Plant Raw Materials Research Articles

Cosmeceuticals based on atemoya peel extract: photoprotective and antimicrobial action

Cosmetic formulations with therapeutic activity have been the focus of research aimed at determining new applications and adding value to natural products. In this context, plant raw materials stand out for their richness in secondary metabolites, many of which have therapeutic properties. That includes the use of fruits considered unfit for sale for not meeting appearance standards for fresh fruit purchase and consumption. Thus, the present work developed cosmeceutical emulsions with atemoya peel extract containing a high content of phenolic compounds and their derivatives with photoprotective, antioxidant and bactericidal action. The emulsions prepared with 2%, 5% and 10% extracts were within the standards suggested for preliminary stability parameters of cosmetic formulations. All extracts and the emulsion containing 10% atemoya peel had a sun protection factor greater than 6 and antibacterial activity against Bacillus cereus and Pseudomonas aeruginosa. Finally, they met the ideal physical and sensory standards, presenting good texture and gloss, low stickiness, adequate residual perception, good spreadability and balanced sensation of freshness. The consumer demand for cosmeceuticals with effects for the prevention of premature aging, cancers caused by free radicals and inflammatory diseases justifies the research and development of multifunctional products, such as the one presented in this study.

BIODEGRADABLE GEL BLENDS WITH ENHANCED SENSING CAPABILITIES: SIO₂-BASED INNOVATIONS FOR SUSTAINABLE AND ECO-FRIENDLY PACKAGING.

Biopolymer blends (GGs) derived from renewable plant or animal-based raw materials hold significant potential for competing in the packaging industry by offering environmentally biodegradable and bioresorbable alternatives. One of the main challenges lies in optimizing the mechanical properties to enhance stress transfer between active additives and the gelatin matrices reinforced with modified SiO₂ compounds. In this study, a 5°C increase in the glass transition temperature and a fourfold improvement in tensile strength (reaching 12 MPa) were achieved by incorporating hydrophilic SiO₂ nano-clay. Ion distribution maps visualized the interactions between silicon derivatives and polypeptide domains within the gel matrix, revealing increased stability attributed to ions such as Si+, SiO+, SiH+, and SiHO+. The absence of heavy metals in the blends underscores their potential as environmentally friendly and sustainable packaging solutions, with promising applications in sectors such as medical packaging.

Rapid assessment of biochemical indicators of agronomic value in amaranth seed accessions from the VIR collection using NIR spectroscopy

Background. Amaranth (Amaranthus L.) is a relatively new crop for the Russian Federation, with huge potential for growth intensity, productivity, and other agronomic traits. Development of new amaranth cultivars is an important solution to the problem of food quality improvement through the use of plant raw materials enriched with health-friendly and highly nutritious components. Calibration models were developed for rapid assessment of useful agronomic characters (the content of protein, oil, moisture, and basic fatty acids: palmitic, stearic, oleic, linoleic, and α-linolenic) in amaranth seeds preserved at theVavilov All-Russian Institute of Plant Genetic Resources (VIR) using near-infrared (NIR)Materials and methods. Thirty accessions of amaranth seeds (A. hypochondriacus L., A. cruentus L., and A. caudatus L.) from the VIR collection served as the material for the study. Biochemical indicators of seed quality and fatty acid composition of oil were studied using analytical methods adopted at VIR: the Kjeldahl method for protein content, the dry fat-free residue method for oil, the thermogravimetric method for moisture, and gas–liquid chromatography for fatty acid composition. Calibration models were constructed with the OPUS software developed for the MATRIX-I IR analyzer (Bruker Optics, Germany).Results and conclusion. Calibration models obtained on a MATRIX-I IR analyzer for measuring the content of protein, moisture, palmitic and oleic acids facilitate mass analysis of amaranth seeds from the VIR collection with an accuracy of 1.5%. Models developed for the quantification of oil, stearic, linoleic and α-linolenic acids require improvement. NIR spectroscopy makes it possible to accelerate the process of obtaining data on major agronomic indicators of amaranth seeds, preserve valuable materials, and determine further steps in breeding practice.

