Objective To study the short-term and medium-term effects of mini- strip anchor and capsulotomy in the treatment of first metacarpophalangeal joint dislocation in rheumatoid arthritis(RA). Methods From January 2015 to December 2016, fifty-eight RA patients with first metacarpophalangeal joint dislocation were randomly divided into study group (20 cases), joint replacement group (19 cases) and non-operation group (19 cases). Postoperative evaluation indexes: the wound healing was observed in accordance with trial standard of functional evaluation of upper limbs of Chinese Medical Association Hand Surgery Society . The surgical outcomes of the three groups were compared.The hand function and quality of life were assessed by Michiga Hand Outcomes Questionnaire (MHQ) and arthritis impact measurement scale 2 (AIMS2) before treatment, 6 months after treatment and 12 months after treatment. Results All the patients in the study group and the joint replacement group healed by first intention without any early complications.According to the criteria of upper extremity functional evaluation of Chinese Medical Association, the curative effect of the operation was evaluated.In the study group, 15 cases were excellent, 3 cases were good, 2 cases were poor, the excellent and good rate was 90.0%.In the joint replacement group, 15 cases were excellent, 3 cases were good, 1 case was poor, and the excellent and good rate was 94.7%.After treatment for 6months, the MHQ scores were improved significantly in the three groups ((48.36±8.24) vs.(73.06±10.55); (47.56±7.75) vs.(81.42±8.54); (48.75±8.85) vs.(65.91±8.26)) (F=33.19, 35.12, 28.42, P 0.05). At 6 and 12 months after treatment, AIMS2 scores of each group were significantly improved, but AIMS2 scores of study group ((216.51±35.28) points, (230.28±23.51) points) and arthroplasty group ((221.45±31.63) points, (234.15±21.42) points) were significantly higher than those of non-operation group ((192.69±41.31) points, (200.43 ±28.42) points) (P 0.05). Conclusion Micro-strip line anchors combined with posterior capsulorrhaphy in the treatment of first metacarpophalangeal joint dislocation in rheumatoid arthritis can achieve good stability of articular reduction, significantly improve the joint function and quality of life and have ideal short-term and mid-term effect. Key words: Micro-strip line anchors; Posterior capsulorrhaphy; Metacarpop halangeal joint dislocation; Rheumatoid arthritis; Short-term and mid-term effect