Polycystic Ovary Syndrome Questionnaire Research Articles

Exploratory factor and confirmatory analyses of the polycystic ovary syndrome health-related quality of life questionnaire (PCOSQ-50)

BackgroundA condition-specific instrument is necessary to measure the health-related quality of life among those with polycystic ovary syndrome (PCOS), the most common chronic endocrinopathy among women. The first instrument was developed in 1988, followed by several revisions. However, further recommendations from all versions include additional application and measurement among different cultural populations of women with PCOS and psychometric testing based on use among larger samples of women with PCOS. Thus, the purpose of this study was to explore the factor structure of the Polycystic Ovary Syndrome Questionnaire (PCOSQ-50) using an international cross-sectional survey data from women with PCOS aged 18–42 years.MethodsUsing data from the largest known international cross-sectional study of women with PCOS aged 18–42 years (n = 935) to date, exploratory factor and confirmatory analyses were conducted for the PCOSQ-50, followed by factor labeling using a thematic analysis approach.ResultsRespondents were 31.0 ± 5.8 years of age, mostly White (72%), well-educated (56% had a college degree), married (69%), and employed full-time (65%). Three-quarters (74%) of the sample had one or more chronic conditions in addition to PCOS. Approximately 20% of the respondents originated from countries such as the United Kingdom, Australia, South Africa, etc. The PCOSQ-50 demonstrated good reliability but may be best described using a 7-factor model. The 7-factor model revealed goodness-of-fit. Thematic analysis suggested the following labels of those seven factors: hirsutism, fertility, isolation/trepidation, sexual function, self-esteem, emotional, and obesity.ConclusionMore research is needed to adapt the current PCOSQ-50, as well as to create an age-appropriate PCOS-specific HRQoL instrument for peri-postmenopausal women with PCOS.

Effect of Callisthenic Exercises vs Yoga on Health Related Quality of Life, Lipid Profile, Anthropometric Measurements and ultrasonography Findings in Polycystic Ovarian Syndrome: A Research Protocol

Introduction: Polycystic Ovarian Syndrome (PCOS) is an endocrine disorder, and individuals with this condition are at a risk of developing complications like metabolic syndromes throughout their lifetime. Not much is known about studies reporting the combined effects of calisthenic exercise with either aerobic exercise or progressive resistive exercises that have shown positive outcomes in PCOS. Need for the study: Extensive literature search has revealed gaps in reporting the individualised effects of calisthenic exercise in PCOS and its comparative effects with yoga. The present research article presents a study protocol comparing calisthenic exercises and yoga protocols prescribed for women with PCOS. Aim of the study: To evaluate and compare the effects of calisthenic exercises and yoga in women with PCOS. Materials and Methods: This research protocol is planned to conduct a randomised clinical trial in Belagavi, Karnataka, India, and will employ a randomised, open-label, parallel-armed, double-blinded clinical experimental design. The duration of the study will be near bout four years, from June 2022 to August 2026. A total of 102 females with PCOS, aged between 18 and 35, will be randomly allocated to either a yoga group (N=51) or a calisthenic exercise group (N=51). For a period of 1½ months (i.e., six weeks), group therapy sessions will be held five times a week. Ultrasonography scans, which will assess ovarian cyst count and size, ovarian volume, and total lipid profile, will be conducted twice (pre- and post-intervention). The PCOS Questionnaire (PCOSQ-26) will be utilised to assess healthrelated quality of life, as well as anthropometric measurements such as waist-hip ratio and Body Mass Index (BMI). These measurements will be assessed prior to the intervention, six weeks following the intervention, and at the 12-week followup. Inferential as well as statistical methods will be used to analyse the gathered data. A test for normal distribution will be conducted, depending on whether parametric tests (Z test and/ or ANOVA) or non-parametric tests (Mann-Whitney U test or Wilcoxon signed-rank test) will be performed. A probability value of less than 0.05 will be considered statistically significant.

