Polybrominated Diphenyl Ethers Contamination Research Articles

Polybrominated diphenyl ether contamination in sediments from rivers in the western Niger Delta of Nigeria

This study investigated the concentrations of 39 polybrominated diphenyl ether (PBDE) congeners in sediments from three rivers in the western Niger Delta of Nigeria that have been affected by pollution from urbanization and industrial activities. The Σ39 PBDE concentrations in sediments from these rivers ranged from 0.29 to 95.5, 5.15 to 121, and 0.73 to 66.1 ng g−1 for the Afiesere (AR), Edor (ER), and Okpare Rivers (OR), respectively. The homologue distribution patterns indicated the prominence of tetra- and penta-BDE congeners in sediments from these rivers. The ecological risk assessment results showed that the penta-BDEs were the primary source of risk to sediment-dwelling organisms in these rivers. However, the human health risk assessment indicated negligible risks for exposure of both adults and children to PBDEs in these sediments. The source apportionment suggests that the PBDE contamination in these river sediments was derived from long-distance migration, debromination of highly brominated congeners, and commercial penta-BDEs. These results reflect the use of penta-BDE formulations in this region rather than octa- and deca-BDE formulations.

A level IV fugacity-based multimedia model based on steady-state particle/gas partitioning theory and its application to study the spatio-temporal trends of PBDEs in atmosphere of northeast China

Particle/gas (P/G) partitioning can significantly affect the environmental behavior of atmospheric pollutants. In this study, we established a large-scale level IV fugacity-based multimedia model (the S-L4MF Model) based on the steady-state P/G partitioning theory. The spatial and temporal trends with the atmospheric contamination of polybrominated diphenyl ethers (PBDEs) in northeastern China under various climate conditions were simulated by the model. There is a reasonable agreement between the simulated and measured gaseous and particulate concentrations of 3 selected PBDE congeners (BDE-47, -99 and -209). For BDE-47, -99 and -209, 91.9 %, 94.8 % and 86.2 % of data points in the evaluation of the spatial trend, whereas 97.4 %, 98.2 % and 91.6 % of data points in the evaluation of the temporal trend, exhibit discrepancies between the modeled and measured data within 1 order of magnitude. The S-L4MF Model performed better than the other model with the same configuration but an equilibrium-state P/G partitioning assumption. The sensitivity and uncertainty analysis indicated that the air temperature and hexadecane-air partition coefficient were the dominant influencing factors on atmospheric concentrations. In addition, the model was successfully applied to study the inter-annual and seasonal variations of gaseous and particulate concentrations of the three PBDEs during 1971–2020 in Harbin, a northeastern Chinese city. Finally, we illustrated the potential to use the model to understand P/G partitioning behavior and the effects of snow and ice on atmospheric concentrations. In summary, the S-L4MF Model provided a powerful and effective tool for studying the environmental behavior of atmospheric organic pollutants, especially in cold regions.

Higher HDL-C levels attenuated the association of plasma polybrominated diphenyl ethers with prediabetes and type 2 diabetes mellitus in rural Chinese adults

BackgroundPlasma polybrominated diphenyl ethers (PBDE) were used as flame retardants widely, however, epidemiological evidence for the association between PBDEs and type 2 diabetes mellitus (T2DM) is inconsistent. Moreover, the combined effects of PBDEs and blood lipid indicators on impaired fasting glucose (IFG) and T2DM remains largely unknown in rural areas lacking good waste recycling infrastructure. MethodsIn this study, a total of 2607 subjects aged 18–79 years were included from the Henan Rural Cohort. Generalized linear and logistic regression models were applied to evaluate the associations of various PBDE pollutants on IFG and T2DM. Quantile g-computation regression and PBDE pollution score created by the adaptive elastic net were applied to evaluate the impact of PBDEs mixtures on IFG and T2DM. Interaction effects of individual PBDE pollutants and blood lipid indicators on IFG and T2DM were assessed by using Interaction plots. ResultsThe geometric mean concentrations (detection rates) were 0.09 ng/mL (100.0%), 0.12 ng/mL (97.8%), 0.22 ng/mL (94.7%), 0.16 ng/mL (99.2%) and 0.28 ng/mL (100.0%) for PBDE-28, PBDE-47, PBDE-99, and PBDE-153 respectively. However, PBDE-28, PBDE-99, PBDE-100, and ΣPBDEs were positively associated with IFG (odds ratios (ORs) (95% confidence intervals (CIs)): 1.14 (1.06, 1.23), 1.16 (1.04, 1.29), 1.25 (1.14, 1.37), and 1.27 (1.08, 1.50)). Similarly, PBDE-28, PBDE-47, PBDE-99, PBDE-100, and ΣPBDEs were positively associated with T2DM (ORs (95% CIs): 1.30 (1.10, 1.54), 1.13 (1.06, 1.22), 1.27 (1.13, 1.43), 1.27 (1.15, 1.40), and 1.30 (1.10, 1.54)). Moreover, five PBDE mixtures or jointly as PBDE pollution score, were significantly associated with an increased risk of T2DM (P < 0.05 for all). In addition, the harmful effect of PBDE exposure on T2DM was decreased with accompanying high‐density lipoprotein cholesterol (HDL-C) levels increased. ConclusionsOur findings highlight the importance of managing PBDEs contamination and suggest that HDL-C may be a novel way to prevent T2DM.

