This study aims to review antiseptics used in pin-site care to prevent pin-site infection in patients with external fixators attached. The research method is a systematic review, which begins with the process of selecting articles through PRISMA, which is followed by the process of reviewing reports to determine then which papers can be reviewed. The results of a systematic review of six articles showed the benefits of using antiseptics for pin site care in preventing pin site infection. The combination of chlorhexidine with other antiseptics such as alcohol and 1% silver sulphadiazine, the use of single chlorhexidine, povidone iodine, emollient, and microbicidal liquid polymer is effective in preventing pin site infection. Chlorhexidine is considered to be used in low concentrations to minimize the risk of skin irritation. Povidone iodine has the advantage of being an antiseptic that can be found easily in hospitals and has a low price. In conclusion, antiseptics can be used to prevent pin site infection, but the use of emollient skincare, a combination of 5% chlorhexidine - 1% silver sulphadiazine, and microbicidal liquid polymer still requires further research due to the lack of literature and the use of unfamiliar materials.
 
 Keywords: Antiseptic, Patient Attached External Fixator, Pin Site Infection