Injectable carbon nanotube-reinforced calcium phosphate bone cements with high-strength and improved osteogenesis for bone regeneration.

In-situ modification of lignin with auxiliaries (polyethylene glycol and mannitol) during dilute acid pretreatment for efficient saccharification of wheat straw

Biomimetic self-sustained ion oscillation in miscibility gap and chemical inductance impact in potassium sensing.

Biocompatible semiconducting molybdenum diselenide nanosheets with glycyrrhizic acid for enhanced photothermal cancer therapy.

Cell flocculation and phase-separation support macro-scale tissue slab construction in a scaffold-free manner.

Evaluation of functionalized gold nanoparticles stability in a microfluidic device to mimic a biological environment.

Highly efficient red-emissive carbon dots in aqueous solution with prolonged circulation for enhanced tumor Theranostics.

Nanopore-confined photosensitizer in metal-organic frameworks enable enhanced multi-responsive photodynamic activities for efficient tumor cell elimination.

Systematic evaluation and hepatic targeting of a dual-fluorescence icaritin microemulsion: elucidating the protein corona-mediated delivery mechanism.

A near-complete electrochemical conversion of wasted polyethylene glycol (PEG) to C1∼2 products with C1 selectivity reaching 90 % over the PDA-NiCu-OH catalyst

Targeted Radionuclide Therapy (TRT) enables selective delivery of radionuclides for cancer treatment. Alpha particle emitters such as 212Pb are emerging as potential gamechangers, representing highly potent payloads for precision therapy and refractory cancer treatment. While small-molecule carriers are widely explored due to favorable pharmacokinetics, nanoparticle-based TRT remains less studied due to perceived non-ideal pharmacokinetics. We report a unique nanoparticle-TRT pretargeting approach using bispecific antibodies (BsAbs) which "prime" tumor surfaces, enhancing tumor-specific delivery and minimizing off-target deposition of 212Pb. We developed a poly(ethylene glycol) (PEG)-based nanomedicine platform to carry 212Pb, and employed in-house designed and manufactured BsAb (α-epidermal growth factor receptor (EGFR)/α-PEG) to prime tumors to receive the nanocarrier. Sequential administration of each component to EGFR-expressing cells produced enhanced receptor-mediated internalization of the BsAb upon nanomedicine binding, resulting in improved radionuclide delivery and efficacy in a series of in vitro assays. The pretargeting approach more than tripled tumor retention of the 212Pb-nanomedicine compared to the untargeted nanomaterial in a murine EGFR+ breast cancer xenograft model, evidenced by single-photon emission computed tomography (SPECT) imaging of 212Pb-loaded nanomaterials and gamma analysis of the excised organs. Therapeutic studies demonstrated the 212Pb-nanomedicine to produce well-tolerated and statistically-enhanced therapeutic outcomes for the pretargeting versus conventional 212Pb-nanomedicine, with no observed long term hematological effects. This work establishes a modular strategy for targeted TRT nanomedicine delivery. The platform has potential for broad applicability, including simultaneous delivery of diverse or synergistic payloads. These findings represent an important advance toward precision nanomedicine approaches in radionuclide therapy.

Intraneural delivery of CBD3A6K-RhB via PEG-PLGA nanoparticles for neuropathic pain therapy.

Alternative therapies to systemic antibiotics are increasingly explored to prevent infections associated with bone implants. Among them, the surface functionalization of titanium with antimicrobial peptides (AMP) is particularly promising due to their broad-spectrum activity and low risk of inducing bacterial resistance. However, a critical challenge remains in achieving both effective antibacterial action and the promotion of osseointegration. This proof-of-concept study investigates different strategies for immobilizing AMP onto bioactive micro-arc oxidation (MAO) coatings on titanium, aiming to combat methicillin-resistant Staphylococcus aureus (MRSA) colonization while preserving the osseointegration potential of MAO surfaces. The peptide MSI-78 was immobilized either by physical adsorption or covalent grafting, using 1,1'-carbonyldiimidazole (CDI) coupling agent or poly(ethylene glycol) (PEG) spacer. All immobilization strategies preserved the heterogeneous porous architecture and calcium/phosphorus doping of the complex MAO coatings. Prior to bacterial incubation, the surfaces were pre-conditioned with human plasma proteins. MSI-78, whether by physical adsorption or covalent grafting, killed MRSA after 5 h, but also promoted bacterial adhesion to the surface. In contrast, the combined strategy of grafted PEG and physically adsorbed AMP promoted a remarkable antibacterial effect, by reducing MRSA colonization and killing about 80% of adherent bacteria. Regardless of the immobilization strategy, bacterial killing appeared to occur via contact-mediated membrane disruption. Moreover, these PEGylated MAO surfaces with adsorbed AMP maintained excellent cytocompatibility with bone-like cells and supported osteogenic response, underscoring their potential as bioactive coatings for titanium implants.

Multifunctional bilayer scaffolds integrating melt electrowriting fibers and drug-loaded microspheres promote posteochondral regeneration through PI3K-AKT-mediated chondro-osteogenic signaling.

Advanced polyethylene glycol based flexible composite phase change materials enabling stable and efficient lithium-ion battery thermal safety management

A new application of pH-dependent/charge transfer-sensitive spectrophotometer: Enhanced selective extraction of trace acrylamide in the selected foods by triplet quenching of Phenosafranine in presence of Sn(IV).

Molecular dynamics simulation of thiol-ene ‘click’ copolymerized and blended carboxymethyl cellulose and 4-arm polyethylene glycol hydrogel used as ciprofloxacin drug carrier

Intrapericardial delivery of FAP-CAR-T cells via a ROS-responsive hydrogel to treat cardiac fibrosis.

Synergistic construction of preferential growth of WO3 and ion channels induced by non-ionic polyethylene glycol to enhance electrochromic performance

Development and evaluation of a whole-virus ELISA for severe fever with thrombocytopenia syndrome virus: Comparison with a recombinant nucleocapsid protein ELISA.