Efficacy of mindfulness meditation to improve quality of life in young women with polycystic ovarian disease

Background: Polycystic ovary syndrome (PCOS) is one of women’s most common endocrine disorders that can cause anxiety, psychological distress, and reduced quality of life (QOL). Aims and Objectives: The present study aimed to determine the effectiveness of a 9-week mindfulness-based meditation program on the QOL and general health parameters in young women with PCOS. Materials and Methods: This study was implemented on women diagnosed with PCOS based on Rotterdam criteria. The program was conducted for 9 weeks, beginning with a 15 min session and gradually increasing it to 60 min. The program included techniques on breath focus, body scan, “Om” chanting, mindful breathing, thinking, seeing, and listening. Pre-intervention questionnaires were given to the participants. These were a PCOS questionnaire (PCOSQ), a general health-related QOL questionnaire, and a five-item questionnaire for acne problems. Responses of participants were analyzed using 22 SPSS statistical software. Results: There was a significant difference in the mean of pre- and post-intervention Likert scale response values for the 26-item PCOSQ. There was no significant difference in the mean of pre- and post-intervention Likert scale response values for the acne questionnaire. Before the intervention, majority of them were unsatisfied with their health condition, only 8% reported “excellent” health, after the intervention 63% reported “very good.” 42% reported a reduction in pain, and 71% reported that they were calm and peaceful “most of the time.” Conclusion: Results showed that mindfulness meditation intervention had caused a significant change in general health and QOL of patients with PCOS.

Effects of High-Intensity Resistance Versus Aerobic Training in PCOS Women at Risk for Psychological Trauma

Background: Polycystic ovarian syndrome (PCOS) is a prevalent and complex endocrine disorder that affects women of reproductive age. Its physical manifestations as the change in body image, fertility challenges, menstrual irregularities, and associated chronic health conditions increase their vulnerability to psychological trauma. Negative effects on psychological health significantly impact their quality of life. Objectives: The current study aimed to compare the effects of high-intensity resistance versus aerobic training on psychological health and quality of life in women with PCOS. Study Design: This was a single-blinded, randomized controlled trial. Methods: A randomized controlled trial was conducted from November 22 to April 23 at Riphah Rehabilitation Center, Islamabad, Pakistan. The female university students (n = 60), with an age range of 18 to 30 years, who were not part of any planned physical activity program, were not taking any medication, and were willing to participate in the exercise trial, were recruited. They were randomly allocated into 2 groups: high-intensity resistance (HIRG) and high-intensity aerobic (HIAG) groups. Both groups underwent exercise interventions for a duration of 12 weeks. Clinical and psychological health and quality of life were assessed using validated measures, including the polycystic ovary syndrome questionnaire (PCOS-Q) and the 36-item Short Form Survey (SF-36). Assessments were conducted at baseline, 6th, and 12th weeks. Data analysis was done using SPSS-21. Results: The mean age of women in the HIRG (n = 30) versus the HIAG (n = 30) was 22.40 ± 2.4 years versus 20.63 ± 2.1 years. Between-group analysis revealed no significant difference (P > .05) between the groups in terms of postintervention total scores of the PCOS-Q and SF-36 quality of life. However, within-group analysis has shown statistically significant improvement (P < .01) in both outcome measures. Conclusion: It is concluded that both high-intensity modes of exercise, resistance, and aerobic training were found to be equally effective interventions for improving psychological health and quality of life in women with PCOS. Individualizing exercise programs to meet individual needs and preferences may aid in maximizing the psychological benefits of each exercise modality. Further investigation into the underlying processes and long-term impact of these therapies in this vulnerable population is required.

P-557 Validating the Dutch polycystic ovary syndrome questionnaire (PCOSQ) and the polycystic ovary syndrome quality of life tool (PCOSQOL) in Dutch and Flemish women with PCOS

