chloride, sodium chloride, and lithium chloride solutions. We combine experimental techniques and molecular dynamics simulations to examine how monovalent ions affect the dielectric spectra of these complex solutions. Our results reveal three key effects of salt addition: (I) A decrease in the permittivity of the solution, a phenomenon known as the dielectric decrement, which is phenomenologically described by the Langevin function. The extent of the dielectric decrement is dependent on the specific ion. (II) An increase in the relaxation time of amino acids. Furthermore, the relaxation time of water is either increased or decreased depending on the specific salt-amino acid combination. The extent of the change in relaxation time compared to binary mixtures is dependent on the charge density of the added ions. (III) Long-range restructuring of amino acids and water leads to changes in their relative orientation over large distances. These findings provide new insights into how ions affect water-amino acid interactions and their impact on the dielectric properties of electrolyte solutions.

Thiosemicarbazide potassium bromide (TSCPB) single crystals were successfully grown by the slow evaporation solution growth technique at ambient temperature. The presence of expected functional groups and the chemical composition of the grown crystal were verified by Fourier transform infrared (FTIR) spectroscopy, which confirmed the formation of the TSCPB compound. The optical transparency of the material was studied using UV–Visible–NIR spectroscopy, which showed a wide transmission window in the visible region, making the crystal suitable for optical device applications. The differential scanning calorimetry (DSC) analysis revealed that the TSCPB crystal possesses good thermal stability, an essential characteristic for nonlinear optical applications. Surface morphology and growth features were examined using optical microscopy, showing smooth and well-defined facets. The nonlinear optical (NLO) property of the TSCPB crystal was evaluated by the Kurtz and Perry powder technique, which confirmed its second harmonic generation (SHG) efficiency. These results demonstrate that TSCPB is a promising material for optoelectronic and nonlinear optical applications.

This study presents the information-theoretic measures and molar thermodynamic properties for an extended cosine hyperbolic potential. The analytic expressions for the Fisher information in both position and momentum spaces are derived. The Shannon entropy for both position and momentum spaces are also derived. The Cramér-Rao bound and Beckner-Bialynicki-Birula-Mycielski (BBM) inequality are tested and confirmed, presenting the model as a good fit for the study of information theory. The study of thermodynamic properties is applied to phosphorus (P₂), potassium (K₂), potassium bromide (KBr), and silicon monoxide (SiO) molecules using specific analytical equations. The results for molar enthalpy (H), molar entropy (S), molar Gibbs free energy (G), and molar heat capacity (Cp) for the four molecules across a temperature range of 0 K to 6000 K are numerically obtained. The predicted results demonstrate excellent consistency with experimental data obtained from the National Institute of Standards and Technology (NIST) database. The discrepancies observed indicate minor variations in the model’s accuracy, providing reliable predictions for the molar thermodynamic properties of the molecules. The performance of the model validates its suitability for studying information theory and accurately representing thermal properties.

This study fabricates free-standing films from the natural polyanion carboxymethyl cellulose (CMC) paired with the synthetic polycation poly-(diallyldimethylammonium chloride) (PDADMAC) using all-aqueous processing. First, the ability of CMC and PDADMAC to form polyelectrolyte complexes (PECs) in the presence of sodium chloride (NaCl) or potassium bromide (KBr) was screened by using turbidity measurements. This revealed that an excess of polycations was required to induce coacervation in CMC/PDADMAC in the presence of either salt, which amassed a net positive charge in the coacervates. The optimized PEC conditions for casting were corroborated via rheological testing, which indicated higher coacervate sensitivity to KBr than to NaCl. Next, blade casting was used to spread the coacervates into a thin layer, which were processed into films using aqueous phase separation (APS). The morphology, thermal properties, and mechanical performance of the films were evaluated by using scanning electron microscopy (SEM), dynamic mechanical analysis (DMA), and tensile testing, respectively. SEM revealed that the films were dense, with Young's moduli ranging from 436 to 975 MPa. Higher salt concentrations in the coacervates yielded films with fractured and unstable surfaces, which resulted in a significant decrease in mechanical strength, though the films were still robust with Young's moduli ranging from 110 to 330 MPa. With the knowledge that our CMC/PDADMAC films were manufactured with an excess of PDADMAC, we hypothesized that their cationic nature would result in intrinsic antimicrobial properties via contact killing. Indeed, all CMC/PDADMAC films inactivated ∼50% of the Escherichia coli and Staphylococcus aureus, supporting that the manufactured films present free cationic groups available to kill microbes or further chemical modifications. We suggest that these high-strength biopolymer-based films produced via sustainable all-aqueous processing hold potential for use as membranes, packaging materials, and high-touch coatings.