Usage of alternative plant raw materials in the production of lactic acid food products based on plant proteins

The review article is dedicated to the analysis of research on the use of alternative plant raw materials in the production of functional food products, with a focus on soybean products. The article discusses the relevance and feasibility of soybean cultivation in Russia, addressing the global issues facing humanity today –namely, ecology and human health. In the context of specialized soybean use, the article examines categories of functional products and analyzes the advantages and disadvantages of soy as a raw material for the food industry. Additionally, the article presents an overview of existing research on the impact of soy products on human health. This scientific work aims to provide readers with insights into the potential use of soybean raw materials for creating functional food products and emphasizes the need for further research in this area. The analysis of global and national healthy food markets shows a high consumer interest in dairy products, especially yogurts. These results indicate a promising niche for creating functional products that utilize alternative protein sources, such as soy. Research on the effects of soy on the human body confirms its preventive properties in combating protein deficiency. Furthermore, soy is a valuable source not only of protein but also of lipids, phytoestrogens, vitamins, minerals, and dietary fibers. Soy processing opens up opportunities for obtaining valuable by-products that can be used in the creation of functional food products. In particular, isoflavones are extracted from soybeans – a group of biologically active substances that positively influence women’s health. Studies indicate that protein levels and textural characteristics affect taste sensations during organoleptic evaluations of food products. However, previous studies have not focused on oat-based yogurts, highlighting the importance of further research in this segment.

Innovative technologies for processing plant raw materials for the production of healthy food from idea to industrial implementation

The relevance of the study is due to the growing demand for healthy food, in particular for tasty but healthy snacks and other products that do not contain harmful ingredients such as sugar, wheat flour, and unhealthy fats. Given the current problems associated with diabetes, obesity, and metabolic disorders, this article focuses on the development of innovative equipment for the production of healthy food products. The aim of the study is to create a technological platform for the production of snacks based on alternative raw materials, which allows preserving the beneficial properties of products, in particular, a low glycemic index. The study uses methods of technological analysis, glycemic index research, and the development of new methods of dehydration and product formation. Particular attention is paid to the use of tunnel dehydrators, which allow drying raw materials at low temperatures while preserving their beneficial properties, such as fiber, vitamins, and antioxidants. The results obtained show the effectiveness of the proposed technology in the manufacture of products with a low glycemic index suitable for people with diabetes and other metabolic disorders. The technology makes it possible to produce healthy snacks on an industrial level using natural ingredients without harmful additives. The conclusions confirm that the developed equipment has the potential to scale up production, which could impact the healthy food market by providing consumers with access to healthier and safer products. The practical application of this technology will contribute to the development of the healthy food industry and solve the problems associated with modern eating disorders

Innovative technologies for processing plant raw materials for the production of healthy food from idea to industrial implementation

The relevance of the study is due to the growing demand for healthy food, in particular for tasty but healthy snacks and other products that do not contain harmful ingredients such as sugar, wheat flour, and unhealthy fats. Given the current problems associated with diabetes, obesity, and metabolic disorders, this article focuses on the development of innovative equipment for the production of healthy food products. The aim of the study is to create a technological platform for the production of snacks based on alternative raw materials, which allows preserving the beneficial properties of products, in particular, a low glycemic index. The study uses methods of technological analysis, glycemic index research, and the development of new methods of dehydration and product formation. Particular attention is paid to the use of tunnel dehydrators, which allow drying raw materials at low temperatures while preserving their beneficial properties, such as fiber, vitamins, and antioxidants. The results obtained show the effectiveness of the proposed technology in the manufacture of products with a low glycemic index suitable for people with diabetes and other metabolic disorders. The technology makes it possible to produce healthy snacks on an industrial level using natural ingredients without harmful additives. The conclusions confirm that the developed equipment has the potential to scale up production, which could impact the healthy food market by providing consumers with access to healthier and safer products. The practical application of this technology will contribute to the development of the healthy food industry and solve the problems associated with modern eating disorders

