Palmar Skin Conductance Research Articles

Changes in autonomic tone during delirium in acute stroke patients assessed by pupillometry and skin conductance

Delirium is a common complication in acute ischemic stroke, possibly caused by alterations in the regulation of the sympathetic autonomic nervous system. We investigated whether such an association could be demonstrated with two easy-to-use measurement techniques: Measurement of palmar skin conductance level (SCL) and pupillometry measuring the dilation velocity in the pupillary light reflex (PLRdil.vel.).The cohort study included 64 patients admitted with acute ischemic stroke. During the study period (median 4.1 days, interquartile range 2.1 days) patients were assessed for delirium once daily as well as with measurements of SCL and PLRdil.vel up to twice daily. SCL and PLRdil.vel. during delirium were lower than without delirium present. For SCL the unadjusted difference was −40.8% (95% CI (−55.1 to −22.0), P value <.001) and for PLRdil.vel the unadjusted difference was −0.22 mm/s (95% CI (−0.42 to −0.01), P value = .041). The results demonstrate changes in sympathetic autonomic nervous system regulation during delirium in acute stroke patients.

Palmar skin conductance variability and the relation to stimulation, pain and the motor activity assessment scale in intensive care unit patients

IntroductionMany intensive care unit (ICU) patients describe pain and other adverse feelings that may impact long-term psychological morbidity. Sympathetically mediated palmar skin conductance variability is related to emotionally induced perspiration and correlates with pain levels in the perioperative setting but has not been studied in ICU patients.MethodsTwenty non-intubated and 20 intubated general ICU patients were included in this observational study. Patients were monitored with the MED-STORM Pain Monitoring System®. The number of skin conductance fluctuations per second (NSCF) was measured in parallel with bedside observation during one hour of intensive care, including rest, procedures and patient-staff interactions. Arousal-agitation level was monitored with the motor activity assessment scale (MAAS). Pain was monitored with the numeric rating scale (0 to 10) in patients able to communicate or by observation in patients unable to communicate.ResultsIn non-intubated patients, NSCF increased with increasing stimulation/pain but also with higher MAAS (P = 0.002). An interaction effect was found, with increased NSCF response to stimulation/pain with increasing MAAS (P < 0.001).In intubated patients, NSCF increased significantly with increasing stimulation/pain (P < 0.001). In contrast to non-intubated patients, no difference in NSCF between MAAS levels was found for any given degree of stimulation in intubated patients.ConclusionsIn critically ill patients, NSCF may be more useful evaluating emotional distress rather than pain alone. It needs to be assessed whether NSCF monitoring is clinically useful and whether controlling emotional distress with the aid of such monitoring may impact on patient care and outcomes.

Early recognition of hypohidrotic ectodermal dysplasia

Hypohidrotic ectodermal dysplasia (HED) is characterized by severe hypohidrosis, hypoplasia of sweat, sebaceous, submucous, meibomian and mammary glands, hypotrichosis, and oligodontia. In early childhood, HED is a life-threatening disorder based on the risks for hyperthermia and pneumonia. Awareness of the hazards related to this rare genetic disease is most helpful in preventing avoidable calamities. Prognosis therefore depends on the time point of diagnosis. Typical facial features (frontal bossing, sparse eyebrows and eyelashes, wrinkling and hyperpigmentation of the periorbital skin, saddle nose, everted lips, hypoplastic mandible) may allow immediate postnatal recognition of HED, if the disease is known to the family or the doctor. Molecular analysis of one or more of the 4 candidate genes EDA, EDAR, EDARADD and NEMO can then be arranged to make a definitive diagnosis. Infants with HED may also be identified by their inability to sweat. A survey conducted among parents of 100 children with ectodermal dysplasia registered with the German-Swiss-Austrian patient support group revealed that almost all parents had observed episodes of unexplained fever during the first year of life. If infants had to be placed in an incubator after birth, body temperature recording proved to be of utmost importance and often allowed early clinical diagnosis of HED. Furthermore, recent studies of our group confirmed a consistent, quantifiable defect of sweat gland function in male individuals with HED as a disease biomarker. Pilocarpine-induced sweat volume, palmar or plantar sweat duct density and skin conductance before and after stimulation were determined also in newborn infants. Genotype-phenotype correlation was seen across all measurements of sweat gland function, but, surprisingly, not with respect to the number of sweat glands (which can be determined very soon after birth) and the degree of oligodontia (diagnosable already by prenatal ultrasonography). This is important, since such easily recognizable signs obviously do not allow prediction of the risk of hyperthermia and the associated morbidity and mortality in HED patients.