Circularly polarized luminescence is crucial for optoelectronics, bioimaging, and three-dimensional display, yet most of current materials suffer from complex synthesis and limited tunability. Herein, we show the regulation of chiroptical properties in metal halides through mechanochemical engineering. Specifically, phosphorescent indium-based chiral metal halides exhibit blue circularly polarized luminescence, along with antimony-doped indium-based metal halides emit orange circularly polarized luminescence. A grinding strategy using bromide salts like potassium bromide induces bright yellow fluorescence and enables versatile circularly polarized luminescence modulation. When antimony-doped indium-based metal halides are ground with five different bromide salts, it exhibits intriguing and tunable properties: (i) enhanced circularly polarized luminescence, with a luminescence dissymmetry factor value up to 10⁻²; (ii) inversion of the circularly polarized luminescence signal; (iii) generation of near-infrared circularly polarized luminescence with a substantial Stokes shift of 370 nm; and most notably, (iv) a 29.71-fold improvement in second-harmonic generation efficiency. This approach also realizes applications in circularly polarized light-emitting diodes.

The aim of this study is twofold: to characterize the epidemiology of idiopathic epilepsy (IE) in a large US primary care provider, and to investigate primary care veterinarians' anti-seizure drugs (ASDs) prescribing practices. A multicenter retrospective study was conducted: Banfield Pet Hospital electronic medical records were searched (01/01/2020-31/12/2023) for dogs aged 6 months to 6 years at first recorded epileptic seizure, with normal general and neurological examinations and unremarkable blood analyses. To further support the IE diagnosis, only dogs prescribed ASDs were included. Signalment, ASDs name and dosing were recorded. Eight-hundred-fifty-three dogs met the inclusion criteria, corresponding to a prevalence of 0.03% (853/2,969,209 over 4 years). Labrador Retriever, Chihuahua and Siberian Husky were the most represented breeds. The median age at diagnosis was 3.3 years. Males accounted for 60.6% of cases. Phenobarbital (34.9%) and levetiracetam (31.3%) were the most prescribed first-line-ASDs, followed by zonisamide (22.9%) and potassium bromide (11.1%). Phenobarbital median maintenance dose was 2.5 mg/kg (IQR 2.2-3.0 mg/kg) per os (PO), with 99.3% of cases receiving it every 12 h. Extended-release levetiracetam was used in 97.4% of cases; the median dose was 29.7 mg/kg (IQR 24.1-34.6 mg/kg) PO, prescribed every 12 h in 87.7% of dogs. Zonisamide was prescribed at a median dose of 5.8 mg/kg (IQR 4.7-7.4 mg/kg) PO every 12 h (98.0%). Potassium bromide maintenance median daily dose was 29.9 mg/kg (IQR 24.0-38.4 mg/kg) PO with a once-daily administration in 83.3% of dogs. Phenobarbital serum concentration was monitored in 77.5% of cases, while bromide serum concentration was monitored in 31.6% of dogs. The estimated prevalence was lower than previous studies, possibly due to strict diagnostic inclusion criteria and data extraction limitations. Labrador Retrievers were the most affected breed, while other predisposed breeds were underrepresented among IE cases. Prescribing practices generally aligned with the ACVIM guidelines, suggesting good implementation of this knowledge in one of the largest US primary care providers. The variability in levetiracetam and potassium bromide dosing highlights the need for updated evidence-based dosing guidelines, while education on the value of therapeutic drug monitoring could support veterinary and pet-owner's decision making in the management of IE.

Trace-level nitrite detection is essential for environmental monitoring. We have developed a rapid, reagent-minimal method for the detection of trace amounts of nitrite. Our study focused on the spectral characteristics of the fluorescent probe 6-amino-1,3-naphthalenedisulfonic acid (ANDSA). We identified the fluorescence intensity at excitation and emission wavelengths of 278nm and 465nm, respectively, as the key indicator of nitrite quantification. This method, utilizing a 278nm excitation wavelength, achieves high sensitivity for trace levels of nitrite. The incorporation of ultrasound assistance has reduced the detection time to 12min. Through method optimization, only two reagents, sulfuric acid and potassium bromide, are required to form the ANDSA solution for sensitive nitrite detection. Nitrite addition reduces the fluorescence emission peak of ANDSA. In the nitrite concentration range of 0 to 3.2 µM, a strong exponential relationship exists between ANDSA's fluorescence response and nitrite concentration, conforming to the equation F0/F = 0.94183 × e^(0.8766C). The proposed method yields reliable results, with relative standard deviations ranging from 0.4% to 2.5% and recovery rates between 89.87% and 101.97% for real water samples. This method provides a highly sensitive solution for nitrite monitoring.