Development of the plant collection prescription and the obtaining a liquid extract technology on its basis for prevention and treatment of musculoskeletal system diseases

Purpose. Development of the composition of the plant collection “Opornofit” and the technology of obtaining a liquid extract on its basis for the prevention and treatment of diseases of the musculoskeletal system, with the determination of quality indicators and stability during their storage. Materials and methods. Plant raw materials for obtaining the collection and liquid extract from it were harvested in Vinnytsia and Kharkiv regions. The numerical parameters of the collection were determined according to the methods of the State Pharmacopoeia of Ukraine 2.0. Results. A screening of the range of medicinal plant raw materials, which in the form of mono- and polycomponent plant collections are used in phytotherapy of diseases of the musculoskeletal system, was carried out and the most promising types of plant raw materials were selected for creating the collection “Opornofit”: Arctium root (Arctium lappa L., Arctium minus (Hill) Bernh., Arctium tomentosum Mill.), Rose root (Rosa majalis Herrm., Rosa canina L.), rhizomes with roots of Sanguisorba officinalis L., rhizomes with roots of Rumex confertus Willd., and herb of Bidens tripartita L. with an equal ratio of components in the collection. Taking into account the conditions of military service and the frequent lack of conditions for preparing a decoction from the collection, we developed a technology for obtaining a liquid extract based on its components. For the developed collection and liquid extract, stability during storage during the year was studied. Conclusions. The composition of the herbal collection “Opornofit” and the technology for obtaining a liquid extract based on it for the prevention and treatment of diseases of the musculoskeletal system have been developed, with the determination of quality indicators and stability during their storage. The developed original herbal collection and liquid extract based on it are predicted to have anti-inflammatory, uricosuric, detoxifying, desensitizing, and immunostimulating effects.

Synthetic Melatonin and/or Phytomelatonin Contents in Different Commercial Phytotherapeutic Supplements

In these times and with the pace of life that we have developed, many people need help falling asleep due to poor sleep hygiene, among other reasons. Thus, in mild cases, it is recommended to use natural therapies, such as phytotherapy, avoiding in the first instance the use of drugs. Melatonin is considered a versatile molecule widely used today. It is included as a main ingredient in dietary supplements that are, in some cases, accompanied by medicinal plants as botanical mixes, generating beneficial products for sleep disorders among other conditions. The dietary phytotherapeutic supplements evaluated in this work contain various concentrations of melatonin and other products, resulting in different effects on sleep therapy. The aim of this work is to reveal the quantitative differences that exist between the melatonin contents labeled in the products and those analyzed. The degradation rate of this hormone at three years in the phytotherapeutic supplements is also studied in order to re-evaluate the expiration dates of these products. In conclusion, the mixture between synthetic melatonin and different botanical mixes is very common in the supplements studied here and aimed at improving sleep. However, the most natural thing would be to be able to use only plants with sufficient phytomelatonin content to eliminate the inclusion of chemically synthesized melatonin in preparation. We propose the use of a particular raw plant material with excellent characteristics for this purpose.

STANDARDIZATION OF RAW MATERIALS OF ERIGERON ANNUUS (ANNUAL FLEABANE)

Medicinal plant raw materials and their derived preparations are widely used by leading pharmaceutical manufacturers and constitute a significant share of the global pharmaceutical market. Standardization plays a crucial role as a quality control mechanism for herbal medicinal products. The term “standardization’ refers to all measures taken during the production process and quality control to ensure the consistent quality of herbal preparations. To obtain high-quality herbal medicines, it is essential to oversee all stages of production, starting from proper cultivation and identification of medicinal plants, considering the season and region of collection, and concluding with the extraction and purification of plant-based preparations. Herbal medicines and finished plant-based pharmaceutical products have been widely used for thousands of years. In recent decades, the growth in the production of herbal medicinal preparations and the increasing popularity of phytotherapy have significantly expanded the share of plant-based pharmaceuticals in the global market. Today, herbal medicines account for 70-95% of the global pharmaceutical industry. According to the World Health Organization (WHO), approximately 80% of the world's population relies on herbs and other traditional medicinal products to meet their primary healthcare needs.

