Background/Objectives: Genetic abnormalities are critical for the diagnosis, prognosis, and therapeutic management of myelodysplastic syndromes (MDS). This study aims to evaluate the clinical utility of Multiplex Ligation-dependent Probe Amplification (MLPA) as a rapid and cost-effective method, determining its place alongside Next-Generation Sequencing (NGS) for the initial genetic assessment of patients with MDS. Methods: Bone marrow samples from 68 patients newly diagnosed with MDS were analyzed. Genomic DNA was investigated using the SALSA MLPA P414-C1 MDS probe mix to detect common copy number variations (CNVs). Results: MLPA detected genetic variants in 25 patients (36.8%). The most common finding was a single chromosomal abnormality (26.5%). Multiple pathological findings were observed in only 1.5% of patients, and a JAK2 mutation was observed in 8.8% of the cohort. However, the presence of these aberrations did not show a statistically significant association with overall survival (OS) in the cohort. Patient sex was identified as the only variable that was associated with a marginal level of statistical significance regarding OS, indicating a worse prognosis for males. Conclusions: MLPA is a valuable, rapid, and cost-effective tool for initial genetic screening in low-resource settings. This was highlighted by our finding that sex was the sole significant prognostic factor, while the MLPA-detected variants were not found to be significant. The findings suggest that comprehensive risk stratification aligned with international standards requires more advanced molecular technologies.

Studies have found that parental care is closely associated with child self-control. In addition to parents, grandparents are also important family members and play a critical role in child development. Many studies have explored the associations between grandparental care and child self-control, especially in the Chinese context. However, the existing findings are inconsistent. To take stock of the literature, this study aimed to synthesize the associations between the quantity (defined as the extent to which grandparents are involved in child rearing) and quality (defined as the quality of grandparenting behavior and coparenting relationships between grandparents and parents) of grandparental care and Chinese children's self-control. Twenty-two studies with 75 effect sizes were included (N = 30,822). Regarding the quantity of grandparental care, the more grandparents were involved in child rearing, the poorer self-control the child had (Hedge's g = -0.376, p = .002). As for the quality of grandparental care, positive grandparenting behavior was linked to children's better self-control at a marginal significance level (r = .426, p = .079). Positive coparenting relationships between grandparents and parents were significantly linked to children's better self-control (r = .220, p < .001). These findings are largely invariant across child gender, child age, study design, and the quality of article. Theoretically, this study broadens our understanding of the ecological underpinnings of child self-control. Practically, the findings underscore the importance of improving grandparents' positive rearing behavior and forging harmonious coparenting relationships between grandparents and parents to nurture Chinese children's self-control. (PsycInfo Database Record (c) 2025 APA, all rights reserved).

Business organization including banks in Africa has involved risk management committee practice due to poor credit risk management. Consequently, studies in the past have explored risk management committee variable to examine credit risk exposure of banks. However, this research observed that a comparative approach between countries in Africa has not been adequately examined on the effect of risk management committee on credit risk exposure of banks. Hence, this research filled this gap and did a comparative analysis between Nigeria, Ghana, and South Africa on the effect of risk management committee (RMC) on credit risk exposure (CRE) of banks. This research covered a period of ten (10) years spanning from 2014 to 2023 and data were collected from the published financial statements of a sample size of fifteen (15) banks, five (5) banks from each of the countries, Nigeria, Ghana and South Africa. The data were analysed using ordinary least square regression and results were interpreted based on F-Statistics, P-Value (PV) and R-Square (R2). The finding revealed that RMC has negative and significant effect on CRE of banks in Nigeria, Ghana and South Africa. The finding further revealed that there is greater significant effect of RMC on CRE of banks in Nigeria (R2 = 63%) than South Africa (R2 = 55%) and Ghana (R2 = 47%), implying that banks in Nigeria has greater CRE as a result of increase in RMC, followed by South Africa and Ghana. Hence, this research concluded that the implementation of RMC is an important strategic management tool to reduce CRE of banks in Nigeria, Ghana and South Africa. This research recommends that, the banking regulatory bodies in Nigeria, Ghana and South Africa should strictly enforce that banks totally implement the adoption of RMC in line with the corporate governance codes on the number of RMC because this will significantly reduce CRE of the banks.

