THE purpose of the investigation here described was to ascertain whether the phospholipid content of the brain is a fixed amount, or an amount subject to changes of the hormone content of the brain tissue. The method used did not reveal any changes of the phospholipid content of the brain after administration of several hormones. It was, however, observed that the phospholipid content of the brain increases after a single intraperitoneal injection of corticotropin (ACTH) and decreases afterpr olonged administration of the thyrotropic hormone of the pituitary gland (TSH). method The contents of phospholipid, nucleoprotein, and total acid-soluble phosphorus containing compounds of the brain were ascertained following a method described by King (1946) with minor modifications. The phospholipid fraction contained lecithins, cephalins, and sphyngomyelins. The nucleoprotein fraction contained ribo- and desoxyribonucleic acid and a small amount of phospho protein (Schmidt et al., 1945). The total acid-soluble ph...
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