BACKGROUND: Urolithiasis is a common chronic disease with a high tendency to recurrence. The high rate of stone recurrence determines the clinical importance of metaphylaxis, which requires precise knowledge of the chemical composition of the calculi. AIM: This work aimed to develop an optimal algorithm for mathematical processing of infrared spectra and differential diagnostic profiles of various mineralogical types of kidney stones. METHODS: The object of the study comprised 115 kidney stones obtained during surgical treatment of patients with urolithiasis. Reference samples of the corresponding salts constituting kidney stones were used as standards. Pure reference substances were ground in an agate mortar with potassium bromide (KBr) crystals; the resulting mixture was compressed into transparent pellets, and infrared spectra were recorded using a Fourier-transform infrared spectrometer (Shimadzu IR Prestige 21, Japan). In the infrared spectra of the reference standards, the most frequently occurring and most intense absorption bands were selected (34 maxima). RESULTS: For chemical compounds commonly present in urinary stones, two differential diagnostic profiles were constructed for each compound based on infrared spectral data. Visual comparison of the differential diagnostic profiles of urinary stones with the reference profiles allowed accurate identification of the chemical composition of the calculi in all cases. CONCLUSION: Differential diagnostic profiles represent individual characteristics of each stone type and can be used to determine its chemical composition and to develop a personalized approach to the metaphylaxis of urolithiasis.

To improve the electrocatalytic methanol oxidation (MOR) performance of platinum (Pt)-based catalysts in direct methanol fuel cells (DMFCs), this study uses phosphorus-doped carbon nanotubes (P-CNTs) as a support material. Through a hydrothermal method, different proportions of potassium bromide (KBr) are introduced as a structural directing agent to prepare a series of Pt/P-CNTs-M catalysts (where M represents the molar ratio of KBr to Pt). The study systematically investigates the mechanism by which KBr regulates the crystal plane of Pt nanoparticles and its structure–activity relationship. Physical characterization revealed that KBr selectively regulates Pt crystal plane growth through Br− adsorption. When M = 30, Pt/P-CNTs-30 exhibited the highest proportion of exposed Pt(111) crystal planes (27.21%), with Pt0 content reaching 51.64%, and featured moderate particle size (2.22 nm) and uniform dispersion. Electrochemical testing indicates that the MOR mass-specific activity of this catalyst reaches 3559.85 mA·mg−1Pt, which is 1.17 times that of Pt/P-CNTs-0; it exhibits the lowest charge transfer impedance, with a current density of 488.25 mA·mg−1Pt still maintained after 3600 s of chronoamperometry testing, and a more negative CO oxidation onset potential, demonstrating optimal resistance to poisoning. The study indicates that an appropriate KBr ratio can synergistically optimize Pt crystal plane structure and electronic states, providing a theoretical basis for the design of high-efficiency fuel cell catalysts.

During the Warring States period in ancient China, the tiger-shaped tally (TST) was used to securely transmit military commands. It served as the ultimate symbol of the emperor for troop mobilization, and its loss could even mean the total collapse of centralized military control. Inspired by this ancient authentication mechanism, an optical encryption strategy is proposed based on dynamically tunable circular dichroism (CD). The TST are metastructure-photonic crystal composed of periodically alternating layers of tilted potassium bromide and silver. Specifically, the configuration consists of an upper fixed Z-shaped configuration (TST1), a SiO2 spacer layer, and a lower rotated Z-shaped configuration (TST2). By varying the tilt angle (φ), the azimuthal rotation angle (δ) of TST2, and the incident angle (θ) of the circularly polarized wave, different CD states can be achieved in perfect coordination with TST1. The strategy integrates computational encryption algorithms with physical encryption mechanisms derived from the verification principle of the TST to achieve multi-level information security protection, offering a technical pathway for the development of optical information security technologies.