Abstract Study question What are the test-retest reliability and the domain structures of the Dutch version of the PCOSQ and PCOSQOL in Dutch and Flemish women with PCOS? Summary answer The Dutch version of the PCOSQ and the PCOSQOL are reliable and can both be used to measure health-related quality of life (HRQoL) in PCOS. What is known already The polycystic ovary syndrome questionnaire (PCOSQ) is recommended to measure the quality of life in women with PCOS. The PCOSQ was developed in 1998 to complement generic health-related QoL instruments. The PCOSQ has been validated in Arabic, German, Chinese, and Swedish. Recent research suggested that the PCOSQ focuses on the physical impact of PCOS and that psychological, social, or environmental aspects are less represented. Therefore, the Polycystic Ovary Syndrome Quality Of Life Scale (PCOSQOL) was developed in 2018. Both questionnaires have not been validated in Dutch yet. Study design, size, duration A forward and backward translation was performed on the original English PCOSQ and PCOSQOL by two independent translators. PCOS patients were contacted with a request to complete both questionnaires (and some additional demographic questions) online in their home environment (T0). A test-retest design was applied to demonstrate stability over time by having all women complete the same questionnaires a second time (T1). Approval of the clinic’s Ethics Committee was obtained in both participating centres. Participants/materials, setting, methods Women of at least 18 years old, who were able to speak and write Dutch, and who were diagnosed with PCOS according to the Rotterdam criteria (ESHRE/ASRM, 2003) or according to the international evidence-based guideline for the assessment and management of PCOS (ESHRE, 2018) were eligible for the study. Women who were pregnant at T0 or T1 were excluded from the study. Participants were included between January and December 2021. Main results and the role of chance In total, 245 women were included in this study. The median age was 31 (19-54) years. For the PCOSQ, the Cronbach alpha statistic for the five domains ranged from 0.88 to 0.96 demonstrating good to excellent internal consistency. The Intra-class Correlation Coefficient (ICC) for the five domains was high to excellent ranging from 0.88 to 0.96. For the PCOSQOL, the Cronbach alpha ranged from 0.91 to 0.96 demonstrating excellent internal consistency. The ICC ranged from 0.91 to 0.96 for the four domains indicating excellent reliability. The factor analysis presented five domains of the PCOSQ and the original domain structure was partly confirmed. An extra domain for acne was included based on previous studies. Therefore, the Dutch version of the PCOSQ contained six domains: Weight, Body hair, Emotions, Infertility, Menstrual problems, and Acne. Based on the factor analysis, an extra domain was added to the original four domains of the PCOSQOL, which included items related to dealing with PCOS. Most women (70.6%) needed approximately 15 minutes to complete both questionnaires and had no preference for one of the two questionnaires (55.9%). Limitations, reasons for caution A limitation of our study could be that women with more PCOS complaints were more motivated to participate in this study. Therefore, potential selection bias should be taken into account. Wider implications of the findings The PCOSQ and PCOSQOL are disease-specific QoL measures for women with PCOS. The Dutch versions can be used in studies and in clinical settings (e.g. by nurses and midwives, counsellors, psychologists) to examine the impact of PCOS on QoL in Dutch and Flemish women. Trial registration number NA

Translation of the Modified Polycystic Ovary Syndrome Questionnaire (mPCOSQ) and the Polycystic Ovary Syndrome Quality of Life Tool (PCOSQOL) in Dutch and Flemish Women with PCOS.

This study aims to determine the test-retest reliability and to confirm the domain structures of the Dutch version of the modified polycystic ovary syndrome questionnaire (mPCOSQ) and the Polycystic Ovary Syndrome Quality of Life Scale (PCOSQOL) in Dutch and Flemish women with Polycystic Ovary Syndrome (PCOS). PCOS patients were contacted with a request to complete both questionnaires (including additional demographic questions) online in their home environment on T0 and on T1. The study was approved by the Ethics Committee of Erasmus Medical Centre and of Ghent University Hospital. In this study, 245 participants were included between January and December 2021. The mPCOSQ has excellent internal consistency (α: 0.95) and a high to excellent Intraclass Correlation Coefficient (ICC) for all six domains (ICC: 0.88-0.96). The PCOSQOL demonstrates excellent internal consistency (α: 0.96) and ICC (ICC: 0.91-0.96) for all four domains. The original six-factor structure of the mPCOSQ is partly confirmed. An extra domain is added to the PCOSQOL which included coping items. Most women have no preference for one of the two questionnaires (55.9%). In conclusion, The Dutch mPCOSQ and PCOSQOL are reliable and disease-specific QoL measures for women with PCOS. Both questionnaires are recommended for clinical practice.

A randomized controlled trial comparing myoinositol with metformin versus metformin monotherapy in polycystic ovary syndrome.

Insulin resistance and hyperinsulinemia plays an important role in pathogenesis of polycystic ovary syndrome (PCOS). Metformin, Myoinositol and d-chiro-inositol acts as insulin sensitizers and exerts a beneficial effects in PCOS. The objective is to compare the effect of metformin monotherapy versus a combination of metformin with Myoinositol and d-chiro-inositol in PCOS. This study is a randomized controlled trial conducted over a period of 6 months. All overweight and obese women with PCOS with the age group between 18 and 35 were included and randomized into two groups, 27 in the metformin monotherapy arm and 26 in the myoinositol combination arm. The variables assessed were duration of menstrual cycle, anthropometric parameters, modified Ferriman Gallwey score, global acne score, Fasting insulin, HOMA-IR, fasting lipid profile, serum testosterone, sex hormone binding globulin, luteinizing hormone, follicle stimulating hormone, anti-Mullerian hormone, and pelvic ultrasound to assess ovarian volume, PCOS Questionnaire score. Changes in the parameters from baseline at the end of 6 months of treatment were assessed and compared between the groups. Menstrual cycle regularity improved in both groups with significantly greater improvement in the group receiving myoinositol-based therapy (p < .001). Pregnancy rate was equal in both the arms. There was a significant improvement in PCOSQ score in myoinositol-based therapy group (p < .001). However, there was no statistically significant difference in other hormonal, metabolic parameters between two groups in spite of symptomatic benefits. The addition of myoinositol to metformin exerts additional benefits in improving menstrual cycle regularity, and quality of life in women with PCOS.

