Performance In Healthy Men Research Articles

Training With Full Body Compression Garments Does Not Improve 40-meter Sprint Performance In Healthy Men

Training With Full Body Compression Garments Does Not Improve 40-meter Sprint Performance In Healthy Men

Longitudinal Association of Arterial Stiffness and Pressure Wave Reflection with Decline of the Cardiac Systolic Performance in Healthy Men.

Aims: This prospective observational study aimed to examine the individual longitudinal associations of the increases in the arterial stiffness and pressure wave reflection with the decline in the cardiac systolic performance during the study period in healthy middle-aged Japanese men. Methods: In 4016 middle-aged Japanese healthy men (43±9 years), the brachial-ankle pulse wave velocity (baPWV), radial augmentation index (rAI), and pre-ejection period/ejection time (pre-ejection period (PEP)/ET) were measured annually during a 9-year study period. Results: The baPWV, rAI, and PEP/ET showed steady annual increases during the study period. According to the results of multivariate linear regression analyses, both the baPWV and rAI measured at the baseline showed significant independent associations with the PEP/ET measured at the baseline (baPWV: beta=0.17,p＜0.01 and rAI: beta=0.11,p＜0.01), whereas neither showed any association with the PEP/ET measured at the end of the study period. The results of the mixed-model linear regression analysis of the repeated-measures data collected over the 9-year study period revealed that the baPWV, but not the rAI, showed a significant longitudinal association with the PEP/ET (estimate=0.69 x 10−4,p＜0.01). Conclusion: In apparently healthy middle-aged Japanese men, the annual increase of the arterial stiffness, rather than the annual increase of the pressure wave reflection, appears to be more closely associated with the annual decline of the cardiac systolic performance as assessed by the systolic time interval.

Effects of Acute Exposure to Thermal Stress on Cardiorespiratory Function, Skeletal Muscle Oxygenation, and Exercise Performance in Healthy Males.

We investigated the effects of acute thermal stress (30 °C and 40 °C) and ordinary temperature (20 °C) on cardiorespiratory function, skeletal muscle oxygenation, and exercise performance in healthy men. Eleven healthy males (21.5 ± 2.3 years) performed a graded exercise test (GXT) using a cycle ergometer in each environmental condition (20 °C, 30 °C, and 40 °C) in a random order with an interval of 1 week between each test. Before the test, they were allowed to rest for 30 min in a given environmental condition. All dependent variables (body temperature, cardiorespiratory function parameters, skeletal muscle oxygenation profiles, and exercise performance) were measured at rest and during GXT. GXT was started at 50 W and increased by 25 W every 2 min until subjects were exhausted. Body temperature increased proportionally at rest and at the end of exercise as thermal stress increased. There were no differences in the rating of perceived exertion, oxygen uptake, respiratory exchange ratio, and carbon dioxide excretion between environmental conditions. Heart rate (HR), minute ventilation (VE), and blood lactate levels were significantly higher at 30 °C and 40 °C than at 20 °C, and oxygen pulse was significantly lower at 40 °C than at 20 °C at various exercise loads. None of the skeletal muscle oxygenation profiles showed significant changes at rest or during exercise. Maximal oxygen uptake, peak power, and exercise time significantly decreased proportionally as thermal stress increased, and this decrease was most pronounced at 40 °C. Acute thermal stress induces a decrease in exercise performance via increased body temperature, HR, VE, and blood lactate levels and decreased oxygen pulse during load-homogenized exercise. This phenomenon was more prominent at 40 °C than at 30 °C and 20 °C.

Combined and isolated effects of alcohol consumption and sleep deprivation on maximal strength, muscle endurance and aerobic exercise performance in healthy men: a cross-over randomized controlled trial

Combined and isolated effects of alcohol consumption and sleep deprivation on maximal strength, muscle endurance and aerobic exercise performance in healthy men: a cross-over randomized controlled trial

Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis.

