Physical Side Research Articles

The Effect of High-Intensity Interval Training on Quality of Life and Incidence of Chemotherapy Side Effects in Women With Breast Cancer.

56 patients (48.56 (7.84) years, range 35-64 years) diagnosed locally advanced (stage II-III) ER + BC receiving doxorubicin/cyclophosphamide-based NAC were randomly assigned to the HIIT group and a control group (CG) for 6 months. The HIIT group performed 2 to 3 HIIT sessions per week according to the study protocol (4 × 4 minutes at 85%-95% peak heart rate (HR)). The CG followed the standard of care instructions by the oncologists. To assess the QoL participants completed the EORTC QLQ-C30 with the additional BC module of QLQ BR-23. Weekly self-reports on NAC side effects were collected through online survey. Study data were analyzed for 37 participants (nHIIT = 17, nCON = 20) who reported at least 14 (60%) weeks. HIIT was effective to reduce BC symptom scale outcomes (ES = 0.113, P = .048), and alleviate systemic therapy side effects (ES = 0.154, P = .020) and cancer related symptoms (ES = 0.124, P = .038). The most common side effect participants experienced at least 1 to 4 days/week was pain (average 50.9% and 56.8% for HIIT and CG, respectively), followed by sleep disturbances (average 50.9% and 49.9%, respectively). About 31% in both groups experienced sleep disturbances 5 to 7 days/week. The NAC induced physical, social and fatigue side effects had significantly lower incidence in HIIT group, while psychological side effects were significantly more common in training group. HIIT is an effective physical exercise program to maintain higher quality of life and help to reduce some of NAC induced side effects for women with BC.

Advanced Practice Providers' Role in Intimacy in Advanced Cancer Patients.

The primary objectives of early phase clinical trials are to determine the safety, tolerability, and recommended doses of an investigational agent for patients with advanced cancer. Although these advances in cancer treatment have resulted in patients living longer, patients often experience psychological side effects that may affect sexual health and intimacy. It is estimated that cancer and its subsequent treatments affect the sexual health and intimacy of 40% to 100% of this patient population. Patients with advanced cancer who have undergone numerous treatments may be impacted negatively, not only physically (such as being disfigured by surgical resection) but also emotionally in relationship aspects with their intimate partners. Health-care providers who treat patients with advanced cancer enrolled in early phase clinical trials tend to focus primarily on treatment, physical side effects, and symptom management. Advanced practice providers (APPs) are accustomed to performing comprehensive physical examinations on patients; however, research indicates that intimacy and sexuality are most often excluded in discussions with patients with advanced cancer. The purpose of the article is to increase awareness of the need to address intimacy and sexuality in this patient population and to encourage APPs to make this a part of their everyday practice.

Attitudes and Subjective Norms Regarding Medication for Opioid Use Disorder Among Individuals in Treatment for Opioid Use Disorder in the Greater St. Louis Area

Medication for opioid use disorder (MOUD) is safe and efficacious for treating opioid use disorder (OUD), yet there is limited understanding of how attitudes and subjective norms regarding MOUD among individuals with OUD may impede treatment uptake. Thus, the current study describes attitudes and subjective norms in a sample of individuals with OUD in the St. Louis area ( N = 183) and compares outcomes among those who were and were not actively taking MOUD. Most endorsed positive views regarding pharmacologic treatment for OUD overall, but concerns about physical side effects, the daily nature of some MOUD options, and uncertainty about the relative risks and benefits of MOUD remained prevalent. Individuals reporting current MOUD use had more accepting attitudes and perceived subjective norms regarding MOUD compared to others, suggesting that interventions targeting improvements in the knowledge of, attitudes toward, and normalization of MOUD are needed to further improve uptake and retention in pharmacotherapy for OUD.

The lived experience of withdrawal from Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants: A qualitative interview study.