VITAL TRACE ELEMENTS IN WILD MEDICINAL PLANTS OF NATURAL ECOTOPES IN THE VORONEZH REGION

The aim of the paper is an experimental study of the content of vital trace elements in wild medicinal plants of natural ecotopes in the Voronezh region. Materials and Methods. The following pharmacopoeial types of medicinal plants were used as research tragets: common knotgrass (Polygonum aviculare L.), herb; common nettle (Urtica dioica L.), leaves; small-leaved linden (Tilia cordata Mill.), flowers; great burdock (Arctium lappa L.), roots; common dandelion (Taraxacum officinale F.H.Wigg), roots; tansy (Tanacetum vulgare L.), flowers; broadleaf plantain (Plantago major L.), leaves; common wormwood (Artemisia absinthium L.), herb; five-bladed motherwort (Leonurus quinquelobatus Gilib.), herb; common yarrow (Achillea millefolium L.), herb. Mass spectrometry was used to examine the trace element composition of samples after acid-microwave digestion. Results. Zinc should be considered as a vital trace element that is strongly accumulated from soils. The highest rates of its biological absorption are noted in roots and herbs. Copper is considered to be intensively accumulated by all types of medicinal plant raw material, except flowers. Molybdenum is actively accumulated by common nettle and broadleaf plantain (leaves), small-leaved linden (flowers), common yarrow and five-bladed motherwort (herb). High biological absorption of cobalt from soils is noted for common dandelion and great burdock (roots). Conclusion. The study results demonstrated a rich composition of trace elements in the studied medicinal plant raw materials. The results of the study can be used in medical and pharmaceutical practice to correct the physiological norms of microelement content in the human organism.

Cardiotropic medicinal products of plant origin. Prospects for use in modern clinical practice

Introduction: The aim of the research was to study the current state of use and improvement of the prospects for the using cardiological medicinal products obtained on the basis of medicinal plant raw materials. Materials and Methods: The work used content analysis, monitoring of scientific articles using the databases PubMed, Scopus, Google Scholar, ResearchGate, analysis of the nomenclature of the State Register of Medicines of the Russian Federation (2024) and the Register of Medicines of Russia (2024). Results and Discussion: The study revealed that diseases of the cardiovascular system are some of the most common causes of death among the population, with at least 37.7 million people suffering from varying degrees of heart failure alone. Despite the constant growth of the range of medicines for the treatment of cardiovascular diseases, medicinal plants and preparations based on them, which are more often used in complex therapy, still play an important role in their therapy. In this review, we consider drugs derived from medicinal plant raw materials used for the treatment of heart failure and arrhythmia of various etiologies, as the most serious cardiovascular pathologies. Conclusion: Preparations based on herbal remedies with cardiotropic and antiarrhythmic effects are relevant in the treatment of cardiovascular diseases. Cardiotropic action is characteristic of the group of cardiac glycosides, and antiarrhythmic activity is more pronounced in alkaloids and flavonoid substances. Taking into account the prospects for the use of herbal preparations with cardiotropic effects in the complex therapy of cardiovascular diseases, an important and unsolved problem today remains the problem of their interaction with other drugs, which in the future can be solved by creating artificial intelligence programs that contribute to the formation of optimal prescriptions for a particular patient.

