Introduction. In recent years, the use of medicinal plants in therapeutic and prophylactic preparations capable of regulating adaptive modifications aimed at maintaining human mental and physical functions in the face of constantly changing natural and social factors has become increasingly important. One interesting plant for medicinal use is Rhodiola rosea L., a member of the Crassulaceae family. This species is highly polymorphic both morphologically and chemically. The main raw material sources are the mountains of southern Siberia (Altai, Sayan), Tuva, and Transbaikalia. However, domestic raw material sources are insufficient, making it necessary to expand them and identify phenotypes with high levels of biologically active substances among cultivated populations. Aim. To establish the morphometric characteristics of different phenotypes of Rhodiola rosea cultivated in Northwest Russia and to conduct a comparative analysis of secondary metabolites in samples of underground organs of Rhodiola rosea of different phenotypes using high-performance thin-layer chromatography (HPTLC). Materials and methods. The study subjects were 24 samples of Rhodiola rosea rhizomes and roots of various phenotypes, collected in 2024 during the flowering and fruiting phases at the medicinal plant nursery of the St. Petersburg Chemical and Pharmaceutical University (Leningrad Region, Vsevolozhsk District, 38 km of Priozerskoye Highway). Extracts from the raw materials were obtained using a Sapphire-4.0-TTC ultrasonic bath (Russia). 70 % ethyl alcohol was used as the extractant. HPTLC analysis was performed on a CAMAG instrument (Switzerland) using MERCK HPTLC plates silica gel 60 F 254 (20 × 10 cm). Results and discussion. 70 % ethyl alcohol was used as the extractant. The resulting solutions were analyzed by HPTLC in a solvent system of chloroform, 96 % alcohol, and water (25 : 16 : 1). After scanning densitometry at 254 nm, the densitograms of individual tracks were compared to identify Rhodiola rosea phenotypes with higher levels of biologically active compounds. A comparison of the tracks of 24 Rhodiola rosea underground organ samples revealed female samples (No. 1, 7, 8 and 14) and male (No. 15, 18, 21, 23 and 24) samples, ranging in height from 23 to 41 cm, were proposed as promising for further study and cultivation. Conclusion. Morphometric characteristics of various phenotypes of Rhodiola rosea cultivated in the north-west of Russia were established. HPTLC analysis of alcohol extracts from Rhodiola rosea rhizomes and roots of different phenotypes revealed both female and male samples had higher levels of secondary metabolites (phenylpropanoids and simple phenols). The height of the plants ranged from 23 to 41 cm.

ObjectiveThis study aimed to construct and evaluate an AI-assisted mobile nursing information closed-loop management model.MethodsThis study adopted a prospective before-after control design to compare nursing indicators before and after model implementation, conducted in the Pediatric Surgery Department of Anqing Municipal Hospital Affiliated with China Pharmaceutical University, where an information management system was implemented. A statistical analysis was conducted on the quality control data of 3891 cases (from 438 hospitalized patients) before model implementation (March to May 2024) and 3697 cases (from 417 patients) after implementation (July to September 2024) to evaluate its effectiveness. Existing quality control indicators were reviewed, and new/updated metrics generated from the implementation of new nursing closed-loop management measures were evaluated. AI-driven tools were leveraged to enhance the early warning capabilities of mobile nursing information systems through data acquisition, collection, and interpretation, and establishing a closed-loop management model for mobile nursing information.ResultsFollowing the model implementation, significant improvements were observed in all evaluated indicators. The bedside settlement completion rate rose from 66.16% to 83.3% (χ²=61.63, *p*<0.001), and the critical value reception rate increased from 51.72% to 93.55% (χ²=21.78, *p*<0.001). The nursing plan and workflow completion rates improved to 98.17% and 94.89% (both *p*<0.001), respectively. Nursing work efficiency surged from 3.03 to 25 tasks per hour, and overall patient satisfaction increased from 83.3% to 97.65%, confirming the model’s effectiveness in enhancing nursing quality and patient experience.ConclusionThe AI-assisted mobile nursing information closed-loop management model presented here was found to enhance nursing work efficiency, improve patient experience, and optimize workflow processes, contributing to a more effective and structured nursing management system.