Regulatory mechanisms of submerged macrophyte on bacterial community recovery in decabromodiphenyl ether contaminated sediment: Microbiological and metabolomic perspectives

Polybrominated diphenyl ether contamination in sediments poses serious threats to human health and ecological safety. Despite the broad application of submerged macrophytes for remediating pollutants, their regulatory influence on bacterial communities in contaminated sediments remains unclear. Herein, we analyzed the effects of decabromodiphenyl ether (BDE-209) and Hydrilla verticillata on sediment bacterial community and function using 16S rRNA gene sequencing and sediment metabolomics. Results showed that BDE-209 significantly inhibited sediment bacterial diversity and metabolic functions. It also enhanced bacterial interactions and altered both the bacterial community and metabolite composition. Uridine and inosine were critical metabolites that positively co-occurred with bacterial taxa inhibited by BDE-209. Notably, planting H. verticillata effectively alleviated the adverse impacts of BDE-209 by reducing its residuals, increasing the total organic carbon, and modifying metabolic profiles. Such mitigation was evidenced by enhancing bacterial diversity, restoring metabolic functions, and attenuating bacterial interactions. However, mitigation effectiveness depended on treatment time. Additionally, propionic acid, palmitic acid, and palmitoleic acid may facilitate the restoration of phylum Proteobacteria and class Planctomycetacia in H. verticillata planted sediment. Together, these findings improve understanding of BDE-209's impacts on aquatic ecosystems and provide valuable insights for ecological restoration using submerged macrophytes.

Brominated flame retardants in breast milk from the United States: First detection of bromophenols in U.S. breast milk

Brominated flame retardants (BFRs) are a class of compounds with many persistent, toxic, and bioaccumulative members. BFRs have been widely detected in breast milk, posing health risks for breastfeeding infants. Ten years after the phaseout of polybrominated diphenyl ethers (PBDEs) in the United States, we analyzed breast milk from 50 U.S. mothers for a suite of BFRs to assess current exposures to BFRs and the impact of changing use patterns on levels of PBDEs and current-use compounds in breast milk. Compounds analyzed included 37 PBDEs, 18 bromophenols, and 11 other BFRs. A total of 25 BFRs were detected, including 9 PBDEs, 8 bromophenols, and 8 other BFRs. PBDEs were found in every sample but at concentrations considerably lower than in previous North American samples, with a median ∑PBDE concentration (sum of 9 detected PBDEs) of 15.0 ng/g lipid (range 1.46–1170 ng/g lipid). Analysis of time trends in PBDE concentrations in North American breast milk indicated a significant decline since 2002, with a halving time for ∑PBDE concentrations of 12.2 years; comparison with previous samples from the northwest U.S region showed a 70% decline in median levels. Bromophenols were detected in 88% of samples with a median ∑12bromophenol concentration (sum of 12 detected bromophenols) of 0.996 ng/g lipid and reaching up to 71.1 ng/g lipid. Other BFRs were infrequently detected but concentrations reached up to 278 ng/g lipid. These results represent the first measurement of bromophenols and other replacement flame retardants in breast milk from U.S. mothers. In addition, these results provide data on current PBDE contamination in human milk, as PBDEs were last measured in U.S. breast milk ten years ago. The presence of phased-out PBDEs, bromophenols, and other current-use flame retardants in breast milk reflects ongoing prenatal exposure and increased risk for adverse impacts on infant development.