Our knowledge of the broader impacts of antidepressant withdrawal, beyond physical side effects, is limited. Further research is needed to investigate the lived experiences of withdrawal, to aid clinicians on how to guide patients through the process. To explore antidepressant users' experiences and views on the withdrawal process and how it affected their quality of life across multiple life domains. We conducted in-depth qualitative interviews with 20 individuals from the community who had attempted to withdraw from Serotonin Reuptake Inhibitor antidepressants in the past year. Semi-structured interviews were conducted online. A topic guide was used to ensure consistency across interviews. The interviews were audio-recorded and transcribed verbatim and analysed using inductive reflexive thematic analysis. Five themes were generated. The first highlighted the challenges of managing the release from emotional blunting and cognitive suppression following antidepressant discontinuation. The second related to the negative impact of withdrawal on close relationships and social interactions. The third showed that concurrent with negative physical symptoms, there was a positive impact on health (exercise was reported by some as a coping mechanism). The fourth theme focused on support from GPs and families, emphasising the importance of mental health literacy in others. The final theme underscored the importance of gradual and flexible tapering in enabling a manageable withdrawal experience,and the consideration of timing. The lived experience of withdrawal significantly impacts individuals' well-being. Participants emphasised that withdrawal is not just about physical side effects but also affects their emotional, cognitive, and social functioning. Eight people attended individual online meetings to share their experiences of antidepressant withdrawal to help inform the study design and recruitment strategy. Insights from these meetings informed the development of the topic guide. Questions about GP involvement, family relationships, and mood and thinking changes were included based on this PPI work. This ensured the inclusion of topics important to antidepressant users and facilitated the researcher's questioning during the interviews.

‘I knew which one I wanted’: Interviews with Illinois patients to explore abortion method decision‐making after insurance expansion

AbstractIntroductionTo understand patient preferences around early abortion methods and care‐seeking during the coronavirus disease 2019 pandemic in a state that expanded insurance coverage for abortion care.MethodsWe conducted phone interviews between July 2021 and February 2022 with 50 Illinois residents (aged 18–45) who had recently sought abortion at 18 clinics throughout Illinois at or before 11 weeks of pregnancy. We used a semistructured interview guide to explore preferences, motivations and decision‐making around the abortion method. We coded transcripts and used code summaries to conduct a thematic content analysis.ResultsHalf of the participants chose medication abortion, and half chose procedural abortion. Some participants relied upon their past abortion experiences to choose a method. Participants' reasons for choosing medication abortion included home setting with support persons, the noninvasive nature, desiring a more ‘natural’ experience or negative perceptions of procedural abortions. Participants choosing procedural abortions valued increased certainty of completion, the option of sedation and the defined timeline of a clinic visit with fewer physical side effects. Some participants without insurance coverage were motivated to select a method based on cost. Around half of the participants expressed interest in considering a telehealth abortion.ConclusionsPatients cited complex and personal preferences influencing their method selection; when cost barriers were reduced, preferences centred physical or emotional experiences, setting, effectiveness and timing. As abortion access is increasingly restricted, many patients may still highly value a choice between medication and procedural abortion when possible.

Behind the Scenes of Isotretinoin: My Journey and Recommendations.

Isotretinoin is a form of Vitamin A used in treatment of severe, refractory acne vulgaris with treatment duration ranging anywhere from 3 to 12 months. The side effects of isotretinoin require monthly dermatologist visits and utilize a risk-management program called iPLEDGE REMS run by the Federal Drug Administration (FDA), which verifies that patients are not pregnant while starting or while taking isotretinoin. The physical and mental side effects experienced on isotretinoin are unique to each patient and can be severely debilitating. My own experience taking isotretinoin for 8 months was filled with multiple unexpected side effects that affected both my physical and mental health. As a result, I strongly believe dermatologists should help patients in analyzing the risk versus benefit profile of isotretinoin, present all other options, and ultimately emphasize patient-provider shared-decision making. Furthermore, at monthly visits dermatologists should be required to implement open dialogue regarding side effects to avoid patient feelings of fear and shame. Additionally, the iPLEDGE REMS system should consider creating a systematic documentation of symptoms to help normalize experiences and guide treatment plans.

Implementation Readiness and Initial Effects of a Brief Mindfulness Audio Intervention Compared With a Brief Music Control During Daily Radiation Therapy for Prostate Cancer: A Randomized Pilot Study.