Ashwagandha (Withania somnifera) is considered a potent adaptogen and anti-stress agent that could have some potential to improve physical performance. This preferred reporting items for systematic reviews and meta-analyses (PRISMA)-based comprehensive systematic review and Bayesian meta-analysis aimed to evaluate clinical trials up to 2020 from PubMed, ScienceDirect, and Google Scholar databases regarding the effect of Ashwagandha supplementation on physical performance in healthy individuals. Besides implementing estimation statistics analysis, we developed Bayesian hierarchical models for a pre-specified subgroup meta-analysis on strength/power, cardiorespiratory fitness and fatigue/recovery variables. A total of 13 studies met the requirements of this systematic review, although only 12 were included in the quantitative analysis. A low-to-moderate overall risk of bias of the trials included in this study was detected. All Bayesian hierarchical models converged to a target distribution (Ȓ = 1) for both meta-analytic effect size (μ) and between-study standard deviation (τ). The meta-analytic approaches of the included studies revealed that Ashwagandha supplementation was more efficacious than placebo for improving variables related to physical performance in healthy men and female. In fact, the Bayesian models showed that future interventions might be at least in some way beneficial on the analyzed outcomes considering the 95% credible intervals for the meta-analytic effect size. Several practical applications and future directions are discussed, although more comparable studies are needed in exercise training, and athletic populations are needed to derive a more stable estimate of the true underlying effect.

Effect of Protective Helmets on Vision and Sensory Performance in Healthy Men

Effect of Protective Helmets on Vision and Sensory Performance in Healthy Men

Effect of Different Recoveries During HIIT Sessions on Metabolic and Cardiorespiratory Responses and Sprint Performance in Healthy Men.

Germano, MD, Sindorf, MAG, Crisp, AH, Braz, TV, Brigatto, FA, Nunes, AG, Verlengia, R, Moreno, MA, Aoki, MS, and Lopes, CR. Effect of different recoveries during HIIT sessions on metabolic and cardiorespiratory responses and sprint performance in healthy men. J Strength Cond Res 36(1): 121-129, 2022-The purpose of this study was to investigate how the type (passive and active) and duration (short and long) recovery between maximum sprints affect blood lactate concentration, O2 consumed, the time spent at high percentages of V̇o2max, and performance. Subjects were randomly assigned to 4 experimental sessions of high-intensity interval training exercise. Each session was performed with a type and duration of the recovery (short passive recovery-2 minutes, long passive recovery [LPR-8 minutes], short active recovery-2 minutes, and long active recovery [LAR-8 minutes]). There were no significant differences in blood lactate concentration between any of the recoveries during the exercise period (p > 0.05). The LAR presented a significantly lower blood lactate value during the postexercise period compared with LPR (p < 0.01). The LPR showed a higher O2 volume consumed in detriment to the active protocols (p < 0.001). There were no significant differences in time spent at all percentages of V̇o2max between any of the recovery protocols (p > 0.05). The passive recoveries showed a significantly higher effort time compared with the active recoveries (p < 0.001). Different recovery does not affect blood lactate concentration during exercise. All the recoveries permitted reaching and time spent at high percentages of V̇o2max. Therefore, all the recoveries may be efficient to generate disturbances in the cardiorespiratory system.

SUN-PO320: Novel Ionic Liquid Creatine Formulation Improves Skeletal Muscle Creatine and Strength Performance in Healthy Men: A Pilot Study

SUN-PO320: Novel Ionic Liquid Creatine Formulation Improves Skeletal Muscle Creatine and Strength Performance in Healthy Men: A Pilot Study

Can Transcranial Direct Current Stimulation Improve Counter-movement Jump Performance ?

