The incidence of positive microscopic margins after gastrectomy for gastric cancer (GC) has been reported between 1% to 5%. The aim of the present study was to identify risk factors associated with positive microscopic resection margin in GC patients undergoing gastrectomy, and to assess the survival outcomes and prognostic factors in these patients. The patients were selected from the consecutive database of Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Department of Gastric Surgery, according to the following criteria: (i) histologically proven gastric adenocarcinoma (ii) patients who underwent curative gastrectomy for gastric cancer as a primary treatment and archived R0 or R1 resection between 2005 and 2025. Positive microscopic resection margin was defined as disease present at the line of luminal transaction in mucosa, submucosa, or serosa on final pathology. Univariate and multivariate logistic regression analyses were performed to identify risk factors for resection margin positivity. A total of 1,996 patients were eligible for the present study. Among these patients, 35 patients (1.8%) had positive microscopic resection margin. Pathological type, macroscopic tumor type, and tumor size were identified as independent risk factors for positive resection margin in multivariate analysis. Moreover, positive peritoneal lavage cytology was identified as an independent predictor of poor overall survival prognostic factor in margin-positive GC patients. Microscopic resection margin positivity after gastrectomy for GC was linked to specific tumor characteristics, while positive peritoneal lavage cytology independently predicted poorer survival. To minimize the occurrence of resection margin-positive GC after gastrectomy, it is essential to identify risk factors during perioperative evaluation. Furthermore, treatment strategies based on lavage cytology status could improve prognosis in high-risk patients.

AimsThis study aimed to investigate whether the efficacy of neoadjuvant chemotherapy differs between HER2-low and HER2-zero subgroups in hormone receptor-positive, HER2-negative breast cancer.Materials and MethodsA total of 61 patients who received neoadjuvant chemotherapy between 2015 and 2025 were retrospectively analyzed. HER2 status was determined from pre-treatment core biopsy specimens and classified as HER2-low (IHC 1 + or 2 + and FISH-negative) or HER2-zero (IHC 0). The pathological complete response (pCR) rates were compared between the two groups.ResultsAmong 61 patients, 28 had HER2-low and 33 had HER2-zero tumors. The pCR rate was 7.1% in the HER2-low group and 27.3% in the HER2-zero group (p = 0.042). A post-hoc power analysis based on these results showed a moderate power (0.59) to detect the observed difference.ConclusionsHER2-low expression may negatively influence chemosensitivity in hormone receptor-positive breast cancer treated with neoadjuvant chemotherapy. Further studies are warranted to evaluate the potential role of trastuzumab deruxtecan (T-DXd) and other antibody-drug conjugates in this newly defined subgroup.

Impact of anticyclic citrullinated peptide antibody positivity on subclinical cardiovascular profile of patients with established rheumatoid arthritis

BackgroundInfective endocarditis (IE) carries high in-hospital mortality, particularly among intensive care unit (ICU) patients. The predictive role of blood culture positivity in these patients remains unclear.MethodsWe analyzed 484 adult IE patients from the Medical Information Mart for Intensive Care III (MIMIC-III) database, divided into training (n = 339) and testing (n = 145) cohorts. A suite of demographic, clinical, laboratory, and blood culture variables was used to develop tree-based machine learning models. Random Forest (RF) and Extreme Gradient Boosting (XGB) emerged as top performers and were combined into an ensemble model. SHapley Additive exPlanations (SHAP) quantified variable importance, while the Generative Adversarial Nets for Inference of Individualized Treatment Effects (GANITE) model assessed the average treatment effect (ATE) and conditional treatment effects (CATE) of blood culture positivity on in-hospital mortality across various clinical subgroups.ResultsThe ensemble model demonstrated robust performance with an area under the receiver operating characteristic curve (AUROC) of 0.826 and an accuracy of 0.821 on the test set. Blood culture positivity consistently ranked among the top predictors of mortality. SHAP analysis revealed that the presence of bacteremia increased the predicted probability of in-hospital mortality. Specifically, the GANITE model estimated that blood culture positivity raised mortality by 0.9% (95% confidence interval [CI]: −0.9% to 2.6%) in the training set, 7.4% (95% CI: 4.3% to 10.4%) in the test set, and 2.8% (95% CI: 1.2% to 4.4%) overall. Furthermore, CATE analysis highlighted that the adverse impact of blood culture positivity was significantly more pronounced in patients aged 60 years and older, those with systolic blood pressure below 100 mmHg, and in certain endocarditis subtypes.ConclusionsBlood culture positivity at ICU admission is associated with a modest yet clinically significant increase in in-hospital mortality among IE patients. The application of advanced machine learning and causal inference models enhances risk stratification and may inform more targeted clinical interventions in this high-risk group.