The most common and debilitating side effects of radiation therapy (RT) for prostate cancer (PC) are fatigue, sleep disturbance, anxiety, and depression. Previous research has reported palliative benefits from certain self-management approaches, such as mindfulness meditation. To develop, pre-test, and evaluate the feasibility, acceptability and initial benefit of brief, audio-based mindfulness delivered during daily RT for PC compared to a relaxing music control. Following intervention development, participants were randomized to either brief guided mindfulness audio recordings or a relaxing music control during daily RT. A pre-testing phase was first conducted to determine optimal program start time, length, and content most associated with retention. A final program (n = 26) was delivered daily, starting on day one of week 2 of RT and lasting 4 consecutive weeks. Feasibility was defined as ≥70% on enrollment rate, retention, and audio program adherence. Acceptability was measured with a 12-item post-study survey. A secondary focus compared between group changes on patient reported outcomes of fatigue, anxiety, depression, sleep disturbance, and related outcomes at baseline and follow up assessments. Descriptive statistics and general linear models were used. Overall, 76% (n = 38) of approached men enrolled. Pre-testing retention rates were <70% while the final program's retention rate was 89%. The majority of acceptability criteria were met in both conditions, with relatively higher ratings in the mindfulness arm. Compared to music controls, mindfulness participants demonstrated significantly less uncertainty intolerance at 4-weeks (P = .046, d = .95); and significantly lower fatigue scores (P = .049, d = 1.3) and lower sleep disturbance scores (P = .035, d = 1.1) at the 3months follow up. The final intervention met feasibility and acceptability criteria. Pre-testing refinements played a key role for optimal program delivery and retention. Audio-based mindfulness delivered during RT for PC hold potential to help decrease RT-related physical and emotional side effects.

Effects of a Phone-Based Support Program for Women With Breast Cancer Undergoing Chemotherapy: A Pilot Study.

The increasing number of women with breast cancer undergoing chemotherapy may result in long-lasting, adverse physical side effects and reduced quality of life. This study aimed to develop and assess the feasibility and preliminary effects of the Phone-Based Support Program for women with breast cancer undergoing chemotherapy. The primary outcome was self-care self-efficacy; secondary outcomes were symptom distress and quality of life. This pilot study was conducted at a tertiary hospital in Jiangsu province, China, from February to March 2023. The Phone-Based Support Program was delivered to 20 participants through the smartphone application WeChat, consisting of learning, discussion, ask-the-expert, and personal stories components. Outcome measures were assessed at three time points: preintervention, postintervention, and follow-up. The Phone-Based Support Program was feasible and could improve self-care self-efficacy, decrease symptom distress, and promote quality of life. The program was well-accepted, and participants engaged actively in the online discussion and sought expert advice. The Phone-Based Support Program showed feasibility and effectiveness in improving self-care self-efficacy, reducing symptom distress, and enhancing quality of life.

Patient-reported treatment satisfaction in essential tremor: levels of satisfaction and predictors of satisfaction.

Although managing symptoms is paramount for both essential tremor (ET) patients and their healthcare providers, studies of treatment satisfaction are surprisingly lacking. We evaluated the satisfaction of patients who used a range of treatments and assessed the relation of a wide array of factors to satisfaction. One hundred four ET participants (age = 74.5 ± 10.2 years) completed a battery of self-report items. These included demographic information, measures of tremor and clinical history, psychological state, current ET treatment, and a series of questions about satisfaction with treatment. Analyses of responses to the four current treatment satisfaction questions revealed that the proportion of participants who were satisfied ranged from 35.0% to 57.3% (i.e., approximately 1/3 to 1/2); conversely, the proportion who were dissatisfied ranged from 9.2% to 37.0%. The remainder were neutral. Higher satisfaction levels were observed in participants who were included in treatment selection and who had undergone deep brain stimulation surgery, p's < 0.05. Lower levels of satisfaction were found in participants with a negative psychological state, higher self-rated tremor severity, head/voice/jaw tremors, and more severe physical side effects; and who used botulinum toxin therapy, p's < 0.05. Between 1/3 and 1/2 of patients were satisfied with their treatment, whereas up to 1/3 were dissatisfied. In this initial exploration of correlates of treatment satisfaction in ET patients, we identified a number of associations between satisfaction and clinical, psychological and treatment variables. Additional research is warranted to further explore the nature of these relations over time.

