A Survey of knowledge and perception of patients towards the serum uric acid levels in musculoskeletal symptoms and systemic diseases.

Peyronie's disease in Spain: a prospective study.

Key terms describing the activity status and clinical outcomes of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) lack standardized definitions. To address the need for uniform definitions, we sought to develop formal consensus-based terminology to define key aspects pertinent to the management of CIDP. In April 2025, the GBS|CIDP Foundation International convened a Task Force of 17 international CIDP experts, 2 guest experts from related specialties, and 3 patient representatives. Task Force panels iteratively reviewed, discussed, and voted on proposed definitions for No Evidence of Disease Activity, Relapse, Response, Refractory, Remission, and Residual Symptoms. Relevant literature was reviewed to inform each definition. A modified Delphi approach was used to achieve consensus, defined as a median rating ≥7 on a 9-point scale with ≥80% agreement. Voting included 17 content experts and 3 patient representatives. Guest experts provided nonvoting input. Composite metrics incorporating disability, strength impairment, and patient perception were determined to provide the most sensitive and specific assessment of clinical change in CIDP. Using commonly used clinical outcome measures, including minimally clinically important differences where available, unique definitions were developed for each clinical term. Definitions for No Evidence of Disease Activity, Relapse, Response (minimal, partial, and optimal), Refractory, Remission, and Residual Symptoms were iteratively refined to integrate patient-reported experiences, standardized disability scores, and objective measures of strength impairment, ensuring that each term captured a multidimensional view of disease status. The development of consensus-based definitions for key clinical terms in CIDP addresses a longstanding gap in standardizing the assessment of disease activity and treatment outcomes. By combining patient-reported experiences with objective disability and strength measures, the Task Force created comprehensive definitions reflecting the patient experience. The iterative Delphi process ensured broad expert agreement while allowing patient perspectives to inform the terminology. These standardized definitions may improve consistent evaluations in clinical practice, facilitate communication among healthcare providers, and support more robust design and interpretation of clinical trials. Furthermore, the incorporation of composite metrics sensitive to meaningful clinical changes may enhance the ability to detect treatment effects and disease progression, ultimately promoting more precise and patient-centered management of CIDP.

To explore the specific needs of patients with diabetic foot ulcers (DFUs), caregivers, and health care professionals (HCPs) for a mobile health (mHealth) app, aiming to inform the design and development of effective mHealth service solutions. This descriptive qualitative study was conducted from June to September 2024 in the wound care clinics of 2 local hospitals. Participants included patients with DFUs, caregivers, and HCPs directly involved in their care. Interview data were analyzed, synthesized, and refined using content analysis. Five key themes emerged: the pressing need to implement mHealth app services, convenient and personalized access to information, continuous and specialized health guidance, a multidisciplinary approach to disease management, and free access alongside privacy and legal protections. This study provides valuable insights for the design and development of an mHealth app for DFU. During the development process, it is essential to consider user needs and ensure the app meets the expectations of patients and related groups for personalized, continuous, and specialized health guidance; free access; privacy protection; and multidisciplinary collaboration. A balance should be struck between convenience and security of the app's features, to encourage user engagement and enhance the app's value and effectiveness.

Conventional grading scales and static image assessments may not capture dynamic facial movement in facial paralysis. We developed a video-based, dynamic, artificial intelligence (AI) application, DynaFace, to objectively quantify facial metrics and determine which measures correspond with patient-reported appearance, function, and psychosocial outcomes, providing insight into how objective dynamics relate to subjective patient experience. DynaFace automatically extracted dynamic facial metrics (facial asymmetry index [FAI], bilateral palpebral fissure, and oral commissure excursion [OCE]) at rest and during smile, laughter, and pucker. Multivariable linear regression, controlling for paralysis duration and baseline trait emotional intelligence, assessed associations between objective metrics and patient-reported outcomes from FACE-Q subsets. Greater asymmetry (higher FAI) during smile and laugh was associated with poorer perceived facial (β = smile: -2.82/laugh: -3.01, p < 0.05), eye (β = -3.99/-3.12, p < 0.05), and smile appearance (β = -4.40/-4.80, p < 0.01), as well as lower overall facial function (β = -3.05/-3.60, p < 0.05) and self-esteem (β = -2.93/-3.12, p < 0.05). In contrast, greater ratio of OCE change (affected to unaffected hemiface)during smile predicted better perceived facial appearance (β = 0.88, p < 0.01), smile appearance (β = 0.69, p < 0.05), and higher self-esteem (β = 0.62, p < 0.05). Greater ratio of OCE change during both smile and laugh predicted improved social function (β = 0.48/0.44, p < 0.05). Palpebral fissure asymmetry was associated with only eye appearance. Dynamic AI-derived facial metrics from DynaFace align with patient perceptions, showing that greater symmetry in movement enhance satisfaction and function. These findings highlight the clinical potential of DynaFace to bridge objective and patient-reported measures in facial paralysis assessment.

