Retention and morale in the ICU: interprofessional team members' perspectives on interprofessional staffing in adult ICUs.

Operating room communication and teamwork: An observational pilot study comparing objective and perceived collaboration.

Psychological safety (PS) is essential for teamwork, communication, and patient safety in complex healthcare environments. In pediatric oncology, interprofessional collaboration occurs under high emotional and organizational demands. Low PS may increase stress, burnout, and adverse events. To assess PS in pediatric oncology teams across Germany, a survey including items on communication, workload, and error management culture was conducted among members of the "Gesellschaft für Paediatrische Onkologie und Haematologie" (GPOH, Society for Pediatric Oncology and Hematology). In October 2025, healthcare professionals from GPOH member institutions completed an online survey on PS. The 38-item questionnaire addressed PS and related aspects like communication, teamwork, leadership, workload, error management, and team climate. Responses were rated on a six-point Likert scale and analyzed descriptively and by subgroups. A total of 273 professionals completed the survey (Cronbach's α = 0.89). Teams reported a respectful, safety-oriented climate but noted challenges with workload, onboarding, and feedback. Only two-thirds indicated that mistakes in patient care were discussed openly. Physicians reported more open communication and constructive problem handling, while nurses experienced greater stress and more dismissive behavior toward "different" colleagues. Leaders showed higher PS, whereas lower PS across all domains was observed among participants who had seriously considered changing their jobs. Job satisfaction closely correlated with PS, particularly with open communication, trust, and respect. The findings emphasize that PS is both essential and improvable in pediatric oncology teams; strengthening leadership, feedback, and interprofessional reflection may enhance staff well-being, retention, and patient safety across this high-stakes field.

Immunisation against vaccine-preventable diseases in individuals receiving immunosuppressive targeted therapies.

Hybrid threats require hybrid solutions: A roadmap for healthcare security.

Integration of spatiotemporal features into machine learning assessment of open surgical skills.

Introduction: Computed Tomography (CT) procedures contribute significantly to medical radiation exposure and therefore necessitate the implementation of optimisation measures that balance diagnostic image quality with patient safety. Body Mass Index (BMI) influences radiation absorption; however, standard CT protocols do not adequately account for patient-specific body dimensions. Aim: To analyse the relationship between BMI categories and radiation dose metrics—volumetric CT Dose Index (CTDIvol), Dose-Length Product (DLP), Effective Dose (ED) and SizeSpecific Dose Estimates (SSDE)—while examining genderbased and protocol-specific differences in adult thoracic and abdominal CT examinations. Materials and Methods: This Cross-sectional study was conducted at the Department of Radiodiagnosis, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pimpri, Pune, India, from April 2025 to July 2025. The study included adult participants (aged 18-70 years) who underwent thoracoabdominal CT examinations 2025 at a tertiary care centre. A total of 200 participants were classified according to the World Health Organisation (WHO) BMI classification as underweight (<18.5 kg/m2 ), normal weight (18.5-24.9 kg/ m2 ), overweight (25.0-29.9 kg/m2 ) and obese (≥30.0 kg/m2 ). Standard acquisition protocols included non contrast and contrast-enhanced abdominal studies, as well as non contrast and contrast-enhanced high-resolution thoracic imaging. Technical parameters (tube voltage, tube current-time product, pitch, slice thickness and field of view) and dosimetry-related data were consistently recorded. Statistical analysis included Pearson’s correlation, Analysis of Variance (ANOVA) and linear regression models. Results: The BMI demonstrated a positive correlation with CTDIvol (r=0.266, p<0.001), DLP (r=0.180, p=0.011) and ED (r=0.168, p=0.017). No significant correlation was observed between BMI and SSDE (r=0.043, p=0.549). Overweight (BMI 25.0-29.9 kg/m2 ) and obese (BMI ≥30.0 kg/m2 ) participants received approximately 30% higher CTDIvol values (mean 14.4 vs. 11.1 mGy, p=0.003) and a 23% higher DLP compared to normal-weight individuals. Gender-related disparities persisted after adjustment for BMI, with male participants exhibiting a 28% higher DLP (647.7 vs. 504.1 mGy•cm, p<0.001). Protocol-specific analysis revealed that contrast-enhanced thoracic CT had the highest radiation dose (mean DLP 746.4 mGy•cm), which was 47% higher than that of high-resolution thoracic protocols. Conclusion: The BMI significantly influences radiation dose in thoracoabdominal CT examinations, supporting the need for BMI-stratified Diagnostic Reference Levels (DRLs). The poor correlation between BMI and SSDE suggests limitations in size calibration for individuals with extreme body habitus. Observed gender-based differences in radiation dose may warrant the development of sex-specific protocol adaptations. Overall, these findings support the personalisation of CT protocols and dose optimisation based on anthropometric parameters and anatomical features, particularly when advanced reconstruction algorithms are employed.

Diagnostic sensitivity: Surgical biopsy versus minimally invasive techniques in bronchopulmonary cancer.

The experiences of psychotherapies for post-traumatic stress disorder in children and adolescents: A meta-synthesis of qualitative literature.

X+Why? A Qualitative Approach to Understanding Pediatric Resident and Faculty Preferences for the X+Y Scheduling Change.