ABSTRACT The present study aims to report the micellization behaviors and thermodynamics of n‐hexadecyl‐4‐methylpyridinium bromide [C 16 ppicoBr] in aqueous solutions at varied temperatures by using conductivity measurements. The Kraft points were determined to be 30.5 °°C and 32.1 °°C , respectively, for 10 and 50 mM [C 16 ppicoBr] in aqueous solution. Critical micellar concentration (CMC) values were determined to be quite low in the range of 0.695‒0.885 mM at 308.15‒328.15 K. Moreover, the CMC value of [C 16 ppicoBr] in aqueous solution was found to be 0.706 mM at 308.15 K by using the Sudan III solubilization method. Also, in aqueous solutions, the effect of [C 16 ppicoBr] on sodium dodecyl sulfate micellization and the effects of sodium bromide (NaBr) and potassium bromide (KBr) salts on micelle formations of [C 16 ppicoBr] were studied. In mixed micellization systems prepared, the presence of [C 16 ppicoBr] in solution facilitates the micellization of sodium dodecyl sulfate, but not much. NaBr and KBr decreased the CMC value of [C 16 ppicoBr] with their increasing concentrations in aqueous solution. The thermodynamic data showed that micellization of [C 16 ppicoBr] in water solution at varied temperatures is spontaneous, endothermic at 308.15 K, exothermic at 313.15 K, and higher temperatures.

Abstract. Empirical electronic polarizabilities of I−, Br−, and Br7+ were determined to predict refractive indices of iodides, bromides, and perbromates, respectively, at λ=589.3 nm. Polarizabilities of the iodine and bromine ions were derived from the total electronic polarizabilities of compounds containing I or Br by subtracting the polarizabilities of the remaining cations and anions, yielding the contribution of the halogen ions to the total electronic polarizabilities calculated from the mean refractive indices using the Anderson–Eggleton relationship. Refractive indices (RIs) of iodides, bromides, and perbromates are taken from literature data and from our own measurements on potassium iodide (KI), sodium iodide dihydrate (NaI ⋅ 2H2O), potassium bromide (KBr), and sodium perbromate monohydrate (NaBrO4 ⋅ H2O). Powder X-ray diffraction analyses were done for basic characterization and to check the purity. Structure analyses were performed using single-crystal X-ray diffraction data on KI, KBr, NaI ⋅ 2H2O, and NaBrO4 ⋅ H2O. Refractive indices were determined using the immersion method with a micro-refractometer spindle stage at λ=589.3 nm, yielding <n> = 1.671(8) for isotropic KI, nx=1.585(9), ny=1.593(4), and nz=1.615(6), with a mean refractive index of <n> =1.598(6) for NaI ⋅ 2H2O; <n> = 1.560(2) for isotropic KBr; and nx=1.470(2), ny=1.491(2), and nz=1.492(2) with a mean refractive index of <n> = 1.484(2) for an optically biaxial NaBrO4 ⋅ H2O crystal. The anion polarizability parameters α-o and No for I− were determined by least-squares methods from 20 iodide compounds with known refractive indices, combined with data from this study. The electronic polarizability of the anion is described by the equation α-=α-o⋅10-No/Van1.20, yielding α-o (I−) = 8.53(5) Å3 and No(I−) = 0.90 Å3.6. Similarly, for Br−, analysis of 20 bromide compounds with established refractive indices, together with data from this study, resulted in α-o (Br−) = 5.4(3) Å3 and No(Br−) = 1.00 Å3.6. The determination of the refractive indices of NaBrO4 ⋅ H2O with four-coordinated Br7+ yielded an electronic polarizability value of 0.938 Å3 for Br7+. Using this value enables the prediction of refractive indices of perbromates. All values were validated against known halide data and used to predict refractive indices of iodine- and bromine-containing compounds. A total of 120 refractive indices was predicted. The results are compared with refractive indices calculated from Gladstone–Dale constants.