ASO Visual Abstract: A Prospective Randomized Trial Comparing Radioguided Occult Lesion Localization (ROLL) and Magnetic Seed Localization for the Localization of Nonpalpable Breast Lesions: Analysis of Surgical Outcomes, Patient's Perception, and Costs.

Patient Perception of Artificial Intelligence Medical Scribes in Urology: A Quality Improvement Study.

Outcome assessment after urethral stricture surgery remains inconsistent, with success traditionally defined by anatomical patency or absence of reintervention. Growing recognition of discordance between objective findings and patient experience has made it necessary to re-evaluate how outcomes are measured. This review explores contemporary approaches to defining success and highlights the need for standardized, patient-centered endpoints. Current literature shows that anatomical and objective functional measures alone fail to capture the complexity of postoperative recovery. Patient-reported outcome measures have gained increasing importance, revealing persistent urinary symptoms, sexual dysfunction, and quality-of-life impairment despite technically successful reconstruction. Functional outcomes such as storage symptoms, ejaculatory changes, and perceived penile alterations are increasingly recognized as key determinants of satisfaction. Emerging composite outcomes aim to integrate anatomical, functional, and patient-reported domains into a unified framework. Outcome evaluation in urethral stricture surgery is shifting toward multidimensional assessment that prioritizes patient perception alongside traditional metrics. Standardized composite endpoints may improve comparability across studies, support shared decision-making, and better align surgical success with patient expectations.

The purpose of this study is to assess if the descriptor "non-compliant" negatively influences a physician's perception of and reaction to a patient. While the term "non-compliant" is often used in the medical record to describe a patient who does not follow prescribed recommendations, there is concern that its use may create a negative bias toward a patient and dissuade a provider from examining specific reasons for non-compliance. Current research evaluated whether the term creates a negative bias toward a patient in medical residents, who are at a pivotal point in their training and development of professional attitudes. Four fictitious scenarios of a patient admitted for diabetic crisis were created-identical except for gender and inclusion of the term "non-compliant." Internal medicine residents across a university-affiliated program were randomly assigned one scenario, and then asked to rate their perceptions of the patient from 0 (very negative) to 7 (very positive) on various parameters. Responses were categorized into "positive" (4-7) vs. "negative" (0-3) perceptions. Categorical variables, reported as numbers and percentages, were compared using the Chi-square test or Fisher's exact test. Continuous variables were reported as mean, standard deviation, and range, and were compared using the Student's t test. All reported P values were two-tailed. For the tests above, statistical significance was considered if P < 0.05. All statistical analyses were performed using SAS version 9.4 (SAS Institute, Cary, NC). No significant differences were found in perceptions of patients based on the presence of the term "non-compliance" nor gender of either patient or physician. Faculty members were less willing to take on non-compliant patients compared to residents. Contrary to the current literature, the term "non-compliant" did not significantly affect resident attitudes or perceptions toward patients. This may represent a shift in attitudes of younger trainees as they may be aware of the effect of bias when treating patients. Future research should include a larger, more diverse cohort.

Fabry disease(FD) is a rare X-linked lysosomal storage disorder associated with progressive multiorgan damage. Because perceptual differences between patients and clinicians regarding diagnosis and treatment can contribute to suboptimal management. We aimed to compare the perceptions of patients with FD and nephrologists in South Korea regarding the diagnostic process, treatment decisions, and genetic counseling. We conducted a cross-sectional survey enrolling 25 patients with FD, 33 patients with chronic kidney disease (without a known genetic etiology), and 27 nephrologists. The surveys assessed diagnostic testing considerations, treatment preferences, attitudes toward angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARB), and genetic counseling priorities. All three groups prioritized diagnostic accuracy, while both patient groups emphasized procedural concerns (e.g., pain from blood draw and blood loss risk) significantly more than clinicians. A perception gap existed regarding ACEi/ARB therapy: 92.3% of clinicians believed in its renoprotective effect, whereas only 26.1% of patients agreed to treatment without strong evidence. Both groups agreed on the importance of genetic counseling for family screening.Regarding treatment, 96% of patients and 81.5% of clinicians preferred oral over injectable enzyme replacement therapy. These significant perception gaps highlight the need for improved patient education and shared decision-making to enhance treatment adherence and clinical outcomes in FD management.