PLANT BASE FOR THE BEVERAGE

The use of local plant raw materials, which have great value due to specific combinations of biologically and physiologically active components, has a wide perspective in the production of food products with high consumer properties. The structure of human nutrition includes vitamins, macro- and microelements, fibers, pectins, etc. fruits, which are the main source, should prevail. Fruit – berry beverages are characterized by a high amount of various micronutrients. Therefore, the production of fruit – berry beverage has not lost its relevance. In addition, the combination of microflora and bioactive substances of plant origin significantly expands the range of products. Apples, oranges, and ginger were selected for processing the beverage production technology. The composition of raw materials is rich in vitamin C, B9, B1, B6, A, and minerals such as calcium, potassium, iron, magnesium, zinc, phosphorus and copper. The ratio of selected raw materials is 50:35:15 for apple, orange, and ginger, respectively. According to organoleptic indicators, the beverage is transparent, without sediments and foreign additives. When a beverage is poured into a glass, foam is created by the release of carbon dioxide bubbles. Physico-chemical parameters of the obtained beverage are as follows: dry matter content – 15,28%; titratable acidity -3,1 ± 0,50Т; carbohydrate content – 12%; fat content – 0,11%; amount of alcohol – 3,12%; ash content, 2%;calcium – 21,74%; phosphorus – 22,96; iron – 7,33; zinc – 7,7; copper – 4,19; magnesium – 11,78; sodium – 24,3. The shelf life of the beverage was 60 days.Pathogenic flora, including salmonella and yeast and mold microorganisms, were not detected.

IMPROVEMENT OF YOGURT TECHNOLOGY BASED ON BIOLOGICALLY ACTIVE ADDITIVES FROM VEGETABLE RAW MATERIALS

The scientific article provides a systematic analysis of the relevance of developing yogurt technology using biologically active additives from plant raw materials based on theoretical research. Based on empirical studies, the composition of medicinal plants growing in the East Kazakhstan region has been studied, the composition of medicinal plants with the optimal content of active substances has been selected, the effect of medicinal plant extract on yogurt quality indicators has been studied, and the technology and formulation of functional yogurt have been developed. To conduct the study, standard and generalized methods were used to study the chemical, physico-chemical, microbiological and organoleptic parameters of dairy raw materials, medicinal plants, medicinal plant extract and yogurt. A method for obtaining a thick extract has been developed to obtain a functionally oriented bio-yogurt. For the experimental development of the technology for obtaining a thick extract, the following modes were set-the extraction temperature was 50-55° C, the duration was 5 hours, the ratio of raw materials to extractant was 1:20, 95% ethyl alcohol was selected as the extractant. The technology of introducing a thick extract into the yogurt has been developed. The quality indicators of bioyogurt produced using an extract of medicinal plants have been studied. The optimal dose for the administration of medicinal plant extract is 6%. Bio-yogurt thick extract of medicinal plants should be stored from 4 to 6% for up to 24 hours, including no more than 12 hours at the factory at a temperature of 4-6°C.

PHYTOCHEMICAL ANALYSIS OF CALLIGONUM SETOSUM LITV.

The study of the chemical composition of plants and their use to produce pharmaceuticals and biologically active additives are becoming increasingly important in the context of the development of the chemical and pharmaceutical industries of the Republic of Kazakhstan. Within the framework of the state program «Digital Kazakhstan» and other national strategies, the country is dedicated to creating innovative solutions in biotechnology, agrochemistry, chemical technology, and pharmaceuticals. Special attention is paid to plants, which can become sources of useful substances. Research on plants such as Calligonum setosum Litv. is especially relevant in the context of increasing domestic pharmaceutical capacities.The article presents data on the study of the amino acid and fatty acid composition of plant material Calligonum setosum Litv., which grows on the territory of Kazakhstan. The study revealed a high content of amino acids, including glutamic and aspartic acids, as well as polyunsaturated fatty acids such as γ-linolenic acid. An analysis of the commodity, evaluation of heavy metal content, and assessment of technological parameters were carried out. The results indicate the potential of using this plant for isolating substances in their pure form, as well as for developing medicines and biologically active additives. The obtained data can become the basis for further research and development of new methods of processing plant raw materials.