Formulation, Nutritional and Sensory Evaluation of Mocaf (Modified Cassava Flour) Noodles with Latoh (Caulerpa lentillifera) Addition

Instant noodles gained widespread popularity, resulting in a surge in global wheat consumption. However, concerns about the health implications of wheat-based products spurred the need for alternative ingredients in noodle production. The substitution of wheat flour with local resources, such as mocaf flour, and the enrichment of noodles with latoh (Caulerpa lentillifera), provided an opportunity to reduce wheat imports while enhancing the quality and potential health benefits of noodles. This study aimed to determine the optimal formulation, assess the characteristics, and evaluate the functional properties of wheat noodles that were substituted with mocaf flour and supplemented with latoh. The formulation of these noodles was conducted using design expert. The research encompassed a comprehensive analysis of physical, chemical, and organoleptic properties. The presence of latoh, in terms of chemical characteristics, increased the water and protein content in the noodles. On the physical side, it increased the final viscosity, setback, peak time, and elongation, as well as reduced the peak viscosity and breakdown. Meanwhile, the presence of mocaf increased carbohydrate content, peak viscosity, and breakdown value. The variations in noodle formulas only affected consumer acceptance of the appearance of the noodles; the noodle formula 99:1 (Mocaf:Latoh) had the most preferred appearance. Based on the sensory test parameters, the elongation value, and the tensile strength, noodles with optimal formulas were obtained, namely mocaf 63%, wheat 36% and latoh 1%. The optimum formula was similar to sample 10 (60:39:1) which exhibited characteristics such as a bright color, a rather smooth appearance with no cracks, a very soft mouthfeel, a bit springiness and elasticity, and a slightly non-sticky texture to the teeth without a fishy aroma. The essential and non-essential amino acids with the highest concentration contained in the Mocaf Noodles’ optimum formula were glutamate and leucine. Mocaf noodles with added latoh had low fat content but high carbohydrates and were rich in essential amino acids compared to other noodles. Additionally, they possessed sensory characteristics that were deemed acceptable by the panelists.

Effects of Ostarine and Endurance Training on Some Functional, Hematological, and Biochemical Parameters in Male Rats

Background: Non-steroidal Selective Androgen Receptor Modulators (SARMs) are currently a group of drug candidates with anabolic effects, tissue selectivity, and the potential to improve the therapeutic process in a number of socially significant diseases. There is insufficient data on their effects during exercise and on their adverse side effects. Objectives: Our objective was to examine the role of selective androgen receptor modulators for the physical working capacity of the body, hematological and biochemical parameters, and to evaluate any side effects of SARMs. We studied the effects of ostarine (S-22, MK-2866, GTx-024, Enobosarm) alone or in combination with submaximal training in sexually mature male Wistar rats. Methods: The rats used were divided into a treadmill-trained group and a sedentary group. Half of each group received either ostarine or vehicle for 8 weeks (n = 10 each). We performed functional tests and blood analysis at the end of the experiment to analyze clinical chemistry and hematological indicators. Results: Ostarine did not affect maximal sprint speed, VO2max, and running economy, while submaximal training increased these parameters. Ostarine increased total plasma cholesterol and energy expenditure and decreased plasma glucose concentration. Neither treatment changed the oxygen-carrying capacity of the blood, the respiratory quotient, the concentration of triglycerides and LDL-cholesterol, or creatine kinase. Combined treatment neutralized the negative effect of ostarine on plasma total cholesterol levels. Conclusions: Ostarine did not affect the examined hematological and physical working capacity parameters, but it changed some clinical chemistry indicators. Training improved the physical working capacity but did not affect the clinical chemistry and hematological parameters. Further research is needed to clarify other aspects of the influence of non-steroidal SARMs on the physical working capacity and possible side effects during long-term use, as their administration, along with physical activity, is becoming popular among healthy adult bodybuilders in gyms.