The Effect of Pain and Comfort Levels of Patients Undergoing Bariatric Surgery on Perception of the Quality of Nursing Care and Related Hospital Service.

Fragmentation of electronic health records in oncology hinders coordinated care, delays diagnoses, and limits therapeutic personalization. Blockchains promise to promote secure, interoperable, and patient-centered data governance; however, patient perceptions of blockchains remain underexplored, particularly in middle-income countries such as Brazil. We assessed opinions, attitudes, and willingness among patients with cancer to digitally share clinical information and the feasibility of applying blockchains to restructuring secure health data sharing in the Brazilian public health context. We had three research questions: (1) What is the level of digital health tool acceptance among patients with cancer in Brazil? (2) Which sociodemographic factors are associated with willingness to share health data? (3) Are blockchains feasible and acceptable for restructuring secure oncology data sharing? An exploratory, descriptive, cross-sectional self-report survey was conducted at Hospital Santa Izabel, a national oncology reference center in Salvador, Bahia, Brazil, between September and November 2023. A convenience sample of 110 outpatients with cancer was recruited systematically; data were collected via a self-administered questionnaire. The 20-item instrument, developed de novo and validated via expert panel and pilot testing, covered 5 content domains yielding 3 composite scoring domains: self-management, adherence, and governance. We used Cronbach α to assess internal consistency, independent 2-tailed t tests, 1-way ANOVA, and Pearson correlations to compare domain scores across sociodemographic groups, and a chi-square goodness-of-fit test to examine trust proportions across recipient types. We received sufficiently complete responses from 94.5% (104/110) of patients. The sample was predominantly female (63/98, 64.3%), self-identified as pardo (mixed-race; 64/98, 65.3%), and lower income (55/96, 57.3% earned less than twice the minimum wage). Acceptance of technology was high: 86.4% (95/110) would use health apps and 89.1% (98/110) expressed interest in prevention-focused applications. Trust in data sharing varied significantly across recipient types (χ23=210.4; P<.001): 79.1% (87/110) trusted health care professionals, 51.8% (57/110) hospitals, 15.5% (17/110) the pharmaceutical industry, and 10% (11/110) the government. Anonymization and encryption significantly increased willingness to share (92/110, 83.6%). Younger patients (18-59 years) showed significantly higher adherence scores than those aged ≥60 years (mean 76.49, SD 19.16 vs mean 65.83, SD 26.66; t95=2.29; P=.02). Domain reliability was good to excellent (Cronbach α=0.8807 [adherence], 0.8504 [self-management], and 0.7576 [governance]). Patients with cancer in Brazil demonstrated high acceptance of digital health tools and openness to data sharing when privacy, security, and governance are guaranteed. This supports the feasibility of blockchain-based health data management systems, provided they incorporate patient-centered principles, digital inclusion strategies, and robust governance aligned with Brazilian regulations (the General Data Protection Law) and the Unified Health System (Sistema Único de Saúde) infrastructure. Importantly, patient support reflected acceptance of blockchain's functional principles, data security, anonymization, and auditability rather than familiarity with the technology itself, a distinction with direct implications for future implementation studies.