31 vs 35 mm: a randomized comparison of the pentaspline pulsed field ablation catheter sizes

To assess the level of metabolic antioxidant-uric acid in obese individuals. ​Obesity is the major health problem worldwide. This condition leads to the development of or causative factors for the many other disease conditions like cardiovascular disease, chronic renal failure, diabetes mellitus and so on. Many metabolic products are synthesized in this condition may prevent or proceed with the disease condition. So, the current study aimed to assess the one of the metabolic product- uric acid level in obese individuals. 20 age and sex-matched healthy individuals with BMI (19.9-24.9), 20obese individuals were selected from those attending the outpatient department of Saveetha Dental College, and hospitals. Informed consent was obtained from the patients before sample collection. 5 ml of venous blood was collected in plain collection tubes and centrifuged in3000rpm. Then serum was separated and analyzed to estimate the Serum Uric acid by Uricase method using ERBA CHEM 5 plus analyzer. Mean BMI and Uric acid level of the control group were 21.89±1.87 and 3.57±0.9respectively. Mean BMI and Uric acid level of the study group were 37.13±5.13 and 6.0±1.28. There is a significant difference between these two groups with the p-value of 0.0001. The data of the present study suggested uric acid level was increased in obese individuals.

Objective: The Christian Orthodox Church (COC) fasting is a periodic vegetarian-type diet lasting 180–200 days annually in which seafood and snails are allowed on all fasting days. Our aim was to investigate the effects of COC fasting on metabolic syndrome (MetS) in adults >50 years. Methods: One hundred seventy-six individuals participated in the study (mean age 59.7 ± 6.0 years). Eighty-nine had been following the COC fasting regime since their childhood and eighty-seven were non-fasters. Anthropometric measurements, blood samples, and nutrient intake data were collected at a scheduled appointment, during a non-fasting period. Results: Fasters had significantly higher hip circumference (102 ± 8.5 vs. 98.8 ± 7.5 cm, p = 0.009), low-density lipoprotein (LDL) cholesterol (136 ± 73 vs. 115 ± 51 mg/dL, p = 0.033), and folic acid levels (6.0 ± 4.0 vs. 3.0 ± 1.2 ng/mL, p = 0.018), as well as lower systolic blood pressure (SBP) (131 ± 13 vs. 136 ± 14 mmHg, p = 0.045), diastolic blood pressure (DBP) (80 ± 8 vs. 83 ± 7 mmHg, p = 0.007), glucose (87 ± 16 vs. 93 ± 25 mg/dL, p = 0.039), and triglycerides (143 ± 94 vs. 175 ± 84 mg/dL, p = 0.040). Fasters had significantly less intake of calories (1493.65 ± 363.74 vs. 1614.65 ± 426.28 kcal, p = 0.044) and fat (81.17 ± 25.47 vs. 90.74 ± 24.75 g, p = 0.012), whereas they also consumed significantly less vitamin A-retinol, vitamin B2, vitamin B12, vitamin E, folic acid, pantothenic acid, calcium, phosphorus, zinc, and significantly more vitamin C (p < 0.005 for all comparisons). BP was significantly higher in non-fasters (44.8 vs. 22.5%, p = 0.002), whereas MetS was more frequently present in non-fasters vs. fasters, with a marginal level of significance (35.6 vs. 22.5%, p = 0.055). Conclusions: COC fasting may affect beneficially MetS prevalence in individuals >50 years, although future research is needed before reaching definite conclusions.

