The uncertainty of the amount of construction and demolition waste (CDW) generation affects the CDW reverse logistics network service level. We investigate a CDW reverse logistics network location-routing problem considering uncertainties. To minimize the total social cost, a two-stage risk-averse distributionally robust optimization model is developed, which aims to optimize the location and number of CDW disposal facilities and the CDW transportation scheme. We introduce the mean-conditional value at risk measure and a joint chance constraint into our model to consider the government’s risk aversion. The above model is approximated as a standard second-order cone programming model (SOCP) considering a special case. To exactly solve the SOCP, we design an outer approximation algorithm. Several performance tests and a case study are proposed, and sensitivity analysis provides helpful managerial insights.