Effects of Microplastics on Living Organisms and their Trophic Transfer: An Ecotoxicological Review

Plastic is used by individuals within many different fields, including the automotive, packaging, cosmetics, textile and apparel, agricultural and fisheries sector and industries. Nevertheless, it has become a hazard to our ecosystem due to its extended degradation and decadences in nature, unceasing rise in manufacture and consumption with the increasing human population. Microplastics (MPs) can enter in both soil and aquatic environments through a variety of channels, including surface runoff, storm water runoff, river flow, and wastewater discharge. As a possible hazard to aquatic life, the existence and consumption of MPs has drawn significant attention from throughout the world. These tiny plastic particles absorb various substances and emit harmful additives, serving as sinks for dangerous substances and enhancing their bioavailability, toxicity, and movement. Additionally, the trophic transfer or bioaccumulation of MPs in a variety of aquatic creatures poses a significant concern. MPs have the potential to seriously harm aquatic life, including reduced eating efficiency, physical side effects, impaired gill function, oxidative stress, neurological damage, suppression of immunity and developmental disruption.

Exploring the effects of extended reality head-mounted display nervous system assessment training for nursing students: A pilot feasibility study

BackgroundHealth assessment is crucial for planning nursing interventions. Specifically, cerebrovascular diseases involve rapid neurological changes that necessitate precise hands-on assessment skills training. ObjectivesThis study developed and implemented an extended reality head-mounted display (HMD) nervous system assessment training program for nursing students to identify the usability and effectiveness of the system by analyzing their experiences. DesignThis was a mixed-methods study that combined the quantitative element of a one-group pre-post-test design with the qualitative element of qualitative content analysis. SettingUniversity in Korea. ParticipantsThe study involved 36 nursing students in their 4th year who completed classes in health assessments and adult nursing (nervous system). MethodsAn extended reality nervous system assessment training program was developed using the National Institutes of Health Stroke Scale and limb strength assessment. The learners wore HMD and received training at their own pace. System usability, confidence in nervous system assessment, learning satisfaction, and performance ability were measured and analyzed using SPSS Windows software version 28.0. Descriptive data were used for qualitative content analysis of the training experience. ResultsThe usability of the extended-reality HMD nervous system assessment training received positive feedback and most participants (94.4 %) agreed with the system's consistency. Confidence in nervous system assessment significantly improved after the training (p < .001). After the training, learning satisfaction and performance ability were high. Furthermore, advantages of XR-based learning devices and positive learning were observed. Nonetheless, issues such as difficulties in operating the device, inconvenience, physical side effects of wearing the device, and technical limitations existed. ConclusionsThis study developed and implemented an extended-reality HMD nervous system assessment training program to confirm its feasibility. However, challenges regarding device utilization need to be resolved for its effective development as a learning tool.

The Psychological Impact of Isotretinoin Therapy on Acne Vulgaris Patients.

Introduction Acne vulgaris is a dermatologic condition that affects the pilosebaceous unit. It is the most common skin disorder worldwide, and it is most prevalent during puberty. For patients with moderate to severe acne that is unresponsive to antibiotic treatment, the main treatment is oral isotretinoin. The objective of this study was to define the impact of isotretinoin and its well-established adverse effects on the psychological status of acne patients during treatment. Methods The sample cohort included 80 patients with acne vulgaris who were treated with isotretinoin. The sample size was calculated using the Raosoft [Raosoft.com (2015) Sample Size Calculator by Raosoft, Inc.] sample size calculator to maintain a confidence interval of 95% and a margin of error of 5%. The participants were assessed using the Depression and Anxiety Stress Scale-21 (DASS-21). The DASS-21 is a self-reporting scale used to measure the emotional states of depression, anxiety, and stress. This study was a cross-sectional survey conducted at the dermatology outpatient clinic at King Abdulaziz Medical City, Jeddah, Saudi Arabia. All patients diagnosed with acne vulgaris between January and April 2020 were included in the study. A multivariate regression analysis was also conducted to determine the presence of any significant independent factors associated with depression, anxiety, and stress. A P-value of ≤0.05 was considered statistically significant. Results We observed that the most prevalent psychiatric disorder among acne patients on isotretinoin therapy was anxiety. Our results also indicate that a history of mental illness is an independent risk factor for developing depression when isotretinoin is used. In addition, known adverse physical effects of isotretinoin treatment, including muscle pain, arthralgia, and headaches significantly increase the likelihood of patients developing psychiatric morbidity during therapy. Conclusion Isotretinoin is a highly potent therapy for acne. Overall, the physical side effects profile is well acknowledged, yet the exact psychological impact the treatment predisposes the patients to is yet to be determined.