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique and has been known to reliably alter motor cortical excitability. Anodal stimulation increases cortical excitability and cathodal stimulation inhibits cortical excitability. However, the effects of tDCS on counter-movement jump (CMJ) is currently unknown. PURPOSE: The aim of this study was to investigate the effects of tDCS on CMJ performance in healthy men. METHODS: A double-blinded crossover design was used. Fourteen male subjects (age: 22 ± 2 yrs, height:174.43 ± 5.74 cm, weight: 68.66 ± 9.47 kg) received three time stimulations, each time an anodal tDCS (a-tDCS) or cathodal tDCS (c-tDCS) or sham tDCS randomly. The electrodes are placed over primary motor cortex (M1) bilaterally and the opposite electrodes pair over the ipsilateral shoulders. Each stimulation lasted 20 min, 48-72 hours apart and current was set at 2mA. Participants were required to get anthropometric measurements and familiar with CMJ in advance. Then, completed five CMJ tests before and after each stimulation, with one minute recovery interval between each test. The best three of the five CMJ in each moment was selected for analysis. Two-way (condition × time) ANOVA with repeated measures were used for CMJ height, flight time, and initial velocity. SUMMARY OF RESULTS: There was a significant interaction between condition and time for CMJ height (F(2,39) = 7.948, p < 0.001), flight time (F(2,39) = 8.228, p < 0.001), and initial velocity (F(2,39) = 8.375, p < 0.001). There were no significant mains effects for condition or moment for any of the outcome measures (p > 0.05). Post-hoc analysis showed that there were no significant differences between conditions both on pre- and post-stimulation moments (p > 0.05). However, post a-tDCS performance was significantly superior to pre a-tDCS for CMJ height, flight time and initial velocity (p < 0.001 for all). There were no significant pre-post changes in both c-tDCS and sham-tDCS conditions (p > 0.05 for all). CONCLUSION: Our findings demonstrate that anodal tDCS may be a valuable tool to enhance vertical jumping ability, which is very important for huamn sport performance.

Montmorency cherry supplement does not affect aerobic exercise performance in healthy men

Aim: To determine the effects of short-term Montmorency cherry (MC) supplementation upon exercise performance, total blood nitrate levels, muscle oxygenation, and slow-component [Formula: see text]O2 kinetics. Methods: Twelve healthy male participants ingested a MC or placebo (PL) supplement in a randomized cross-over fashion over a six day period then cycled at a power output achieved at 70% of [Formula: see text]O2 peak for a maximum of 30 minutes or until exhaustion. Near-Infrared Spectroscopy sensors were used to determine muscle oxygenation. Blood was collected one hour post-supplement consumption on day one, day six, and one hour post-exercise. Results: All results are presented as mean±SEM. Blood nitrate (μM/L) levels were not different one hour post-ingestion (MC=8.30±2.15, PL=8.18±1.86), following six days of supplementation (MC=9.14±1.89, PL=7.24±1.75) or one hour post-exercise (MC=9.63±1.61, PL=7.97±1.92) for treatment F=0.26, p=0.62; for time F=0.45, p=0.64; or treatment by time interaction F=2.28, p=0.13. Muscle oxygenation was not different between treatments for the right or left vastus lateralis, F=0.68, p=0.81 nor was time to respiratory compensation point (minutes) (MC=18.40±1.48, PL=17.16±1.78) F=0.52, p=0.60. MC supplement ingestion does not alter blood nitrate levels. Conclusion: Short-term MC ingestion does not increase muscle oxygenation during cycling exercise nor does it change slow-component [Formula: see text]O2 kinetics.

Acute Effects of Citrulline Supplementation on High-Intensity Strength and Power Performance: A Systematic Review and Meta-Analysis.

