From code to cancer: CircRNAs and lncRNAs regulate kinesin functions in tumorigenesis.

Introduction: The oral cavity is the second largest microbial niche in the human body, following the gut. The colonisation of microorganisms on the teeth and gums harbours harmful bacteria, which can trigger inflammation, potentially leading to periodontal breakdown and tooth loss. To eliminate bacterial biofilms, several methods are employed. Among these, the most effective are chemical methods, which include antiseptic and antimicrobial agents. Although these agents can have potential benefits, they also come with side-effects. To minimise the sideeffects of chemical-based plaque control, there is a paradigm shift towards herbal alternatives. One such plant known for its medicinal properties is Commiphora myrrha, which possesses antimicrobial properties that improve plaque control. Aim: To assess the efficacy of Commiphora myrrha in the management of gingivitis. Materials and Methods: A comprehensive search was conducted using Medline via PubMed, Cochrane, ProQuest and Google Scholar. The combination of keywords used was: Myrrh OR Commiphora myrrha OR Herbal extract AND Gingivitis AND Plaque AND Inflammation, Myrrh AND Commiphora myrrha AND Gingivitis. Articles published from January 1, 2014, to December 31, 2024, were included to identify the efficacy of Commiphora myrrha in the management of gingivitis. After a thorough search, a total of five articles were included in the review. The inclusion criteria were: patients aged between 18-35 years, signs of chronic gingivitis in at least six sites, Bleeding on Probing (BOP) and periodontal pockets with a depth of no more than 3 mm. Exclusion criteria included patients with periodontal pockets greater than 3 mm, those with severe malocclusion, use of antibiotic or anti-inflammatory medication, pregnant or breastfeeding women, oral prophylaxis in the past six months, a history of allergy to chemical or herbal products and patients using smoking or smokeless tobacco. The reporting of this systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The quality assessment of the studies was performed using the Cochrane risk of bias assessment tool for Randomised Controlled Trials (RCT), the Risk of Bias in Non randomised Studies (ROBINS) tool for non randomised trials and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. Results: A total of five studies were included (four randomised and one non randomised controlled trial), comprising 166 patients who met the inclusion criteria. One of these studies was conducted in India, three in the Kingdom of Saudi Arabia and one in Egypt. Diagnoses in all five studies were based on clinical and histological examination. The p-values of the included studies were as follows: p<0.006, p<0.05, p=0.08, p<0.001 and Zahid p>0.05. All five studies found Commiphora myrrha to be effective in reducing gingival inflammation, with results comparable to chemical plaque control and minimal side-effects. Therefore, Commiphora myrrha shows promise as an effective adjunct therapy for managing gingivitis. Conclusion: The present systematic review demonstrates that Commiphora myrrha exhibits significant anti-inflammatory properties. When used in combination with other oral healthcare regimens, Commiphora myrrha could offer beneficial effects in improving overall oral health and managing gingivitis.

A decade of progress and paradigm shifts in osteoporosis therapeutics: A bibliometric analysis.

A paradigm shift from penetration: Material-based solutions for multidimensional spatiotemporal, hypoxic, and optical challenges in cutaneous photodynamic therapy.

Paradigm shift in water-energy nexus: Cognitive reconstruction and methodological innovation from resource dependency to system coupling

Unmasking the role of tumor microenvironment in the advanced stage of cancer treatment to mitigate risks during chemotherapy.

Evolving surgical strategies for management of genitourinary fistula repair over 25 years: Insights from a paradigm shift.

Colorimetric detection of kasugamycin via silver oxide nanoparticles with intrinsic laccase activity.

Tgfbr2 deficiency promotes mitochondrial dysfunction of vascular smooth muscle cells in thoracic aortic aneurysms and dissections.

Ammonia inhibition in anaerobic digestion: A critical review of inhibition mechanisms and mitigation strategies.

Trastuzumab deruxtecan in non-breast solid tumors: Expanding indications, efficacy, and future directions.

Ferroptosis-driven cryoinjury in porcine testicular tissue: Mechanisms, antioxidant-based cryoprotection, and translational strategies for fertility preservation.

ATR inhibitors: from targeting the DNA damage response to exploiting synthetic lethality-A paradigm shift in Cancer therapy.

Calibration-free ion-selective electrodes: A critical review of design strategies, materials, and applications in sensing.

Deep learning for psychiatric genomics: from tools to applications.

Recent evidence highlights a fundamental link between masticatory function and brain health. Once regarded solely as a peripheral motor activity for food processing and occlusal balance, mastication is now recognized as a key factor in maintaining and enhancing cognitive function across the lifespan. This narrative review was conducted using relevant keywords through searches in PubMed, Scopus, and Web of Science, as well as manual searching of the bibliographies of journal articles. Basic research has shown that chewing stimulates neurogenesis in the hippocampus, resulting in increased neuronal and synaptic density, as well as the upregulation of brain-derived neurotrophic factor (BDNF), which leads to improvements in memory and cognition. This effect has been documented in both animal and clinical research, particularly among the elderly, and is supported by data from national health programs, which indicate that adequate prosthodontic rehabilitation can help preserve cognitive function. Etiopathogenetic insights suggest that loss of posterior teeth, rather than overall tooth count, is particularly detrimental, as these teeth are essential for effective mastication. Proposed mechanisms involve exercise-induced myokines, such as Cathepsin B, and chewing-induced neprilysin production, which may mediate hippocampal neuroprotection. Collectively, these findings support a paradigm shift: mastication should be promoted as a preventive strategy for both oral and neural health. Public health efforts and clinical practices should integrate education on maintaining posterior dentition, promoting diets with adequate texture, and supporting prosthetic rehabilitation to sustain neuromuscular activity, thereby protecting cognitive function from early development through old age.

Bridging the translational gap in HNSCC immunotherapy: From resistance mechanisms to high-fidelity preclinical models.

Neoadjuvant Radiation is Causally Linked to Increased Operative Time and Perioperative Blood Transfusion in Pancreatic Ductal Adenocarcinoma.

The gut microbiota in Salmonella Typhi infection and translocation: Mechanisms of colonization resistance, pathogen subversion, and prospects for microecological intervention.

Anorexia nervosa (AN) in adolescents is a severe disorder with complex aetiology. The role of childhood maltreatment (CM) in the development and course of AN remains unclear. The study aimed to analyse the co-occurrence of CM with the severity of psychopathology in patients with AN and to assess their relationship with the dynamics of clinical improvement. The study included only girls under 18 years of age: 39 patients hospitalised for the first time with a diagnosis of AN and 43 healthy participants from the control group (CG). Questionnaires were used to assess trauma (CTQ), symptoms of depression (BDI), anxiety (STAI), eating disorders (EAT), impulsivity (BIS), self-harm (NSSI), and suicidal behaviour (SB). The analysis did not reveal any statistically significant differences between the AN and control groups in overall frequency or specific CM subtypes. Despite no differences in trauma exposure, the clinical group showed a significant co-occurrence of emotional abuse with higher levels of self-destructive behaviour and anxiety as a trait, while emotional neglect correlated with anxiety as a state. Notably, the presence of reported trauma did not differentiate patients in terms of response to hospital treatment or rate of symptom reduction. In the sample of adolescent girls studied, the mere occurrence of reported trauma was not a factor differentiating patients with AN from healthy peers, nor was it a negative predictor of early hospital treatment outcomes. These results suggest that although specific forms of emotional abuse may co-occur with a more severe psychopathological picture (anxiety, self-destruction), childhood maltreatment does not necessarily constitute a direct obstacle to symptomatic improvement during the first hospitalisation.