Distributed cyber-physical intrusion detection using stacking learning for wide-area protection system

Wide-area protection systems (WAPSs) heavy depends on communication technologies to operate, which leaves space for cyberattacks. A well-designed stealthy and coordinated cyberattacks can disrupt the seamless operation of WAPS by compromising measurement signals, control signals, or both. In this paper, we present a distributed cyber-physical intrusion detection system (DCPIDS) that utilizes the bilateral data from both the cyber side and the physical side to accurately detect cyberattacks on both measurement and control signals in WAPSs. DCPIDS consists of multiple slave agents (SAs) scattered in every area of the power system for regional-area intrusion detection and a master agent (MA) embedded in the system protection center for system status awareness. For the SAs, a hybrid-based intrusion detection method is utilized to conduct regional-area intrusion detection. The proposed method receives the bilateral data to simultaneously detect data integrity attacks on measurement and control signals using three classification models and performs the identification of single and coordinated attacks using a rule-based approach. Further, to train the classification models in the proposed method, a NewStacking-based model training algorithm is adopted. The proposed algorithm combines different selected classifiers that operate on two different feature subsets, which improves the detection accuracy of the models and extends the generalization ability with better robustness. Experimental results reveal that the proposed algorithm has better performance than existing machine learning algorithms and state-of-art works, the proposed method can identify single and coordinated attacks with high accuracy, and our DCPIDS satisfies the real-time requirements for practical online application.

Lived experiences of closeness to a person using Anabolic androgenic steroids a next of kin perspective

ABSTRACT Purpose Anabolic androgenic steroids (AAS) are used for their aesthetic and performance-enhancing effects and are associated with physical and psychological side effects. Behavioural changes/side effects as mood swings, aggressiveness, depression, potency problems, anxiety, and emotional coldness have been reported by next of kin to people using AAS. Methods This phenomenological study is based on the reflective lifeworld research approach. Interviews were conducted with twelve next of kin about their experiences of living close to persons using AAS. Results Next of kin to persons using AAS are particularly vulnerable because they experience little opportunity to influence their situation. Their given and safe context is lost, and their lives are circumscribed by feelings of insecurity, fear, powerlessness, and grief. Feelings of loneliness develop when their problems are not noticed by others and support is lacking from family and society. Conclusions Our research adds important knowledge on how the use of AAS affects next of kin. Understanding is required to approach the lifeworld of next of kin with flexibility and empathy in their difficulties and vulnerability. Healthcare professionals and other concerned professions need to be aware of next of kin existential needs to be able to meet and support them in their life situation.

Reproductive decision making in women with medical comorbidities: a qualitative study

BackgroundA growing number of reproductive-age women in the U.S. have chronic medical conditions, increasing their risk of perinatal morbidity and mortality. Still, they experience unintended pregnancies at similar rates to low-risk mothers. We have limited understanding of how these individuals consider decisions about pregnancy and contraceptive use. The purpose of this study was to understand factors that influence reproductive decision-making among pregnant women with chronic medical conditions.MethodsWe conducted 28 semi-structured interviews with pregnant women with pre-existing medical conditions admitted to a tertiary maternal hospital to examine factors influencing reproductive decision making. Maternal demographic characteristics, medical history, and pregnancy outcome data were obtained through participant surveys and abstraction from electronic health records. Interview transcripts were coded and analyzed using Dedoose® with both deductive and inductive content analysis.ResultsOut of 33 eligible participants, 30 consented to participate and 28 completed interviews. The majority of participants identified as black, Christian, made less than $23,000 yearly, and had a variety of preexisting medical conditions. Overarching themes included: 1) Perceived risks-benefits of pregnancy, 2) Perceived risks-benefits of birth control, 3) Determinants of contraceptive utilization, and 4) Perceived reproductive self-agency. Contraception was viewed as acceptable, but with concerning physical and psychological side effects. Although some considered pregnancy as a health threat, more experienced pregnancy as positive and empowering. Few planned their pregnancies.ConclusionsPreexisting health conditions did not significantly influence reproductive decision-making. Barriers to birth control use were generally based in patient value-systems instead of external factors. Interventions to improve uptake and use of birth control in this cohort should focus on improving care for chronic health conditions and influencing patient knowledge and attitudes toward contraception.

