Five semi-continuous flow anaerobic digesters treating a mixture of food waste (FW) and municipal biosolids (primary sludge and thickened wasted activated sludge) at an solids retention time (SRT) of 20 days and different blend ratios i.e. 0, 10%, 20%, 40% by volume with the fifth digester treating only biosolids at the same COD/N ratio as the 40% FW digester were operated to investigate co-digestion performance. Sixty days of steady-state operation at organic loading rates (OLR) of 2.2–3.85kgCOD/m3/d showed that COD removals were higher for the three co-digesters than for the two municipal biosolids digesters i.e. 61–69% versus 47–52%. Specific methane production per influent CODs were 1.3–1.8 folds higher in co-digestion than mono-digestion. The first-order COD degradation kinetic constants for co-digestion were more than double the mono-digestion. Additional methane production through synergism accounted for a minimum of 18–20% of the overall methane production. The estimated non-biodegradable fraction of the FW particulate COD was 7.3%. However, the co-digesters discharged 1.23–1.64 times higher soluble nitrogen than the control.