Clinical errors stemmed from intricate relationships between organizational, environmental, and individual factors. Although it was widely acknowledged that safety culture and error culture management improved patient safety, little is known about how these elements affected nurses' working environments and error occurrence. To investigate the relationship between the safety attitude, error culture management, errors and work environment variables, including stress, workload, and interpersonal conflicts. A cross-sectional multicenter study was conducted on 636 nurses dedicated to direct patient care in Italian healthcare organizations. Safety attitude, work-related stress, interpersonal conflicts, error culture management and clinical errors were collected through a survey composed of validated scales. To verify the hypotheses under study, descriptive analysis and structural equation modeling were performed. Error culture management significantly influenced error occurrence. Interpersonal conflicts and workload increased clinical errors. The work environment mediated the relationship between error culture management and errors. Stress had a non-significant mediator role. An unexpected positive correlation was found between safety attitude and errors, without any mediation. Strong error culture management, a positive nursing environment, and team collaboration prevented clinical errors. Enhancing the work environment and fostering positive interpersonal relationships contributed to patient safety. Further longitudinal studies could assess specific interventions to enhance safety and the quality of nursing care. We adhered to STROBE guidelines for cross-sectional research. This study did not include patient or public involvement in its design, conduct, or reporting.

Fibrin hydrogel incorporated with microspheres containing vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) accelerated the healing of diabetic wounds in rats.

Delandistrogene moxeparvovec is a recombinant adeno-associated virus rhesus isolate serotype 74 vector-based gene therapy that addresses the absence of functional dystrophin in Duchenne muscular dystrophy (DMD). EMBARK is a phase 3, two-part, crossover, randomized, placebo-controlled trial assessing the safety and efficacy of delandistrogene moxeparvovec (single intravenous dose 1.33 × 1014vector genomes/kg) in ambulatory male patients with DMD aged 4 to < 8years; N = 125. One-year results demonstrated the manageable safety of delandistrogene moxeparvovec, consistent with previous clinical trials. The primary endpoint (change from baseline in North Star Ambulatory Assessment [NSAA] total score at 52weeks compared with placebo) did not meet statistical significance. However, key secondary endpoints, comprising timed function tests, suggested slowing or stabilization of disease progression with delandistrogene moxeparvovec, which could become increasingly evident over longer periods of time. We report 2-year follow-up of safety and functional outcomes in patients receiving delandistrogene moxeparvovec in EMBARK part1. As a result of the crossover study design, 2-year functional outcomes of patients receiving delandistrogene moxeparvovec in part1 of EMBARK were compared, by pre-specified analysis, with a matched propensity score-weighted external control (EC). At 2years, EMBARK patients showed statistically significant benefit versus the EC cohort in functional outcomes prognostic for delaying loss of ambulation (NSAA, Time to Rise, 10-m Walk/Run), demonstrating sustained stabilization or slowing of disease progression. Delandistrogene moxeparvovec micro-dystrophin expression and sarcolemmal localization were maintained over 64weeks. No new safety signals were observed between week52 and week104. Between baseline and week104, there were no treatment-related deaths, study discontinuations due to adverse events, or clinically significant complement-mediated adverse events. At 2years, stabilization or slowing of DMD disease progression was observed in ambulatory male patients with DMD aged 4 to < 8years receiving delandistrogene moxeparvovec versus a matched EC cohort. Safety was consistent with EMBARK 1-year data and manageable with appropriate monitoring. GOV: NCT05096221.

Real-World Experience With Secukinumab for Hidradenitis Suppurativa: A Multicenter Retrospective Analysis of 263 Patients From the SECU-SPAIN Study.

Respiratory physiotherapy is a treatment option for children on paediatric intensive care units (PICUs), aiming to facilitate airway clearance and improve ventilation. Given the vulnerable nature of this patient group, safety and adverse events related to respiratory physiotherapy are important considerations. The aim of this qualitative study was to understand what physiotherapists perceive to be risk factors for instability and adverse events and how they manage these. This study involved virtual semi-structured interviews and focus groups with PICU physiotherapists. Sixteen interviews and two focus groups (n=7) were completed. These were audio-recorded and transcribed verbatim. Framework analysis was used. From the interview analysis, a framework Strategies for managing instability and adverse events was developed. Two frameworks were developed from the focus group analysis: Instability and adverse events and Managing instability and adverse events. Physiotherapists provided a comprehensive list of perceived risk factors for instability and adverse events, including clinical presentations and support required. Practical strategies were reported to promote efficiency, including readiness of equipment and two-person treatments. Physiotherapists described accepting short-term unwanted effects for longer-term improvement, discussed in terms of risk versus benefit. The patient's parents/family were involved in the sharing of responsibility for treatment decisions. Multidisciplinary team involvement included collaborative discussion with practical assistance as required. This study provides novel data about physiotherapists' management of instability and adverse events in PICUs. Preparation and planning, involving the multidisciplinary team, family inclusion, reacting and adapting, and accepting instability were important strategies. The findings from this study highlight several areas that require consideration from a workforce support and education perspective.

An old disease, a new linguistic challenge for large language models: patient education on psoriasis and psoriatic arthritis in an underrepresented medical language.

Transitions of care are the movement of a patient from one care setting or provider to another. Interprofessional collaboration is critical in ensuring patient safety and satisfactory health outcomes. Each time an interprofessional team transfers a patient, the team performs three important roles: representing the patient, providing patient information for other team members, and coordinating the transition. Poor transitions of care may contribute to negative health outcomes, especially for patients with chronic health conditions, complex medication regimens, and high-risk treatments. We present a case study of a patient with complicated chronic obstructive pulmonary disease that depicts the importance of successful interprofessional collaboration during the transition of care from hospital to home illustrating the unique contributions of the various disciplines involved in the patient's care.

A low dose is better than no dose: Is it time to consider lowering the US minimum plateletpheresis yield?

The Mediating Role of Motivation in The Relationship Between Nurses’ Professional Competence and The Nursing Work Environment with Patient Safety Management Activities

Implementing a televisiting program in a tertiary university hospital: Failure modes and effect analysis (FMEA) and solutions for improving patient safety and sustainable care