Longitudinal prospective cohort study evaluating prognosis in idiopathic intracranial hypertension patients with and without comorbid polycystic ovarian syndrome

IntroductionIdiopathic intracranial hypertension (IIH) and polycystic ovary syndrome (PCOS) are hyperandrogenic metabolic disorders that affect women of reproductive age living with obesity. The previously reported prevalence of comorbid PCOS in IIH patients is highly variable and the longitudinal impact on visual and headache outcomes are unknown.MethodsIn this prospective longitudinal cohort study patients were identified from the IIH: Life database over a nine-year period (2012–2021). Data collected included demographics and PCOS questionnaire data. Key visual and detailed headache outcomes were recorded. We analysed the key variables for influential outcomes of vision and headache. Logistical regression methods were used to model long term visual and headache outcomes.ResultsOverall 398 women with IIH and documented PCOS questionnaires were followed up for a median of 10 months (range 0–87). Prevalence of PCOS in IIH was 20% (78/398) diagnosed by the Rotterdam criteria. Patients with IIH and comorbid PCOS reported higher self-reported fertility problems (3.2-fold increased risk) and increased need for medical help in becoming pregnant (4.4-fold increased risk). Comorbid PCOS in IIH patients does not adversely impact long-term vision or headache outcomes. The headache burden was high in both cohorts studied.ConclusionsThe study demonstrated that comorbid PCOS in IIH is common (20%). Diagnosing comorbid PCOS is important as it can impact on fertility and is known to have long-term adverse cardiovascular risks. Our data suggest that a diagnosis of PCOS in those with IIH does not significantly exacerbate long-term vision or headache prognosis.

Health Related Quality of Life among Reproductive Age Women Having Polycystic Ovarian Syndrome

INTRODUCTION: Polycystic ovarian syndrome (PCOS) is a common endocrine disorder commonly seen in young reproductive age women and is manifested by polycystic appearing ovaries on ultrasonography along with oligomenorrhoea or amenorrhoea, hirsutism, obesity and emotional disturbances further leading to infertility and metabolic disturbances as well as chronic illness. These symptoms, however, are frequently linked to decline woman's self-esteem and self-image, and may have an impact on her health-related quality of life (HRQoL). MATERIALS AND METHODS: Descriptive, web based-cross sectional study was conducted among 686 reproductive age women of Facebook page named PCOS WARRIOR Nepali woman selected conveniently. Structured and standardized health related quality of life questionnaire (German PCOS Questionnaire -g) was used to collect data by posting google form on Facebook page. Obtained data were analysed in Statistical Package for Social Science (SPSS) version 20, descriptive statistics and inferential statistics. RESULTS: More than half (50.9%) of the respondents were found to have good quality of life. The most common health related concern was for Infertility (28.57%) and least was for Acne (71.43%). There was statistically significance between Health-related quality of life and Body Mass Index (BMI) (p=&lt;0.001), menstruation Pattern (p=0.013), duration of medication (p=0.002) and presence of co-morbidities (p=0.010) respectively. CONCLUSIONS: It is concluded that more than half of the respondents have good quality of life. Various programmes should be conducted regarding infertility and assisted reproductive technologies giving special attention to the women having PCOS. Management of PCOS should be directed to improve quality of life of PCOS patients.