Few studies have assessed patient perception of the management of their hypertensionin Europe. We aimed to compare the attitudes, barriers, and expectations of patients receiving treatmentfor hypertension in 7 European countries. Cross‑sectional data were obtained between January and April 2023, usinga web‑based questionnaire translated into each country's official language and distributed in the Czech Republic, France, Germany, Italy, Poland, Spain, and the United Kingdom (UK). A total of 4001 treated hypertensive adults returned a valid questionnaire. Their mean (SD) age was 68.3 (9.2) years (median, 70 y), 59.7% were men, and 91% were treated for longer than 1 year. The participants from Poland and the Czech Republic had a more unfavorable cardiovascularrisk profile than those from other countries (P <0.001). Differences across the countries were found for lifestyle, medical, and emotional risk scores (P <0.001). A total median number of pills per day was 4 (range, 3-5/d; P <0.001 between countries) and 2 for antihypertensive drugs. The frequency of follow‑up visits per year was the highest in France and lowest in the UK (P <0.001). In all countries, 10%-20% of the participants expressed a wish for more information mainly on treatment, drug side effects, and hypertension complications. Nonintentional interruption of medications was the main cause of nonadherence. According to patients, the management of hypertension is highly variable in differentEuropean countries. Our survey identified features that could be improved, such as increasing the amount of information provided to the patients, empowering the patients through adequate home blood pressure monitoring, and supporting medication adherence.

Missed healthcare appointments, or "Did Not Attends" (DNAs), pose challenges for healthcare systems. Technology-facilitated reminder systems, such as SMS and phone calls are often implemented to improve attendance. This scoping review aimed to map the evidence on patient and carer perspectives and experiences of technology-enabled appointment reminders in healthcare and, secondly, examine how equity-relevant characteristics were reported. A scoping review which searched EMBASE, MEDLINE, PsycINFO, Web of Science, Scopus, and EBSCO from September to October 2025 for studies published between 2010 and 2025. Studies examining patient or informal/unpaid carer perceptions and experiences of technology-based reminder systems were included. Equity-relevant dimensions were examined using the PROGRESS-Plus framework. Data were extracted and summarised using a structured form; with findings synthesised thematically. A total of 45 studies were included. Most focused on patient perspectives, with comparatively fewer centered specifically on carers. The majority were cross-sectional surveys, with fewer longitudinal and theory-informed designs. SMS reminders were the most studied modality, followed by phone calls and app-based notifications. Patients and carers reported high satisfaction. Recurring barriers included digital exclusion, language challenges, confidentiality concerns, and socio-economic inequalities. Equity reporting across studies was inconsistent, with many studies describing sociodemographic characteristics without examining how they influenced engagement with reminder systems. Technology-enabled appointment reminders are widely perceived as useful. Digital exclusion, privacy, language, and trust-related barriers limit engagement and access. Greater user involvement is needed to ensure reminder systems support, rather than reproduce, healthcare inequalities. Future research and implementation efforts should prioritise equity-informed design and evaluation.

To examine the relationship between side effect severity and self-management ability in patients taking capecitabine and investigate whether medication beliefs mediate this relationship. A secondary analysis was conducted using data from a descriptive study of 50 patients with gastrointestinal cancer receiving capecitabine at the University of Michigan Rogel Cancer Center. Self-management ability was assessed using the Measure of Drug Self-Management. The severity of capecitabine-related side effects was measured using the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events. Patients' perceived necessity of and concerns about capecitabine were evaluated using the Beliefs about Medicines Questionnaire (adapted for capecitabine). Descriptive statistics, multiple linear regression, and PROCESS macro mediation analysis were employed. Self-management ability was significantly associated with total side effect severity (beta = -1.09, p = 0.003). This relationship was partially mediated by patients' overall beliefs about capecitabine (beta = -0.74, p = 0.04) and fully mediated by concerns about its potential harms (beta = -0.6, p = 0.11). Oncology nurses should adopt a patient-centered approach that includes counseling about the benefits of capecitabine, addressing concerns about adverse effects, and reinforcing patients' self-efficacy and social support networks to enhance self-management during therapy.

To examine surgical experiences of diverse participants with obesity who underwent bariatric surgery and interacted with nurses and physicians in the prior 2-5 years. Qualitative analysis of a prospective longitudinal cohort study to understand adult experiences of people with obesity before and after bariatric surgery. Semi-structured interview data (n = 68) were analysed to identify patterns in supportive practices and unmet needs of participants with obesity. Two theme categories emerged describing supportive care and care gaps. Supportive themes were Appreciation, Support, Listening, and Understanding,Impact of Classes, and Importance of Information. Care gap themes included Stigma, Bias, and Judgement Lack of Decision Support, More Than Losing Weight, Weight Bias, Lack of Support/Communication, Lack of Follow-Up, Few Mental Health Supports, and Not Being Seen and Heard. Participants with obesity described experiences of bias, stigma, and concerns about knowledge and communication. Our study found stigma, bias, and judgement experienced by patients with obesity are barriers to bariatric care and successful outcomes. Gaps in communication, follow-up, and mental health contributed to feelings the participants expressed of "not being seen and heard." Active listening, transparent communication, and coordinated care were perceived by participants with obesity as essential for trust, respect, and belonging.

