Phase Of Dermatitis Research Articles

Interdependence of Sebaceous Lipids and the Microbiome in Atopic Dermatitis

Dysfunction of the skin barrier, immune system, and microbiome all occur in atopic dermatitis (AD), but a single cause for this disease has not been clearly identified for all patients. Evidence supporting that AD is a multistep process that can involve lipid synthesis has been provided in a recent publication by Morimoto et al. (2022). In Tmem79‒/‒ mice used in this study, previous work of Ito et al. (2021) showed that skin inflammation occurs in a biphasic pattern, with a first phase of dermatitis that occurs independently of the microbiota and a second phase that is microbiota dependent.