Current status of indoor dust PBDE pollution and its physical burden and health effects on children.

Polybrominated diphenyl ethers (PBDEs) are widely detected in indoor dust, which has been identified as a more important route of PBDE exposure for children than food intake. The physical burden and health hazards to children of PBDE exposure in house dust have not been adequately summarized; therefore, this article reviews the current status of PBDE pollution in indoor dust associated with children, highlighting the epidemiological evidence for physical burden and health risks in children. We find that PBDEs remain at high levels in indoor dust, including in homes, schools, and cars, especially in cars showing a significant upward trend. There is a trend towards an increase in the proportion of BDE-209 in household dust, which is indicative of recent PBDE contamination. Conversely, PBDE congeners in car and school indoor dust tended to shift from highly brominated to low brominated, suggesting a shift in current pollution patterns. Indoor dust exposure causes significantly higher PBDE burdens in children, especially infants in early life, than in adults. Exposure to dust also affects breast milk, putting infants at high risk of exposure. Although evidence is limited, available epidemiological studies suggest that exposure to indoor dust PBDEs promotes neurobehavioral problems and cancer development in children.

Polybrominated diphenyl ethers (PBDEs) in Indian wastewater treatment plant: Occurrence, mass flow and removal.

Polybrominated diphenyl ethers (PBDEs) are categorized as a group of brominated flame retardants that cause hazardous health impacts but are still being used consistently worldwide. The studies on their occurrence and fate in wastewater treatment plants are scarce, and considering the Indian scenario, no study has been reported till date in this context. Therefore, in the present study, PBDE congeners of primary concern were investigated first time to assess the existence, dissemination and fate of PBDEs in the municipal wastewater treatment plant (MWTP) located in Nagpur city, Maharashtra, India. BDE 209 and 47 were detected as the predominant PBDE contaminants in all the analysed samples. The concentration of PBDEs was primarily found in the particulate phase of wastewater. According to mass loading analysis, 1297mg/day concentration of PBDEs is disposed of at landfill sites in the form of sludge, while 77.46mg/day is released via final effluent. The present investigation is the first of its kind of study conducted to evaluate the PBDE contamination in Indian MWTP, which reveals the presence of high PBDE concentration in Indian municipal sewage. The findings of the current study exhibit the need for appropriate action toward the sound surveillance of PBDEs in the Indian context.

Effects of decabromodiphenyl ether (BDE-209) on a mangrove plant, Kandelia obovata and the uptake, translocation and accumulation of BDE-209

Due to close proximity to urban development, mangroves exposed to the contamination of polybrominated diphenyl ethers (PBDEs). Decabromodiphenyl ether (BDE-209) is one of the most predominant PBDE congener. The present study aimed to investigate the toxic effects of BDE-209 on the antioxidative and non-antioxidative responses of Kandelia obovata, a very common mangrove species, under different concentrations of BDE-209, 0.1, 1, 5 and 10 mg l-1. BDE-209 did not exhibit any negative effects on the growth of K. obovata seedlings. The stimulatory effects of BDE-209 on the enzymes including superoxide dismutase, peroxidase and catalase only occurred in weeks 1 and 4 and diminished in week 8. The concentrations of total polyphenols (TP) and extractable condensed tannins (ECT) were not affected by BDE-209. The production of O2·- was induced only at the very high level of BDE-209 (10 mg l-1). H2O2 was induced only in weeks 1 and 4 under BDE-209 treatment. BDE-209 was taken up by the roots of K. obovata, translocated to above-ground tissues, and accumulated in plant tissues with the concentrations declined in the order of root &amp;gt; propagule &amp;gt; stem &amp;gt; leaf. Although BDE-209 has higher molecular weight and higher log Kow than other PBDE congeners, the K. obovata seedlings could absorb, translocate and accumulate BDE-209. These findings suggested that mangrove plants could take up, accumulate PBDEs, and BDE-209 are less toxic than other congeners but more difficult to be removed by mangrove systems.