Workplace mindfulness and clinical belongingness among nursing interns: The mediating role of subjective well-being.

The article provides an overview of the primary accreditation data of graduates of the Medical and Pharmaceutical College of the Far Eastern State Medical University in terms of assessing the quality of education and developing professional skills.

To evaluate the impact of QHN combined with FH versus FH monotherapy on vestibular migraine (VM) METHODS: The study included patients treated for VM with either QHN+FH or FH alone between September 2022 and September 2023 at The First Affiliated Hospital of Guangdong Pharmaceutical University in Guangzhou, Guangdong Province, China. The primary outcome was the change of Dizziness Handicap Inventory (DHI) before and after 8 weeks of treatment. Secondary outcomes included changes in the Video Head Impulse Test (v-HIT) results before and after 8 weeks of treatment, and the recurrence of vertigo attacks at 4 and 8 weeks post-treatment. This study included 59 patients, with 29 receiving QHN+FH treatment and 30 receiving FH monotherapy. Both the QHN+FH and FH groups showed significant reductions in DHI scores before and after treatment. After treatment, the QHN+FH group demonstrated an improvement in v-HIT (0.74±0.14 vs. 0.64±0.14, p<0.05), while the FH group showed no significant changes. At 4 weeks, the recurrence rate of vertigo in the QHN+FH group was lower than that in the FH group (13.79% vs. 43.33%), and at 8 weeks, it remained lower (34.48% vs. 53.33%). This study suggested that QHN combined with FH might had a potential advantage in improving treatment outcomes and reducing short-term recurrence of vertigo in VM patients.

Screening and identification of covalent Nrf2 activators with α,β-unsaturated imide structures.

Objective — to determine the features of the clinical profile and psychopathological symptoms in patients with atopic dermatitis, to assess the impact, taking into account the presence of pruriginous component as a potential factor that can affect the dynamics of the disease and the formation of psychoemotional disturbances. Materials and methods. This study was conducted on the basis of the Department of Dermatovenereology and Aesthetic Medicine of Zaporizhzhia State Medical and Pharmaceutical University. Verification of the diagnosis of atopic dermatitis was performed in 30 patients on the basis of clinical examination. The intensity of pruritus was assessed using a visual analog scale (VAS), rating parameters from 0 to 10, and the quality of life was assessed using a standardized questionnaire of the Dermatological Life Quality Index (DLQI). The profile of psychopathological symptoms was evaluated using the SCL­90­R symptom questionnaire. Results and discussion. The study included 21 (70 %) men aged 22 to 75 years (mean age (50.1 ± 4.0) years) and 9 (30 %) women aged 24 to 75 years (mean age (43.2 ± 6.1) years). In 23 (76.7 %) patients, atopic dermatitis had a classic course with the first appearance of eflorations in childhood and the corresponding official registration in medical records. At the same time, 11 (36.7 %) patients noted the course of dermatosis as chronic with alternating periods of remission and exacerbation throughout life. 12 (40 %) patients also had anamnestic data on atopy, but the period of remission was almost uninterrupted by exacerbations: the last episode in childhood and adolescence. In addition, 7 (23.3 %) patients with dermatosis after adulthood were examined, with categorical denial of efloriscence at any age. The average severity of itching was 4.9 ± 0.44, and the criterion of the maximum degree of intensity of this sensation was 7.0 ± 0.4. The dermatological quality of life index for the studied sample was 9 (7—12), which corresponds to moderate impact. A notable finding is the identified intragroup correlation between symptoms of the obsessive­compulsive spectrum and other psychopathological domains, highlighting the clinical significance of a comprehensive understanding of this component within the psycho­emotional profile of patients with atopic dermatitis. Conclusions. The presence of the disease debut in adulthood indicates the diversity of the course of dermatitis and actualizes the need to focus on these phenotypic features at the stage of history taking and clinical examination. The definition of psychopathological symptoms for patients with atopic dermatitis complements the data on the clinical profile of these patients. Such an approach contributes to the formation of a comprehensive clinical assessment of the patient’s condition and justifies the feasibility of interdisciplinary management.