A STUDY OF SOCIODEMOGRAPHIC CHARACTERSTICS, ANXIETY &amp; DEPRESSION IN WOMEN WITH POLYCYSTIC OVARIAN SYNDROME

Background: Polycystic ovarian syndrome (PCOS) is the most common and distressing disorder of reproductive age group female which include symptoms like amenorrhea, hirsutism, obesity, acne, infertility etc. Because of these distressing symptoms PCOS has been associated with signicant psychiatric morbidity. Aims &amp; objectives: 1.To study the sociodemographic characterstics of females with PCOS. 2.To nd out the frequency of different symptoms in females suffering from PCOS. 3.To study the prevalence of anxiety and depression among females suffering from PCOS. Materials &amp; methods: 30 consecutive female patients attending gynae OPD from 1/3/2022 to 1/4/2022 suffering from PCOS as per Rotterdam criteria diagnosed by a consulatant gynaecologist were taken for the study. They were thoroughly evaluated on a specially designed semistructred proforma,GHQ-12,Hamilton anxiety rating scale, Beck's depression inventory and PCOS questionnaire. Results were analysed using suitable statistics. Result and conclusion: Majority (60%) of the patients were from the age group 25-30 years. Most common symptom of PCOS in the patient was menstrual irregularity(90%) followed by obesity(80%), hirsutism(50%), acne(40%), alopecia(20%) and acanthosis nigricans(10%), 33%of the patients showed clinically signicant anxiety symptoms, 10% shown clinically signicant depression and 10% showed mixed anxiety depression disorders.

The Reliability and Validity of the Malay Version of Polycystic Ovarian Syndrome Health-Related Quality of Life Questionnaire.

The Polycystic Ovary Syndrome Questionnaire is a reliable instrument for measuring health-related quality of life. This study aimed to develop a Malay version of the Polycystic Ovary Syndrome Questionnaire and to evaluate the health-related impact of Malaysian women with polycystic ovary syndrome. The participants were women who were diagnosed with polycystic ovary syndrome using Rotterdam criteria in a gynecology clinic. Reliability was determined by internal consistency using Cronbach’s coefficient alpha and test–retest reliability using an intra-class correlation coefficient. Validity was assessed through convergent and discriminant validity. Examining the correlation between similar content of the Malay version of the Polycystic Ovary Syndrome Questionnaire and the SF-36 assessed the convergent validity. The discriminant validity was assessed using the known group comparison. Cronbach’s alpha coefficient was over 0.70 for the total scale and over 0.60 for each subscale. Known group comparison supported the discriminant validity. The Malay version of the Polycystic Ovary Syndrome Questionnaire differentiated between the subgroups of women who differed in polycystic ovary syndrome-specific symptoms. Convergent validity was consistent with the good positive correlation between related subscales of the two instruments. Polycystic ovary syndrome women in Malaysia scored the lowest for the weight (3.74) and infertility (3.41) domains, thereby indicating worse health status in these domains. Body hair (5.42) was the least troublesome for the local population. The Malay version of the Polycystic Ovary Syndrome Questionnaire is a reliable and valid tool for assessing the health-related quality of life among women in the local population. It can be used to objectively assess the quality of life among Malaysian women with polycystic ovary syndrome and evaluate their responsiveness to treatment modalities.

The impact of peer-led support groups on health-related quality of life, coping skills and depressive symptomatology for women with PCOS

ABSTRACT Support groups can be a powerful medium in providing psychological support to women with Polycystic Ovary Syndrome (PCOS). The study evaluated the impact of peer support group on Health-Related Quality of Life (HRQoL), depressive symptomatology and coping strategies among women with PCOS. The pre- and post-test experimental design was used. Women with PCOS not receiving psychiatric medication and attending clinics of a teaching hospital in Colombo were recruited. They were randomly allocated based on clinic days to the experimental (n = 20) and control (n = 22) groups. The Intervention group participated in the specific peer support program for 10 weeks, while the control group received general health reading material for 10 weeks through the post. The Modified Polycystic Ovary Syndrome Questionnaire (M-PCOSQ), Centre for Epidemiologic Studies Depression Scale (CES-D) and Brief COPE inventory were administered to both groups before and 1 month after completing the intervention. Before the intervention, there was no significant difference between the two groups regarding the scores of HRQoL, depressive symptomatology and coping skills. One month after the intervention, the support group exhibited improvement in HRQoL, depressive symptomatology and coping skills (p < 0.01) compared to the control group. The peer support group is an effective intervention to uplift the psycho-social wellbeing of women with PCOS through receiving emotional support from those similarly afflicted.

The Effect of Free Androgen Index on the Quality of Life of Women With Polycystic Ovary Syndrome: A Cross-Sectional Study.