Abstract Background and Aims The use of GLP-1 receptor agonist (ra) has become one of the cornerstones for CKD type 2 diabetic patients (T2DM) treatment. Oral formulation of semaglutide appeared as new therapeutical tool to increase the use of drugs with proved renal benefit. However, method of administration of the oral formulation and oral absorption limitations in CKD patients could adversely affect drug efficacy. The aim of this study was to compare the efficacy of semaglutide sbc vs oral in CKD patients Method Prospective, real-world study performed in T2DM-CKD patients with indication of initiation of GLP-1ra therapy in which semaglutide sbc or oral was initiated. Patients were assigned to sbc or oral formulation according to drug accessibility and patient preferences. Patients previously treated with any other GLP-1ra were excluded. Results 70 patients were included, 50 with sbc and 20 with oral semaglutide with mean follow up time of 407 [180-753] and 154 [75.5-205] days respectively (mean, IQR) Basal characteristic of the patients are shown in the table. More male patients were included but age eGFR and UACR showed no significant differences between groups. 80% and 50% of the patients were on maximum semaglutide dose (1.0 mg sbc and 14 mg or respectively) and 12% and 45% were on the low dose (0.25 mg sbc and 3mg or respectively). We observed similar percentage of HbA1C reduction sbc: -6.2% [-10.8 a 0] and oral -6.2% [-11.5 a 0] (p 0.9). Differences on BMI and weight loss were slightly higher on sbc group though non-significant. We observed no significant effects on eGFR or UACr, nor on blood pressure during the observation period. and main side effect was gastrointestinal intolerance, similar in both groups (7 (14%) in subc and 3 (20%) in oral group, pv alue 0.9. Conclusion Oral formulation of semaglutide was equally effective in terms of glucose control and body weight in patients with T2DM and CKD even with more patients on the low-medium doses. Gi side effects were similar with both formulations though the lower number of patients on the higher oral dose does not allow further conclusions.

Religious fasting that involves abstinence from specific food(s) is part of many religions worldwide and has been gaining attention by the research community during the last years. The study aimed to investigate whether the periodic Christian Orthodox fasting mitigates the changes in body composition, dietary intake, and metabolic syndrome (MetS) in postmenopausal women. One hundred and thirty-four postmenopausal women aged 57.3 ± 6.7 years participated in this study. The Christian Orthodox fasting was followed by 68 postmenopausal women since their childhood, whereas 66 postmenopausal women were non-fasters. Data collection involved anthropometric, biochemical, clinical, and dietary information. Postmenopausal women who fasted according to Christian Orthodox Church recommendations had significantly higher mean fat free mass (45 vs. 44 kg, p = 0.002), hip circumference (104 vs. 99 cm, p = 0.001), and diastolic blood pressure (79 vs. 82 mmHg, p = 0.024). No other differences were found with regards to anthropometric data. Fasters also consumed significantly less fat (78 vs. 91 g, p = 0.006), as well as saturated (19 vs. 23 g, p = 0.015), monounsaturated (41 vs. 47 g, p = 0.018), and polyunsaturated fat (8.5 vs. 10 g, p = 0.023), trans fatty acids (0.5 vs. 2.3 g, p = 0.035), and cholesterol (132 vs. 176 g, p = 0.011). In terms of MetS features, non-fasters had more frequently elevated fasting blood glucose (11.8 vs. 24.2%, p = 0.039) and elevated blood pressure (13.2 vs. 36.4%, p = 0.041) compared with fasters. MetS was more common in non-fasters versus fasters with a marginal level of significance (30.3 vs. 23.5%, p = 0.052). Postmenopausal women who follow the Christian Orthodox fasting regime had lower fat intake, and no other difference in nutrient intake, compared with non-fasters. The latter were more likely to have MetS and some of its components. Overall, periodic abstinence from meat, dairy products, and eggs might play a protective role in postmenopausal women with regard to MetS.

This paper is about the generalized proposition of inflation irrelevance. The weak-form version of inflation irrelevance holds that stock prices are independent of inflation rates. The semi-strong form version is that stock prices are independent of both domestic and foreign inflation rates. The strong, or generalized, version is that stock returns are independent of all three rates, domestic and foreign inflation rates, and changes in foreign exchange rates. Overall, the three forms fail to be rejected separately and jointly under conventional marginal significance levels. The conclusion from this paper is that inflation irrelevance, or nominal neutrality, is a common characteristic in the two countries studied, Japan and the United Kingdom. Therefore, the statistical evidence is mounting manifestly, and is pervasive and applies to diverse economies, among which Japan and UK. This regularity amounts to an international stylized empirical fact that cannot be ignored.