Citrulline is an increasingly common dietary supplement that is thought to enhance exercise performance by increasing nitric oxide production. In the last 5years, several studies have investigated the effects of citrulline supplements on strength and power outcomes, with mixed results reported. To date, the current authors are unaware of any attempts to systematically review this emerging body of literature. The current study sought to conduct a systematic review and meta-analysis of the literature describing the effects of citrulline supplementation on strength and power outcomes. A comprehensive, systematic search of three prominent research databases was performed to find peer-reviewed, English language, original research studies evaluating the effects of citrulline supplementation on indices of high-intensity exercise performance in healthy men and women. Outcomes included strength and power variables from performance tests involving multiple repetitive muscle actions of large muscle groups, consisting of either resistance training sets or sprints lasting 30s or less. Tests involving isolated actions of small muscle groups or isolated attempts of single-jump tasks were not included for analysis due to differences in metabolic requirements. Studies were excluded from consideration if they lacked a placebo condition for comparison, were carried out in clinical populations, provided a citrulline dose of less than 3g, provided the citrulline dose less than 30min prior to exercise testing, or combined the citrulline ingredient with creatine, caffeine, nitrate, or other ergogenic ingredients. Twelve studies, consisting of 13 total independent samples (n = 198 participants), met the inclusion criteria. Between-study variance, heterogeneity, and inconsistency across studies were low (Cochrane's Q = 6.9, p = 0.86; τ2 = 0.0 [0.0, 0.08], I2 = 0.0 [0.0, 40.0]), and no funnel plot asymmetry was present. Results of the meta-analysis identified a significant benefit for citrulline compared to placebo treatments (p = 0.036), with a small pooled standardized mean difference (SMD; Hedges' G) of 0.20 (95% confidence interval 0.01-0.39). The effect size was small (0.20), and confidence intervals for each individual study crossed the line of null effect. However, the results may be relevant to high-level athletes, in which competitive outcomes are decided by small margins. Further research is encouraged to fully elucidate the effects of potential moderating study characteristics, such as the form of citrulline supplement, citrulline dose, sex, age, and strength versus power tasks.

Ergogenic properties of metformin in simulated high altitude.

Metformin augments glucose/glycogen regulation and may acutely promote fatigue resistance during high-intensity exercise. In hypobaric environments, such as high altitude, the important contribution of carbohydrates to physiological function is accentuated as glucose/glycogen dependence is increased. Because hypoxia/hypobaria decreases insulin sensitivity, replenishing skeletal muscle glycogen in high altitude becomes challenging and subsequent physical performance may be compromised. We hypothesized that in conditions where glycogen repletion was critical to physical outcomes, metformin would attenuate hypoxia-mediated decrements in exercise performance. On three separate randomly ordered occasions, 13 healthy men performed glycogen-depleting exercise and ingested a low-carbohydrate dinner (1200kcals, <10% carbohydrate). The next morning, in either normoxia or hypoxia (FiO2 =0.15), they ingested a high-carbohydrate breakfast (1225kcals, 70% carbohydrate). Placebo (719mg maltodextrin) or metformin (500mg BID) was consumed 3days prior to each hypoxia visit. Subjects completed a 12.5km cycle ergometer time trial 3.5hours following breakfast. Hypoxia decreased resting and exercise oxyhemoglobin saturation (P<.001). Neither hypoxia nor metformin affected the glucose response to breakfast (P=.977), however, compared with placebo, metformin lowered insulin concentration in hypoxia 45minutes after breakfast (64.1±6.6μU/mL vs 48.5±7.8μU/mL; mean±SE; P<.001). Post-breakfast, pre-exercise vastus lateralis glycogen content increased in normoxia (+33%: P=.025) and in hypoxia with metformin (+81%; P=.006), but not in hypoxia with placebo (+27%; P=.167). Hypoxia decreased time trial performance compared with normoxia (P<.01). This decrement was similar with placebo (+2.6±0.8minutes) and metformin (+1.6±0.3minutes). These results indicate that metformin promotes glycogen synthesis but not endurance exercise performance in healthy men exposed to simulated high altitude.

Acute administration of cyclosporine A does not impair attention or memory performance in healthy men.