Validation of measurable residual disease as a surrogate endpoint in acute myeloid leukemia: A HARMONY Alliance study of European randomized trials

Impact of inhibitors positivity on treatment patterns and disease burden in Chinese patients with hemophilia: A cross-sectional real-world study

One of the recurring economic issues is the challenge of poverty faced by various countries worldwide, including Indonesia. Poverty is evident through a high number of unemployed individuals. Those living in poverty and those facing unemployment generally encounter difficulties in accessing job opportunities, limited business development, income disparities, and lack of workplace protections, especially for women. These issues also affect economically disadvantaged groups in society. This study aims to analyze the impact of job opportunities and minimum wage on unemployment and poverty rates in the Regencies/Cities of Bali Province. The research utilizes secondary data from the period 2012-2021. The study covers 9 Regencies/Cities within Bali Province. Path Analysis is the employed analytical technique. The findings of this research indicate that: 1) Job opportunities have a significant negative impact on unemployment, while minimum wage has a significant positive impact on unemployment. 2) Job opportunities have a positive but insignificant impact on the poverty rate, while minimum wage has a significant negative impact on the poverty rate. Unemployment, on the other hand, has a positive but insignificant impact on the poverty rate. 3) Job opportunities do not have a direct impact on the poverty rate through unemployment, whereas minimum wage directly affects the poverty rate through unemployment. Keyword: Employment Opportunity, Minimum Wage, Unemployment, Poverty Rate.

This study aims to simultaneously or partially analyze multiple factors that affect the informal sector income of Angklingan enterprises in Denpasar city: working capital, working hours and business duration. All data for this study used primary data obtained by distributing questionnaires to 71 interviewees. Samples are determined by random sampling techniques. The analytical technique used is multiple regression analysis. As a result, it was found that working capital, working hours and operating period simultaneously had a significant impact on the informal sector income of Angklingan companies in Denpasar city. Variables such as working capital, working hours and length of operation have had some positive impact on the income of the informal business sector in Denpasar city.. keyword: Angkringan Business, Income, Working Capital, Working Hours, Length of Business

Poverty is a problem faced by every country, especially in developing countries like Indonesia. Efforts are always made to minimize poverty, and even eliminate it if possible. However, in reality, poverty continues to remain an integral part of various aspects of human life. The complexity of the poverty issue continues to be a recurring focus in every developmental phase across different regions. It's worth noting that Bali Province has experienced rapid economic growth, but the unemployment rate and the number of people living in poverty remain high. Addressing the issue of poverty remains a primary focus that requires additional attention. Therefore, government policies are needed to address this problem, particularly in the districts and cities of Bali Province. This study aims to analyze the per capita Gross Regional Domestic Product (GRDP), unemployment, health complaints, and population numbers in relation to poverty in the districts and cities of Bali Province. The research employs secondary data spanning a period of 10 years, from 2012 to 2021. The study is conducted in Bali Province, encompassing 9 districts and cities. The analytical technique used is multiple linear regression analysis. The results of this study indicate that per capita GRDP does not have a negative impact on poverty in the districts and cities of Bali Province. Meanwhile, unemployment, health complaints, and population growth have a positive impact on poverty in the districts and cities of Bali Province. Keywords: Poverty, GRDP Per Capita, Unemployment, Health Complaints, Population Growth

The problem of poverty has a very urgent nature and has no clear boundaries. This is due not only to its continued upward trend, but also to its impact that transcends the economic sphere, encompasses social aspects and even threatens political stability within the country. Most countries with large populations also tend to have higher poverty rates compared to countries with smaller populations. Likewise, with the level of education and TPAK where inmany communities with low economies, opportunities to get adequate education, ranging from elementary to higher, are often limited, furthermore, if TPAK increases this can have a positive impact on economic growth. This study uses time series data with variables of population growth, education level, , TPAK, and poverty rate in the last 26 years, namely 1996-2021 until the number of observations is 26 observation points. Based on the results of data processing and testing simultaneously shows that population growth, education rate, and labor force participation rate (TPAK) affect simultaneously in Papua Province. Population growth has a negative and significant effect on poverty. The level of education, that is, the average length of schooling, has a negative and insignificant effect on poverty. The labor force participation rate (TPAK) has a negative and significant effect on poverty. keyword: Population Growth, Education Level, TPAK, Poverty