It has been two years since the outbreak of Covid 19, and we still live with the pandemic. No one knows when the pandemic will finish and how long it will take until all is back to normal and the global economy fully recovers from the pandemic. Undoubtedly, the Corona crisis has had devastating effects on the global economy. The global GDP decreased by 3.5%, the global FDIs were below $ 1 trillion for the first time in the last 20 years in 2020, falling 35% compared to 2019, and the global trade dropped 5.3% at the same time. The main objective of this paper is to discover the impact of a pandemic on the Turkish economy, or more precisely, on the Turkish GDP growth rate, FDI inflows, and export. To get the most reliable results, a multiple regression analysis has been conducted, using the contemporary economic software EViews 12. World Pandemic Uncertainty Index (WPUI) that was introduced by the International Monetary Fund (IMF) in 2020 was used as a measure of the uncertainty caused by the pandemic. For the robustness of the analysis, World Uncertainty Index (WUI), which measures the overall uncertainty caused by the economic and political factors, was also included. The data about GDP growth rate and export were provided from the World Bank Database, while the data for the FDI inflows from UNCTAD. Different independent variables were used in the research for each dependent variable (GDP growth rate, FDI inflows, and export). The research has shown that Covid 19 pandemic has a significant negative impact on the Turkish GDP growth rate (if we consider a 5% level of significance) and on the Turkish export (if we consider a 10% marginal level of significance). However, the regression analysis has shown that the pandemic has a positive but insignificant impact on FDI inflows to Turkey. The study will be a great benefit for further analysis of the impact of Covid 19 on economies as it is one of the first empirical studies that analyzes the effect of Covid 19 on a specific economy.&#x0D; &#x0D; Received: 16 March 2022 / Accepted: 12 May 2022 / Published: 5 July 2022

Number Of Apheresis Days To Reach Target Stem Cell Dose May Be a Predictor Of Secondary Myelodysplastic Syndrome and Acute Myelogenous Leukemia

What Is The Best Time Sampling For The Two Direct Oral Anticoagulants, Dabigatran and Rivaroxaban?

The objective of this study was to assess the prevalence of diaper rash and identify associated factors with diaper rash among children between 0 and 24 months of age in Adama Ethiopia. A cross-sectional study was conducted with mothers using structured questionaries during face to face interview to assess risk factors associated with diaper rash. Data were analyzed using SPSS version 21 and Chi-square test was used to establish the association between diaper rash and socio-demographic and socio-economic characteristics at p-value <0.05. Multivariate logistic regressions are used to test the significancy of risk factors. About 62.5% (235/376) of children in the study had experienced diaper rash. Multivariate logistic regression analysis revealed that diarrhea (AOR=0.424; 95%CI=0.203-0.902; P=0.032), food types consumed by baby (AOR=0.21; 95%CI=0.050-0.882; P=0.033), use of barrier cream (AOR=0.012; 95%CI: 0.005-0.029; P=0.000) and frequency of diaper change (AOR=3.174; 95% CI=0.068-9.438; P=0.038) were among factors associated with diaper rash. In this study changing diaper frequently, using cream and breast feeding with baby formula milk were identified as a factor that reduce the prevalence of diaper rash whereas diarrhea was identified as a risk factor that aggravate diaper rash. Thus, educating mothers on the importance of breast feeding, use of cream and diaper change is useful. Key words: Diaper rash, prevalence, babies.