Context:Comparison of the degree of conversion (DC) of resin composites for reinforcement of structurally weakened roots.Aims:To compare the DC of flowable bulk-fill resin composites (BFRCs) and dual-cure resin composite (DCRC) at different depths for root reinforcement material using Fourier-transform infrared spectroscopy analysis.Materials and Methods:The study included a total of 24 samples from four different resin composite materials, namely Tetric N Flow BFRC (Group 1), Filtek flowable bulk fill composite resin (Group 2), smart dentin replacement (SDR) (Group 3), and ParaCore DCRC (Group 4). These materials were placed into Teflon molds and light-cured. The samples were sectioned into three segments and pulverized. The powdered samples were then mixed with potassium bromide powder in a ratio of 1:100 and subjected to Fourier-transform infrared spectroscopy analysis.Statistical Analysis:The data were statistically analyzed using SPSS software using parametric tests.Results:ParaCore dual-cure composite showed the highest DC among all the materials tested, followed by SDR, Filtek bulk fill flowable resin composite, and Tetric bulk fill flowable resin composite. The results of one-way ANOVA revealed a statistically significant difference, P ≤ 0.05 (0.000). The post hoc Tukey HSD test revealed a statistically significant difference between groups 1, 2, 3, and 4 (P < 0.0001).Conclusion:When the DC is inadequate, the physical, mechanical, and biological properties of the resin composite are compromised. Therefore, dual-cure resins could be better suited to be used for root canal reinforcement.

Conventional phosphor-converted light-emitting diodes (LEDs) using silicone binders often suffer from yellowing, moisture degradation, and limited spectral tunability, restricting their performance in high-power street lighting. To overcome these limitations, this study aims to develop an advanced LED illumination system integrating a KBr-doped sol-gel/silica phosphor with total internal reflection (TIR) lenses and a reflective housing, encapsulated by an atomic layer deposition (ALD)-coated minilens panel. The sol-gel matrix, synthesized from MTEOS, TEOS, and silica granules, was engineered to achieve uniform KBr particle dispersion, reduced thermal quenching, and improved chromatic stability. The ALD laminate provides an additional moisture and heat barrier, sealing micro-defects and minimizing stress-induced cracking. Optical performance was quantitatively assessed using Monte Carlo beam-tracking simulations under various street configurations, including focal, zigzag, and single-plane pole layouts. Results demonstrated enhanced luminous efficacy, precise glare control, and high uniformity in street illumination. Overall, this integrated sol-gel/ALD LED design effectively addresses the durability and color instability problems of traditional silicone systems, offering a scalable and energy efficient solution for next-generation street lighting.

In order to solve the problem that Gastrodia elata is easy to mildew and produce mycotoxins during storage, and overcome the limitations of traditional detection methods, such as strong subjectivity and low efficiency, the spectral characteristics of normal and laboratory mildew samples were systematically analyzed by Fourier transform infrared spectroscopy combined with potassium bromide compression method. The results showed that although there were differences in the background spectra of Gastrodia elata in different production areas, the mildew samples showed consistent changes in the three key spectral areas of 3400 cm-1, 1630 cm-1 and 1050 cm-1, which revealed the chemical nature of microbial biomass and water increase, protein degradation and transformation, and polysaccharide system reconstruction, respectively, providing a reliable spectral basis for mildew identification. This study confirmed that mid infrared spectroscopy technology can surpass the differences of production areas, and achieve rapid and nondestructive identification of moldy Gastrodia elata by capturing common chemical changes, which provides an effective means for quality and safety control.

Per- and polyfluoroalkyl substances (PFAS), often referred to as "forever chemicals," are persistent organic compounds with strong carbon-fluorine (C-F) bonds, making them highly stable and resistant to degradation. Since the 1940s, PFAS have been widely used in firefighting foam, food packaging, cookware, cosmetics, and paints. Their bioaccumulation in the environment raises significant concerns, as PFAS exposure—primarily through contaminated drinking water and food—has been linked to DNA modification, reproductive toxicity, immunotoxicity and cancer. To mitigate these risks, it is essential to develop effective methods for PFAS removal from water supplies.Perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), are the most studied PFAS due to their wide use and bioaccumulation. These substances are being progressively eliminated worldwide, however, addressing contamination in existing water supplies remains an urgent priority. The capture and/or degradation of PFAS in water requires the development of successful separation methods and an understanding of its adsorption mechanisms. Whether for degradation, capture or detection applications, electrosorption is a key area of interest in the mitigation of PFAS in water. Understanding the mechanisms of surface adsorption and relationship with water is essential to innovation in remediation technology.Potential dependent surface-enhanced infrared absorption spectroscopy (SEIRAS) provides a powerful tool for studying PFAS adsorption at the electrode interface. PFOA and PFOS were analyzed with cyclic voltammetry and SEIRAS protocols in a NaClO4 supporting electrolyte, across a range of pHs. Experimental observations describe PFOA adsorbing to the electrode via the hydrophobic tail, rather than the electronegative carboxylic acid head, confirmed by the large increase in C-F bond molecular vibrations at positive potentials. Potential cycling demonstrated weak adsorption hysteresis, and a disruption of surface interactions was observed in the presence of potassium bromide. For comparison, PFOS was also tested and observed to adsorb via the hydrophobic carbon-fluorine tail. Time-dependent adsorption behavior for PFOS was noted, with higher pH solution showing a higher rate of surface adsorption. These findings demonstrate the complexities involved in competition between electrostatic and hydrophobic interactions and contribute to future innovation in electrosorption methods for remediation of PFAS contamination. Figure 1