The purpose of this study is to (1) analyze the joint effects of economic growth, investment, technology and minimum wage on employment opportunities in districts/cities in Bali; (2) Analysis of partial effects of economic growth, investment, technology and minimum wage on employment opportunities in districts/cities in Bali. (3) Analyze the order of impact of economic growth, investment, technology and minimum wage on employment opportunities in districts/cities of Bali. This study is an associative quantitative study using panel data of up to 72 observations. Data sources for this study are secondary data from the Bali Provincial Central Bureau of Statistics and primary data obtained from informants through in-depth interviews. The collected data were then analyzed using several linear regression analysis techniques. Based on the analysis results, it is shown that (1) economic growth, investment, technology and minimum wage simultaneously have a great impact on employment opportunities in provinces/cities in Bali. (2) Economic growth and minimum wages can have a significant positive impact on employment opportunities in provinces/cities of Bali Province. Investments and technology may not affect employment opportunities in districts and cities in Bali. (3) Minimum wage has the greatest impact, followed by economic growth, investment and technology

This study aimed to investigate the relationship between human papillomavirus (HPV) positivity, genotype, and female sexual dysfunction, particularly anorgasmia and psychosexual stress, among women participating in a cervical cancer screening program. It also examined whether HPV infection or genotype independently contributes to sexual dysfunction after adjusting for sociodemographic and reproductive factors. This prospective, cross-sectional study included 1,353 sexually active women aged 25-65 years who underwent HPV testing at Antalya City Hospital between May and September 2025. Participants completed validated questionnaires including the Female Sexual Function Index, Arizona Sexual Experiences Scale, Beck Depression Inventory, and Beck Anxiety Inventory. Sociodemographic, reproductive, and clinical characteristics were recorded, and HPV genotyping was performed using polymerase chain reaction-based assays. Anorgasmia was identified in 31.5% of participants (n=427). It was significantly more common among unemployed women (84.1% vs. 71.6%; odds ratio =2.09, 95% confidence interval: 1.56-2.82; p=0.0001). Higher gravidity, parity, number of living children, and elevated vaginal pH were all associated with anorgasmia (p<0.05). No significant association was found between HPV positivity or genotype and anorgasmia (p>0.05). Anorgasmia is primarily influenced by sociodemographic and reproductive factors, such as occupation, education level, parity, and vaginal environment, rather than HPV infection or genotype. These findings emphasize the importance of biopsychosocial and culturally sensitive approaches in evaluating and managing women's sexual health.

Tourist satisfaction is an emotion that is felt by visitors when they there are in a place, in this case a tourism place. The satisfaction felt by visitors makes certain behaviours, which in this case share information using social media. This study examines and analyzes the predictors of tourist satisfaction and tourist engagement on the behaviour of sharing tourism experience on social. This study had 115 respondents, using the SEM-PLS analysis technique the results showed that all influence tests were acceptable. Novelty in this study is the existence of tourist engagement that is able to make something unique because both the visitor and the place visited have an emotional engagement

Association of Plasma Septin9 Methylation Status With Therapeutic Response to Antitumor Agents in Colorectal Cancer Patients.

Objective: To Investigate Urogenital Infections In Patients Diagnosed With Preterm Premature Rupture Of The Membranes (PPROM) And Their Impact On Perinatal Outcomes. Material and Method: This retrospective study was conducted at the Perinatology Clinic of Ankara Bilkent City Hospital between June 2020 and December 2023 and included 250 patients diagnosed with PPROM who were followed up and treated in the high-risk pregnancy Vaginal and urine cultures were obtained from each patient, and the impact of culture positivity on perinatal outcomes was assessed. Results: Among these, 72 patients tested positive on culture, while 178 tested negative. Of the obtained vaginal cultures, 46 patients were identified as culture-positive. Among these culture-positive cases, Candida was detected in 36 patients(78%).Additionally, 32 patients had positive results on urine culture. The distribution of microorganisms in urine cultures revealed that 21 patients (65%) had results indicating diverse species. Membrane rupture was found to occur at significantly earlier weeks in those with a positive culture test (p

