Post-treatment Imaging Findings Research Articles

Outcome Predictors in Acute Basilar Artery Occlusion

to identify predictors of good outcome in acute basilar artery occlusion (Bao). Background: acute ischemic stroke (aiS) caused by Bao is often associated with a severe and persistent neurological deficit and a high mortality rate. the set consisted of 70 consecutive aiS patients (51 males; mean age 64.5 ± 14.5 years) with Bao. the role of the following factors was assessed: baseline characteristics, stroke risk factors, pre-event antithrombotic treatment, neurological deficit at time of treatment, estimated time to therapy procedure initiation, treatment method, recanalization rate, change in neurological deficit, post-treatment imaging findings. 30- and 90-day outcome was assessed using the modified rankin scale with a good outcome defined as a score of 0– 3. the following statistically significant differences were found between patients with good versus poor outcomes: mean age (54.2 vs. 68.9 years; p=0.0001), presence of arterial hypertension (52.4% vs. 83.7%; p=0.015), diabetes mellitus (9.5% vs. 55.1%; p=0.0004) and severe stroke (14.3% vs. 65.3%; p=0.0002), neurological deficit at time of treatment (14.0 vs. 24.0 median of national institutes of health Stroke Scale [nihSS] points; p=0.001), successful recanalization (90.0% vs. 54.2%; p=0.005), change in neurological deficit (12.0 vs. 1.0 median difference of nihSS points; p=0.005). Stepwise binary logistic regression analysis identified age (or=0.932, 95% Ci=0.882–0.984; p=0.012), presence of diabetes mellitus (or=0.105, 95% Ci=0.018-0.618; p=0.013) and severe stroke (or=0.071, 95% Ci=0.013-0.383; p=0.002) as significant independent negative predictors of good outcome. in the present study, higher age, presence of diabetes mellitus and severe stroke were identified as significant independent negative predictors of good outcome.

Posttreatment imaging of pediatric musculoskeletal tumors.

Pediatric patients who are diagnosed with musculoskeletal tumors often require serial imaging both during and after treatment. Although many of the treatments used in adults overlap with those used in children and adolescents, the growing skeleton presents specific challenges that require a unique approach. Surgical treatment of benign osseous lesions typically requires only curettage and bone grafting, whereas that of osseous malignancies generally consists of wide excision and limb salvage, with either endoprosthetic or biologic reconstruction. Current conventional endoprostheses consist of modular components that allow intraoperative customization; however, if there is great potential for future growth, an expandable endoprosthesis may be required. Biologic reconstruction may consist of an allograft and/or autograft and, in some circumstances, can spare the growth plates in a child, thereby allowing normal growth. Expected posttreatment imaging findings in soft-tissue tumors may include muscle flaps and postoperative fluid collections. Medical treatment, including radiation therapy and chemotherapy, can have predictable imaging manifestations, including signal alterations in bone marrow, muscle, and subcutaneous fat. Finally, treatment complications may manifest with clinical symptoms and include infection or mechanical failure, although other complications such as local tumor recurrence may go clinically undetected until surveillance imaging. Familiarity with the expected posttreatment imaging findings in pediatric patients with musculoskeletal tumors can aid in the detection of complications.

Endovascular treatment of acute basilar artery occlusion

Endovascular treatment of acute basilar artery occlusion

Optimized amide proton transfer imaging of ischemic stroke

Optimized amide proton transfer imaging of ischemic stroke

Ectopic growth hormone-secreting pituitary adenoma involving the clivus treated with octreotide: role of magnetic resonance imaging in the diagnosis and clinical follow-up

Ectopic pituitary adenomas (EPAs) are rare neoplasms, mainly described in the sphenoid sinus (SS) and suprasellar region; hormone-secreting EPAs with clival involvement have been rarely reported. We describe a case of a pharmacologically treated GH-secreting EPA involving the clivus and SS, with satisfactory clinical outcome and tumor size reduction. As transsphenoidal resection is the standard approach, post-treatment imaging findings in the nonsurgical management of this entity, to our knowledge, have not been reported before. Ectopic growth hormone-secreting pituitary adenoma involving [...]

Posttreatment CT and MR Imaging in Head and Neck Cancer: What the Radiologist Needs to Know

In patients with head and neck cancer, posttreatment imaging can be complicated and difficult to interpret because of the complexity of the surgical procedures performed and the postirradiation changes, but such imaging is critical for the evaluation of (a) the response to therapy and (b) tumor control. Posttreatment changes are affected by the type of surgery performed, reconstruction, neck dissection, and radiation therapy. Three types of flaps are used for reconstruction in the head and neck region: (a) the local flap, with geometric repositioning of adjacent tissue; (b) the pedicle flap, with rotation of donor tissue and preservation of the original vascular system; and (c) the free flap, with transfer of tissue that is revascularized by using microvascular surgical techniques. The posttreatment imaging findings in patients with head and neck cancer can be divided into four groups: altered anatomy secondary to surgical reconstruction, tumor recurrence, potential postsurgical complications, and possible postirradiation changes. Potential postsurgical complications are wound infection, abscess, fistula, flap necrosis, hematoma, chylous fistula, and serous retention. Possible postirradiation changes include mucosal necrosis, osteoradionecrosis, radiation-induced vasculopathy, radiation pneumonitis, radiation lung fibrosis, radiation-induced brain necrosis, and radiation-induced secondary malignancies. A familiarity with the imaging characteristics of posttreatment changes and of the potential complications caused by surgery and irradiation and an ability to differentiate these findings from tumor recurrence are essential for posttreatment surveillance and follow-up management of patients with head and neck cancer.