Emotional sweating across the body: Comparing 16 different skin conductance measurement locations

Skin conductance (SC) is one of the most commonly used measures in psychophysiological studies involving emotional arousal and is traditionally measured at the fingers or the palms (i.e., the palmar locations) of the hand. Palmar skin conductance recording positions are, however, not always preferred for ambulatory recordings in real-life situations. This study quantifies the responsiveness and similarity with the finger of 16 different recording positions of skin conductance while watching emotional film fragments. Findings indicated foot, fingers and shoulders being most responsive, whereas arm, back, armpit, and thighbone were least responsive. The measurements at the foot were most similar with those of the finger. In contrast, arm, back, and armpit traces differed most from the finger trace. Taken together, foot and shoulders are the best alternatives to the finger for ambulatory measurement of skin conductance to reflect emotional arousal. These findings can help new applications using skin conductance, like automated emotion measurements, to come to fruition.

Sweating ability and genotype in individuals with X-linked hypohidrotic ectodermal dysplasia

BackgroundX-linked hypohidrotic ectodermal dysplasia (XLHED), the most common type of ectodermal dysplasia, is caused by EDA gene mutations. Reduced sweating contributes substantially to XLHED associated morbidity and mortality. To characterise...

Dual temperamental risk factors for psychopathic personality: Evidence from self-report and skin conductance.

Psychopathy is a personality disorder consisting of dysfunctional affective interpersonal features (Factor 1) and impulsive-antisocial behavior (Factor 2) that exhibit differential associations with palmar skin conductance (SC) reactivity. The goal of this study was to determine whether the distinct SC reactivity observed in incarcerated psychopaths generalizes to university students who score high on personality dimensions hypothesized to be the risk factors for these psychopathy factors. Lilienfeld's Psychopathic Personality Inventory (PPI; Lilienfeld & Andrews, 1996) was used to compute scores on 2 factor-analytically derived dimensions that have been the focus of recent research in psychopathy. PPI-1 is hypothesized to relate to the low-fear temperamental risk factor, whereas PPI-2 is hypothesized to relate to regulatory dysfunction. SC reactivity was measured during tasks previously used in studies of diagnosed psychopaths. Results indicated that PPI-1 was associated with reduced SC during anticipation of an aversive noise and PPI-2 was associated with enhanced SC reactivity during presentation of a speech about one's faults. Additional analyses explored an 8-factor solution of the PPI and 3 temperament dimensions derived from factor analysis of several personality measures. Together, the SC results suggest that the Factor 1 pathway, best captured with refined assessments of behavioral fearlessness, related to reduced SC reactivity to an aversive noise-consistent with a weak defense system. The Factor 2 pathway, best captured by higher order dimensions reflecting externalizing, disinhibited forms of negative temperament, related to enhanced SC reactivity to a speech stressor-consistent with high stress reactivity.

Prospective study of lactational vasomotor instability episodes (VIE) with palmar skin conductance validation

Prospective study of lactational vasomotor instability episodes (VIE) with palmar skin conductance validation

Effects of synthetic conjugated estrogens A on sleep quality in postmenopausal women with nocturnal diaphoresis and/or hot flushes: a pilot study

In a single-center, double-blind, placebo-controlled pilot study, patients who received 0.625 mg daily of synthetic conjugated estrogens A experienced a statistically significant reduction in the average number of hot flushes and galvanic skin responses. The polysomnographic change in sleep measures did not reach statistical significance, but the data suggest an overall improvement in sleep quality in the treatment group.