Empirical analysis of factors influencing postdoctoral academic growth in pharmaceutical schools and universities: A case study of Peking University School of Pharmaceutical Sciences

Although aggressive care at the end of life (ACEOL) for advanced gastrointestinal cancer can impose a significant burden on patients and healthcare systems, its prevalence and underlying determinants remain poorly understood. This study aimed to quantify the frequency of ACEOL and identify risk factors associated with such care in a Japanese population. We retrospectively reviewed 275 patients with advanced gastrointestinal cancer who initiated first-line palliative chemotherapy at Osaka Medical and Pharmaceutical University between 2017 and 2022. ACEOL was defined according to established indicators, including prolonged hospitalization, multiple emergency department visits or hospital admissions, initiation of a new chemotherapy regimen, intensive care unit admission, and death in an acute care hospital during the last month of life. Logistic regression analyses were performed to explore factors predictive of ACEOL. Overall, 57.8% of patients (159/275) received at least one indicator of ACEOL. The most common factors were death in an acute hospital (38.5%) and prolonged hospitalization (>14 days; 33.8%). Patients receiving ACEOL had significantly shorter overall survival (OS) than those not receiving ACEOL (8.5 vs. 12.9 months, P=0.02). Younger age [odds ratio (OR) 2.01] and opioid use at the start of chemotherapy (OR 3.39) were identified as independent predictors. More than half of these patients with advanced gastrointestinal cancer received ACEOL, partly driven by younger age and opioid use at baseline. These findings highlight the need for early identification of high-risk patients and proactive integration of palliative care services to decrease ACEOL.

In recent years, China has sought the integration of aesthetic education into nonart disciplines in its higher education policy to promote emotional, cultural, and interdisciplinary development. The aim of this study was to investigate the implementation, experience, and perception of vocal music courses by students and instructors and to evaluate their contributions to future healthcare professionals’ communication skills, empathy, and overall well-being. The research sites were Chongqing Medical and Pharmaceutical College and five other medical colleges. Data were collected through a mixed methods approach, including a questionnaire survey with 50 students taking elective vocal music classes, focus group interviews with 9 representative students, in-depth interviews with 8 key informants, field observations, and an analysis of institutional documents. The quantitative data are presented in pie charts, whereas the qualitative data were subjected to thematic analysis. The results indicated strong intrinsic motivations, a preference for pop and folk genres, varied participation levels, practice time and insufficient infrastructure to support and address routine difficulties. Students preferred interactive teaching over lectures. The study recommends improving practice settings, adding relevant cultural materials, and using blended instructional strategies to address identified issues. These findings emphasize the practicality of vocal music for interdisciplinary development in medical education and provide useful recommendations for curriculum changes and policy development.

Comparative efficacy of reactor vs. accelerator-based boron neutron capture therapy in U87MG glioblastoma models.

This brief sketch is dedicated to the life and scientific work of pharmacologist Vladislav Alekseevich Kraus, who made significant contributions to the study of the functional organization of the brain and the mechanisms of memory. It outlines the main stages of his professional career, from his studies at the Leningrad Sanitary-Hygienic Medical Institute and postgraduate studies at the Institute of Experimental Medicine of the USSR Academy of Medical Sciences, to his headship of the pharmacology departments of the Orenburg and Dnepropetrovsk Medical Institutes, and his leadership of a laboratory at the Research Institute of Industrial and Marine Medicine in St. Petersburg. Particular attention is paid to the period of V.A. Kraus's work at St. Petersburg State Chemical Pharmaceutical University (SPCPA), where he engaged in pedagogical activity for over 20 years and contributed to the training of pharmaceutical personnel. The main scientific achievements of V.A. Kraus are presented, including the establishment of mechanisms of drug action on neurotransmitter systems, the reproduction of memory engrams, and energy metabolism in the brain. His research is highlighted, focusing on the study of the effects of psychotropic drugs, hemoperfusion, arginine vasopressin, and other compounds on the nervous system and cognitive functions.

