Characteristics of online medication consultation from home-based patients on a tertiary hospital WeChat platform: a cross-sectional study.

When Infections Hurt More: Black Patients Experience More Severe Surgical Site Infections Following Lower Extremity Bypass.

The effect of Dual Orexin Receptor Antagonists on sleep: a systematic review and pairwise meta-analysis.

Pharmacologic synergy versus independent action in androgen receptor-axis-targeted agent-docetaxel triplet therapy for metastatic hormone-sensitive prostate cancer: a copula-based analysis.

Predicting suicide in patients who have received acute psychiatric inpatient treatment - the longitudinal and prospective SIPEA study.

Cardiovascular disease mortality among women diagnosed with de novo metastatic breast cancer.

Progress in risk assessment and management: Forecasting updates across international cholesterol guidelines.

Pregnancy Outcomes in Women With Cardiovascular Disease:A Retrospective Cohort Study from Kaiser Permanente Northern California.

Metabolic dysregulation: Its role in diabetes mellitus and cancers.

Osteoarthritis (OA) often results in significant degeneration of the knee’s tendons, ligaments, muscles, and joint capsules, frequently resulting in reduced proprioception. Total Knee Arthroplasty (TKA) is a widely used surgical intervention aimed at alleviating pain and improving the Quality of Life (QoL) for individuals with end-stage Knee Osteoarthritis (KOA). However, despite its effectiveness, many patients experience only modest functional improvements following surgery, highlighting the need for enhanced rehabilitation strategies. The present narrative review explores the impact of incorporating balance and proprioceptive training into postoperative rehabilitation for TKA patients, focusing on physical function, pain relief, and overall well-being. The purpose of the present review is to evaluate how proprioceptive and balance training affects physical function, pain management, and general QoL in postoperative rehabilitation for TKA patients. Regaining stability, mobility, and confidence in performing daily tasks is often challenging for individuals who have undergone TKA. Although the procedure primarily addresses structural joint damage and alleviates pain, it does not automatically improve sensory-motor function or neuromuscular coordination, both of which are essential for independent mobility and fall prevention. Findings indicate that early integration of balance and proprioceptive exercises can significantly improve recovery outcomes after TKA, enhancing balance, physical function, and QoL. Techniques such as Progressive Dynamic Balance Training (PDBT), combined kinetic chain exercises, and Neuromuscular Electrical Stimulation (NMES) have demonstrated particular effectiveness. However, variability in study designs and outcome measures underscores the need for standardised rehabilitation protocols. In conclusion, balance and proprioceptive training appear to offer substantial benefits for TKA patients by improving functional outcomes and reducing fall risk. Further research is needed to develop consistent training protocols, examine long-term outcomes, and validate findings in larger and more diverse patient populations.

A low dose is better than no dose: Is it time to consider lowering the US minimum plateletpheresis yield?

Efficacy of radiotherapy to metastatic lesion in de novo metastatic nasopharyngeal carcinoma patients: A multicenter, propensity score matching study.

Biologic therapeutics have revolutionized treatment of disorders for which there were previously limited options. Biologic products are typically very expensive. However, the emergence of biosimilars (a biologic product that is nearly identical to a Food and Drug Administration [FDA]-approved "branded" version) offers an opportunity to reduce costs after the branded product's period of patent protection ends. Despite the promise of biosimilars, some physicians have expressed concern regarding interchangeability, especially in specific patient populations. The American Academy of Neurology (AAN) supports the cost-saving potential of biosimilar therapeutics while emphasizing the importance of a balance between reducing costs, maintaining clinical efficacy, and preserving the integrity of the physician-patient relationship. This position statement from the AAN offers a framework to aid neurologists in deciding whether to switch a patient from a branded biologic product to a biosimilar therapeutic. This framework aligns with broader AAN policies on drug pricing and medical decision-making autonomy.

Association Between Health Plan Design and the Demand for Naloxone: Evidence From a Natural Experiment in New York.

In 2020, a children's hospital-sponsored pediatric dentistry program affiliated with the school-based dental clinic (SBDC) was established to improve equity in dental access and provide a community-based dental training environment. The creation of this comprehensive SBDC provides valuable lessons for sponsor and partner institutions on legal, compliance, epidemiology, information technology, and safety considerations. This program met the goals of providing treatment for a diverse and underserved patient population while providing unique experiences for trainees. The mobile equipment model is feasible for school and community settings. Careful planning is needed when designing staffing models, selecting equipment, and selecting appropriate partners. Comprehensive SBDC programs require considerable investment but provide critical dental access to vulnerable populations and can benefit sponsor and partner institutions.

Rethinking Competency-Based Medical Education in Radiation Oncology: Early Lessons and Future Directions.

Peripherally administered vasopressin initiated in the emergency department.

Post-traumatic care is evolving from a reactive, protocol-driven paradigm to a predictive, personalized approach. This review examines how artificial intelligence and machine learning are redefining postoperative management by predicting complications before they manifest. Recent literature (2023-2025) highlights three major advances: (a) the validation of gradient boosting algorithms (e.g. Extreme Gradient Boosting) that significantly outperform traditional scoring systems for predicting trauma-induced coagulopathy; (b) the development of interpretable, phenotype-specific models for venous thromboembolism risk stratification, particularly in traumatic brain injury; and (c) the emergence of real-time sepsis prediction tools that account for the sterile inflammation inherent to trauma. However, a recurring limitation in current research is the reliance on retrospective datasets and single-center validations, underscoring the critical need for rigorous external validation across diverse patient populations before widespread clinical adoption. Artificial intelligence is not merely a monitoring tool but a driver of precision medicine in trauma. By leveraging diverse modalities, from computer vision in radiology to natural language processing in electronic health records, clinicians can now anticipate adverse events. To bridge the gap between algorithm and bedside, future efforts must focus on overcoming significant implementation barriers, such as data interoperability, and ensuring model generalizability.

Real-world management and clinical outcomes of first line treatment of advanced renal cell carcinoma in older patients in Canada.

The Minnesota Electronic Health Record Consortium (MNEHRC) was established during the early days of the COVID-19 pandemic to provide data for public health surveillance from the eleven largest health care systems in Minnesota. This is a descriptive study of the Consortium, which is a federated network that implements best practices for governance and data infrastructure to support public health surveillance and clinical research. We conducted an analysis of the Consortium members, governance structure, infrastructure, and the characteristics of the patient population. The Consortium health systems collect information from 105 hospitals, 773 clinics, 100 emergency departments and 29 040 providers. Information about the health systems and the demographic and clinical characteristics of its 5 471 367 patients is provided, which represents more than 90% of the patients in Minnesota. This manuscript also details the MNEHRC governance structure, working groups, data use agreements and technical infrastructure. The Consortium has produced several studies with state-wide impact. One study, Health Trends Across Communities in Minnesota, is described in detail to illustrate aspects of this collaboration. MNEHRC has been a successful collaboration and vital resource for public health surveillance in the state of Minnesota. Initially, the Consortium focused on surveillance related to COVID-19 infections and vaccinations but has recently expanded into other public health and chronic disease research.