Palmar skin conductance compared to a developed stress score and to noxious and awakening stimuli on patients in anaesthesia

The number of fluctuations in the skin conductance per s (NFSC) as a measure of the sympathetic nervous system may be a tool for monitoring physiological stress during surgery and general anaesthesia. The purpose of this study was to find the sensitivity and specificity of the NFSC when compared to a peroperative clinical stress score. Moreover, different patterns of skin conductance responses were compared with the BIS score to find out if the mean level of skin conductance (SC) and NFSC monitoring could differentiate between awakening and noxious stimuli. Fourteen patients were studied during stressful or non-stressful registration periods. During each registration period, the NFSC was compared to a five-point clinical stress score (CSS) (systolic blood pressure >130 mmHg, cough, tears, EMG in the forehead >50 or movements) and BIS score. The NFSC and the CSS both indicated physiological stress at 12 registrations and no stress at 186 registrations. The NFSC indicated physiological stress without signs of clinical stress (CSS = 0) in 28 registrations, whereas signs of clinical stress (CSS > 0) were indicated on two occasions without signs of stress in the NFSC. The sensitivity of the NFSC when compared to the CSS was 86% and the specificity was 86%. Moreover, in all situations (n = 16) where NFSC indicated stress and the BIS score >50, the SC increased. This was different from situations (n = 13) where NFSC indicated stress and the BIS score <50, then the SC did not increase (P < 0.001). The NFSC is sensitive to clinical stress during surgical stimulation. Moreover, the combined use of SC and NFSC may have a potential to differentiate between situations of stress due to inadequate hypnotic effect vs. inadequate analgesic effect.

Palmar skin conductance compared to a developed stress score and to noxious and awakeness stimuli on patients in anaesthesia to study the sensitivity and specificity of skin conductance

Palmar skin conductance compared to a developed stress score and to noxious and awakeness stimuli on patients in anaesthesia to study the sensitivity and specificity of skin conductance

Context-dependent effects of steroid chemosignals on human physiology and mood

We examined the physiological and psychological effects of nanomolar amounts of steroids applied directly under the nose (Δ4,16-androstadien-3-one and 1,3,5,(10),16-estratetraen-3-ol). These potential human chemosignals were not consciously discernible in a strong-odor carrier (clove oil and propylene glycol). In a double-blind, within-subject, repeated-measures experiment with 65 subjects, we demonstrated that both steroids produced sustained changes in digit skin temperature and palmar skin conductance (an indicator of sympathetic nervous system tone) while the subjects were completing psychological questionnaires or reading. These effects, however, did not follow the sex-stereotyped pattern predicted by a sex attractant function. Both androstadienone and estratetraenol raised the skin temperature of men's hands and lowered it in women. Likewise, each steroid increased skin conductance, with a significantly greater effect on women than men. Women's responses were observed only in the sessions run by the male tester, an effect that may or may not be solely attributable to tester sex. Men's responses, in contrast, were not affected by this difference in socioexperimental condition. Similarly, women experienced an immediate increase in positive mood only in the presence of the male tester, while men's responses were unaffected by this socioexperimental context. One source of this sex difference may be the fact that the majority of women were in the late follicular phase of their menstrual cycle. Although it is premature to classify these steroids as pheromones, our data suggest that they function as chemosignals that modulate autonomic nervous system tone as well as psychological state.

The development of a software program for analyzing skin conductance changes in preterm infants

Objectives: Changes in palmar and plantar skin conductance (SC) are due to outgoing bursts in the postganglionic efferent sympathetic cholinergic fibres, which respond to changes in the central arousal state. An apparatus that measures SC by applying an alternating voltage is sensitive enough to measure SC changes in preterm infants. The purpose of this study was to develop a software program for analyzing SC in premature infants. Methods: The software program was designed to calculate the number and mean amplitude of the waves and the mean SC changes during a given period. Different pre-set values for minimum amplitude, maximum slope and minimum width of the waves were used in the program and the results were compared with manually counted waves. Results: For SC waves, the optimal minimum amplitude was found to be 0.015 μS, the maximum slope of the waves could, with the same result, be 1, 2 or 5 μS/s and the optimal width of the waves was found to be unlimited. Conclusions: SC in preterm infants is easily analyzed by this software program.