ASSESSMENT OF QUALITY AND FOOD SAFETY OF LOCAL PLANT RAW MATERIALS FOR ENRICHMENT OF CONFECTIONERY PRODUCTS

The development of functional confectionery products enriched with plant biologically active substances is an important and urgent task for the food industry.The presented in the article data on the quality and food safety of wild berry raw materials confirm their potential for use in functional products as a source of organic compounds of various types with a variety of physiological effects. According to the information on the possibility of raw material procurement on the territory of Ile-Alatau State National Natural Park, the optimal variant is the use of local fruit and berry raw materials. This will not only expand the raw material base, but also reduce transportation costs, which will lead to a reduction in the cost of production.The main objective of the study is to assess the quality and safety of fruits, stems and leaves of plants growing in Ile-Alatau State National Natural Park for their further use in the food industry.The researched local plant raw materials (sea buckthorn, hawthorn, rosehip) according to the quality and safety indicators meet the established regulatory requirements for raw materials. Based on the quality and safety of local plant raw materials allows us to recommend it for use as a raw material for enrichment of confectionery products. The use of berries contributes not only to the increase in the content of BAS, but also allows to minimize or completely eliminate synthetic dyes and flavoring additives from confectionery products.

Characterization of Lactiplantibacillus plantarum strains isolated from Algerian fruits for probiotic and biotechnological applications.

Twenty-one lactic acid bacteria (LAB) strains were isolated from Algerian fruits such as white mulberry (Morus alba L.), prickly pear (Opuntia ficus-indica), date (Phoenix dactylifera L.), grape (Vitis vinifera) and fig (Ficus carica). The initial screening showed that ten out of twenty-one strains were tolerant to acid pH and bile salts and were further identified as Lactiplantibacillus (L.) plantarum strains by MALDI-TOF mass spectrometry and 16S rDNA sequencing. The identified strains were then characterized for their surface properties such as self-aggregation, hydrophobicity and biofilm formation. The resulting data were then statistically processed using Principal Component Analysis (PCA), after which only 5 strains were selected for further analysis. These five strains, designated L. plantarum F8, F13, FB23, D21 and M1, were found to be safe and able to adhere to human epithelial colorectal adenocarcinoma Caco-2 cells. In particular, all these strains were active against Escherichia coli ATCC 8739 and Staphylococcus aureus ATCC 6538 through the production of lactic acid (up to 12g.l-1) or bacteriocins, namely plantaricins, or their combination. In addition, these strains showed high antioxidant activity against the synthetic free radicals 2,2-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azino-bis: 3-ethyl-benzothiazoline-6-sulphonic acid (ABTS +) radical. These results demonstrate the importance of these L. plantarum strains for the development of new functional foods and probiotics and as biopreservatives. This study deepens and enriches the knowledge of lactobacilli from plant raw materials by focusing on the functional properties of new strains of L. plantarum isolated from Algerian fruits. In fact, with the growing interest in natural preservatives and probiotics, the results of this study could contribute to the development of new biotechnological products aimed at improving gut health, reducing food-borne illnesses and extending the shelf life of food by preventing spoilage.

