Nuclear fragmentation generates a diverse dosimetric environment in the path of 12C ion beams. Concise parametrization of the beam's composition is paramount for determining key correction factors in clinical dosimetry. This study sets out to provide such a parametrization based on detailed Monte Carlo simulations of clinically relevant 12C beams. Special attention was paid to the products of nuclear fragmentations and their importance in determining the stopping power ratios. Using the Monte Carlo simulation package GATE, the spectral fluence of all primary and secondary particles in water were computed at different depths for selected clinically relevant incident energies. Collision-stopping power data was taken from the ICRU90, SRIM and MSTAR database, as well as from previous publications. The choice of stopping power data was shown to have a bigger impact on the resulting stopping power ratio than the choice of physics lists for the simulations. A comprehensive analysis of the relationship between fragmentation and dosimetric data has been provided. This study compared different methods for determining spectral fluence-based stopping power ratios, which is essential for accurate ion beam dosimetry.
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