ObjectiveThis study aims to develop a machine learning (ML) model that integrates computed tomography (CT) radiomics with clinical features to predict the progression of pulmonary interstitial fibrosis in patients with coalworker pneumoconiosis (CWP).MethodsClinical and imaging data from 297 patients diagnosed with CWP at The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College between December 2021 and December 2023 were analyzed. Of these patients, 170 developed pulmonary interstitial fibrosis over a 3-year follow-up and were classified as the progression group, while 127 patients showed stable conditions and were classified as the stable group. The patients were divided into a training cohort (n = 207) and a test cohort (n = 90). Radiomic features were extracted from CT images of lung fibrosis lesions in the training cohort. These features were reduced in dimensionality to construct morphological biomarkers. ML methods were then used to develop three models: a clinical model, a radiomics model, and a multimodal joint model. The performance of these models was evaluated in the test cohort using receiver operating characteristic (ROC) curves and decision curve analysis (DCA).ResultsIn the training cohort, the area under the curve (AUC) for the clinical, radiomics, and joint models were 0.835, 0.879, and 0.945, respectively. In the test cohort, the AUC values for these models were 0.732, 0.750, and 0.845, respectively. The joint model demonstrated the highest predictive performance and clinical benefit in both the training and test cohorts.ConclusionThe multimodal model, combining CT radiomics and clinical features, offers an effective and accurate tool for predicting the progression of pulmonary fibrosis in CWP.

BackgroundAutism spectrum disorder (ASD) is a serious neurodevelopmental disorder with no effective treatment. This study explored the short-term clinical effects of washed microbiota transplantation (WMT) with different numbers of donors on autism.MethodsConsecutive ASD patients treated with two continuous WMT courses from March 2020 to March 2022 at the First Affiliated Hospital of Guangdong Pharmaceutical University were retrospectively assessed. Basic information, aberrant behavior checklist (ABC) scores, childhood autism rating scale (CARS) scores, sleep disturbance scale for children (SDSC) scores, adverse reactions, and feces were collected.ResultsForty-four patients were included (single-donor group: 17 patients; multidonor group: 27 patients). The CARS, ABC and SDSC scores didn’t differ between the two groups before treatment. After two courses, the scores for the 44 patients were lower than those at baseline (P<0.05), with no severe adverse reactions observed. After the first course, the mean ABC (P=0.049) and SDSC (P=0.019) scores were significantly different between the single-donor and multidonor groups, but the difference disappeared after two courses. The alpha-diversity of the faecal flora in the effective-group was greater than that in the ineffective-group (Shannon index P=0.0018). Lactobacillus was the predominant genus in the effective group, whereas Faecalibacterium, Campylobacter, and Sphingomonas were predominant genera in the ineffective group.ConclusionAfter two WMT courses, the symptoms of ASD improved, with good short-term treatment efficacy. The ASD symptom improvement did not differ between the single-donor and multidonor groups. Changes in the alpha-diversity and abundance of the faecal microbiota after WMT may be related to treatment efficacy.