The use Dental radiographs has become an integral part of modern clinical dentistry to investigate complaints of patients. This study aimed at determining the level of awareness of dental radiological examination among patients attending dental treatment at the Muhimbili University of Health and Allied Sciences (MUHAS) dental clinic in Dar es salaam, Tanzania. This was a descriptive cross-sectional study, which included patients who underwent radiological examination. A specially designed questionnaire was used to gather information on the demographics and level of awareness of the patients regarding X-ray examination. The data obtained was analyzed using the Statistical Package for Social Science-V23. The association between variables was assessed by the Chi-square test, and p-value was set at p<0.05. A total of 322 participants were included in the study of which 184 (57.1%) were females. The age range of the participants was 18 to 89 years (mean of 37.2 ± 15.2 years). There was a statistically significant association between self-perceived awareness about dental radiographs and level of education, age and previous experience of the participants. Only 39.4% reported to have had some information regarding dental X-rays and among them, in 89%, the source was dental personnel. Only 36% said there was no problem in exposing a pregnant woman to dental X-rays. 92.7% said there is a need of using special protective gear when exposing a pregnant woman to dental X-ray. Generally, there was a low awareness of dental X-ray examination in this group of patients. Key words: Awareness, dental X-ray examination, Muhimbili, Tanzania.

Demographic characteristics consist of age, sex, religion, length of employment, tribe, place of work and level of education. Caring behavior is a form of basic nursing practice that looked with patience, honesty, confidence, presence, touch, affection in implementing nursing actions. The study aims to analyze the comparative between demographic characteristics with caring behavior of nurses in nursing practice in Kumpulan Pane hospitals Tebing Tinggi of North Sumatera 2019. This research type a descriptive comparative with cross sectional approach. Sampling by using stratified random sampling with 75 respondents. The results showed caring behavior nurses consists of either category 25 (32.9%) and a very good 50 (67.1%). Data analysis using Manalysis with One way ANOVA. Demographic characteristics by age and caring behaviors of nurses is p-value 0.965 (p>0.05), practice areas namely p-value 0.066 (p>0.05), religion is p-value 0.135 (p>0.05), tribe is p-value 0.186 (p>0.05), length of work 0.366 p-value (p>0.05). Independent analysis of the comparative test sample demographic characteristics by gender with the nurse caring behaviors, namely p-value 0.312 (p>0.05), education namely p-value 0.336 (p>0.05). Efforts to improve or special coaching ability nurse caring behaviors by providing seminars to nurse twice a year and given a reward in the form of appreciation to those who run the caring in nursing actions

Non-communicable diseases (PTM) were currently a public health problem, one of them was Diabetes Mellitus (DM). DM type 2 one of the common, which is more than 90-95% and the fourth most prevalent PTM in South Sumatera with 4.386 cases. The problem that was often experienced by DM patient was the continued effect of hyperglycemia that caused peripheral neuropathy and could caused foot ulcers to have amputations. The longer a person was DM, more to had complications. The combination of active lower range of motion and heel raise exercise was one of physical exercise carried out by moving the lower extremities so that blood flow could smooth and transported nutrients to the peripheral. This study aimed to find out the effect of combination active lower range of motion and heel raise exercise on the risk of foot ulcer on typed 2 DM patient. This was a pre-experimental design with a one-group pretest-posttest. Intervention carried out for 6 days with a practice in the morning and evening. The samples through purposive sampling method were 16 people. The results before the intervention 43,8%n of respondents moderate risk and after intervention became low risk (75%). Analysis of marginal homogeneity statistical test showed that there was a significant influence on the risk of foot ulcer before and after intervention of combination active lower range of motion and heel raise exercise (p value 0,001), and there was a relation between compliance medication (p= 0,01), smoking status (p= 0,005) on the risk of foot ulcers. To reduce the risk of complications on DM patient, combination active lower range of motion and heel raise exercises could be applied independently to reduce the risk of diabetic foot ulcers.

