BackgroundThe leadership practices of nurse managers significantly impact the creativity of staff nurses; however, the effects of ambidextrous leadership on nurses’ creativity are not yet clear. Additionally, the underlying mechanism of this relationship remains to be identified.AimThe study aimed to examine the effect of ambidextrous leadership on nurses’ creativity, directly and indirectly through psychological safety.MethodsIn this cross-sectional study, data were collected from October 2023 to January 2024 involving 241 nurses working at three hospitals in Port Said, Egypt. The Ambidextrous Leadership Scale, Psychological Safety Scale, and the Individual Creativity Scale were employed. Descriptive analysis, correlation analysis, and structural equation modeling were conducted.ResultsNurse managers’ ambidextrous leadership was positively associated with nurses’ creativity. Psychological safety fully mediated the association between ambidextrous leadership and nurses’ creativity.ConclusionThe study suggests that enhancing the ambidexterity of nurse leaders can foster a sense of psychological safety, which, in effect, contributes to increased creativity among nurses.Implication for nursing policymakingThere is a need for healthcare policies and strategies that are supportive of the implementation of ambidextrous leadership practices and promote psychological safety among nurses.