Myrtus communis is a common species in tropical and subtropical regions. Myrtle is cultivated as an ornamental plant in areas with a temperate climate, such as Ukraine. It was introduced to the Nikitskyi Botanical Garden in 1967. The pharmacological properties of galenic preparations derived from Myrtus communis are primarily determined by the presence of essential oils. Galenic preparations from myrtle leaves have general tonic, antimicrobial (notably demonstrating high bactericidal activity against gram-positive bacteria and antibiotic and resistant strains, Mycobacterium tuberculosis), analgesic, astringent, expectorant, and anti-inflammatory effects. For a comprehensive study of this plant, it is essential to investigate the volatile fractions of its raw material. The aim of the work is to conduct a chromatography-mass spectrometric analysis of the chemical composition of Myrtus communis L. leaf essential oil. Materials and methods. The object of the study is the essential oil of Myrtus communis, cultivated at the Department of Pharmacognosy, Pharmacology and Botany of Zaporizhzhia State Medical and Pharmaceutical University, and obtained through hydrodistillation. Qualitative and quantitative determination of the essential oil components was carried out using the chromatography-mass spectrometric method on a high-performance gas chromatograph “Agilent 7890B GC System” (Agilent, SantaClara, CA, USA) with a mass spectrometric detector “Agilent 5977 BGC/MSD” (Agilent, SantaClara, CA, USA) and a DB-5ms chromatographic column (30 m × 250 μm × 0.25 μm). The component identification was performed using the NIST14 mass spectral library. Results. Chromatography-mass spectrometric analysis revealed the presence of 42 key volatile compounds in Myrtus communis leaf essential oil, three of which were in isomeric forms. The five major components were myrtenyl acetate (24.12 %), linalool (16.73 %), cyclofenchene (10.37 %), o-xylene (7.85 %) and myrtenol (4.35 %). Terpenes were identified as the dominant group in Myrtus communis leaves, comprising 72.04 %. Conclusions. The chemical composition of Myrtus communis leaf essential oil showed some differences compared to literature data that deal with geographical features (temperature, soil quality, day length), harvesting time and genotype variations. The research findings can serve as a basis for developing new pharmaceutical and cosmetic products containing myrtle essential oil. Besides, the analysis of the chemical composition of the essential oil can contribute to improving extraction technology and standardizing essential oils.

On April 11, 2025, a scientific and practical conference “Current Issues of Modern Traumatology and Orthopedics” was held in Zaporizhzhia, organized by the Zaporizhzhia State Medical and Pharmaceutical University together with the NGO “Zaporizhzhia Regional Association of Orthopedists and Traumatologists”.

Objective — to analyze the clinical profile of patients with climacteric keratoderma, taking into account the features of visual and dermatoscopic manifestations in the context of a comprehensive diagnostic algorithm for dermatosis. Materials and methods. On the basis of the Educational and Scientific Medical Center «University Clinic» and the Department of Dermatovenerology and Aesthetic Medicine of the Zaporizhzhya State Medical and Pharmaceutical University, a clinical and dermatoscopic (FotoFinder BodyStudio ATBM, Germany) examination of 62 patients with manifestations of palmoplantar keratoderma was conducted. Since there are no specific objective scales or indices in assessing the course of this dermatosis, the modified severity index for palmoplantar psoriasis (mm-PASI) was used in this work. The subjective discomfort of the presence of skin lesions was assessed using a visual analog scale, where «0» corresponds to the absence of any manifestations, while «10» corresponds to maximum discomfort. Results and discussion. The age of the patients ranged from 41 to 67 years, (M ± m) — 53.1 ± 0.88. The duration of menopause as a key factor in the appearance of the pathological process on the skin was (4.9 ± 0.5) years, and the average age of manifestation of this condition was (48.1 ± 0.5) years with a general variability of the onset of the climacteric period from 40 to 57 years. m-PPPASI in patients with lesions of both palms and soles is represented by a median of 17.7 (16.8—18.6), which is characteristic of a severe course of dermatosis with the following distribution among individuals in this sample: moderate (n = 1; 20 %), severe (n = 3; 60 %) and very severe (n = 1; 20 %). The modified dermatosis severity index in the presence of asymmetric isolated changes only on the plantar surface of the feet corresponds to an average degree with a median of 6.6 (3.83—8.4). The most representative group of patients with symmetrical foot lesions demonstrates a median dermatosis severity index of 9 (6.6—10.95). Taking into account the general discomfort from the existing efflorescences, the average value on the visual analog scale was 7.0 ± 0.25. Dermatoscopically, some patients (n = 11; 17.7 %) have patterns corresponding to the V level of intensity of hyperkeratotic changes, while moderate or noticeable changes in the keratotic profile are presented in 18 (29 %) and 20 (32.3 %) patients, respectively. At the maximum level of hyperkeratotic manifestations (n = 4; 6.5 %) there are continuous unstructured stratifications that cover the physiological structures of the acral skin while minimal hyperkeratotic manifestations (n = 9; 14.5 %) are represented by intermittent white lines and the presence of unaffected furrows. Conclusions. Creating a clinical profile of patients with climacteric keratoderma, which includes not only the assessment of visual manifestations of dermatosis, but also dermatoscopic patterns, will contribute to the formation of a logical and personalized algorithm for choosing further management tactics.