Using homing pigeons to monitor atmospheric organic pollutants in a city heavily involving in coal mining industry

Coal is the most extensively used fossil fuel in China. It is well documented that coal combustion detrimentally affected air quality, yet the contribution of coal mining activity to air pollution is still largely unknown. Homing pigeons have been applied to assess the occurrence of atmospheric pollutants within cities. Herein, we sampled homing pigeons from both urban and mining areas in a typical coal industry city (Datong, China) as biomonitors for assessing local air pollution. Target organic contaminants, including polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs) were frequently detected in lung, liver, and fat tissues of the pigeons. The pollutants were predominately accumulated in lung, validating that respiration was the main accumulation route for these compounds in homing pigeons. In addition, pathological damage examination in lung and liver tissues revealed that the exposure to atmospheric pollutants impaired pigeon health. While the concentrations of PCBs and OCPs were similar in pigeons from urban and mining areas, the concentrations of PAHs were higher in pigeons from urban area. In contrast, more elevated levels of PBDEs (particularly BDE-209) were found in the mining area, which was consistent with the greater pathological damages and particulate matter levels. Unlike coal combustion, coal mining activities did not increase atmospheric PAH exposure to homing pigeons, but intensified PBDE contamination along with increasing emission of particulate matters. Overall, homing pigeons are promising biomonitors for assessing the respiratory exposure and risk of atmospheric pollutants within cities.

Occurrence and levels of polybrominated diphenyl ethers (PBDEs) in deep-sea sharks from Suruga Bay, Japan

Few studies have investigated the prevalence of polybrominated diphenyl ethers (PBDEs) in deep-sea sharks. In this study, the levels and profiles of PBDEs were determined in liver samples of eight different species of deep-sea sharks collected in Suruga Bay, Japan. Widespread contamination of PBDEs in the deep-sea environment was reconfirmed in this study as these persistent organic pollutants (POPs) were detected in all specimens analyzed. Mean ΣPBDE levels in the deep-sea sharks ranged from 7 to 517 ng/g of lipid weight. The distribution patterns of BDE homologues were similar in all species where tetra-BDEs provided the dominant contribution to total PBDEs (46%). PBDEs levels were similar to, or higher than, those seen in other deep-sea sharks from different regions. The levels of PBDEs were likely to reflect their feeding preferences as higher PBDE levels were seen in species with higher trophic positions.

Assessment of polybrominated diphenyl ether contamination and associated human exposure risk at municipal waste dumping sites.

The reports concerning the occurrence and fate of polybrominated diphenyl ethers (PBDEs) at municipal solid waste (MSW) dumping sites are scarce, and considering the Indian context, no study has been conducted to assess PBDE contamination at MSW dumping sites and associated exposure and health risk. Therefore, in the present study, the concentration of PBDE congeners was investigated in soil samples amassed from MSW dumping sites of India and the factors affecting the dissemination of different PBDE congeners in soil were evaluated. Also, the human exposure and health risk through soil intake and dermal contact were also evaluated the first time in India. The total PBDE concentrations from tri- to deBDE congeners in soil ranged from 6.81 to 33.67μg/g dw and showed a trend towards higher levels of PBDEs in the dumping sites of more populous cities. BDE 183 was found to be the main congener in the soil of the dumping sites. The congener profile in the soil exhibited the composition of the octa- and deBDE technical mixture and possibilities of biological and photodegradation of deBDE into lower brominated congeners. A significant correlation was observed between the measures of BDE 183 and BDE 209 congeners and carbon, nitrogen and hydrogen contents of the soil. The measured exposure doses of PBDEs through soil intake and dermal contact and the hazard index was estimated higher in children as compared to adults, which indicates the increased risk and susceptibility of infants and children to PBDE exposure. The results of the present study revealed that the MSW dumping sites in India are a sink of PBDEs and might have detrimental effects on human health.

Polybrominated diphenyl ethers (PBDEs) concentrations in soil, sediment and water samples around electronic wastes dumpsites in Lagos, Nigeria