Purpose: Free androgen index (FAI) and anti-Mullerian hormone (AMH) are independently associated with polycystic ovary syndrome (PCOS). This study aimed to describe the relationship between these two markers and health-related quality of life (HR-QoL) in women with PCOS.Methods: This cross-sectional study consisted of 81 women in the Hull PCOS biobank, who fulfilled the Rotterdam consensus criteria for the diagnosis of PCOS. The primary outcome was to measure the various domains of the QoL in the modified polycystic ovary syndrome questionnaire (MPCOSQ).Results: Mean age of the study participants was 28 ± 6.0 years, mean body mass index (BMI) 33.5 ± 7.8 kg/m2, mean FAI (6 ± 5.5), free testosterone (2.99 ± 0.75) and mean AMH (3.5 ± 0.8 units). In linear regression analysis, the FAI was associated with overall mean MPCOSQ score (Beta = 0.53, P-value = 0.0002), and with depression (Beta = 0.45, P-value = 0.01), hirsutism (Beta = 0.99, P-value = 0.0002) and menstrual irregularity (Beta = 0.31, P-value = 0.04). However, with adjustment for age and BMI, FAI was only associated with the hirsutism domain (Beta = 0.94, P-value = 0.001) of the MPCOSQ. FAI was also associated with the weight domain (Beta = 0.63 P-value = 0.005) of MPCOSQ. However, AMH was not associated with the overall mean MPCOSQ score or with any of its domains.Conclusion: FAI but not AMH was associated with QoL in women with PCOS, and this effect was mediated by BMI.

The Impact of Polycystic Ovary Syndrome on the Sporting Performance of Female Players

Polycystic Ovary Syndrome (PCOS) is perhaps the most widely recognized endocrine issues in females of reproductive age, influencing up to 20% of individuals of this populace. Many recent studies indicate that testosterone, which can increase muscle mass and strength, stimulates erythropoiesis, promotes competitive behavior, and enhances sporting performance of female athletes. Methods: The comparative study was designed and conducted in which a sample of female athletes (n=40) who had been diagnosed with PCOS by a qualified gynecologist based on clinical features and lab tests. At the same time, a healthy group of female athletes (n=40) was selected from participants of the same population and having regular menses and showing no clinical features of PCOS. The main objectives of the study included: 1) to compare both the groups of female athletes on clinical features of PCOS, and 2) to compare both the groups on self-perceived sports performance. Data was collected from The University of Central Punjab, The University of Lahore, and The University of Lahore College for Women. Data collection was done using two different instruments involving “Polycystic Ovary Syndrome Questionnaire (PCOSQ)” and “Athlete’s Subjective Performance Scale (ASPS)”. Data analyses involved descriptive analysis followed by “Independent Sample t test’ to compare the physical and psychological impact of PCOS and ANOVA was applied to analyze the impact of PCOS on sports performance. Results: There were significant differences between female athletes with PCOS and those with Non-PCOS on physical and psychological conditions. Weight issues t (78) =15.104, (p= .000), Body Hair t (78) =25.108, (p= .000), Menstrual Problems t (78) =20.976, (p= .000), Helplessness t (78) =17.775, (p= .000), and Low mood t (78) =8.449, (p= .000). Significance value (p = .000), which is below 0.05 and, therefore, there is a statistically significant difference in the mean sporting performance. Conclusion: Based on the results, it can be concluded that female athletes with PCOS were more concerned about their physical and psychological conditions. Moreover, their sporting performance was statistically significantly higher than Non-PCOS athletes, which is attributed to higher energy level caused by PCOS itself. Future research must focus on measuring energy level of female athletes with PCOS and Non-PCOS.

The translation and validation of the Arabic Version of the Polycystic Ovary Syndrome Health-Related Quality of Life Questionnaire (AR-PCOSQ)

BackgroundPolycystic ovarian syndrome (PCOS) is a hormonal disorder that is prevalent in females of reproductive age with signs and symptoms that significantly reduce self-esteem and have a negative impact on their quality of life. The management of PCOS signs and symptoms should result in an improvement in the health-related quality of life (HRQoL) of patients. Polycystic ovarian syndrome questionnaire (PCOSQ) is a disease-specific scale. The PCOSQ has been translated into different languages and assessed in different populations. The validity and reliability of PCOSQ varied depending on the ethnicity and culture of the respondents. The objective of the study was to establish a valid and reliable version of the PCOSQ (AR-PCOSQ) in Arabic.MethodsA cross-sectional study using the translated and validated AR-PCOSQ questionnaire was conducted by interviewing 117 women with PCOS.ResultsThe mean age (years) and BMI (kg/m2) of subjects were 29.90 ± 6.33 and 27.21 ± 5.54, respectively. Most of the patients had ≥ 1-year long history of PCOS (73.5%) and a post-school degree (64.96%). The content validity index (CVI) for the AR-PCOSQ from 10 gynecologists was 0.9, indicating satisfactory validity content. The internal consistency for reliability confirmation measured by Cronbach’s alpha coefficient was applied. Alpha coefficients for all items together was 0.863, indicating good reliability. The intraclass correlation coefficients for each item for 30 participants were also acceptable, ranging from 0.911 to 0.986 with p value < 0.001. As far as the factor analysis is concerned, the overall Kaiser–Meyer–Olkin sampling adequacy measure was 0.772. The Bartlett sphericity test was significant (p ≤ 0.001), Indicating that there were interrelated variables.ConclusionOur results demonstrated the initial reliability and validity of the Arabic version of the PCOSQ as a measure of specific HRQoL in Saudi women with PCOS. This will fill an important gap in measuring the HRQoL for patients with PCOS in research and community settings in Saudi Arabia. The AR-PCOSQ can be used to help prioritize health-related concerns from the patient’s perspective.

