Pathological Changes Research Articles

The impact of cognitive impairment and Alzheimer's disease neuropathological changes on gait, freezing and falls in Parkinson's disease.

The impact of cognitive impairment and Alzheimer's disease neuropathological changes on gait, freezing and falls in Parkinson's disease.

Liver morphometry and histopathology effects in Astyanax lacustris exposed to lambda-cyhalothrin pyrethroid insecticide.

Liver morphometry and histopathology effects in Astyanax lacustris exposed to lambda-cyhalothrin pyrethroid insecticide.

Paeoniflorin alleviated experimental Sjögren's syndrome by inhibiting NLRP3 inflammasome activation of submandibular gland cells via activating Nrf2/HO-1 pathway.

Paeoniflorin alleviated experimental Sjögren's syndrome by inhibiting NLRP3 inflammasome activation of submandibular gland cells via activating Nrf2/HO-1 pathway.

Effects of Oxidative Stress on Serum Metabolism in Acute Pancreatitis Rats Based on Untargeted Metabolomics.

Acute pancreatitis(AP) is a common digestive tract disease, often accompanied by severe metabolic disorders, but there are no specific markers and treatment methods, and the potential metabolic pathways behind it remain to be explored. Establish mild acute pancreatitis and severe acute pancreatitis models in rats and intervene with antioxidant NAC. Analyze serum oxidative stress indicators and pathological changes in pancreatic tissue. In addition, non-targeted metabolomics analysis of serum differential metabolites between groups was conducted based on the LC/MS system. The pathological score of the model group rats increased, and the levels of oxidative stress factors ROS and MDA significantly increased, while the activity of the antioxidant enzyme SOD decreased. After NAC intervention, oxidative stress damage in rats was alleviated. Non-targeted metabolomics experiments suggest significant differences in serum metabolic profiles among different groups of rats. Metabolomics results show that the obtained differential metabolites are expected to become serum biomarkers for AP.

Study on the mechanism of acteoside in treating purinomycin aminonucleoside-induced chronic glomerulonephritis in childhood rats based on Cxcr4-PI3K-Akt-eNOS axis.

Study on the mechanism of acteoside in treating purinomycin aminonucleoside-induced chronic glomerulonephritis in childhood rats based on Cxcr4-PI3K-Akt-eNOS axis.

Reprogramming of lipids and amino acids metabolism is an early event in myocardium of type 1 diabetic rhesus monkeys.

Reprogramming of lipids and amino acids metabolism is an early event in myocardium of type 1 diabetic rhesus monkeys.

GRP94 mediates blood-brain barrier permeation and substantia nigra-specific drug distribution in Parkinson's disease.

GRP94 mediates blood-brain barrier permeation and substantia nigra-specific drug distribution in Parkinson's disease.

Ginsenoside Rg1 alleviated experimental colitis in obesity mice by regulating memory follicular T cells via Bcl-6/Blimp-1 pathway.

Ginsenoside Rg1 alleviated experimental colitis in obesity mice by regulating memory follicular T cells via Bcl-6/Blimp-1 pathway.

Mice mortality induced by dexmedetomidine is non-alpha2-adrenergic receptor-dependent.

Mice mortality induced by dexmedetomidine is non-alpha2-adrenergic receptor-dependent.

Methyl supplemented diet reduces liver pathology in lupus-prone MRL/lpr mice.

Methyl supplemented diet reduces liver pathology in lupus-prone MRL/lpr mice.

Quantitative assessment of brain metabolism in mice using non-contrast MRI at 11.7T.

Quantitative assessment of brain metabolism in mice using non-contrast MRI at 11.7T.

Potential of recombinant CAV1-Fc in the treatment of ApxI toxin-induced damage by Actinobacillus pleuropneumoniae.

Potential of recombinant CAV1-Fc in the treatment of ApxI toxin-induced damage by Actinobacillus pleuropneumoniae.

Spectrum of kidney pathological patterns and association with clinical characteristics in patients with increased serum creatinine in a single Chinese centre.

Spectrum of kidney pathological patterns and association with clinical characteristics in patients with increased serum creatinine in a single Chinese centre.

Repeatability of radiomic features from brain T1-W MRI after image intensity normalization: Implications for longitudinal studies on structural neurodegeneration.

Repeatability of radiomic features from brain T1-W MRI after image intensity normalization: Implications for longitudinal studies on structural neurodegeneration.

Fudosteine attenuates lung inflammation in mice with PM2.5-induced asthma exacerbation by inhibiting pyroptosis via the NLRP3/caspase-1/GSDMD pathway.

Fudosteine attenuates lung inflammation in mice with PM2.5-induced asthma exacerbation by inhibiting pyroptosis via the NLRP3/caspase-1/GSDMD pathway.

Ivabradine ameliorates doxorubicin-induced cardiotoxicity through improving mitochondrial function and cardiac calcium homeostasis.

Ivabradine ameliorates doxorubicin-induced cardiotoxicity through improving mitochondrial function and cardiac calcium homeostasis.

Age-related differences in locus coeruleus intensity across a demographically diverse sample.

Age-related differences in locus coeruleus intensity across a demographically diverse sample.

Potential roles of inhalation aromatherapy on stress-induced depression by inhibiting inflammation in the peripheral olfactory system.

Potential roles of inhalation aromatherapy on stress-induced depression by inhibiting inflammation in the peripheral olfactory system.

Therapeutic effects of Carissa edulis aqueous extract against L-glutamic acid-induced neurotoxicity in brain mice.

Therapeutic effects of Carissa edulis aqueous extract against L-glutamic acid-induced neurotoxicity in brain mice.

Molecular structure and protein function of mitochondrial fusion protein Mfn2 alleviate Alzheimer's disease: exercise assisted regulation.

Molecular structure and protein function of mitochondrial fusion protein Mfn2 alleviate Alzheimer's disease: exercise assisted regulation.