Polybrominated diphenyl ethers (PBDEs) were listed in the Stockholm Convention as POPs because of their bio-accumulative, long-range and toxicity characteristics. Therefore, these should be managed and assessed by Parties of the convention in an environmentally sound manner. This present study assessed the status of PBDEs contamination at e-waste dumpsites in Lagos, Nigeria. Soil and sediment samples were collected from 3 e-waste dumpsites and water samples were collected from rain water ponds located within the e-waste dumpsites vicinities and control sites over a period of two years. The concentrations of ∑7PBDEs in soils from the e-waste dumpsites at 0–15 cm depth for the first and second year ranged from 141 to 302 ngg−1 dry weight, respectively while that of the control soils was 13.2–27.2ngg−1 dry weight. These high concentrations may be attributed to the fact that open burning of electronic waste was the regular method of reducing the volume of e-waste at the sites. PBDE levels across the soil profile from 0 to 45 cm depth showed a gradual increase in PBDEs accumulation in the topsoil and migration into the sub-soil over the period of 2 years, but with no significant difference (p-value = 0.89). Sediments and water from the rain water ponds around the dumpsites were found to be contaminated by PBDEs with levels ranging from 51.4 to 85.8ngg−1 and 14.4 to 27.4ngg−1, respectively, while levels in control for sediment and water are 11.5ngg−1 and 2.43ngg−1respectively.These, however indicates that there was significance difference between the PBDEs levels in water and sediment from the study sites with those of their respective controls (p-value for water was 0.01, while that for sediment was 0.03).The levels of PBDEs in this study sites were higher than those of the respective control. The range of PBDEs in e-waste dumpsites was comparable to those reported in USA and Europe but lower than those from China. Environmental samples from the e-waste dumpsites in Lagos were contaminated with PBDEs, there is therefore the need for proper disposal methods for end-of-life products especially those containing PBDEs in Nigeria.

Spatial Distribution, Bioconversion and Ecological Risk of PCBs and PBDEs in the Surface Sediment of Contaminated Urban Rivers: A Nationwide Study in China.

Surface sediments of polluted urban rivers can be a reservoir of hydrophobic persistent organic pollutants (POPs). In this study, we comprehensively assessed the contamination of two groups of POPs, that is, polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs), in 173 black-odorous urban rivers in China. Spatial distribution of PCBs and PBDEs showed similar patterns but very different contamination levels in surface sediments, that is, average concentrations of 10.73 and 401.16 ng/g dw for the ∑PCBs and ∑PBDEs, respectively. Tetra-/di-CBs and deca-BDE are major PCBs and PBDEs and accounted for 59.11 and 95.11 wt % of the ∑PCBs and ∑PBDEs, respectively. Compared with the persistence of PBDEs, the EF changes of chiral PCBs together with previous cultivation evidence indicated indigenous bioconversion of PCBs in black-odorous urban rivers, particularly the involvement of uncharacterized Dehalococcoidia in PCB dechlorination. Major PCB sources (and their relative contributions) included pigment/painting (25.36%), e-waste (22.92%), metallurgical industry (13.25%), and e-waste/biological degradation process (10.95%). A risk assessment indicated that exposure of resident organisms in urban river sediments to deca-/penta-BDEs could pose a high ecological risk. This study provides the first insight into the contamination, conversion and ecological risk of PCBs and PBDEs in nationwide polluted urban rivers in China.

Enhancement effect of nanoscale zero-valent iron addition on microbial degradation of BDE-209 in contaminated mangrove sediment

Chemical and biological methods have been employed to remedy polybrominated diphenyl ether contamination, but the removal of decabromodiphenyl ether (BDE-209) by either method still has limitations. The present study aims to evaluate the combined effect of nanoscale zero-valent iron (nZVI) (from 0.1 to 10%) reduction and microbial debromination on BDE-209 removal in mangrove sediments under an anaerobic condition. During the 12-months incubation, nZVI significantly enhanced BDE-209 removal, with 17.03% to 41.99% reduction in sterilized sediments. The reduction was even higher in non-sterilized sediments with living indigenous microorganisms, achieving 15.80%, 33.50%, 55.83% and 66.95% removal of BDE-209 at 0 (control without nZVI), 0.1%, 1% and 10% nZVI, respectively. In control sterilized sediments, no debromination was found, and debromination occurred according to spiked levels of nZVI, with BDE-153 being the dominant congener. The concentrations of debrominated congeners in non-sterilized sediments also increased with nZVI levels, but were significantly higher than the respective sterilized sediment. The relative proportions of different debrominated congeners in non-sterilized sediments depended on nZVI levels, with BDE-99 being the dominant congener in low nZVI amended sediments but shifted to BDE-153 under high nZVI. Higher concentrations of ferrous iron (Fe2+) were detected in both sterilized and non-sterilized sediments spiked with more nZVI, and their concentrations significantly correlated with BDE-209 removal. Growth of total bacteria in sediments with 1% and 10% nZVI was inhibited within first two months, but their numbers resumed to that in the control at the end of 12 months. The present study demonstrates the synergy between chemical and microbiological methods, and a combination of nZVI and indigenous microorganisms could be an efficient and feasible mean to remedy BDE-209 in contaminated sediments.

