Aims: More than two million American soldiers have served in Iraq and Afghanistan, and returning home from deployment has proven to be a difficult task (Hinojosa and Hinojosa, 2011). Although social support may be a healthy means of relieving postdeployment distress (Campbell et al., 2007), marijuana use has become a common mechanism for coping with reintegration difficulties (Boden et al., 2013; Golub and Bennett, 2014) and is prevalent in returning veterans (Bonn-Miller et al., 2012). This study examined the associations betweenmarijuana-related problems, DSM-IV cannabis dependence, and post-deployment social support and distress in OIF/OEF/OND veterans. Methods: Returning veterans (n=152, mean age (SD) =32.30 (9.09); 93%male)whodeployedpost9/11/01completed self-report measures of current depression (CES-D), marijuana use problems (MPS), and perceived social support (DRRI). Structured Clinical Interviews for DSM-IV were conducted to determine past year cannabis dependence diagnosis. Results: 41% of veterans reported marijuana use in the past year, and 28% reported use in the past month. Of past year marijuana users, 22% met criteria for DSM-IV cannabis dependence diagnosis. Post-deployment social support (B=−0.71, 95% CI [−0.84, −0.58], sr2 = 0.43, p< .001), marijuana-related problems (B=2.31, 95% CI [0.76, 3.86], sr2 = 0.03, p< .01), and number of current cannabis dependence symptoms (B=3.0, 95% CI [0.72, 5.28], sr2 = 0.02, p< .05) independently predicted CES-D depression. Marijuana problems and dependence symptoms did not moderate the relationship between social support and depression. Conclusions: Social support and marijuana-related problems and dependence were independently associated with depression. Findings suggest that veterans may benefit from increased social support as a way of coping with post-deployment distress. Engagement in interventions and treatments focused on reducing marijuana use may help improve post-deployment outcomes. Financial support: R01 DA033425 (Metrik, Borsari).