During the course of post-operative enteral nutrition in cases of gastric cancer, the changes occurring in the intestinal microflora and their relationship to clinical symptoms or biochemical examination levels were investigated. Nutritive agents used were Elental, Besvion and Hinex-R, each of which had a different carbohydrate composition. The subjects were divided into three groups: Elental group (group E), Besvion group (group B) and Hinex-R group (group H). Diarrhea occurred in 40% of cases in groups E and H and in 10% of those in group B while enteral nutrition was being carried out. Observation of the changes in intestinal microflora during use of the nutritive agents revealed that anaerobes decreased to 1/100-1/10000 in the three groups due to the antibiotics used postoperatively. There were different changes in Bifidobacterium among the three groups, in particular a marked decrease in groups E and H, both during and after the use of antibiotics which was not marked in group B, the levels of which returned to those existing preoperatively. These results were considered to be caused by the difference in carbohydrates contained in the nutritive agents, suggesting that in group B, the nutritive agent of which contained not only dextrin but also galactose, glucose and lactose, the carbohydrates accelerated an increase in Bifidobacterium, inhibiting the occurrence of diarrhea. Hardly any changes in electrolyte, GOT, GPT, LDH, BUN, creatinine and serum protein (T-p) were found, showing levels within the normal range. It was therefore thought that there was no relation between changes in intestinal microflora and biochemical examination levels.
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