Background: Menstruation is a physiological process that all women go through. Menstrual Health and Hygiene (MHH) is essential to the well-being and empowerment of women and adolescent girls but appropriate MHH is hampered by taboos, secrecy and even stigma. The GOI/GOAP have launched several initiatives such as Health Education sessions in schools and celebration of menstrual hygiene week. Despite several initiatives, studies in India reveal that gaps exist in knowledge, perceptions and practices related to MHH Objectives: 1. To Assess the Knowledge of Menstruation among adolescents. 2. To explore the Perceptions about menstruation among school going adolescents. Methodology: A Mixed Method Study was conducted among school going adolescent girls and the study Participants were selected by convenient sampling technique during October 2023. Qualitative data was collected from adolescents by conducting 2 Focus group discussions (FGD) with 20 adolescent girls in 2groups and Quantitative data collected by using Pretested Semi Structured questionnaire from 50 students who are in class 10th of P.R.G. Girls high school Kakinada, after obtaining subjects assent and informed consent from the Parents/guardians of the adolescents. Prior approval from Institutional ethics committee was taken. Data was entered and analysed using MS Word, MS Excel & SPSS 21. Results: 88% have fair knowledge about menstruation. Mothers were the main source of information and advice regarding menstruation. FGDs revealed that the adolescents face stigma, embarrassment and hardships during menstruation both at school & home. Conclusion: Taboos, stigma and embarrassment and hindering the adolescents from appropriate MHM practices. Strategic approach towards menstruation would help to promote well - being of the adolescents.