Study of the effect of Saponaria officinalis herb extract on histological changes in the marginal vein of the ear under conditions of experimental thrombophlebitis

Thrombophlebitis is recognized as one of the most common complications of chronic venous insufficiency (CVI). Its course is characterized by inflammation of the venous wall and the formation of blood clots in the lower extremities of varicose veins. Thrombophlebitis is diagnosed according to various data in 5-60 % of patients with CVI. The number of drugs with a phleboprotective effect and the ability to reduce the processes of thrombus formation in veins on the pharmaceutical market of Ukraine and the world is extremely limited. As a promising object, as a new phleboprotective drug, medicinal plant raw materials can be considered, namely the extract of the herb Saponaria officinalis, for which venotonic and antiexudative effects have been established in previous studies. The aim of this work was to study the effect of Saponaria officinalis herb extract on changes in the histological parameters of the ear vein in rabbits under conditions of experimental thrombophlebitis. Experimental thrombophlebitis was modeled on rabbits according to the standard method with applying a ligature to the marginal vein of the animal's ear and injecting Lugol's solution. Histological changes after phytocomposition administration (ETML) (20 mg/kg intragastrically) were compared with the effectiveness of the reference drug Eskuvit (7.2 mg/kg for escin intragastrically). It was established that the therapeutic and prophylactic administration of ETML at a dose of 20 mg/kg significantly prevented thrombus formation in the marginal ear vein of rabbits, contributing to the softening of the thrombus material, thrombolysis, preventing the acquisition of an obliterating character for thrombotic masses. in all rabbits of the group. probably reduces the clinical indicators of transudative edema, which developed as a result of acute venostasis. ETML prevented the destruction of the vascular wall, reduced or eliminated degenerative changes and inflammatory reaction in the surrounding tissues. Significant advantages of ETML over the comparison drug Eskuvit have been established. Under the conditions of experimental thrombophlebitis, the therapeutic and prophylactic administration of ETML at a dose of 20 mg/kg has a powerful phleboprotective effect, reduces the processes of thrombus formation in the vein. The effect of ETML is statistically significantly higher than the effectiveness of the comparison drug Eskuvit.

Prospects for the use of plants of northern kazakhstan in the production of functional food products

The article presents the results of a study of the physico-chemical composition, antioxidant activity, vitamin and mineral composition of wild raw materials of Northern Kazakhstan (sweet clover, St. John's wort and purslane). It has been established that this vegetable raw material contains a significant amount of bioactive compounds - polyphenols, vitamins and minerals. Polyphenols, β-carotene have antioxidant, immune-restoring properties. The article also presents the results of an assessment of the chemical composition, including the content of secondary metabolites, quality and safety indicators of the initial plant raw materials. The article contains the results of studying the biological activity of the aboveground parts of sweet clover, St. John's wort and purslane, and the prospects for using the selected plant raw materials for the extraction of secondary metabolites with a wide range of biological activity are established. These studies open up new opportunities for the use of native plants in the food industry. The expediency of using these plants as sources of natural antioxidants and biologically active additives to improve human health is substantiated. The possibilities of integrating these plants into formulations of food additives and functional products to improve the overall condition of the body are also considered. The use of biologically active substances of plants of Northern Kazakhstan in the food industry opens up new opportunities for the development of the region and the expansion of the range of functional nutrition.

The use of the medicinal plant raw material and bee products in the treatment of dermatological diseases

Aim. To analyze the application of natural components in dermatological practice, as well as to study the potential benefits of using extracts from the medicinal plant raw material (MPRM) (Curcuma longa, Aloe vera, Calendula officinalis) and bee products (propolis, bee venom, honey) in the treatment of skin diseases. Materials and methods. To achieve this aim, methods of logical-content issue formation, content-analysis of publications in scientific and practical-oriented medical and pharmaceutical publications, comparative analysis and graphic tools of visual presentation of the data obtained were used. This study presents the results of scientific and practical work of leading scientists and the own experimental research materials of the authors of the article. Determination and observational studies cover clinical tests that diagnose acne on the skin. Results. Traditional treatments, including topical retinoids, benzoyl peroxide, and systemic antibiotics, while effective, are not without side effects and limitations, requiring the study of alternative therapies. The combination of bee products and medicinal plant extracts proposed is a potentially synergistic approach to improving acne treatment outcomes. These materials show a clear effect of using natural components in dermatological practice. Conclusions. The analysis of scientific literature has shown that the plant raw material and bee products have significant therapeutic potential due to a wide range of biologically active substances. The use of honey, propolis and bee venom in the treatment of dermatological diseases, as well as plant extracts that enhance the effect of bee products is of particular interest. The studies conducted have confirmed the effectiveness of the medicinal compositions developed on the basis of the MPRM and bee products for the treatment of dermatological pathologies.

