Synergistic reductive dechlorination and oxidative mineralization of chlorinated organic compounds in a UV-anaerobic Fenton system: UV-driven Fe(II)/Fe(III) cycling and continuous radical generation.

Effect of the non-covalent complex of anthocyanins and whey protein on fish oil emulsions: Evaluation of stability, antioxidant properties, and bioaccessibility.

Ice-temperature storage suppresses starch retrogradation and enhances shelf life of slippery pork: mechanistic insights and kinetic Modeling.

Synergistic effects of metal pollution and habitat degradation from artisanal gold mining drive species-specific oxidative stress and biodiversity loss in a semi-arid river catchment.

Synergistic staggered heterojunction and surface plasmon resonance in P-doped Fe3O4/Zn3V2O7(OH)2.2H2O/Ag for enhanced photocatalytic degradation of ketoprofen.

Sustainable remediation of tetracycline-contaminated soil: A Fe-g-C3N4 nanozyme driven abiotic-biotic strategy.

Biochar-immobilized microorganisms drive removal and transformation of polycyclic aromatic hydrocarbons and their derivatives in soil: Efficiency and microbial succession dynamics.

Extracellular reactive oxygen species generated by LAB-yeast consortium: A sustainable strategy for degrading extracellular antibiotic resistance genes in water.

Simultaneous Sulfur Black 1 dye removal and Na2S recovery via a sulfur-circular process: Advancing closed-loop textile wastewater treatment.

Assessment of oxidative behaviour in polyunsaturated fatty acid-rich oils using spectroscopic techniques and multivariate analysis.

Two-dimensional (2D) materials, including graphene and MXenes, have garnered significant interest for enhancing both the mechanical and multifunctional properties of advanced structural ceramics. These materials encounter operational limitations under high temperatures, particularly due to oxidative degradation of 2D reinforcement architectures that induces composition instability and property deterioration. In this study, we developed a processing methodology for fabricating 2D Al2O3 platelet-reinforced yttria-stabilized zirconia (YSZ) composites, which can be stable up to 1300 oC in an atmosphere. Through a multi-field coupling strategy combining gravitational field modulation, high-intensity vibrational alignment, and controlled pressure densification, we achieved densified composites with parallel-aligned Al2O3 platelet array in YSZ matrix.‌ The composite demonstrates reduced near-infrared (NIR) transmittance below 10%, effectively blocking radiative thermal transfer. Meanwhile, The YSZ-Al2O3 platelet composite (YSZ-Al2O3-PL) simultaneously demonstrates enhanced resistance to CaO-MgO-AlO1.5-SiO2 (CMAS) molten salts and improved fracture toughness. The cost-effective 2D oxide/ceramic composites possess exceptional thermo-mechanical stability, promising for harsh environments.

Per- and polyfluoroalkyl substances, commonly referred to as ″forever chemicals″ due to their robust C-F bonds, remain persistent in aquatic environments and resist conventional remediation efforts. This review critically examines current treatment strategies, such as adsorption, membrane filtration, advanced oxidation, reduction, and thermal degradation, highlighting their limitations in terms of energy efficiency, selectivity, and byproduct management. The discussion then focuses on MXenes, a class of two-dimensional transition metal carbides/nitrides known for their high surface area and tunable surface terminations (-OH, -O, -F). Despite their promise, MXenes face challenges, such as aqueous instability and limited reusability. A systematic evaluation is provided on how surface functionalization, through amination, carboxylation, and surfactant modification, enhances PFAS adsorption, particularly for difficult-to-remove short-chain variants. Integration with covalent organic frameworks, metal-organic frameworks, and metal oxides boosts catalytic degradation under ambient conditions. Importantly, this review introduces two innovative strategies: (1) a MXene-microbial fuel cell hybrid that enables in situ regeneration and bioelectrochemical degradation of PFAS and (2) a chemically staged MXene surface with spatially distinct domains that promote sequential PFBS fragmentation without external reagents. These approaches offer scalable, low-energy alternatives that address the critical shortcomings of conventional methods. By tackling persistent issues such as short-chain PFAS degradation, byproduct toxicity, and material recyclability, this review positions MXenes as a multifunctional platform integrating adsorption and catalysis. Our findings pave the way for scalable, next-generation MXene-based materials tailored for sustainable PFAS remediation.

Citral, a natural monoterpene aldehyde, is used in fragrances, food, and pharmaceuticals. However, its high hydrophobicity, volatility, and sensitivity to oxidative degradation limit its applications. This study aims to address these challenges by developing novel citral derivatives with antibacterial and drug resistance reversal properties. Citral was used as a primary synthon for the synthesis of chalcone-like derivatives (C-1 - C-6) via aldol condensation, and imine derivatives were obtained by condensing citral with hydrazine (C-7), heptyl amine (C-8), glycine ethyl ester (C-9), and 4-amino piperidine (C-10). Citral showed MICs of 500 and 1000 μg/mL against a sensitive strain of Staphylococcus aureus (MTCC-96) and a methicillin-resistant S. aureus (MRSA) clinical isolate, respectively. Compared with the parent compound citral, its derivatives C-6, C-8, and C-10 showed 8-fold greater antibacterial activity against the MRSA clinical isolate. In fixed-dose combinatorial studies, at a 10 μg/mL concentration of the derivatives, the MIC of ethidium bromide (EtBr, MIC 7.81 μg/mL) was reduced up to fourfold. The derivatives showed favorable physicochemical and ADMET profiles in in silico predictions and docked well with the efflux pump proteins NorA, NorB, and MepA, as well as the biofilm targets IcaA, IcaB, and IcaC. The binding affinities of C-4, C-8, and C-10 for biofilm protein icaC were further verified through 200 ns molecular dynamics simulations. Overall, C-8 and C-10 may be useful for developing safe and cost-effective treatments for S. aureus infections.