Patient Perceptions of Medicare Annual Wellness Visits: Findings From a Pilot Survey.

BackgroundThe use of generative artificial intelligence (AI) by pharmaceutical companies and other organizations for preparing patient-facing documents reporting results of clinical research is becoming more common. This raises concerns about whether the accuracy and quality of these documents could be affected, as well as the potential impact on patient perceptions and trust. Accurate and trustworthy information is critical to health care decision-making. Little is known about patient perceptions of AI-generated content.ObjectiveThis study aimed to better understand patient experience and familiarity with AI, their resulting confidence in the abilities of AI, and their trust in the use of AI by research organizations to generate clinical research documents.MethodsAn online survey was conducted using an online health care panel of patients in Europe and the United States to assess familiarity with AI, trust in organizations reporting on research, and trust in the use of AI to prepare clinical research documents. The survey also asked directly about the importance of human involvement and of transparency in disclosing AI use.ResultsA total of 1010 respondents completed the online survey. About half of respondents were from the United States and half from Europe. Survey results showed that 63.6% (642/1010) of respondents had used AI before with 74.9% (756/1010) reporting being “Somewhat” or “Very” familiar with AI. AI use was influenced by country, gender, education level, race/ethnicity, and clinical trial experience. Higher familiarity with AI was observed among younger participants. Respondents were generally confident in the capabilities of AI, as more than half believed AI use would reduce grammar and data errors. Trust in clinical trial documents generally increased with greater human oversight, as trust was lowest for documents created by AI with no human involvement (12.3% “A lot” of trust, 124/1010) and highest for documents created by humans without AI (39.1% “A lot” of trust, 395/1010). 95.0% (959/1010) of respondents considered human involvement in clinical trial document review as “Very important” or “Somewhat important.” The majority (62.4%, 630/1010) of respondents felt it was “Very important” for pharmaceutical companies and academic institutions to be transparent about their use of AI in public-facing documents. Transparency was considered more important among respondents in the United States and the United Kingdom compared to those in the European Union.ConclusionsThe survey results reveal high familiarity with, and confidence in the capabilities of, AI. Despite this confidence, respondents emphasized the need for human involvement in the creation of clinical trial documents and the importance of disclosing AI usage, underscoring the critical role of human oversight in maintaining patient trust. Transparent integration of AI with deliberate human involvement remains essential to ensure trust in patient-facing documents.

3D back surface asymmetry reflects radiographic deformity but not patient perception in Lenke type 1 adolescent idiopathic scoliosis.

The opioid crisis in North America continues to cause immense harm and loss of life. The distribution of naloxone has been recognized as an important tool to combat the opioid crisis. The emergency department (ED) setting provides an important opportunity to distribute naloxone to people that use opioids. The purpose of this scoping review was to summarize the literature surrounding ED-based take-home naloxone with a focus on key patient-centered health outcomes. We performed a scoping review of naloxone distribution from the ED utilizing PRISMA Extension for Scoping Reviews guidelines. The databases MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and CINAHL were searched for keywords related to naloxone and the ED. Abstracts were screened for relevance and a full text review was undertaken applying inclusion and exclusion criteria. Data were extracted and summarized by outcome of interest. 3475 studies were identified and screened for relevance. 24 studies were included in the results and analysis. Seven studies reported health outcomes related to take-home naloxone. Nine studies reported patient perceptions of take-home naloxone, and eight studies reported provider perceptions of take-home naloxone. No studies were identified that reported cost-effectiveness data. We found that take-home naloxone distribution in the ED setting is supported by both patients and ED providers. Knowledge gaps exist as to whether these programs are effective to improve patient health outcomes, or whether they are cost-effective. Take-home naloxone distribution in the ED setting to combat the opioid overdose crisis is supported by patients and ED providers. Knowledge gaps exist as to whether these programs improve health outcomes for people who use opioids, or whether they are cost-effective. Take-home naloxone should be considered as part of a harm reduction strategy for patients presenting to the ED at risk for opioid overdose.