The development of a software program for analyzing spontaneous and externally elicited skin conductance changes in infants and adults

Objectives: Changes in palmar and plantar skin conductance (SC) are due to outgoing bursts in the postganglionic efferent sympathetic cholinergic fibres, which responds to changes in central arousal state. The purpose of this study was designed to develop a software program for analyzing spontaneous and external elicited SC changes for infants and adults.Methods: The program was designed to calculate the number and mean amplitude of the waves as well as the mean basal level in a given period. Different pre-set values for the minimum amplitude, maximum slope and minimum width of the spontaneous waves were used in the analysis program, and the results were compared with manually counted waves. The program was also used to perform coherent averaging of repeated elicited SC changes. For the mean elicited skin conductance responses, the latency time, response amplitude and recovery time were calculated. The habituation pattern could be calculated semi-automatically by analyzing each response.Results: For SC waves, the minimum amplitude and the maximum slope should be, respectively, 0.02 microsiemens (μS) and 2 μS/s for infants and adults, and the width of the waves should be at least 1 s for adults, and unlimited for infants. The coherent average method was found to be a satisfactory method for revealing whether a subject responded to stimuli, and is recommended, especially for infants.Conclusions: Spontaneous and stimulated skin conductance are easily analyzed by this software program.

Psychology of Computer Use: XLII. Problem Solving and Humor as a Function of Computer Anxiety

From a pool of 115 undergraduate women, 20 were placed in a Computer-anxious group and 20 in a Computer-nonanxious group based on their scores on the Computer Anxiety Scale. Half of the subjects were randomly assigned to a group to which the computer presented the problems first and half to a group to whom the computer presented the jokes first. Electromyograms from subjects' zygomatic muscles were monitored as well as palmar skin conductance. Behavioral measures were collected prior to and following the computer interaction. Although the electromyogram for zygomatic tension (smiles) was higher in the jokes condition, indicating that subjects responded to jokes as humorous, Computer-anxious subjects showed increased scores on anxiety and depression and relatively high skin conductance on the initial joke. Subjects with high computer-anxiety had less experience with computers, had lower scores on the Rosenberg Self-esteem test, and, likely not being familiar with computer humor, reacted anxiously.

PSYCHOLOGY OF COMPUTER USE: XLII. PROBLEM SOLVING AND HUMOR AS A FUNCTION OF COMPUTER ANXIETY

From a pool of 115 undergraduate women, 20 were placed in a Computer-anxious group and 20 in a Computer-nonanxious group based on their scores on the Computer Anxiety Scale. Half of the subjects were randomly assigned to a group to which the computer presented the problems first and half to a group to whom the computer presented the jokes first. Electromyograms from subjects' zygomatic muscles were monitored as well as palmar skin conductance. Behavioral measures were collected prior to and following the computer interaction. Although the electromyogram for zygomatic tension (smiles) was higher in the jokes condition, indicating that subjects responded to jokes as humorous, Computer-anxious subjects showed increased scores on anxiety and depression and relatively high skin conductance on the initial joke. Subjects with high computer-anxiety had less experience with computers, had lower scores on the Rosenberg Self-esteem test, and, likely not being familiar with computer humor, reacted anxiously.

Measurement of menopausal hot flushes: validation and cross-validation.

Specificity and sensitivity of two physiological markers for hot flushes were investigated. One marker, proposed by Freedman, is an increase of sternal skin conductance, the second marker, proposed by Swartzman, is a physiological profile which consists of skin conductance changes in combination with circulation changes. In our laboratory 20 menopausal women, 15 with frequent hot flushes and 5 without hot flushes, and 5 women with regular menstrual cycles were continuously monitored for 2.5 h on subjective hot flush experience, sternal and palmar skin conductance, dorsal and palmar finger temperature and pulse blood volume. Increase in sternal skin conductance proved to be very specific in contrast to Swartzman's physiological profile, although it was less sensitive. Receiver operating characteristics revealed that an increase combined with a preceding decrease in sternal skin conductance as most specific for, and most sensitive to, subjectively reported hot flushes. This was confirmed by a cross-validation with 34 "flushing' menopausal women.