There is clinical and experimental evidence that treatment with immunosuppressive and antiproliferative drugs such as the calcineurin inhibitor cyclosporine A (CsA) is associated with mental health problems and neuropsychological disturbances in patients. However, it remains unclear whether and to what extent cognitive functions such as memory and attention processes are affected by the pharmacological treatment. This is partly because of the fact that it is difficult to refer the observed neuropsychological disturbances in patients to the drug itself, to drug-induced immune suppression, or to interaction with other medication or comorbidities. Thus, in a double-blind study with healthy male participants (n=30), we investigated whether short-term intake of therapeutic doses of CsA (4×2.5 mg/kg) affects attention, working memory performance, and anxiety levels, measured with the Tests of Attentional Performance and the State-Trait Anxiety Inventory. The data indicate that short-term CsA-administration and subsequent suppression in interleukin-2 production are accompanied neither by a decrease in attention or memory performance nor by increased anxiety levels in healthy male volunteers, suggesting that the short-term intake of CsA does not impair cognitive functioning. Further studies in healthy humans are needed to determine neurocognitive functions and mood states after short-term or subchronic treatment with different immunosuppressive and antiproliferative drugs.

Effects of a distinct phenolic complex on working memory performance in healthy men and women with age-associated memory impairment (P7.105)

Effects of a distinct phenolic complex on working memory performance in healthy men and women with age-associated memory impairment (P7.105)

Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study

Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study

Influence of methylsulfonylmethane on markers of exercise recovery and performance in healthy men: a pilot study

BackgroundMethylsulfonylmethane (MSM) has been reported to provide anti-inflammatory and antioxidant effects in both animal and man. Strenuous resistance exercise has the potential to induce both inflammation and oxidative stress. Using a pilot (proof of concept) study design, we determined the influence of MSM on markers of exercise recovery and performance in healthy men.MethodsEight, healthy men (27.1 ± 6.9 yrs old) who were considered to be moderately exercise-trained (exercising <150 minutes per week) were randomly assigned to ingest MSM at either 1.5 grams per day or 3.0 grams per day for 30 days (28 days before and 2 days following exercise). Before and after the 28 day intervention period, subjects performed 18 sets of knee extension exercise in an attempt to induce muscle damage (and to be used partly as a measure of exercise performance). Sets 1–15 were performed at a predetermined weight for 10 repetitions each, while sets 16–18 were performed to muscular failure. Muscle soreness (using a 5-point Likert scale), fatigue (using the fatigue-inertia subset of the Profile of Mood States), blood antioxidant status (glutathione and Trolox Equivalent Antioxidant Capacity [TEAC]), and blood homocysteine were measured before and after exercise, pre and post intervention. Exercise performance (total work performed during sets 16–18 of knee extension testing) was also measured pre and post intervention.ResultsMuscle soreness increased following exercise and a trend was noted for a reduction in muscle soreness with 3.0 grams versus 1.5 grams of MSM (p = 0.080), with a 1.0 point difference between dosages. Fatigue was slightly reduced with MSM (p = 0.073 with 3.0 grams; p = 0.087 for both dosages combined). TEAC increased significantly following exercise with 3.0 grams of MSM (p = 0.035), while homocysteine decreased following exercise for both dosages combined (p = 0.007). No significant effects were noted for glutathione or total work performed during knee extension testing (p > 0.05).ConclusionMSM, especially when provided at 3.0 grams per day, may favorably influence selected markers of exercise recovery. More work is needed to extend these findings, in particular using a larger sample of subjects and the inclusion of additional markers of exercise recovery and performance.