Occurrence and Distribution of Polybrominated Diphenyl Ethers in Sediments from Nairobi River Basin, Kenya, East Africa

This study was set to determine the levels and spatial distribution of selected PBDEs in sediments of Nairobi River during the four seasons experienced in Nairobi. Sediment samples were collected from nine sites along the river and analyzed for brominated diphenyl ethers 28, 47, 66, 85, 99, 100, 153, 154, and 183 using gas chromatography coupled with mass spectrometer. The mean concentration of polybrominated diphenyl ethers residue in sediment samples ranged between 134.70±3.07 to 24386.13±207.22 ng/Kg. The high mean concentration of PBDEs in the river sediments indicates that anthropogenic activities along the Nairobi River basin have contributed to polybrominated diphenyl ethers contamination of the river sediment posing a potential risk to aquatic organisms that inhabit the river.

Polybrominated diphenyl ethers (PBDEs) concentrations in soil and plants around municipal dumpsites in Abuja, Nigeria.

Polybrominated diphenyl ethers (PBDEs) are listed as persistent organic pollutants (POPs) in the Stockholm Convention. It has been established that PBDEs may be released into the environment during improper handling and disposal of e-waste and other products containing PBDEs that is prevalent in developing countries. This research work assessed the status of PBDE contamination at dumpsites in Nigeria. Soil and edible plant samples were collected from the dumpsites and control sites for analysis. The concentrations of ∑7PBDE in the topsoils around the dumpsites at 0-15cm depth ranged from 112 to 366ng/g dry weight (dw) while that of the topsoil of the control site 500m from the dumpsite ranged from 26.8 to 39.7ng/g dw. These high concentrations stem likely from open burning of waste including electronic waste on the landfills. Plant samples (bentgrass, spinach, tomatoes, pumpkin and sweet potatoes) around the dumpsites were found to be contaminated by PBDEs with levels ranging from 25.0 to 60.5ng/g dw in plant roots and from 8.45 to 32.2ng/g dw in plant shoots for ∑7PBDE. This suggests that consumption of vegetables by humans and ingestion of contaminated soils and feed by chickens and cows can transfer PBDEs into the human food chain around the dumpsites. The comparison of PBDE levels in soils and the PBDE levels in chicken eggs from the former study indicate that PBDE levels in the soils are sufficient to explain the levels in the chicken eggs with a reasonable carry-over rate for PBDEs of 0.28 on average. The PBDE contamination in the soil was sufficient to result in a relevant exposure of humans via accumulation in eggs. The study shows that a better management of end-of-life products containing PBDEs is needed to reduce PBDE exposure risk in Africa.

Preliminary results on polybrominated diphenyl ether contamination status in Croatian households and insights into children's exposure

Polybrominated diphenyl ether (PBDE) congeners were analyzed in house dust samples collected in Croatian households. ∑PBDEs ranged between 1.1 ng g−1 dust and 17662.4 ng g−1 dust with BDE-99 being the most dominant congener accounting for approximately 60 %. The estimated daily intake (EDI) for toddlers as the most vulnerable population group ranged from 0.003 to 55.04 and from 0.01 to 110.07 ng kg−1 bw day−1 in the central and worst case scenario, respectively. The EDI calculated for the dominant BDE-99 in the sample with the highest ∑PBDE was in the worst case scenario 68.99 ng kg−1 bw day−1, which was quite close to the reference dose of 100 ng kg−1 bw day−1.

Feeding behavior toxicity in the marine rotifer Brachionus plicatilis caused by 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47): Characteristics and mechanisms

