Artificial intelligence and big data, as emerging technologies that have attracted much attention in recent years, have broad application and development space in improving the development of intelligent and refined education in colleges and universities. The application of artificial intelligence and big data to the mental health education practice of college students has a very positive effect on accurately discovering and scientifically solving the mental health problems of college students. In order to combine big data and cloud computing platform organically, this paper introduces an intelligent algorithm based on multi-output support vector regression (MSVR) model and immune clone selection algorithm (ICSA). At the same time, we couple the two to obtain a new intelligent algorithm, namely, immune multiple output support vector regression (ICSA-MSVR) algorithm. Based on the prediction results of health education on students' knowledge and behavior by cloud computing platform, the necessary conditions for three intelligent algorithms to complete the task are summarized. Numerical experimental results show that ICSA-MSVR plays a role in both local search and global search, and is more effective in large-scale cloud computing task scheduling. In addition, in task scheduling, when the task completion time is short, ICSA-MSVR has a lower load imbalance than ICSA and MSVR, which can achieve better load balancing, and the load between virtual machines is closer. Finally, combined with the problems and the needs of students’ health education, suggestions are put forward to deepen the application of technology in students’ mental health education. This approach can provide corresponding ideas and reference methods for improving the scientificity, pertinence, and effectiveness of mental health education.
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