Effect of the Selective Cardiac Myosin Activator, Omecamtiv Mecarbil, on Left Atrial Performance in Healthy Men

Effect of the Selective Cardiac Myosin Activator, Omecamtiv Mecarbil, on Left Atrial Performance in Healthy Men

Effect of Glycine Propionyl-L-Carnitine on Aerobic and Anaerobic Exercise Performance

The purpose of this study was to evaluate the effect of glycine propionyl-L-carnitine (GPLC) supplementation and endurance training for 8 wk on aerobic- and anaerobic-exercise performance in healthy men and women (age 18-44 yr). Participants were randomly assigned to 1 of 3 groups: placebo (n=9), 1 g/d GPLC (n=11), or 3 g/d GPLC (n=12), in a double-blind fashion. Muscle carnitine (vastus lateralis), VO(2peak), exercise time to fatigue, anaerobic threshold, anaerobic power, and total work were measured at baseline and after an 8-wk aerobic-training program. There were no statistical differences (p> .05) between or within the 3 groups for any performance-related variable or muscle carnitine concentrations after 8 wk of supplementation and training. These results suggest that up to 3 g/d GPLC for 8 wk in conjunction with aerobic-exercise training is ineffective for increasing muscle carnitine content and has no significant effects on aerobic- or anaerobic-exercise performance.

Effect of water deprivation on cognitive-motor performance in healthy men and women

Whether mental performance is affected by slowly progressive moderate dehydration induced by water deprivation has not been examined previously. Therefore, objective and subjective cognitive-motor function was examined in 16 volunteers (8 females, 8 males, mean age: 26 yr) twice, once after 24 h of water deprivation and once during normal water intake (randomized cross-over design; 7-day interval). Water deprivation resulted in a 2.6% decrease in body weight. Neither cognitive-motor function estimated by a paced auditory serial addition task, an adaptive 5-choice reaction time test, a manual tracking test, and a Stroop word-color conflict test nor neurophysiological function assessed by auditory event-related potentials P300 (oddball paradigm) differed (P > 0.1) between the water deprivation and the control study. However, subjective ratings of mental performance changed significantly toward increased tiredness (+1.0 points) and reduced alertness (-0.9 points on a 5-point scale; both: P < 0.05), and higher levels of perceived effort (+27 mm) and concentration (+28 mm on a 100-mm scale; both: P < 0.05) necessary for test accomplishment during dehydration. Several reaction time-based responses revealed significant interactions between gender and dehydration, with prolonged reaction time in women but shortened in men after water deprivation (Stroop word-color conflict test, reaction time in women: +26 ms, in men: -36 ms, P < 0.01; paced auditory serial addition task, reaction time in women +58 ms, in men -31 ms, P = 0.05). In conclusion, cognitive-motor function is preserved during water deprivation in young humans up to a moderate dehydration level of 2.6% of body weight. Sexual dimorphism for reaction time-based performance is present. Increased subjective task-related effort suggests that healthy volunteers exhibit cognitive compensating mechanisms for increased tiredness and reduced alertness during slowly progressive moderate dehydration.

Validity of the Baltimore Therapeutic Equipment Work Simulator in the Measurement of Lifting Endurance in Healthy Men

To examine the criterion validity of the Baltimore Therapeutic Equipment (BTE) work simulator by comparing endurance time, oxygen uptake (VO2), and heart rate measured during real and simulated lifting tasks and to derive a regression equation for predicting actual lifting endurance from measurements on the work simulator. Twenty healthy male volunteers repetitively lifted and lowered a load of 40 lb using the BTE work simulator and actual weights at a laboratory workstation. Postures, location, and frequency of lifts were kept constant. Endurance (defined as the time taken for the rating of perceived exertion to increase 2 units on the Borg scale) was measured under both conditions. VO2 and heart rate were also recorded, using standard physiological procedures. The mean values for endurance time, steady-state VO2, and heart rate were significantly different between the real and simulated tasks (p < .05). Correlation of endurance time between the two tasks was significant (r = .71, p < .05). Step wise regression analysis resulted in the following equation for predicting real endurance from simulated time measurements: predicted real time = .34 simulated time + 3.29; r = .71; SE = 1.00 min. The BTE work simulator tends to overestimate real lifting endurance performance in healthy men. The lower physiological stress during the simulated task suggests a significant difference between the real and simulated loads. Occupational therapists should exercise caution when using the results of the BTE work simulator during functional capacity evaluations.