Background:Indirect immunofluorescence (IIF) is a useful diagnostic modality for anti-neutrophilic cytoplasmic antibody (ANCA) detection in ANCA associated with vasculitis and diseases beyond vasculitis. As per latest guidelines, the IIF has been replaced by enzyme-linked immunosorbent assay (ELISA) as first line of screening for ANCA. The study intends to evaluate the performance of IIF and ELISA for ANCA testing and the impact of antinuclear antibody (ANA) positivity on ANCA reporting across these platforms.Methods:A total of 70 samples, 53 ANA positive and 17 ANA negative, were included in the study. They were tested for ANCA across three different platforms based on IIF and ELISA. An attempt was also made to identify if presence and pattern of ANA affected ANCA reporting across any particular platform.Results:The impact of ANA positivity on ANCA reporting was done using logistic regression analysis. An evaluation of the sensitivity and specificity of each ANCA testing platform was done considering ELISA as the reference method. Subgroup analyses were conducted on the basis of ANA patterns to further know their impact on the specificity and sensitivity of ANCA tests. The use of a 3-biochip combination for ANCA reporting by IIF resulted in a significant reduction of false positive ANCA due to ANA when a combination of ethanol and formalin fixed granulocytes were used.Conclusion:There are notable differences in ANCA diagnostics between IIF based on ethanol fixed granulocytes alone and combination of three biochip. However, the addition of Proteinase 3/myeloperoxidase (PR3/MPO) dots to the 3-chip combination did not offer any added advantage.

Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by low platelet counts due to the destruction of platelets by autoantibodies. The presence of hepatitisB core antibodies (anti-HBc) is amarker of previous or occult hepatitisB virus (HBV) infection, which may influence the clinical course and treatment outcomes in ITP patients. This retrospective study investigated the impact of anti-HBc positivity on the clinical outcomes and response to treatment in ITP patients. Atotal of 116 patients with ITP were divided into 2 groups: those who were anti-HBc positive (n = 31) and those who were anti-HBc negative (n = 85). Clinical data, including platelet counts at diagnosis and during follow-up, response to corticosteroid treatment and remission rates were analyzed. The results indicated that anti-HBc positive patients had significantly lower platelet counts at diagnosis (p = 0.009) and alonger hospital stay (p = 0.042). Additionally, these patients demonstrated lower complete response rates to initial corticosteroid treatment at 1month (p = 0.001) and 6months (p = 0.021) compared to anti-HBc negative patients; however, there were no significant differences in overall response or durable response rates between the groups at 12months. The risk of relapse was higher in anti-HBc positive patients (p = 0.041). These findings suggest that anti-HBc positivity may be associated with amore severe disease course and reduced treatment efficacy in ITP, highlighting the importance of assessing hepatitisB serological markers when managing ITP patients.

This study aims to investigate whether thyroid peroxidase antibodies (TPOAb) affect the ovarian reserve using the anti-Müllerian hormone (AMH), basal follicle-stimulating hormone (bFSH), and estradiol (bE2) as markers. A large retrospective cross-sectional study was conducted, including women who visited our clinic between May 2016 and April 2024 and underwent same-day assessments of basal sex hormones, thyroid function, and AMH. Women with thyroid cancer, ovarian cancer, or clinical/subclinical hypo- or hyperthyroidism were excluded. Participants were stratified into TPOAb-positive and TPOAb-negative groups. Ovarian reserve markers and thyroid function were compared between the groups, and the impact of TPOAb positivity on ovarian reserve was analyzed. Totally, 3,465 women were eligible for analysis, 2,992 women were TPOAb-positive, and 543 (15.67%) were TPOAb-negative. Compared with the TPOAb-negative group, the median age of the TPOAb-positive group was significantly older (33.0 vs 32.0) (P = 0.008), and the median serum TSH levels were significantly higher (1.56 vs 1.40) (P = 0.0003). However, FT4, AMH, bFSH, and bE2 levels did not demonstrate any difference between the two groups. Multivariable median regression models showed that different TPOAb titers had no effect on serum AMH, bFSH, and bE2 levels. Age-stratified analysis showed no association of TPOAb positivity with AMH, bFSH, and bE2 levels in different age groups. Our study indicates that TPOAb positivity is highly unlikely to impair the ovarian reserve in euthyroid women of reproductive age. A larger prospective cohort study on population should be conducted to determine this issue.

0323 Exploring the impact of ANA positivity on vitiligo: Consequences for disease activity and phototherapy dosage

THE IMPACT OF CONSUMER PERSONALITY TRAITS ON POSITIVE AND NEGATIVE EWOM MOTIVATIONS