Place Aversion In Rats Research Articles

Drug-induced hypothermia and conditioned place aversion.

This study examined the relationship between ethanol's thermal and motivational effects in a place conditioning task. In three experiments, male albino rats were exposed to a differential conditioning procedure that paired a distinctive tactile stimulus with ethanol (1.2 or 1.8 g/kg) or lithium chloride (3 meq/kg); a different stimulus was paired with saline. Different groups were exposed to ambient temperatures (Ta) of 5 degrees, 21 degrees or 32 degrees C during each 60-min conditioning trial. Both ethanol and lithium chloride produced hypothermia and conditioned place aversion in rats conditioned at normal Ta. Exposure to high Ta reduced drug-induced hypothermia, increased activity, and decreased conditioned place aversion. Exposure to low Ta did not enhance drug-induced hypothermia or change conditioned place aversion. In general, these findings support the suggestion that the hedonic effects of ethanol and lithium chloride interact with their thermal effects.

Estradiol-induced conditioned taste aversion and place aversion in rats: Sex- and dose-dependent effects

Effects of various doses (0–250 μg/kg, SC) of estradiol-17β (E 2) in a two-bottle choice conditioned taste aversion and a two-compartment conditioned place preference procedure were studied in male and female rats. Dose-dependent taste aversion and place aversion effects of E 2 were established, and the conditioned taste aversion procedure was found to be more sensitive in detecting aversive properties of E 2 than the conditioned place preference procedure. Although aversive properties of E 2 were found in both sexes, the effects were clearly more prominent in males as compared to females. From this study, it was concluded that E 2 acts as an unconditioned aversive stimulus in both male and female rats capable of gaining control over different types of behavior by associative learning.