Ocular fundus neovascularization (OFN) is a leading cause of irreversible vision loss. Conventional antivascular endothelial growth factor (anti-VEGF) therapies indiscriminately suppress pathological and reparative angiogenesis and fail to correct the senescence- and inflammation-driven microenvironment that sustains disease progression. Senescent endothelial cells (ECs) form the structural scaffold of pathological vessels, while neighboring senescent microglia exacerbate inflammatory signaling, together deteriorating the reactive oxygen species (ROS)-rich vascular-immune microenvironment. Here, we develop an injectable ROS-responsive senolytic hydrogel (PCC1/PHCF-Gel) that enables lesion-activated, sustained intraocular release of procyanidin C1 (PCC1), overcoming rapid clearance, oxidative degradation, and poor lesion retention associated with free PCC1. In oxygen-induced retinopathy and choroidal neovascularization models, PCC1/PHCF-Gel markedly reduces retinal senescence, suppresses pathological neovascularization, and restores neuroretinal function, outperforming symptom-directed therapies anti-VEGF therapy. Single-cell RNA sequencing reveals selective elimination of two pathogenic senescent cell subpopulations-CXCR4+ ECs and IFITM3+ microglia-thereby disrupting the reinforcing cycle of vascular and immune senescence and promoting reparative vascular regeneration. These findings establish a multifunctional, spatiotemporally controlled therapeutic paradigm and highlight PCC1/PHCF-Gel as a promising translational strategy for the precision treatment of OFN.

The full-component utilization of lignocellulosic biomass under mild conditions remains a formidable challenge for both biocatalytic systems and industrial processes. Herein, we report a Lewis pair engineering strategy to construct a defective Cu-doped Mn oxide nanozyme (D-CuMnOx) featuring the simultaneous introduction of manganese and oxygen vacancies. The resulting undercoordinated Mn sites act as Lewis acids to activate glycosidic bonds, while adjacent oxygen species serve as Lewis bases to promote nucleophilic attack and electron transfer, thereby collectively lowering the energy barriers for both hydrolytic and oxidative reactions. As a consequence, D-CuMnOx exhibits an approximately fourfold enhancement in glycosidase activity and markedly improved cold-adapted performance compared with oxygen-vacancy-only CuMnOx, while simultaneously maintaining robust oxidase-like activity. Benefiting from these advantages, D-CuMnOx serves as a cooperative hydrolytic-oxidative platform that enables the depolymerization of cellulose and hemicellulose alongside the oxidative cleavage of lignin, thereby achieving simultaneous degradation of the major components in raw corn stalks under mild and low-temperature conditions. This work establishes Lewis pair engineering as a versatile strategy for the rational design of multifunctional cold-adapted nanozymes and highlights their considerable potential for sustainable biomass valorization.

Infected wound repair remains a global healthcare challenge, primarily due to bacterial infection and a pathological microenvironment characterized by elevated glucose levels and oxidative stress. In this work, a quaternized carboxymethyl chitosan (QCMCS)/oxidized sodium alginate (OSA)/tannic acid (TA)/sodium tetraborate (STB) hydrogel was developed for controlled TA release and diabetic wound repair. The QCMCS/OSA/TA/STB hydrogel exhibited potent antibacterial activity, with inhibition rates exceeding 99% against S. aureus and MRSA and 86% against E. coli, arising from the synergistic action of QCMCS and TA. Meanwhile, the introduction of TA enhanced antioxidant performance (radical scavenging rates of 66.72% and 93.16% against DPPH and ABTS, respectively), and STB reinforced mechanical strength with a compressive resistance of 140.78 kPa through a dual cross-linking network. In vitro biocompatibility evaluations demonstrated that the hemolysis ratios of all hydrogels were below 5%, and the survival rate of Human umbilical vein endothelial cells (HUVECs) was over 93%. Reversible borate ester linkages between STB and the catechol groups of TA protect TA from oxidative degradation and allow stimulus-responsive release under elevated glucose and oxidative conditions. This responsive hydrogel represents a promising multifunctional platform for diabetic wound management.