Habituation of the galvanic skin response in adult males as a function of age

Habituation of the galvanic skin response (GSR) to electric shock was studied in 28 male college students, 18–39 years old. A 60-Hz shock of 244.0-msec duration was presented every 1–3 min above the right ankle in a preprogrammed sequence. The GSR, measured as a change in palmar skin conductance to the shock, was examined over the first 17 shock trials. The habituation curve showed the typical large decrement over the first few trials followed by a smaller one over several more trials. The initial rate of habituation (percent decrement between shock trials 1 and 3) was shown to be age related even though none of the subjects would be considered old (18–39 years old). The younger the subject, the faster the initial habituation or, conversely, the older the subject the slower the rate (r s = −.50, N = 28, p<0.005). The asymptote did not vary with age. That such dramatic changes occur in the CNS of young males over a relatively few years is not unknown. PET studies of the caudate nucleus in normal males showed an exponential decrease in dopamine receptors with about half of the decrease occurring rapidly between the ages of 20 and 30 (Wagner, H. N., Jr. Diag. Imaging Nov.:138–145; 1985). The usefulness of the GSR in detecting age effects in other kinds of learning, such as Pavlovian conditioning, is being explored, as well as its usefulness in detecting early learning/memory loss in aging and the dementias.

Components of type A behavior and task-induced cardiovascular activation.

The present study sought to determine whether there are subcomponents of the Type A behavior pattern that are more closely related to cardiovascular reactivity than others. The components studied were factor analytically derived subscales of the Jenkins Activity Survey denoting Irritation and Impatience, on the one hand, and Hard-Driving and Competitive, on the other. Heart rate, pulse transit time, forearm electromyography, and palmar skin conductance were measured while the subjects performed a continuous perceptual motor task, as well as during baselines before and after the task. The Irritation and Impatience dimension was consistently related to task-induced changes in heart rate, both in regression analyses and in extreme group analyses of variance. A significant relation was also observed for pulse transit time but not for electromyography. The Hard-Driving and Competitive dimension, on the other hand, was not related to any psychophysiological measures. These results were interpreted to mean that Irritable and Impatient subjects showed a cardiovascular reaction pattern indicative of active coping processes during task performance.

Chronic schizophrenic disorder. I. Psychophysiological responses, laterality and social stress.

Bilateral palmar skin conductance and heart rate were measured throughout a series of psychological tests and during both sitting and ambulant social interactions in 14 right-handed men with chronic schizophrenic disorder and 12 healthy volunteers matched for age and handedness. Miniature radio telemetry equipment was used to collect the physiological data. The schizophrenic group was effectively unresponsive to 70-dB auditory stimuli, while all but one of the control group responded and habituated to a nil response by the tenth tone in sequence. The schizophrenic group showed some evidence of increased skin conductance activity at rest, and in socially demanding conditions skin conductance level and variability were increased in the right hand. The present group of electrodermal 'non-responders' was not in general autonomically under-active. Asymmetry of skin conductance activity during social interaction may be a characteristic of chronic schizophrenic disorder.

The relationship between induced emotional arousal and amnesia.

An experiment was conducted to test a hypothesis emanating from a similarity in data pattern between studies on amnesia and studies on the effects of arousal on memory. The hypothesis was that arousal and amnesia might be related, or more precisely, that amnesia induced in the laboratory might be mediated by high levels of arousal. Subjects in this experiment were presented with a thematic, short story in pictorial form. One version of the story consisted of a traumatic, arousal‐inducing event placed between neutral events. A second version of the story contained the same neutral events in the beginning and the end, but also a neutral event in the middle. Palmar skin conductance, heart rate, and subjective self‐ratings were used to determine that the manipulation made had caused different degrees of emotional arousal for the two groups of subjects presented with the different versions of the story. The methods used to determine memory performance were recall and recognition. The data obtained indicate that amnesia induced in the laboratory is mediated by emotional arousal in terms of concepts of attention and reconstruction.