Objectives: The objectives of this study were to develop and test a teaching and learning model in clinical nursing education to integrate the key concepts of self-learning, demonstration (simulation – zone I) and preceptorship (SDP). Coronavirus disease has affected adults and a significant proportion of children globally. All nurses must know the stabilisation and management of children affected by coronavirus disease-2019 (COVID-19). Materials and Methods: A paediatric nursing emergency preparedness program for COVID-19 of 8 days duration was developed with the help of a team of 42 medical and nursing experts. The training program was conducted for 300 nurses using a SDP model with a blended learning approach. The effectiveness of the SDP model was evaluated using a one-group pre-test and post-test design in terms of change in knowledge and self-confidence of the participants. Feedback from the participants, experts and preceptors about the program and teaching methodology was obtained at the end of the training program. Results: The mean gain in knowledge (12.57 ± 2.96 vs. 16.36 ± 4.26, P < 0.001) and self-confidence scores (84.08 ± 18.20 vs. 106.65± 9.86, P < 0.001) after the training program were statistically significant. The overall mean preceptors rating of the participants in various observed skills was 55.88 ± 15.21 with the majority of observations graded as competent. All the experts, preceptors and participants were satisfied with the training program. Conclusion: The SDP model using a blended learning approach was effective in improving the knowledge and self-confidence of the nurses in managing children with COVID-19. It can be used to train nurses in both technical and non-technical skills in patient care areas.