Epilepsy is a neurological disease present in a wide range of mammals, including humans and domestic canines and felines. The most commonly used pharmacological treatments for canines are phenobarbital and potassium bromide (KBr). However, both of these medications are partially eliminated through the kidneys, which could potentially cause damage at this level. Current diagnostic methods for kidney damage typically identify issues only at advanced stages, highlighting the need for early detection techniques. Thus, this study aims to evaluate early renal alterations in canines diagnosed with idiopathic epilepsy and treated with phenobarbital and/or KBr, using specific biomarkers such as kidney injury molecule 1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL), alongside non-specific biomarkers such as C-reactive protein (C-RP). Data from 39 canines treated at the Veterinary Hospital Centre (Udelar) and private clinics in Montevideo, Uruguay, were analysed. Subjects were categorised into two groups: a control group (healthy animals) and a group of subjects previously diagnosed with idiopathic epilepsy. The latter group was subdivided into three additional groups: one treated with phenobarbital, one treated with phenobarbital/KBr, and one treated with KBr alone. Laboratory results were evaluated for new biomarkers and conventional analytes. No alterations were found in laboratory tests for liver function, profiles, or urinalysis among the 30 canines subjected to the different treatments. Regarding specific biomarkers, no statistically significant differences (p &gt; 0.05) were observed among the groups. However, alterations in C-RP were found in the group treated only with KBr. Under the conditions of the trial, no significant changes were detected in urinalysis or renal profiles associated with the administration of phenobarbital and/or potassium bromide in canines with idiopathic epilepsy.

Tough to treat: What we know about managing PCDH19-related epilepsy - Systematic review.

To obtain reliable measurement results for the content of components in various materials, reference materials with certified content of the studied component are required. Elemental bromine, being a volatile and toxic liquid, is unsuitable as a source material for the preparation of a reference material for the chemical element bromine. The most optimal choice for the reference material is a bromine salt – potassium bromide.The aim of the study is to develop a certified reference material for composition of potassium bromide based on the same high-purity salt with the certified characteristic «mass fraction of potassium bromide». The mass fraction of the main component in potassium bromide was measured using two methods: a direct method employing coulometric titration with corrections for interfering impurities determined by ion chromatography, and an indirect method based on the scheme of 100% minus the sum of impurities, taking into account their ionic forms.It is shown that the direct and indirect methods for determining the mass fraction of potassium bromide yield consistent results: (99.871 ± 0.029) and (99.873 ± 0.017)%, respectively. Studies of homogeneity, as well as short-term and long-term stability, were conducted using the coulometric titration. A reference material for potassium bromide composition, GSO 12300-2023, was developed with an interval of certified values of the mass fraction of potassium bromide (99.5–100)% and an expanded uncertainty of the certified value of 0.05% at k=2. The certified value and expanded uncertainty of the mass fraction of potassium bromide for a batch of the reference material were (99.87 ± 0.05)%.A distinctive feature of the indirect method for determining the mass fraction of potassium bromide implemented in this work is the construction of a chemical composition model of the analyzed object. This model is based on both a priori and experimental data and utilizes two fundamental principles when summing impurity contents: the condition of material (mass) balance and the principle of electroneutrality. The described indirect method is sufficiently universal. For high-purity salts, it enables achieving a relative expanded uncertainty (at k=2) of less than 0.02%. This method can be adopted in analytical practice for assessing the purity of other metal salts where high accuracy is required.The developed certified reference material can be used to ensure the metrological traceability of measurement results in both titrimetry (precipitation titration) and elemental analysis. It can also be utilized for the preparation or control of certified values for reference materials of bromide ion solution composition, including those in multicomponent mixtures with other anions.