Smart Lithium-Ion Battery Monitoring in Electric Vehicles: An AI-Empowered Digital Twin Approach

This paper presents a transformative methodology that harnesses the power of digital twin (DT) technology for the advanced condition monitoring of lithium-ion batteries (LIBs) in electric vehicles (EVs). In contrast to conventional solutions, our approach eliminates the need to calibrate sensors or add additional hardware circuits. The digital replica works seamlessly alongside the embedded battery management system (BMS) in an EV, delivering real-time signals for monitoring. Our system is a significant step forward in ensuring the efficiency and sustainability of EVs, which play an essential role in reducing carbon emissions. A core innovation lies in the integration of the digital twin into the battery monitoring process, reshaping the landscape of energy storage and alternative power sources such as lithium-ion batteries. Our comprehensive system leverages a cloud-based IoT network and combines both physical and digital components to provide a holistic solution. The physical side encompasses offline modeling, where a long short-term memory (LSTM) algorithm trained with various learning rates (LRs) and optimized by three types of optimizers ensures precise state-of-charge (SOC) predictions. On the digital side, the digital twin takes center stage, enabling the real-time monitoring and prediction of battery activity. A particularly innovative aspect of our approach is the utilization of a time-series generative adversarial network (TS-GAN) to generate synthetic data that seamlessly complement the monitoring process. This pioneering use of a TS-GAN offers an effective solution to the challenge of limited real-time data availability, thus enhancing the system’s predictive capabilities. By seamlessly integrating these physical and digital elements, our system enables the precise analysis and prediction of battery behavior. This innovation—particularly the application of a TS-GAN for data generation—significantly contributes to optimizing battery performance, enhancing safety, and extending the longevity of lithium-ion batteries in EVs. Furthermore, the model developed in this research serves as a benchmark for future digital energy storage in lithium-ion batteries and comprehensive energy utilization. According to statistical tests, the model has a high level of precision. Its exceptional safety performance and reduced energy consumption offer promising prospects for sustainable and efficient energy solutions. This paper signifies a pivotal step towards realizing a cleaner and more sustainable future through advanced EV battery management.

Retirement: strengths and weaknesses for a full and healthy old age

Abstract Retirement is a coveted goal for working people. Although it is seen as a period of relaxation and tranquillity, retirement from work, also because it is associated with other relevant changes in an individual’s life related to family relationships, brings with it a number of potential risks that may trigger problems of a psychosocial nature (identity crisis, change of parental role, adaptation to new marital relationships, possible marital crisis and divorce, depressive symptoms and suicidal ideas) which, in turn, may be facilitators of fragility also on the physical side. The attention of the various governments is generally focused on the health problems of those who are retired with a view to containing public expenditure, without considering the fact that the main problems for this particular segment of the population may come from problems of reintegration into social life and occupation of leisure time. When there is no adequate adaptation to the changed conditions of life in the transition from worker to pensioner one fatally exposes oneself to the risk of progressive isolation. the reduction of social contracts, the contraction of the use of one’s cognitive functions with possible consequences in the medium to long term on one’s ability to remain self-sufficient. This would ultimately turn into a socio-medical problem, with the associated costs, when an appropriate policy of psycho-social interventions could delay the effects.

ПИРИНГТІК ЖЕЛІЛЕР ТЕХНОЛОГИЯСЫ АРҚЫЛЫ БЕЙНЕБАЙЛАНЫСТЫ ҰЙЫМДАСТЫРУ БОЙЫНША ҚОСЫМШАНЫ ӘЗІРЛЕУ

This work is devoted to the description and modeling of information systems of the subject area, as well as technologies that were used for project implementation. The article discusses methods from the point of view of project effectiveness, moving from the general to the details, separating and decomposing functions as necessary. Particular attention is paid to peer-to-peer networks, since their main purpose is to share resources and ensure collaboration between devices to perform certain tasks, which is required by the specifics of the physical side. The result of the work was the physical structure of the application with the totality of all the files that are located in the root directory of the project.