Master of engineering (MEng) education focuses on developing applied talents with strong theoretical and practical skills, emphasizing alignment with industry needs to enhance hands-on training and innovation. The interdisciplinary Biology and Pharmacy program demands particularly high practical and innovative competencies. However, current models often lack sufficient practical components and industry relevance. To address this, Guangdong Pharmaceutical University partnered with companies like Perfect (China) and Nanxin Medical to create a "dual-scenario" model. Students engage in real-world enterprise projects, solving actual technical challenges while improving their research and practical skills. This approach bridges the gap between academia and industry, offering valuable insights for MEng education.

ObjectiveTo establish a prediction model for the risk of inadequate bowel preparation for colonoscopy in the elderly, and to validate the model to test its prediction effect.MethodsA total 927 patients who underwent colonoscopy in the First Affiliated Hospital to Chongqing Medical and Pharmaceutical College from January to December 2023 were selected as the modeling group, and were divided into the success group (839 patients) and failure group (88 patients) according to whether or not inadequate bowel preparation occurred, and then a logistic regression prediction model was established and transformed into a risk scoring system. The area under the ROC curve and the Hosmer-Lemeshow test were used for model differentiation and calibration, respectively, and the 10-fold cross-validation method was used for internal validation of the model. A total of 548 patients who underwent colonoscopy in our hospital from January to June 2024 were selected for external validation of the model.ResultsLogistic regression analysis showed that age ≥65 years, diabetes mellitus, exercise habits, Bristol stool characterization scale, frailty, and ambulatory functional status were independent factors influencing the inadequate bowel preparation for colonoscopy in the elderly. The area under the ROC curve for the modeling group was 0.806, and the Hosmer-Lemeshow test showed p=0.870. The area under the ROC curve of the validation group was (0.785±0.090). The area under the ROC curve of the validation group was 0.824, and the Hosmer-Lemeshow test showed P=0.907, with a sensitivity of 73.13%, a specificity of 80.70%, and a Jordon’s index of 0.538.ConclusionThe predictive model of the risk of inadequate bowel preparation for colonoscopy in elderly people can predict the risk of inadequate bowel preparation in elderly people, and can be used as a tool for clinical caregivers to screen the high-risk group of inadequate bowel preparation in the elderly.

Objective:To examine the efficacy of donepezil combined with rehabilitation training for treating Alzheimer’s disease (AD) and its impact on nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF).Methods:This single center retrospective analysis was conducted at the First Affiliated Hospital of Chongqing Medical and Pharmaceutical College and included 184 patients with AD treated between January 2022 to May 2024. Of them, 92 patients who received donepezil combined with rehabilitation training (combined group) were matched in a 1:1 ratio with a cohort that received donepezil alone (donepezil group). The treatment efficacy, cognitive function, ability to engage in daily living activity before and after the treatment, serum NGF and BDNF levels, and incidence of adverse reactions were compared between the two groups.Results:The total efficacy of patients in the combined group was higher than that of the donepezil group (P<0.05). After the treatment, mini-mental state examination (MMSE) and activity of daily living (ADL) scores of patients in the combined group were significantly higher than in the donepezil group (P<0.05). In contrast, the combined treatment method was associated with considerably lower Alzheimer’s disease assessment scale–cognitive subscale (ADAS-Cog) scores (P<0.05). Patients who received the combined treatment had significantly higher serum NGF and BDNF levels than those treated by donepezil alone (P<0.05).Conclusions:Compared with donepezil alone, the combination of donepezil and rehabilitation training is associated with significantly improved therapeutic effects and better serum NGF and BDNF levels.