Enhancing the interfacial stability between layered oxide cathodes (LOCs) and the electrolyte is considered to be pivotal for sodium-ion batteries (SIBs). However, the critical challenges of electrolyte oxidation and cathode degradation driven by the interfacial electric field remain unsolved, particularly under high-voltage and high-temperature conditions. Herein, we harness the interfacial electric field to precisely steer the species adsorption and solvation structure configuration of the Helmholtz plane (HP) through the steric exclusion effects of cations and the competitive coordination of multiple anions, thereby tailoring the interfacial chemistry of LOCs. Under electric field activation, the synergistic effect of ionic-molecular adsorption and coordination facilitates the formation of a robust inorganic-rich cathode electrolyte interphase, equipped with a uniform thickness and low energy barrier for smooth Na+ diffusion. These endow the O3-NaNi1/3Fe1/3Mn1/3O2 cathode with an enhanced capacity retention of 73.5% after 250 cycles under extreme operating conditions of 4.5 V and 60 °C. Furthermore, the viability of HP engineering is proven in practical Ah-level pouch cells, showcasing 79.5% capacity retention after 80 cycles at 4.3 V and 60 °C. This work underscores the relevance of HP regulation and interfacial chemistry manipulated by the electric field, providing valuable insights into electrolyte engineering for SIBs.

Abstract The long-term durability of natural rubber (NR) in demanding applications depends critically on the stability and evolution of its sulfur crosslinked network, as thermo-oxidative aging alters both the polymer backbone and the crosslink structure. Post-curing treatments—often referred to as maturation—can reshape the sulfur network architecture and, in turn, influence resistance to degradation. While some studies have considered how the topology of the initial sulfur crosslink network affects aging, the specific effects of maturation remain underexplored. To address this gap, this study examines the impact of maturation on the aging behavior of NR vulcanizates cured to t’95 at 180 °C. The evolution of the elastically active chain (EAC) density and mechanical properties was tracked using equilibrium swelling experiments and tensile testing under both thermal and thermo-oxidative conditions.Findings show that post-curing enhances crosslink density, reduces network defects, and delays the onset of oxidative degradation. In contrast, unmatured samples exhibit an initial crosslinking phase, driven by residual curatives and oxygen, followed by accelerated degradation. Ultimately, both systems converge to similar EAC densities, underscoring the overriding influence of oxidative degradation on long-term material performance.

Addressing the intertwined challenges of sustainable wastewater remediation and the development of efficient heterogeneous photocatalysts for visible-light applications remains a pivotal objective in environmental nanotechnology. This study presents the rational design and development of oxygen-vacancy-engineered Cd1-x Ag x O1-y nanostructures as next-generation visible-light-active photocatalysts for environmental remediation. The incorporation of Ag dopants in a CdO matrix not only modulates the lattice architecture but also promotes the formation of electronically active oxygen vacancies, thereby enhancing the material's optoelectronic properties. Detailed structural and spectroscopic investigations confirm that 3 wt % Ag doping induces lattice strain, narrows the bandgap, and introduces midgap states conducive to visible-light absorption and prolonged charge carrier lifetimes. These tailored features culminate in superior photocatalytic degradation of Amido Black 10B dye, achieving 91% removal within 24 min under 450 nm LED illumination, adhering to zero-order kinetics and yielding a high apparent quantum yield of 27.5%. Mechanistic insights derived from scavenger assays and ESR spectroscopy reveal that superoxide radicals (O2 •-) are the principal reactive species driving oxidative degradation. Electrochemical analyses, including Mott-Schottky profiling and impedance spectroscopy, further substantiate the enhanced charge separation, elevated carrier density, and favorable energy band alignment induced by Ag doping and oxygen vacancy generation. The photocatalyst exhibits robust operational durability over five cycles without structural compromise or significant metal leaching. Phytotoxicity evaluation via chickpea (Cicer arietinum L.) germination assays confirms the nontoxic nature of the treated effluent, underscoring its environmental compatibility. Collectively, this work advances Cd1-x Ag x O1-y as a high-efficiency, defect-engineered photocatalyst with significant promise for sustainable, real-world wastewater remediation under ambient visible-light conditions.

PrC-210 is a direct-acting reactive oxygen species (ROS) scavenger. It is active when administered orally, IV, or subcutaneously. Its profound efficacy in preclinical models makes it a candidate to prevent human ROS-induced i) ionizing radiation toxicities, ii) neurodegenerative disease, and iii) organ ischemia-reperfusion injuries. A simple, highly sensitive, specific LC-MS/MS method was developed to measure the PrC-210 molecule in mouse plasma and tissue homogenates. To prevent oxidative degradation or disulfide formation of the PrC-210 thiol form, its free sulfhydryl group was protected by derivatization with N-ethylmaleimide (NEM), which produced the stable, quantifiable, PrC-210-NEM thioether conjugate. The PrC-210-NEM conjugate, and acyclovir used as an internal standard, were extracted from plasma or tissue homogenate with acetonitrile/0.1% formic acid. The reconstituted dried extracts were chromatographed and then monitored using a triple quadrupole spectrometer operating in the positive ion spray ionization mode. The method was validated over the concentration range of 7.5 nM-5000 nM. Inter- and intra-assay precision and accuracy of PrC-210-NEM quantitation were better than 10%. The limit of PrC-210-NEM quantitation was 2.5 nM. The method was applied to measure plasma and tissue homogenate concentrations of PrC-210 in over 126 mice administered either oral, itraperitoneal, or subcutaneous PrC-210 doses.