The substantiation of the composition and pharmaco-technological studies of the herbal medicine for the complex therapy of post-traumatic stress disorder

Post-traumatic stress disorder (PTSD) is a mental condition that can develop after experiencing or being presentat a traumatic event (war, natural disasters, violence, accidents or other stressful situations). Over the past two years,the number of patients with this diagnosis in the electronic healthcare system has significantly increased. Therefore, itis urgent to create safe, including for long-term use, medications to help patients with PTSD.Aim. To study the potential of the plant raw material for the development of herbal medicines intended for thetreatment of post-traumatic stress disorder, as well as to develop the composition of a new original medicinal productof natural origin.Materials and methods. The study object was the raw material of Gaillardia pulchella L. Herba, Ocīmum basilīicum,L Herba, Hyperіcum perforatum L. Herba, Chamomilla recutita L. flos, Melissa officinalis L. Herba, Ginkgo biloba L. Folia.NEWS OF PHARMACY 1 (109) 2025 ISSN 2415-8844 (Online) 41The pharmaco-technological indicators were studied according to the standard methods of the State Pharmacopeiaof Ukraine (SPhU).Results. The main place in the phytotherapy of PTSD is given to plant components that have various complexesof biologically active substances (BAS), which exhibit antidepressant, anxiolytic, nootropic, angioprotective, antispasmodic, metabolic, venotonic effects. The combination of selected types of the raw material creates favorable conditions for the manifestation of the pharmacological activity of the drug due to the fact that its components affect differentparts of the body, enhancing the expected therapeutic effect. Such a multifaceted effect of the components of theherbal medicine not only improves its therapeutic effectiveness, but also minimizes the risk of side effects. The studyof pharmaco-technological indicators allows us to find out that the values of loss on drying for the samples of the medicinal plant raw material (MPRM) studied are in the range from (5.11 ± 0.20) to (7.24 ± 0.20) %, which corresponds tothe current standards of the SPhU for plant materials. The specific gravity values vary in the range from (1.380 ± 0.021)to (1.580 ± 0.022) g/cm³, which indicates a decrease in the probability of stratification of the raw material in herbalmedicine compositions during mixing of ingredients. The bulk density parameters for the components of the herbalmedicine ranges from (0.476 ± 0.012) to (0.724 ± 0.020) g/cm³, which indicates the presence of significant differencesin this indicator for different samples of the MPRM. In addition, the bulk density indicators of the raw material in theherbal medicine developed changed almost twice – from (0.114 ± 0.007) to (0.231 ± 0.002) g/cm³. This difference wastaken into account when developing the technological process for the production of the herbal medicine in order toensure uniform distribution of components in the finished product.Conclusions. Modern scientific data on the spread of PTSD, as well as on the pharmacological properties, chemical composition and botanical characteristics of the MPRM and the herbal medicine have been analyzed and systematized. A theoretical and experimental substantiation of the composition of the herbal medicine for the complex therapyof PTSD has been developed. The influence of various pharmaco-technological characteristics of the MPRM and theherbal medicine on their quality has been studied. The combined herbal medicine proposed, the components of whichmutually enhance and complement their pharmacological properties during the complex treatment of PTSD will notonly increase the effectiveness of pharmacotherapy, but also reduce the risk of side effects associated with the use ofsynthetic drugs. It should be noted that the research of the drug being created is still ongoing. In the future, it is plannedto study in detail the composition of BAS, develop methods for their analysis, study the effect of these substances onthe pharmacological action, as well as expand the range of dosage forms for this product.