<p><strong>Background:</strong> Mexico is the third producer and the first exporter of papaya in the world. The crop has multiple phytosanitary limitations, among which anthracnose stands out, which can cause substantial production losses. The main management method is with chemical synthesis fungicides. <strong>Objective:</strong> To evaluate treatments with biorational characteristics to control anthracnose in papaya crops in pre- and post-harvest. <strong>Methodology:</strong> The causal agent of anthracnose was isolated and identified, the growth inhibitory effect of<em> </em><em>C. gloeosporioides</em><em> </em>was evaluated <em>in vitro</em> with extracts of <em>Datura stramonium</em>, <em>Argemone mexicana</em>, <em>Citrus sinensis</em> essential oil and <em>Eucalyptus globulus</em> essential oil; In addition, biorational treatments were applied pre- and post-harvest (botanical extracts, essential oils and <em>Trichoderma harzianum</em>); The incidence and severity were evaluated and the percentage of efficacy was calculated. A randomized complete block design was used and analysis of variances and comparisons of means were performed (Tukey, P ≤ 0.05). <strong>Results:</strong> The <em>E. globulus</em> oil extract reached the highest in vitro growth inhibition levels, followed by the <em>C. sinensis</em> essential oil and the <em>A.</em><em> mexicana</em> extract; In the field phase, <em>T. harzianum</em> reached 80.7% efficacy and 8% incidence, the essential oil of <em>E. globulus</em> and the essential oil of <em>C. sinensis</em> reached 73 and 66% efficacy, respectively. The effect of the treatments applied in pre-harvest demonstrated that successive applications of <em>T. harzianum</em> reduced severity by 81% and incidence on papaya fruits by 30%, the essential oil of <em>E. globulus</em> and that of <em>C. sinensis</em> achieved efficacy of 64 and 68%, in their order. Finally, in the storage phase, <em>T. harzianum</em> achieved a control efficiency of 89%, <em>C. sinensis</em> oil 84% and 85% for the essential oil of <em>E. globulus</em>, <em>A. mexicana</em> managed to inhibit 76.46%. <strong>Implications:</strong> Comparison of other biorational management treatments such as the use of essential elements (silicon, sulfur, etc.), nanotechnology, UV irradiation and resistance inducers is suggested. <strong>Conclusion:</strong> These results support that a successful and biorational control of anthracnose in papaya must be based on comprehensive management that considered the preharvest and storage phases.</p>