The rapid developing international of internet, Semantic Web has become a platform for intelligent agents mainly in the healthcare sector. Inside the beyond few years there is a widening in the Semantic web data field in the healthcare industry. With a growth in the quantity of Semantic web data field in health industry, there exist some challenges to be resolved. One such challenge is to provide an efficient querying mechanism that can handle large number of Semantic web data. Consider many query languages; especially SPARQL (SPARQL Protocol and RDF Query Language) is the most popular query language. Each of these query languages has their own design strategy and it was identified in research that it is difficult to handle and query large quantity of RDF data efficiently using these languages. In the proposed process, Harmony search identify met heuristic algorithm to optimize the SPARQL queries in the healthcare data in the applicable manner. The application of Harmony search algorithm is evaluated with large Resource Description Framework (RDF) datasets and SPARQL queries. To assess performance, the algorithm’s implementation is compared to existing nature-inspired algorithms. The performance analysis shows that the proposed application performs well for large RDF datasets.
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