Phenotypic features and fertility outcomes of women with polycystic ovary syndrome: The effect of quality of life.

This work sought to evaluate the correlation between the five domains of the Polycystic Ovary Syndrome Questionnaire (PCOSQ) and anxiety and depression scales and the clinical phenotype and fertility outcomes in infertile polycystic ovary syndrome (PCOS) patients and to determine the effect of quality of life (QOL) on the clinical, biochemical and fertility disorders in these patients. The data in this study came from a large-scale hospital-based cohort survey of infertile PCOS patients across mainland China. A total of 1000 infertile PCOS subjects diagnosed according to the modified Rotterdam criteria ranging in age from 20 to 40 years in 21 sub-centers (27 hospitals) were enrolled. Baseline anthropometric parameters, endocrine indexes, metabolic panel, QOL questionnaires and the fertility outcomes of ovulation, conception, pregnancy, pregnancy loss and live birth were collected. PCOSQ scores were significantly correlated with most of the baseline parameters. PCOSQ-weight domain scores of National Institute of Health-PCOS group were significantly lower compared with non-National Institute of Health-PCOS group. The five domains scores of PCOSQ were significantly negatively correlated with the body mass index levels of PCOS patients. The serum testosterone levels (total testosterone, free testosterone and free androgen index) were significantly negatively correlated to the scores for the weight, body hair, infertility and emotion domains of PCOSQ. Scores on the anxiety and depression scales were significantly and positively correlated with luteinizing hormone, luteinizing hormone/follicle-stimulating hormone levels. In the low-score group of infertility domain, the rates of conception, pregnancy and live birth decreased significantly. QOL appears to have an impact on the physical symptoms of PCOS, and the emotional stress of infertility affects fertility outcomes.

Assessment of Psycho-emotional Distress Due to Age, Body Mass Index, and Marital Status in Polycystic Ovary Syndrome in North Indian Population

Objectives: Polycystic ovary syndrome (PCOS) is a multifaceted endocrine disorder in reproductive age having a greater impact on health-related quality of life (HRQOL). The aim of this study was to find out PCOS demographics and its related HRQOL effects for improving psychological understanding in disease management. Materials and Methods: A prospective questionnaire-based study was conducted for a period of twelve months at All India Institute of Medical Sciences, Patna, India. The data of 100 PCOS cases were collected about socio-demographic status, clinical history, and dietary intake. Then, a validated PCOS questionnaire (PCOSQ) was used to observe the impact of PCOS symptoms on patients’ HRQOL. Results: The overall 57% and 48% of PCOS cases belonged to the age range of 20-30 years and had a body mass index (BMI) of &gt;25-30, respectively. Based on the results, a significant difference was observed in the mean score of PCOSQ vs. marital status in PCOS cases with respect to emotion (P=0.039), body weight (P=0.002), and infertility (P=0.001). Furthermore, the result showed a significant difference in the domain of emotion (P=0.008), body hair (P=0.035), body weight (P&lt;0.001), and infertility (P=0.018) among BMI group, and a high score was observed in the BMI group &lt;18 in comparison to the other groups of BMI. Conclusions: In general, our findings indicated that infertility, emotions, and BMI had extremely higher impacts on the HRQOL of women suffering from PCOS although their educational status failed to affect HRQOL.