Background: Depression can influence the treatment of diabetes mellitus, because it causes physiological alterations in the neurochemical and hormonal functions, which could cause hyperglycemic effects. Methods: This systematic review with meta-analysis follows the recommendations of the Cochrane Handbook and Prisma. Inclusion/exclusion criteria that had been previously selected for the sample were adopted by using the MEDLINE/PubMed, LILACS/BIREME, SciELO, ScienceDirect, Cochrane Library and Scopus databases, through the keywords “depression”, “risk factors” and “diabetes mellitus” in DeCS/MeSH, and “depressive cognition scale”, which were combined using the Boolean operator “AND”. The statistical analysis used the Bioestat 5.0 and Review Manager 5.3 programs. Results: With regard to the results, 26,292 publications were identified; however, after submitting them to the criteria and to the reviewers’ analyses, only 12 studies remained. Sensitivity and specificity were found higher than 78%, which is statistically significant. The test accuracy represented 0.79, thus it confirmed the applicability of the instrument. The combined Odds Ratio value presented a result of 6.3 CI (5.7 – 7.1). This fact shows the great association between diabetes and depression and the importance of the Depressive Cognition Scale in patients with diabetes mellitus. The p-value obtained (<0.0001) seemed to be statistically significant for the analyzed data. Limitations: Scarcity of studies assessing the Depression Cognitive Scale about diabetes mellitus. Conclusions: The Depressive Cognition Scale presents statistically significant sensitivity, specificity, and accuracy. This scale is a reliable and applicable tool for screening and identification of depression risk factors in diabetic patients.

ABSTRACT Background: Stomach cancer is known as gastric cancer. Knowing any disease risk factors is an important task which is varied from country to country. In this study, we aim to find out all possible preoperative significant risk factors for stomach cancer and increase awareness among the people of Bangladesh. Methodology: Personal interview methods have been applied and the same questionnaire is maintained to collect Case and Control Group Data. The total number of sample size is 300 (Case = 150 and Control = 150). Case group people’s data are collected from the National Institute of Cancer Research and Hospital (NICRH) Bangladesh and Control groups data are collected from outside of the hospital. The entire analysis took place by frequency distribution with P-value and finally doing binary logistic regression modeling by odds ratio. Results: After analyzing 300 subjects’ records with 26 risk factors, we have received 21 statistically significant (P< 0.05) risk factors where “Skin Color Turn into Pale” including (P<0.001, OR =139.462), and “Abdominal Pain” are the first and second most pre-operative risk factors of stomach cancer including (P<0.001, OR = 66.769). Besides, we have found other significant high-risk factors like “Age”, “BMI”, “Education Level”, “Get Ill Too Much (frequently affected by the disease)”, “Working Status”, “Monthly Income”, “Family Member”, “Blood Group”, “Daily Food Intime”, “Take Spicy and Salted Food”, “Menetrier Disease”, “Previous Stomach Surgery” and so on. Conclusion The investigated outcomes of this study will help to increase awareness among the people of Bangladesh as well as the rest of the world.

To P or not to P: A P-value Comic.

Background: Pregnancy with the help of a third party, including the use of sperm, oocyte, embryo, and uterus, can be considered as an option for some infertile couples. Due to the important role of health professionals in infertility treatments, their attitudes are of particular importance in the acceptance or rejection of fertility suggestions involving the help of a third party. This study aimed to determine the attitudes of medical students at medical universities in Tehran toward third-party reproduction. Methods: This descriptive cross-sectional study was carried out at the Medical University of Tehran in 2018. Medical students (n=187) filled out the questionnaire, which consisted of two parts: the demographic characteristics of the research subjects and the questionnaire consisted of 76 questions about attitudes toward third-party reproduction. The content and face validity of the questionnaire were determined, and test-retest reliability of the questionnaire was established (0.89). Results: According to gender, participants’ attitudes toward childbearing, the importance of genetic dependency between parents and children, law issues, anonymity in donation programs, parental affection, the importance of the recipient's and donor's characteristics, surrogacy, gamete, and embryo donation were all statistically non-significant (Pvalue>0.05). According to age and also to year of entering the university, participants’ attitude only toward childbearing was statistically significant (Pvalue= 0.018 and 0.01, respectively). Conclusion: Since medical school students may set on the road to a specialty associated with infertility and its ramifications, it’s better to educate our soon-to-be health system professionals on all necessary aspects of infertility and third-party reproduction. Key Words: Attitude; Donor Conception; Infertility; Medical Students; Assisted Reproductive Technique.