Polybrominated diphenyl ether contamination in marine environments has received special attention due to its accumulation and magnification in the marine food web and toxicity to organisms. In the present study, a series of short-term toxicological tests were conducted with the marine rotifer Brachionus plicatilis to assess the effects on ingestion and digestive performance after treatment with 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) at nonlethal concentrations under controlled laboratory conditions and to analyze the possible mechanism. The results showed that with accumulation in rotifers, BDE-47 caused a significant decline in the filtration and feeding rates in a concentration-dependent manner. Moreover, the activities of amylase (AMS) and protease were affected, indicating that BDE-47 impaired ingestion and digestion efficiency. BDE-47 exposure did not lead to abnormal microstructures in the main digestive tract (e.g., cilia around the corona, mastax, stomach, digestive gland and esophagus), but the gastric parietal cells shrank, suggesting nutritional deficiency. BDE-47 prominently induced the occurrence of irregular mitochondria at the cilia root, and mitochondrial and isocitrate dehydrogenase activity declined, indicating mitochondrial dysfunction. Furthermore, the activity of ATPase, which catalyzes ATP hydrolysis, decreased as the BDE-47 concentration rose, implying that BDE-47 retarded rotifer ATP dynamics, inevitably interfering with cilia movement to ingest food. Additionally, a significant decline in acetylcholine esterase activity was observed, which led to a hindrance in neurotransmission involved in food intake and digestion. Altogether, our results demonstrated that nonlethal concentrations of BDE-47 could induce feeding depression in rotifers, which is mainly attributed to stymied energy metabolism and nerve conduction.

Spatial distribution, source identification, and anthropogenic effects of brominated flame retardants in nationwide soil collected from South Korea.

Soil samples were collected at 61 sites of the national monitoring network for persistent organic pollutants (POPs) in South Korea. The target compounds were brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs), hexabromocyclododecanes (HBCDDs), and tetrabromobisphenol A (TBBPA). The mean concentrations of Σ27 PBDEs, Σ3 HBCDDs, and TBBPA in soil were 222, 17.2, and 4.4ng/g, respectively, but PBBs were not detected. Industrial sites had statistically higher BFR concentrations than suburban sites but no significant difference compared with urban sites. The commercial deca-BDE mixtures were the most likely source of PBDE contamination in the soil samples, with the minor influence of commercial penta-BDE and octa-BDE mixtures. The profiles of HBCDDs in most soil samples differed from those in the powder types of technical HBCDD mixtures, indicating that they are affected by the HBCDDs contained in commercial products and the conversion of HBCDD diastereoisomers (γ-HBCDD to α-HBCDD) in the environment. The concentrations of Σ27 PBDEs, Σ3 HBCDDs, and TBBPA were significantly correlated with population density, gross domestic product, and the number of companies (p<0.01), indicating a direct impact of anthropogenic activities. Significant correlations among BFRs were determined (0.63<r<0.74, p<0.01), suggesting that these pollutants had similar sources. Relatively good correlations (0.44<r<0.98, p<0.01) between BDE-209 and other light BDEs (except for BDE-71, -77,-126,-156, and-205) might result from the degradation of heavy BDEs under anaerobic and natural sunlight conditions. To the best of our knowledge, this study provides the most comprehensive soil monitoring data for various BFRs in South Korea. Furthermore, it is the first report on soil contamination by deca-BDE, HBCDDs, and TBBPA in South Korea.

Polybrominated diphenyl ethers in indoor dusts from university dormitories and printing shops in Xinxiang, China

Polybrominated diphenyl ethers (PBDEs) were investigated in indoor dusts from university dormitories and printing shops in Xinxiang, China. The mean concentrations of ∑13PBDEs were 105 ± 64.2 ng/g dry weight (dw), 31.7 ± 26.4 ng/g dw and 695 ± 379 ng/g dw in dusts from male dormitory, female dormitory and printing shop, respectively. Notably, significantly higher PBDE concentrations were found in printing shop than in university dormitory. BDE-153 (84.5 ± 165 ng/g dw), BDE-190 (76.1 ± 179 ng/g dw) and BDE-138 (24.2 ± 29.7 ng/g dw) displayed the highest levels in the 29 indoor dust samples. BDE-138, -153, -190 and -71 showed higher proportion in indoor dusts from university dormitories and printing shops. More debromination process of PBDEs occurred in dust from university dormitory, whereas PBDEs in printing shop were more likely to come directly from external electronic devices. Significantly positive correlations were revealed between the PBDE levels and the quantity of electronic equipment in dust, indicating that electronic devices had significant influence on PBDE contamination in indoor environment. Generally, PBDE concentrations in the present study were lower than the levels in indoor dusts from other studies worldwide. The estimated daily intake values of ∑13PBDEs displayed printing shop (80.4 ng/kg body weight (bw)/day) > male dormitory (11.3 ng/kg bw/day) > female dormitory (3.97 ng/kg bw/day), which were generally higher than other researches, but well below the EPA reference doses.