An improvement of the expansion methods, namely, the improved tanΦξ/2-expansion method, for solving nonlinear second-order partial differential equation, is proposed. The implementation of the new approach is demonstrated by solving the generalized Fitzhugh-Nagumo equation with time-dependent coefficients. As a result, many new and more general exact travelling wave solutions are obtained including periodic function solutions, soliton-like solutions, and trigonometric function solutions. The exact particular solutions contain four types: hyperbolic function solution, trigonometric function solution, exponential solution, and rational solution. We obtained further solutions comparing this method with other methods. The results demonstrate that the new tanΦξ/2-expansion method is more efficient than the Ansatz method and Tanh method applied by Triki and Wazwaz (2013). Recently, this method is developed for searching exact travelling wave solutions of nonlinear partial differential equations. Abundant exact travelling wave solutions including solitons, kink, and periodic and rational solutions have been found. These solutions might play an important role in engineering fields. It is shown that this method, with the help of symbolic computation, provides a straightforward and powerful mathematical tool for solving the nonlinear physics.