Clinical Care Pathways (CCP) optimize quality of care and resource allocation in health systems. They translate guidelines or evidence into local practice. This work aims to provide a methodological approach for drafting a CCP, referring to a model for the prevention, diagnosis and treatment of post-stroke disability. The research method is based on a six-stages process: identification of health needs to priorities in the local care system; establish a multidisciplinary working group; selection of guidelines and evaluation of quality with the Grilli criteria, the AGREE and GRADE methodology; integration of gaps/updates among guidelines; adaptation to the local context; regular updating. The output is an integrated flow-chart. Indicators are identified for auditing. Three international guidelines were selected (NICE 2013, Canadian 2015, AHA/ASA 2016). The US one was excluded because of non-comparable health services in the two countries. Evidence for upper limb robotic rehabilitation was obtained with a narrative review by the authors. Outpatient rehabilitation is the most appropriate context for management of post-stroke disability. Access to outpatients is regulated by the rehabilitation physician, the GP or other specialists involved in stroke care. A clinical and instrumental assessment will provide indication to physical, medical and/or surgical treatments. Cognitive deficits will be already been identified and treated from the Stroke Unit. Follow-up entails clinical and/or instrumental re-evaluations, treatment modifications, or exit from the pathway. The “process” indicators include: number of first accesses; number of visits/year; time to access to service from prescription; number of control visits and retreatment. Among “outcome” indicators there are: complications; number of resolved cases; access within 6 months of the acute event. This CCP was designed according to international standards for CCPs. Adaptation to the local context led to the development of a codified and univocal pathway with a specialized and personalized care for patients with post-stroke disability.