Effectiveness of Lifestyle Modification in Late Adolescent Females with Normal BMI Polycystic Ovarian Syndrome

Background and Objectives: The prevalence of PCOS varies from 2.2% to 26% in different countries. Between 20-50% of women with PCOS are normal weight or lean and the pathophysiology of the disorder in these women may differ from that of obese women; It has been suggested that PCOS develops in non obese women because of a hypothalamic pituitary defect that results in increase release of LH. To determine the effectiveness of life style modification in late adolescent with normal BMI polycystic ovarian syndrome . Material and Methodology: 28 Normal BMI women with polycystic ovary syndrome were selected for the study. They received the life style modification including diet plan exercise plan. Pre –assessment of body weight is measured by body mass index (BMI),waist-hip ratio(W-H Ratio) and quality of life was scored as per polycystic ovarian syndrome questionnaire(PCOSQ) and post-interventional assessment was taken for the same after 3 months. The exclusion criteria included Type II diabetes, Cardio vascular problems, any concurrent hormone therapy within 6 weeks, pregnant women’s or who are willing to conceive. Result: Statistical analysis for PCOSQ was extremely significant (P value=0.0001).Statistical analysis for BMI revealed not significant in post intervention .Statistical analysis for W-H Ratio revealed not significant in post intervention. Conclusion: Lifestyle modification helped in maintaining weight and showed increased quality of life in women with polycystic ovarian syndrome (PCOS).

PIH66 POLYCYSTIC OVARIAN SYNDROME (PCOS): A LITERATURE REVIEW OF THE POLYCYSTIC OVARY SYNDROME QUESTIONNAIRE (PCOSQ) FROM 2013-2018

Polycystic ovarian syndrome (PCOS) is associated with hormonal disturbance and psychological consequences, resulting in reduced health-related quality of life (HRQoL). The Polycystic Ovary Syndrome Questionnaire (PCOSQ), the only validated PCOS specific patient reported outcome (PRO), was developed in 1998. This review looks at the use of PCOSQ in conjunction with other QoL instruments in recently published research. The literature search was performed on the following terms: PCOS, PCOSQ and HRQoL on research studies that were published from 2013 to 2018 in PubMed and Scopus. Only articles that utilized PCOSQ in research were used in this analysis. The search yielded 23 articles of which 6 included the PCOSQ as the primary PRO instrument. One study was cross-sectional and the other 5 were prospective. Additional PROs used in these studies included: Short Form-36 Health Survey (SF-36) and World Health Organization QoL Instruments (WHOQOL-BREF). The SF-36 was used in 5 studies, and the WHOQOL-BREF was used in 1 study. PCOSQ measures 6 domains including emotions, hirsutism, weight, infertility, and menstrual disorders. Patient reported PCOS symptoms frequently expressed but not captured by PCOSQ include domains covering pain, bleeding intensity and coping behaviors. The PCOSQ includes PCOS specific questions not included in general HRQoL instruments. Hirsutism and infertility are aspects of PCOS that exert negative impacts on HRQoL that would not easily be detected by general PRO instruments. Still, there are some aspects of PCOS that are not adequately assessed by the PCOSQ despite being well documented patient reported outcomes. In order to comprehensively assess patient reported PCOS outcomes and to overcome key HRQoL indicators not captured in the PCOSQ, the PCOSQ can be utilized alongside other general PRO instruments to obtain a more comprehensive patient view for assessing HRQoL.

Effect of Structured Awareness Programme on Polycystic Ovarian Syndrome (PCOS) among Adolescent Girls

OBJECTIVE: The aim of the study is to evaluate the effect of structured awareness program on polycystic ovarian syndrome (PCOS), to create awareness on PCOS, to find out high risk adolescents for PCOS and to co-relate clinical symptoms of PCOS with biochemical tests. BACKGROUND: Polycystic ovarian syndrome is a gynaecological endocrine disorder affecting females in reproductive age and is most commonly seen in adolescent girls. Females with PCOS might have problems like irregular menstruation, obesity, acne, hirsutism, hyperinsulinemia etc., due to hyperandrogenemia which results in oligovulation/anovulation. PCOS is one of lifestyle disorder which can be preventable. Though the incidence of PCOS is rapidly increasing, the adolescent girls are unaware and have inadequate knowledge about PCOS and its complications. Hence this study focuses in evaluating the knowledge of PCOS and provides an awareness program which helps to recognize high risk individuals. METHODOLOGY: The present study is an observational study conducted among 300 adolescent girls aged between 14-18years. Adolescent girls were given structured awareness program. High risk adolescents were screened by using Polycystic Ovarian Syndrome Questionnaire (PCOSQ) after giving awareness program. All the adolescents with the age 14-18years are included in this study and adolescent girls who are seriously ill and those who are not willing to participate are excluded from the study. RESULT: The present study findings showed that among 300 adolescent girls, 96.3% were not aware of PCOS. PCOSQ findings revealed that 32% had irregular menstrual cycle, 26.3% had hirsutism and 13.2% had weight gain. On whole, statistical results of present study revealed the prevalence rate of PCOS is about 12.3% and we also identified 10.3% high risk girls and 23.3% low risk girls for developing PCOS.