The importance of gray scale and color Doppler ultrasonography in the diagnosis of spontaneous renal pelvis rupture: case report

Peripelvic extravasation associated with spontaneous rupture of renal pelvis is a rare occurrence, caused mostly by the obstruction due to calculus. However, the presence of renal anomalies increases the risk of rupture. Urinary extravasation leads to flank pain and may cause acute abdominal symptoms. Especially, the displacement of viscera by extravasated urine and the presence of gastrointestinal symptoms arising through intestinal reflex stimulation renders diagnosis more difficult. Ultrasonography, intravenous urography and computed tomography are the most efficient diagnostic tools in the diagnosis of pelvic renal rupture. In the present study, pre- and post-treatment radiological imaging findings of a case with renal pelvis rupture due to right ureter stone and the use of gray scale and color Doppler ultrasonography in the diagnosis has been discussed.

Pelvic Imaging Following Chemotherapy and Radiation Therapy for Gynecologic Malignancies

Gynecologic malignancies account for 10%-15% of all malignancies in females. A variety of oncologic options are available depending on organ of origin, histologic diagnosis, and disease grade and stage. Gynecologic malignancies are usually treated with surgery, chemotherapy, or radiation therapy. Posttreatment imaging plays a crucial role in the assessment of treatment response and tumor recurrence. Imaging of the female pelvis following chemotherapy and radiation therapy is particularly challenging due to alteration of the normal anatomy and loss of tissue planes. Expected changes in appearance occur following chemotherapy-radiation therapy, as do complications such as fistulas, proctitis, enteritis, typhlitis, cystitis, and insufficiency fractures. Radiologists should be familiar with both the expected posttreatment imaging findings and the imaging features of common complications to help make the correct interpretation and avoid possible pitfalls.

The Accuracy of MRI in Predicting Pathologic Complete Response in Invasive Breast Cancer Patients Receiving Neoadjuvant Systemic Treatment.

Abstract Background: Magnetic resonance imaging (MRI) has increased sensitivity to detect abnormalities in breast tissue as compared with mammography or ultrasound. Published reports of MRIs ability to predict pathologic response to neoadjuvant chemotherapy have shown conflicting results that vary depending on baseline molecular characteristics and chemotherapeutic regimens, with some studies suggesting higher predictive accuracy in Her2 positive patients receiving trastuzumab. This study examines both the ability of MRI to predict pathologic response and how tumor molecular profiles and treatment regimens influence MRI sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV). Sensitivity, specificity, PPV, and NPV for the combination of post-treatment mammogram, ultrasound, and MRI studies in predicting pathologic complete response (pCR) was also explored.Methods: Eighty-one patients with invasive breast cancer treated with neoadjuvant systemic therapy between 2002 to 2009 and imaged pre and post-treatment with breast MRI were reviewed. Patient, tumor, and treatment characteristics including tumor grade, histologic type, receptor status (ER, PR, and Her2), breast cancer subtype [luminal A, luminal B, Her2 positive, triple negative (TN)], correlative pre- and post-treatment mammographic and ultrasound imaging, drug regimen, and pathologic findings were recorded. Complete pathologic response was defined as no residual invasive or pre-invasive disease in the breast.Results: Patients had the following subtypes of breast cancer: 21/81 (26%) luminal A, 13/81 (16%) luminal B, 23/81 (28%) Her2 positive, and 24/81(30%) TN. Of the Her2 positive, only 12/23 (52%) treated after May 2005 received adjuvant trastuzumab. Twenty patients (25%) had a complete radiographic response (rCR) on post-treatment MRI and 23/81(28%) had a pCR. The sensitivity, specificity, PPV, and NPV of MRI for predicting pathologic response was 57%, 88%, 65%, and 84%, respectively. Analysis of breast cancer subtype did not demonstrate a predilection in any particular subtype for correlation of radiographic and pathologic response, although MRI sensitivity (100%) and NPV (100%) were highest in luminal A disease, and specificity and PPV were highest for patients with ER negative (96% and 90%) and triple negative (100% and 100%) disease, respectively. Mammographic and ultrasound post-treatment findings of residual disease did not significantly correlate with pathologic findings in the setting of a rCR on MRI. Multivariate analysis of factors potentially influencing MRIs sensitivity and specificity failed to show that tumor characteristics (ER status, PR status, HER2 status) or neoadjuvant treatment (ACT vs other or trastuzumab) had any effect on these parameters.Conclusions: MRI has the highest specificity and PPV in the setting of ER negative and TN breast cancer. Although treatment results and breast cancer subtype did not influence the sensitivity, specificity, PPV, or NPV of MRI in predicting pathologic response, only half of the Her2 positive subset received trastuzumab. Results from an ongoing large multi-institutional study will further clarify these results. Citation Information: Cancer Res 2009;69(24 Suppl):Abstract nr 4022.

Distinguishing post-treatment changes from recurrent disease in cholangiocarcinoma: a case report

IntroductionThree-dimensional techniques for radiotherapy have expanded possibilities for partial volume liver radiotherapy. Characteristic, transient radiographic changes can occur in the absence of clinical radiation-induced liver disease after hepatic radiotherapy and must be distinguished from local recurrence.Case presentationIn this report, we describe computed tomography changes after chemoradiotherapy for cholangiocarcinoma as an example of collaboration to determine the clinical significance of the radiographic finding.ConclusionBecause of improved three-dimensional, conformal radiotherapy techniques, consultation across disciplines may be necessary to interpret post-treatment imaging findings.